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Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity Source: MGI
  3. glucocorticoid receptor activity Source: MGI
  4. protein dimerization activity Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  7. sequence-specific DNA binding Source: MGI
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. steroid binding Source: MGI
  10. steroid hormone binding Source: MGI
  11. zinc ion binding Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. cellular response to steroid hormone stimulus Source: MGI
  3. glucocorticoid metabolic process Source: MGI
  4. glucocorticoid receptor signaling pathway Source: MGI
  5. mammary gland duct morphogenesis Source: MGI
  6. maternal behavior Source: MGI
  7. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  8. positive regulation of neuron apoptotic process Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. regulation of glucocorticoid biosynthetic process Source: MGI
  11. regulation of gluconeogenesis Source: MGI
  12. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. intracellular Source: MGI
  4. membrane Source: MGI
  5. nucleoplasm Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiE9Q310.
ExpressionAtlasiE9Q310. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q310.
SMRiE9Q310. Positions 436-488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9Q310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA
60 70 80 90 100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV
110 120 130 140 150
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS
160 170 180 190 200
TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK
210 220 230 240 250
LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD
260 270 280 290 300
PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF
310 320 330 340 350
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH
360 370 380 390 400
YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF
410 420 430 440 450
AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG
460 470 480
VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC IIDKIRRK
Length:488
Mass (Da):52,374
Last modified:April 5, 2011 - v1
Checksum:iF08D19E75B3C37D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei488 – 4881Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000152853; ENSMUSP00000120082; ENSMUSG00000024431.
UCSCiuc008eta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q310.
SMRiE9Q310. Positions 436-488.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000152853; ENSMUSP00000120082; ENSMUSG00000024431.
UCSCiuc008eta.1. mouse.

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiNr3c1. mouse.
NextBioi35554927.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q310.
ExpressionAtlasiE9Q310. baseline and differential.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q310_MOUSE
AccessioniPrimary (citable) accession number: E9Q310
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 1, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.