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Protein
Submitted name:

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. misfolded protein binding Source: MGI
  2. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. cell morphogenesis Source: MGI
  2. central nervous system myelin maintenance Source: MGI
  3. chaperone-mediated protein complex assembly Source: MGI
  4. chaperone-mediated protein folding Source: MGI
  5. intrinsic apoptotic signaling pathway Source: MGI
  6. microglial cell activation Source: MGI
  7. microglial cell proliferation Source: MGI
  8. negative regulation of beta-amyloid formation Source: MGI
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  10. negative regulation of protein homooligomerization Source: MGI
  11. positive regulation of apoptotic process Source: MGI
  12. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  13. positive regulation of neurofibrillary tangle assembly Source: MGI
  14. positive regulation of neuron death Source: MGI
  15. positive regulation of NF-kappaB transcription factor activity Source: MGI
  16. positive regulation of nitric oxide biosynthetic process Source: MGI
  17. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  18. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  19. positive regulation of tau-protein kinase activity Source: MGI
  20. positive regulation of tumor necrosis factor production Source: MGI
  21. protein import Source: MGI
  22. protein stabilization Source: MGI
  23. regulation of beta-amyloid clearance Source: MGI
  24. regulation of neuronal signal transduction Source: MGI
  25. regulation of neuron death Source: MGI
  26. response to misfolded protein Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ClusterinImported
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

GO - Cellular componenti

  1. apical dendrite Source: MGI
  2. blood microparticle Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular matrix Source: MGI
  5. extracellular space Source: MGI
  6. extracellular vesicular exosome Source: MGI
  7. mitochondrion Source: MGI
  8. neurofibrillary tangle Source: MGI
  9. perinuclear region of cytoplasm Source: MGI
  10. spherical high-density lipoprotein particle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q2G2.
ExpressionAtlasiE9Q2G2. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063668.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
SMARTiSM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9Q2G2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGDRRGMFA CFGRGIFSIW HVKYALETQE IHLPCLRLLW EERDSAWSSA
60 70 80 90 100
PPTPDSLAPL CSRAMVLPRA SLSPVSIEGD SRFQGGHAMK ILLLCVALLL
110 120 130 140 150
IWDNGMVLGE QEVSDNELQE LSTQGSRYIN KEIQNAVQGV KHIKTLIEKT
160 170 180 190 200
NAERKSLLNS LEEAKKKKED ALEDTRDSEM KLKAFPEVCN ETMMALWEEC

KPCLKHTCM
Length:209
Mass (Da):23,651
Last modified:April 5, 2011 - v1
Checksum:iF72D36DF562DE292
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei209 – 2091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126444 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000144619; ENSMUSP00000117953; ENSMUSG00000022037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126444 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000144619; ENSMUSP00000117953; ENSMUSG00000022037.

Organism-specific databases

MGIiMGI:88423. Clu.

Phylogenomic databases

GeneTreeiENSGT00530000063668.

Miscellaneous databases

ChiTaRSiClu. mouse.
NextBioi35554846.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q2G2.
ExpressionAtlasiE9Q2G2. baseline and differential.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
SMARTiSM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q2G2_MOUSE
AccessioniPrimary (citable) accession number: E9Q2G2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.