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Protein
Submitted name:

Alpha-actinin-4

Gene

Actn4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-actinin-4Imported
Gene namesi
Name:Actn4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1890773. Actn4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9Q2W9.
PaxDbiE9Q2W9.
PeptideAtlasiE9Q2W9.
PRIDEiE9Q2W9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054808.
ExpressionAtlasiE9Q2W9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066068.

Structurei

3D structure databases

ProteinModelPortaliE9Q2W9.
SMRiE9Q2W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 155Actin-bindingInterPro annotationAdd BLAST105
Domaini164 – 267Actin-bindingInterPro annotationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 484Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR029637. ACTN4.
IPR001715. CH-domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR11915:SF271. PTHR11915:SF271. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00435. Spectrin. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00150. SPEC. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9Q2W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYHAANQA YQYGPNSGGG NGAGGGGSMG DYMAQEDDWD RDLLLDPAWE
60 70 80 90 100
KQQRKTFTAW CNSHLRKAGT QIENIDEDFR DGLKLMLLLE VISGERLPKP
110 120 130 140 150
ERGKMRVHKI NNVNKALDFI ASKGVKLVSI GAEEIVDGNA KMTLGMIWTI
160 170 180 190 200
ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YKNVNVQNFH ISWKDGLAFN
210 220 230 240 250
ALIHRHRPEL IEYDKLRKDD PVTNLNNAFE VAEKYLDIPK MLDAEDIVGT
260 270 280 290 300
LRPDEKAIMT YVSCFYHAFS GAQKAETAAN RICKVLAVNQ ENEHLMEDYE
310 320 330 340 350
RLASDLLEWI RRTIPWLEDR VPQKTIQEMQ QKLEDFRDYR RVHKPPKVQE
360 370 380 390 400
KCQLEINFNT LQTKLRLSNR PAFMPSEGRM VSDINNGWQH LEQAEKGYEE
410 420 430 440 450
WLLNEIRRLE RLDHLAEKFR QKASIHEAWT DGKEAMLKQR DYETATLSDI
460 470 480 490 500
KALIRKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYYDSH NVNTRCQKIC
510
DQWDNLGSLT HSRREALE
Length:518
Mass (Da):59,898
Last modified:April 5, 2011 - v1
Checksum:i56F8D4DAAE61C767
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei518Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166357 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000127210; ENSMUSP00000115436; ENSMUSG00000054808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166357 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q2W9.
SMRiE9Q2W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066068.

Proteomic databases

MaxQBiE9Q2W9.
PaxDbiE9Q2W9.
PeptideAtlasiE9Q2W9.
PRIDEiE9Q2W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000127210; ENSMUSP00000115436; ENSMUSG00000054808.

Organism-specific databases

MGIiMGI:1890773. Actn4.

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.

Miscellaneous databases

ChiTaRSiActn4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054808.
ExpressionAtlasiE9Q2W9. baseline and differential.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR029637. ACTN4.
IPR001715. CH-domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR11915:SF271. PTHR11915:SF271. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00435. Spectrin. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00150. SPEC. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q2W9_MOUSE
AccessioniPrimary (citable) accession number: E9Q2W9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.