ID   E9Q2G2_MOUSE            Unreviewed;       209 AA.
AC   E9Q2G2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Clusterin {ECO:0000313|Ensembl:ENSMUSP00000117953.2};
DE   Flags: Fragment;
GN   Name=Clu {ECO:0000313|Ensembl:ENSMUSP00000117953.2,
GN   ECO:0000313|MGI:MGI:88423};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117953.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000117953.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117953.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000117953.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117953.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000256|ARBA:ARBA00004556}. Microsome
CC       {ECO:0000256|ARBA:ARBA00004144}. Mitochondrion membrane
CC       {ECO:0000256|ARBA:ARBA00004325}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the clusterin family.
CC       {ECO:0000256|ARBA:ARBA00010069}.
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DR   AlphaFoldDB; E9Q2G2; -.
DR   SMR; E9Q2G2; -.
DR   MaxQB; E9Q2G2; -.
DR   PeptideAtlas; E9Q2G2; -.
DR   ProteomicsDB; 348872; -.
DR   Antibodypedia; 631; 1388 antibodies from 52 providers.
DR   Ensembl; ENSMUST00000144619.2; ENSMUSP00000117953.2; ENSMUSG00000022037.16.
DR   AGR; MGI:88423; -.
DR   MGI; MGI:88423; Clu.
DR   VEuPathDB; HostDB:ENSMUSG00000022037; -.
DR   GeneTree; ENSGT00530000063668; -.
DR   HOGENOM; CLU_1318070_0_0_1; -.
DR   ChiTaRS; Clu; mouse.
DR   Proteomes; UP000000589; Chromosome 14.
DR   Bgee; ENSMUSG00000022037; Expressed in iris and 298 other cell types or tissues.
DR   ExpressionAtlas; E9Q2G2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR033986; Clusterin_CS.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; CLUSTERIN; 1.
DR   PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00030; CLb; 1.
DR   PROSITE; PS00492; CLUSTERIN_1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Proteomics identification {ECO:0007829|MaxQB:E9Q2G2,
KW   ECO:0007829|PeptideAtlas:E9Q2G2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          110..209
FT                   /note="Clusterin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00030"
FT   COILED          147..181
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         209
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000117953.2"
SQ   SEQUENCE   209 AA;  23651 MW;  F72D36DF562DE292 CRC64;
     MEGDRRGMFA CFGRGIFSIW HVKYALETQE IHLPCLRLLW EERDSAWSSA PPTPDSLAPL
     CSRAMVLPRA SLSPVSIEGD SRFQGGHAMK ILLLCVALLL IWDNGMVLGE QEVSDNELQE
     LSTQGSRYIN KEIQNAVQGV KHIKTLIEKT NAERKSLLNS LEEAKKKKED ALEDTRDSEM
     KLKAFPEVCN ETMMALWEEC KPCLKHTCM
//