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E9Q242

- E9Q242_MOUSE

UniProt

E9Q242 - E9Q242_MOUSE

Protein

Adenylosuccinate lyase

Gene

Adsl

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: MGI

    GO - Biological processi

    1. AMP biosynthetic process Source: MGI

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Purine biosynthesisUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00132.
    UPA00075; UER00336.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
    Short name:
    ASLUniRule annotation
    Alternative name(s):
    AdenylosuccinaseUniRule annotation
    Gene namesi
    Name:AdslImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:103202. Adsl.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q242.
    BgeeiE9Q242.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q242.
    SMRiE9Q242. Positions 5-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000013486.

    Family and domain databases

    Gene3Di1.10.275.10. 1 hit.
    InterProiIPR019468. AdenyloSucc_lyase_C.
    IPR024083. Fumarase/histidase_N.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    IPR004769. Pur_lyase.
    [Graphical view]
    PANTHERiPTHR11444. PTHR11444. 1 hit.
    PfamiPF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view]
    PRINTSiPR00149. FUMRATELYASE.
    SMARTiSM00998. ADSL_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48557. SSF48557. 1 hit.
    TIGRFAMsiTIGR00928. purB. 1 hit.
    PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q242-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASGDPGSA ESYRSPLAAR YASREMCFLF SDRYKFQTWR QLWLWLAEAE    50
    QTLGLPITDE QIQEMKSNLN NIDFQMAAEE EKRLRHDVMA HVHTFGHCCP 100
    KAAGIIHLGA TSCYVGDNTL ARVISRLADF AKDRADLPTL GFTHFQPAQL 150
    TTVGKRCCLW IQDLCMDLQN LKRVRDELRF RGVKGTTGTQ ASFLQLFEGD 200
    HQKVEQLDKM VTEKAGFKRA FIITGQTYTR KVDIEVLSVL ASLGASVHKI 250
    CTDIRLLANL KEMEEPFEKQ QIGSSAMPYK RNPMRSERCC SLARHLMALT 300
    MDPLQTASVQ WFERTLDDSA NRRICLAEAF LTADTILNTL QNISEGLVVY 350
    PKVIERRIRQ ELPFMATENI IMAMVKAGGS RQDCHEKIRV LSQQAAAVVK 400
    QEGGDNDLIE RIRADAYFSP IHSQLEHLLD PSSFTGRAPQ QVHRFLEEEV 450
    RPLLKPYGNE MAVKAELCL 469
    Length:469
    Mass (Da):53,130
    Last modified:April 5, 2011 - v1
    Checksum:i56CAD8A1FCF88727
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC125540 Genomic DNA. No translation available.
    AC141880 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000168756; ENSMUSP00000127593; ENSMUSG00000022407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC125540 Genomic DNA. No translation available.
    AC141880 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9Q242.
    SMRi E9Q242. Positions 5-457.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000168756 ; ENSMUSP00000127593 ; ENSMUSG00000022407 .

    Organism-specific databases

    MGIi MGI:103202. Adsl.

    Phylogenomic databases

    GeneTreei ENSGT00390000013486.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00132 .
    UPA00075 ; UER00336 .

    Miscellaneous databases

    NextBioi 35554797.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q242.
    Bgeei E9Q242.

    Family and domain databases

    Gene3Di 1.10.275.10. 1 hit.
    InterProi IPR019468. AdenyloSucc_lyase_C.
    IPR024083. Fumarase/histidase_N.
    IPR020557. Fumarate_lyase_CS.
    IPR000362. Fumarate_lyase_fam.
    IPR022761. Fumarate_lyase_N.
    IPR008948. L-Aspartase-like.
    IPR004769. Pur_lyase.
    [Graphical view ]
    PANTHERi PTHR11444. PTHR11444. 1 hit.
    Pfami PF10397. ADSL_C. 1 hit.
    PF00206. Lyase_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00149. FUMRATELYASE.
    SMARTi SM00998. ADSL_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48557. SSF48557. 1 hit.
    TIGRFAMsi TIGR00928. purB. 1 hit.
    PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q242_MOUSE
    AccessioniPrimary (citable) accession number: E9Q242
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3