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Protein
Submitted name:

Protein Adamts3

Gene

Adamts3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. endopeptidase activity Source: MGI
  2. metalloendopeptidase activity Source: InterPro
  3. peptidase activity Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. collagen biosynthetic process Source: MGI
  2. positive regulation of vascular endothelial growth factor signaling pathway Source: MGI
  3. protein processing Source: MGI
  4. vascular endothelial growth factor production Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_285754. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Adamts3Imported
Gene namesi
Name:Adamts3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3045353. Adamts3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiE9Q287.
ExpressionAtlasiE9Q287. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q287.
SMRiE9Q287. Positions 258-825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 peptidase M12B domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118880.
InParanoidiE9Q287.
KOiK08619.
OMAiAEEWEHC.
OrthoDBiEOG76HQ0N.
TreeFamiTF313537.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFLSLWLIA ASLVEVRTSA DGQAGTDEMV QIDLPTKRYR EYELVTPVST
60 70 80 90 100
NLKGHYLSHI LSANHKKRSP RDVSSNSEHL FFNVTAFGRD FHLRLKPNTH
110 120 130 140 150
FIAPGAVVEW HETAPRPGNT TDPRNSHLHG SASEGSWRSE PLQTSCAYVG
160 170 180 190 200
DIMDIPGTSV AISNCDGLAG MIKSDDEEYF IEPLERGKQM DEENGRIHVV
210 220 230 240 250
YKRSAVEQPP RDVSEDVYHR ESDLEGLDDL GTVYSNIGQQ LNKTMRRRRH
260 270 280 290 300
TGENDYNIEV LLGVDDSVVR FHGKEHVQNY LLTLMNIVNE IYHDESLGVH
310 320 330 340 350
INVVLVRMIM LGYAKSISLI ERGNPSRSLE NVCRWACQQQ KTDPNHAEHH
360 370 380 390 400
DHAIFLTRQD FGPAGMQGYA PVTGMCHPVR SCTLNHEDGF SSAFVVAHET
410 420 430 440 450
GHVLGMEHDG QGNRCGDETA MGSVMAPLVQ AAFHRYHWSR CSGQELKRYI
460 470 480 490 500
HSYDCLLDDP FEHDWPKLPE LPGINYSMDE QCRFDFGVGY KMCTAFRTFD
510 520 530 540 550
PCKQLWCSHP DNPYFCKTKK GPPLDGTECA AGKWCYKGHC MWKNANQQKQ
560 570 580 590 600
DGNWGSWTKF GSCSRTCGTG VRFRTRQCNN PTPINGGQDC PGVNFEYQLC
610 620 630 640 650
NTEECQKHFE DFRAQQCQQR NSHFDYQNTK HHWLPHEHPD SKKRCHLYCQ
660 670 680 690 700
SKETGDVAYM KQLVHDGTRC SYKDPYSICV RGECVKVGCD REIGSNKVED
710 720 730 740 750
KCGVCGGDNS HCRTVKGTFT RTPRKLGKTR GAFVLPKGAR NISLAETRET
760 770 780 790 800
KNVLAIKNQA TGHYILNGKG EEAKSRTFID LGVEWDYNIE DDIETLHTDG
810 820 830 840 850
PLHDPVIVLI IPQENDTRSS LTYKYIIHED SVPTINSNNV IQEELDTFEW
860 870 880 890 900
ALKSWSQCSE PCGGGFQYTK YGCRRKSDSK MVHRSFCEVN KKPKPIRRMC
910 920 930 940 950
NIQECTHPVW AADEWEHCSR SCGSSGNQLR TVRCLQPLQD GTNRSVHSKY
960 970 980 990 1000
CLGDRPESRR PCNRVPCPAQ WKTGSWNECS VTCGEGTEVR QVLCRTGDHC
1010 1020 1030 1040 1050
DGEKPESVRP CQLPPCNDEP CLGDKSIFCQ MEVLARYCSI PGYNKLCCES
1060 1070 1080 1090 1100
CSKRSGTLPP PYLQEAAEIH SDAIFGPSDL PRSLVMPTPF LPSSSGTRAE
1110 1120 1130 1140 1150
KKSLSSFSSM ANPNADAAFR ASSRASADFP RKRAHQAGRK TLESVPSSSS
1160 1170 1180 1190 1200
IKTDHLRPAS PVAAAPSPAI SDSIGASPQT RTPKKDDAKS VSRRHPTRST

ASER
Length:1,204
Mass (Da):135,185
Last modified:April 4, 2011 - v1
Checksum:i9B261F73622A1D75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102039 Genomic DNA. No translation available.
AC102056 Genomic DNA. No translation available.
AC156611 Genomic DNA. No translation available.
RefSeqiNP_808540.2. NM_177872.2.
UniGeneiMm.133062.

Genome annotation databases

EnsembliENSMUST00000163159; ENSMUSP00000132219; ENSMUSG00000043635.
GeneIDi330119.
KEGGimmu:330119.
UCSCiuc012dyf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102039 Genomic DNA. No translation available.
AC102056 Genomic DNA. No translation available.
AC156611 Genomic DNA. No translation available.
RefSeqiNP_808540.2. NM_177872.2.
UniGeneiMm.133062.

3D structure databases

ProteinModelPortaliE9Q287.
SMRiE9Q287. Positions 258-825.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi330119.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163159; ENSMUSP00000132219; ENSMUSG00000043635.
GeneIDi330119.
KEGGimmu:330119.
UCSCiuc012dyf.1. mouse.

Organism-specific databases

CTDi9508.
MGIiMGI:3045353. Adamts3.

Phylogenomic databases

GeneTreeiENSGT00760000118880.
InParanoidiE9Q287.
KOiK08619.
OMAiAEEWEHC.
OrthoDBiEOG76HQ0N.
TreeFamiTF313537.

Enzyme and pathway databases

ReactomeiREACT_285754. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi399154.
PROiE9Q287.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q287.
ExpressionAtlasiE9Q287. baseline and differential.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 4 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q287_MOUSE
AccessioniPrimary (citable) accession number: E9Q287
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2011
Last sequence update: April 4, 2011
Last modified: March 31, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.