ID   E9Q2A0_MOUSE            Unreviewed;       153 AA.
AC   E9Q2A0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=Epidermal growth factor-containing fibulin-like extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSMUSP00000132194.2};
DE   Flags: Fragment;
GN   Name=Efemp2 {ECO:0000313|Ensembl:ENSMUSP00000132194.2,
GN   ECO:0000313|MGI:MGI:1891209};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000132194.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000132194.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000132194.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000132194.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000132194.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the fibulin family.
CC       {ECO:0000256|ARBA:ARBA00006127}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; E9Q2A0; -.
DR   SMR; E9Q2A0; -.
DR   MaxQB; E9Q2A0; -.
DR   PeptideAtlas; E9Q2A0; -.
DR   ProteomicsDB; 302473; -.
DR   Antibodypedia; 16033; 415 antibodies from 33 providers.
DR   Ensembl; ENSMUST00000167855.8; ENSMUSP00000132194.2; ENSMUSG00000024909.16.
DR   AGR; MGI:1891209; -.
DR   MGI; MGI:1891209; Efemp2.
DR   VEuPathDB; HostDB:ENSMUSG00000024909; -.
DR   GeneTree; ENSGT00940000159437; -.
DR   OMA; DPLTEHC; -.
DR   ChiTaRS; Efemp2; mouse.
DR   Proteomes; UP000000589; Chromosome 19.
DR   Bgee; ENSMUSG00000024909; Expressed in humerus cartilage element and 211 other cell types or tissues.
DR   ExpressionAtlas; E9Q2A0; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 1.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   PANTHER; PTHR24034:SF96; EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR   PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 2.
DR   SUPFAM; SSF57196; EGF/Laminin; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Proteomics identification {ECO:0007829|MaxQB:E9Q2A0,
KW   ECO:0007829|PeptideAtlas:E9Q2A0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          55..95
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          96..134
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          23..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         153
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000132194.2"
SQ   SEQUENCE   153 AA;  17022 MW;  979D538E55048F61 CRC64;
     MKCINHYGGY LCLPRSAAVI SDLHGEGPPP PAAHAQQPNP CPQGYEPDEQ ESCVDVDECT
     QALHDCRPSQ DCHNLPGSYQ CTCPDGYRKI GPECVDIDEC RYRYCQHRCV NLPGSFRCQC
     EPGFQLGPNN RSCVDVNECD MGAPCEQRCF NSY
//