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E9Q310

- E9Q310_MOUSE

UniProt

E9Q310 - E9Q310_MOUSE

Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. glucocorticoid receptor activity Source: MGI
    3. protein binding Source: MGI
    4. protein dimerization activity Source: MGI
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: InterPro
    7. steroid binding Source: InterPro
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adrenal gland development Source: MGI
    2. glucocorticoid metabolic process Source: MGI
    3. glucocorticoid receptor signaling pathway Source: MGI
    4. mammary gland duct morphogenesis Source: MGI
    5. maternal behavior Source: MGI
    6. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
    7. positive regulation of neuron apoptotic process Source: MGI
    8. regulation of glucocorticoid biosynthetic process Source: MGI
    9. regulation of gluconeogenesis Source: MGI
    10. regulation of transcription, DNA-templated Source: MGI
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glucocorticoid receptorImported
    Gene namesi
    Name:Nr3c1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:95824. Nr3c1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. intracellular Source: MGI
    4. membrane Source: MGI
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q310.
    BgeeiE9Q310.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q310.
    SMRiE9Q310. Positions 436-488.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110451.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    InterProiIPR001409. Glcrtcd_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF02155. GCR. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00528. GLCORTICOIDR.
    PR00047. STROIDFINGER.
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    E9Q310-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA    50
    AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV 100
    SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS 150
    TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK 200
    LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD 250
    PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 300
    IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH 350
    YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF 400
    AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG 450
    VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC IIDKIRRK 488
    Length:488
    Mass (Da):52,374
    Last modified:April 5, 2011 - v1
    Checksum:iF08D19E75B3C37D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei488 – 4881Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007995 Genomic DNA. No translation available.
    AC124417 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000152853; ENSMUSP00000120082; ENSMUSG00000024431.
    UCSCiuc008eta.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007995 Genomic DNA. No translation available.
    AC124417 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9Q310.
    SMRi E9Q310. Positions 436-488.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000152853 ; ENSMUSP00000120082 ; ENSMUSG00000024431 .
    UCSCi uc008eta.1. mouse.

    Organism-specific databases

    MGIi MGI:95824. Nr3c1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110451.

    Miscellaneous databases

    ChiTaRSi NR3C1. mouse.
    NextBioi 35554927.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q310.
    Bgeei E9Q310.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    InterProi IPR001409. Glcrtcd_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF02155. GCR. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00528. GLCORTICOIDR.
    PR00047. STROIDFINGER.
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q310_MOUSE
    AccessioniPrimary (citable) accession number: E9Q310
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3