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Protein

WD repeat-containing protein 25

Gene

Wdr25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 25
Gene namesi
Name:Wdr25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:3045255. Wdr25.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535WD repeat-containing protein 25PRO_0000415827Add
BLAST

Proteomic databases

PaxDbiE9Q349.
PeptideAtlasiE9Q349.
PRIDEiE9Q349.

PTM databases

iPTMnetiE9Q349.

Expressioni

Gene expression databases

BgeeiE9Q349.
GenevisibleiE9Q349. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035553.

Structurei

3D structure databases

ProteinModelPortaliE9Q349.
SMRiE9Q349. Positions 231-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati235 – 27743WD 1Add
BLAST
Repeati281 – 32040WD 2Add
BLAST
Repeati321 – 36242WD 3Add
BLAST
Repeati365 – 41147WD 4Add
BLAST
Repeati415 – 45440WD 5Add
BLAST
Repeati460 – 50142WD 6Add
BLAST
Repeati504 – 53532WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQTX. Eukaryota.
ENOG410XQV4. LUCA.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000007841.
HOVERGENiHBG069845.
InParanoidiE9Q349.
OMAiYSVGCEC.
OrthoDBiEOG79W96M.
TreeFamiTF329325.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: E9Q349-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLVAYDDS DSETEADPAR SGDAAGQISD ASGMSRPSGM GFASSTVGVT
60 70 80 90 100
KEGAQHTGNS PNEDPGMQRL PLARLWRSDP GSCPSQRLQW PSKEPDTTFP
110 120 130 140 150
PSEPPRPSLW MSRAPVGHVP LAAACLKPLK PAWDVLKPSH DQSTFESTAG
160 170 180 190 200
NASSSQRKRG EDCVLPYIPK RLRQLQALNP EAGGGKDGEP PGPPAGCAPA
210 220 230 240 250
PLCVAPTVSE FIQPYLNSQY RETTVPKKVL FHLRGHRGPV NSIQWCPVFC
260 270 280 290 300
KSHMLLSASM DKTFKVWNAV DSGHCLQTYS VHSEAVRAAR WSPCGRRILS
310 320 330 340 350
GGFDFALHLT DLETGTQVFS GQSDFRVTTL KFHPKDHNVF LCGGFSSEIK
360 370 380 390 400
AWDMRTGKVV KGYKATIQQT LDILFLQEGS EFLSSTDAST RDSADRTIIA
410 420 430 440 450
WDFRTAAKIS NQIFHERYTC PSLALHPREP VFLAQTNGNY LALFSSVWPY
460 470 480 490 500
RMSRRRRYEG HKVEGYAVGC ECSPCGDLLV TGSADGRVLM FSFRTASRAC
510 520 530
TLQGHTQACL GTTYHPVLPS VLGTCSWGGD IKIWH
Note: No experimental confirmation available.
Length:535
Mass (Da):58,480
Last modified:April 5, 2011 - v1
Checksum:i3DB21C99DDB29B1A
GO
Isoform 2 (identifier: E9Q349-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-352: Missing.
     353-357: DMRTG → MSEIY

Show »
Length:183
Mass (Da):20,467
Checksum:i0ABA1DA879513C2E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 352352Missing in isoform 2. 1 PublicationVSP_042397Add
BLAST
Alternative sequencei353 – 3575DMRTG → MSEIY in isoform 2. 1 PublicationVSP_042398

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081117 mRNA. Translation: BAC38138.1.
AC122811 Genomic DNA. No translation available.
AC140111 Genomic DNA. No translation available.
CCDSiCCDS49172.1. [E9Q349-1]
RefSeqiNP_808270.2. NM_177602.3. [E9Q349-1]
XP_006515720.1. XM_006515657.2. [E9Q349-1]
XP_006515721.1. XM_006515658.2. [E9Q349-1]
XP_006515723.1. XM_006515660.2. [E9Q349-1]
XP_011242356.1. XM_011244054.1. [E9Q349-1]
XP_011242357.1. XM_011244055.1. [E9Q349-1]
UniGeneiMm.342082.
Mm.450850.

Genome annotation databases

EnsembliENSMUST00000047115; ENSMUSP00000035553; ENSMUSG00000040877. [E9Q349-1]
ENSMUST00000167816; ENSMUSP00000129855; ENSMUSG00000040877. [E9Q349-1]
GeneIDi212198.
KEGGimmu:212198.
UCSCiuc011yrx.1. mouse. [E9Q349-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081117 mRNA. Translation: BAC38138.1.
AC122811 Genomic DNA. No translation available.
AC140111 Genomic DNA. No translation available.
CCDSiCCDS49172.1. [E9Q349-1]
RefSeqiNP_808270.2. NM_177602.3. [E9Q349-1]
XP_006515720.1. XM_006515657.2. [E9Q349-1]
XP_006515721.1. XM_006515658.2. [E9Q349-1]
XP_006515723.1. XM_006515660.2. [E9Q349-1]
XP_011242356.1. XM_011244054.1. [E9Q349-1]
XP_011242357.1. XM_011244055.1. [E9Q349-1]
UniGeneiMm.342082.
Mm.450850.

3D structure databases

ProteinModelPortaliE9Q349.
SMRiE9Q349. Positions 231-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035553.

PTM databases

iPTMnetiE9Q349.

Proteomic databases

PaxDbiE9Q349.
PeptideAtlasiE9Q349.
PRIDEiE9Q349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047115; ENSMUSP00000035553; ENSMUSG00000040877. [E9Q349-1]
ENSMUST00000167816; ENSMUSP00000129855; ENSMUSG00000040877. [E9Q349-1]
GeneIDi212198.
KEGGimmu:212198.
UCSCiuc011yrx.1. mouse. [E9Q349-1]

Organism-specific databases

CTDi79446.
MGIiMGI:3045255. Wdr25.

Phylogenomic databases

eggNOGiENOG410IQTX. Eukaryota.
ENOG410XQV4. LUCA.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000007841.
HOVERGENiHBG069845.
InParanoidiE9Q349.
OMAiYSVGCEC.
OrthoDBiEOG79W96M.
TreeFamiTF329325.

Miscellaneous databases

ChiTaRSiWdr25. mouse.
PROiE9Q349.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q349.
GenevisibleiE9Q349. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiWDR25_MOUSE
AccessioniPrimary (citable) accession number: E9Q349
Secondary accession number(s): Q8C4T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.