ID   E9Q310_MOUSE            Unreviewed;       488 AA.
AC   E9Q310;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   RecName: Full=Glucocorticoid receptor {ECO:0000256|ARBA:ARBA00015625};
DE   AltName: Full=Nuclear receptor subfamily 3 group C member 1 {ECO:0000256|ARBA:ARBA00031162};
DE   Flags: Fragment;
GN   Name=Nr3c1 {ECO:0000313|Ensembl:ENSMUSP00000120082.2,
GN   ECO:0000313|MGI:MGI:95824};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000120082.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000120082.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120082.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0007829|PubMed:24129315}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24129315;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000120082.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120082.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Mitochondrion
CC       {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000256|ARBA:ARBA00005413}.
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DR   AlphaFoldDB; E9Q310; -.
DR   SMR; E9Q310; -.
DR   jPOST; E9Q310; -.
DR   MaxQB; E9Q310; -.
DR   PeptideAtlas; E9Q310; -.
DR   ProteomicsDB; 347560; -.
DR   Antibodypedia; 1329; 1586 antibodies from 44 providers.
DR   Ensembl; ENSMUST00000152853.2; ENSMUSP00000120082.2; ENSMUSG00000024431.16.
DR   UCSC; uc008eta.1; mouse.
DR   AGR; MGI:95824; -.
DR   MGI; MGI:95824; Nr3c1.
DR   VEuPathDB; HostDB:ENSMUSG00000024431; -.
DR   GeneTree; ENSGT00940000156385; -.
DR   HOGENOM; CLU_604904_0_0_1; -.
DR   OMA; GLYMGDT; -.
DR   ChiTaRS; Nr3c1; mouse.
DR   Proteomes; UP000000589; Chromosome 18.
DR   Bgee; ENSMUSG00000024431; Expressed in median eminence of neurohypophysis and 273 other cell types or tissues.
DR   ExpressionAtlas; E9Q310; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0004883; F:nuclear glucocorticoid receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   CDD; cd07172; NR_DBD_GR_PR; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   InterPro; IPR001409; Glcrtcd_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR48092:SF5; GLUCOCORTICOID RECEPTOR; 1.
DR   PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR   Pfam; PF02155; GCR; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00528; GLCORTICOIDR.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteomics identification {ECO:0007829|EPD:E9Q310,
KW   ECO:0007829|MaxQB:E9Q310}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          434..488
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         488
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000120082.2"
SQ   SEQUENCE   488 AA;  52374 MW;  F08D19E75B3C37D9 CRC64;
     MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA AASQADSKQQ
     RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV SLSMGLYMGE TETKVMGNDL
     GYPQQGQLGL SSGETDFRLL EESIANLNRS TSRPENPKSS TPAAGCATPT EKEFPQTHSD
     PSSEQQNRKS QPGTNGGSVK LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN
     LLSPLAGEDD PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF
     IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH YDMNTASLSQ
     QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF AGRSVFSNGY SSPGMRPDVS
     SPPSSSSTAT GPPPKLCLVC SDEASGCHYG VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC
     IIDKIRRK
//