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Protein

WD repeat-containing protein 25

Gene

Wdr25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 25
Gene namesi
Name:Wdr25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:3045255. Wdr25.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158271 – 535WD repeat-containing protein 25Add BLAST535

Proteomic databases

PaxDbiE9Q349.
PeptideAtlasiE9Q349.
PRIDEiE9Q349.

PTM databases

iPTMnetiE9Q349.
PhosphoSitePlusiE9Q349.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040877.
GenevisibleiE9Q349. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035553.

Structurei

3D structure databases

ProteinModelPortaliE9Q349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati235 – 277WD 1Add BLAST43
Repeati281 – 320WD 2Add BLAST40
Repeati321 – 362WD 3Add BLAST42
Repeati365 – 411WD 4Add BLAST47
Repeati415 – 454WD 5Add BLAST40
Repeati460 – 501WD 6Add BLAST42
Repeati504 – 535WD 7Add BLAST32

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQTX. Eukaryota.
ENOG410XQV4. LUCA.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000007841.
HOVERGENiHBG069845.
InParanoidiE9Q349.
OMAiWNAVDSG.
OrthoDBiEOG091G0DDH.
TreeFamiTF329325.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: E9Q349-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLVAYDDS DSETEADPAR SGDAAGQISD ASGMSRPSGM GFASSTVGVT
60 70 80 90 100
KEGAQHTGNS PNEDPGMQRL PLARLWRSDP GSCPSQRLQW PSKEPDTTFP
110 120 130 140 150
PSEPPRPSLW MSRAPVGHVP LAAACLKPLK PAWDVLKPSH DQSTFESTAG
160 170 180 190 200
NASSSQRKRG EDCVLPYIPK RLRQLQALNP EAGGGKDGEP PGPPAGCAPA
210 220 230 240 250
PLCVAPTVSE FIQPYLNSQY RETTVPKKVL FHLRGHRGPV NSIQWCPVFC
260 270 280 290 300
KSHMLLSASM DKTFKVWNAV DSGHCLQTYS VHSEAVRAAR WSPCGRRILS
310 320 330 340 350
GGFDFALHLT DLETGTQVFS GQSDFRVTTL KFHPKDHNVF LCGGFSSEIK
360 370 380 390 400
AWDMRTGKVV KGYKATIQQT LDILFLQEGS EFLSSTDAST RDSADRTIIA
410 420 430 440 450
WDFRTAAKIS NQIFHERYTC PSLALHPREP VFLAQTNGNY LALFSSVWPY
460 470 480 490 500
RMSRRRRYEG HKVEGYAVGC ECSPCGDLLV TGSADGRVLM FSFRTASRAC
510 520 530
TLQGHTQACL GTTYHPVLPS VLGTCSWGGD IKIWH
Note: No experimental confirmation available.
Length:535
Mass (Da):58,480
Last modified:April 5, 2011 - v1
Checksum:i3DB21C99DDB29B1A
GO
Isoform 2 (identifier: E9Q349-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-352: Missing.
     353-357: DMRTG → MSEIY

Show »
Length:183
Mass (Da):20,467
Checksum:i0ABA1DA879513C2E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0423971 – 352Missing in isoform 2. 1 PublicationAdd BLAST352
Alternative sequenceiVSP_042398353 – 357DMRTG → MSEIY in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081117 mRNA. Translation: BAC38138.1.
AC122811 Genomic DNA. No translation available.
AC140111 Genomic DNA. No translation available.
CCDSiCCDS49172.1. [E9Q349-1]
RefSeqiNP_808270.2. NM_177602.3. [E9Q349-1]
XP_006515720.1. XM_006515657.2. [E9Q349-1]
XP_006515721.1. XM_006515658.3. [E9Q349-1]
XP_006515723.1. XM_006515660.3. [E9Q349-1]
XP_011242356.1. XM_011244054.2. [E9Q349-1]
XP_011242357.1. XM_011244055.2. [E9Q349-1]
UniGeneiMm.342082.
Mm.450850.

Genome annotation databases

EnsembliENSMUST00000047115; ENSMUSP00000035553; ENSMUSG00000040877. [E9Q349-1]
ENSMUST00000167816; ENSMUSP00000129855; ENSMUSG00000040877. [E9Q349-1]
GeneIDi212198.
KEGGimmu:212198.
UCSCiuc011yrx.1. mouse. [E9Q349-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081117 mRNA. Translation: BAC38138.1.
AC122811 Genomic DNA. No translation available.
AC140111 Genomic DNA. No translation available.
CCDSiCCDS49172.1. [E9Q349-1]
RefSeqiNP_808270.2. NM_177602.3. [E9Q349-1]
XP_006515720.1. XM_006515657.2. [E9Q349-1]
XP_006515721.1. XM_006515658.3. [E9Q349-1]
XP_006515723.1. XM_006515660.3. [E9Q349-1]
XP_011242356.1. XM_011244054.2. [E9Q349-1]
XP_011242357.1. XM_011244055.2. [E9Q349-1]
UniGeneiMm.342082.
Mm.450850.

3D structure databases

ProteinModelPortaliE9Q349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035553.

PTM databases

iPTMnetiE9Q349.
PhosphoSitePlusiE9Q349.

Proteomic databases

PaxDbiE9Q349.
PeptideAtlasiE9Q349.
PRIDEiE9Q349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047115; ENSMUSP00000035553; ENSMUSG00000040877. [E9Q349-1]
ENSMUST00000167816; ENSMUSP00000129855; ENSMUSG00000040877. [E9Q349-1]
GeneIDi212198.
KEGGimmu:212198.
UCSCiuc011yrx.1. mouse. [E9Q349-1]

Organism-specific databases

CTDi79446.
MGIiMGI:3045255. Wdr25.

Phylogenomic databases

eggNOGiENOG410IQTX. Eukaryota.
ENOG410XQV4. LUCA.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000007841.
HOVERGENiHBG069845.
InParanoidiE9Q349.
OMAiWNAVDSG.
OrthoDBiEOG091G0DDH.
TreeFamiTF329325.

Miscellaneous databases

ChiTaRSiWdr25. mouse.
PROiE9Q349.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040877.
GenevisibleiE9Q349. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR25_MOUSE
AccessioniPrimary (citable) accession number: E9Q349
Secondary accession number(s): Q8C4T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.