E9Q3E3 (E9Q3E3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glycine receptor subunit beta Ensembl ENSMUSP00000103372

Gene names

Name:

Glrb Ensembl ENSMUSP00000103372 MGI 95751

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000103372

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification] RuleBase RU000687
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000103372

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS006202
Molecular function	Ion channel RuleBase RU000687
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acrosome reaction Inferred from mutant phenotype PubMed 11076688. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 4323808. Source: MGI neuromuscular process Inferred from mutant phenotype PubMed 10651857PubMed 8635460PubMed 9087981. Source: MGI regulation of membrane potential Inferred from mutant phenotype PubMed 16672662. Source: MGI righting reflex Inferred from mutant phenotype PubMed 6285205. Source: MGI synaptic transmission, glycinergic Inferred from mutant phenotype PubMed 12809985PubMed 1338094PubMed 16672662. Source: MGI visual perception Inferred from mutant phenotype PubMed 1338094. Source: MGI
Cellular_component	endoplasmic reticulum Inferred from sequence alignment PubMed 17145751. Source: MGI external side of plasma membrane Inferred from sequence alignment PubMed 17145751. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	extracellular-glycine-gated chloride channel activity Inferred from mutant phenotype PubMed 12809985PubMed 16672662. Source: MGI glycine binding Inferred from mutant phenotype PubMed 2983837PubMed 6285205. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9Q3E3 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 51EE9D4B1FBA88A3	FASTA	307	35,307
	10 20 30 40 50 60 MKFSLAISFF ILMSLLFEDA CAKEKSSKKG KGKKKQYLCP SQQSPEDLAR VPPNSTSNIL 70 80 90 100 110 120 NRLLVSYDPR IRPNFKGIPV DVVVNIFINS FGSIQETTMD YRVNIFLRQK WNDPRLKLPS 130 140 150 160 170 180 DFRGSDALTV DPTMYKCLWK PDLFFANEKS ANFHDVTQEN ILLFIFRDGD VLVSMRLSIT 190 200 210 220 230 240 LSCPLDLTLF PMDTQRCKMQ LESFGYTTDD LRFIWQSGDP VQLEKIALPQ FDIKKEDIEY 250 260 270 280 290 300 GNCTKYYKGT GYYTCVEVIF TLRRQVGFYM MGVYAPTLLI VVLSWLSFWI NPDASAARVP LGKLPCF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000103372.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000103372.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC121908 Genomic DNA. No translation available.
IPI	IPI00856938.
3D structure databases
ProteinModelPortal	E9Q3E3.
SMR	E9Q3E3. Positions 55-302.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000107743; ENSMUSP00000103372; ENSMUSG00000028020.
Organism-specific databases
MGI	MGI:95751. Glrb.
Phylogenomic databases
GeneTree	ENSGT00550000074453.
Gene expression databases
ArrayExpress	E9Q3E3.
Bgee	E9Q3E3.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR008060. Glycine_rcpt_B. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit. PTHR18945:SF29. PTHR18945:SF29. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR01677. GLYRBETA. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35554978.
SOURCE	Search...

Entry information

Entry name

E9Q3E3_MOUSE

Accession

Primary (citable) accession number: E9Q3E3

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)