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E9Q310

- E9Q310_MOUSE

UniProt

E9Q310 - E9Q310_MOUSE

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Protein
Submitted name: Glucocorticoid receptor
Gene
Nr3c1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. glucocorticoid receptor activity Source: MGI
  3. protein binding Source: MGI
  4. protein dimerization activity Source: MGI
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding transcription factor activity Source: InterPro
  7. steroid binding Source: InterPro
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. glucocorticoid metabolic process Source: MGI
  3. glucocorticoid receptor signaling pathway Source: MGI
  4. mammary gland duct morphogenesis Source: MGI
  5. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  6. positive regulation of neuron apoptotic process Source: MGI
  7. regulation of glucocorticoid biosynthetic process Source: MGI
  8. regulation of gluconeogenesis Source: MGI
  9. regulation of transcription, DNA-templated Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. intracellular Source: MGI
  4. membrane Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiE9Q310.
BgeeiE9Q310.

Structurei

3D structure databases

ProteinModelPortaliE9Q310.
SMRiE9Q310. Positions 436-488.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110451.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9Q310-1 [UniParc]FASTAAdd to Basket

« Hide

MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA    50
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV 100
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS 150
TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK 200
LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD 250
PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 300
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH 350
YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF 400
AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG 450
VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC IIDKIRRK 488
Length:488
Mass (Da):52,374
Last modified:April 5, 2011 - v1
Checksum:iF08D19E75B3C37D9
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei488 – 4881Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000152853; ENSMUSP00000120082; ENSMUSG00000024431.
UCSCiuc008eta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9Q310.
SMRi E9Q310. Positions 436-488.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000152853 ; ENSMUSP00000120082 ; ENSMUSG00000024431 .
UCSCi uc008eta.1. mouse.

Organism-specific databases

MGIi MGI:95824. Nr3c1.

Phylogenomic databases

GeneTreei ENSGT00730000110451.

Miscellaneous databases

ChiTaRSi NR3C1. mouse.
NextBioi 35554927.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9Q310.
Bgeei E9Q310.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
InterProi IPR001409. Glcrtcd_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF02155. GCR. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00528. GLCORTICOIDR.
PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q310_MOUSE
AccessioniPrimary (citable) accession number: E9Q310
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi