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Protein
Submitted name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Gene

Abcc4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi445 – 452ATPPROSITE-ProRule annotation8
Nucleotide bindingi1075 – 1082ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-382556 ABC-family proteins mediated transport

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette, sub-family C (CFTR/MRP), member 4Imported
Gene namesi
Name:Abcc4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2443111 Abcc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei134 – 157HelicalSequence analysisAdd BLAST24
Transmembranei208 – 227HelicalSequence analysisAdd BLAST20
Transmembranei233 – 254HelicalSequence analysisAdd BLAST22
Transmembranei321 – 342HelicalSequence analysisAdd BLAST22
Transmembranei348 – 369HelicalSequence analysisAdd BLAST22
Transmembranei704 – 728HelicalSequence analysisAdd BLAST25
Transmembranei767 – 791HelicalSequence analysisAdd BLAST25
Transmembranei835 – 857HelicalSequence analysisAdd BLAST23
Transmembranei863 – 882HelicalSequence analysisAdd BLAST20
Transmembranei948 – 970HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiE9Q236
PaxDbiE9Q236
PRIDEiE9Q236

Expressioni

Gene expression databases

BgeeiENSMUSG00000032849
ExpressionAtlasiE9Q236 baseline and differential
GenevisibleiE9Q236 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042186

Structurei

3D structure databases

ProteinModelPortaliE9Q236
SMRiE9Q236
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 377ABC transmembrane type-1InterPro annotationAdd BLAST285
Domaini410 – 633ABC transporterInterPro annotationAdd BLAST224
Domaini715 – 1005ABC transmembrane type-1InterPro annotationAdd BLAST291
Domaini1041 – 1274ABC transporterInterPro annotationAdd BLAST234

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00880000137856
InParanoidiE9Q236
KOiK05673
OMAiMRVVKYF
OrthoDBiEOG091G00IN
PhylomeDBiE9Q236
TreeFamiTF105202

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030240 ABCC4
IPR027417 P-loop_NTPase
PANTHERiPTHR24223:SF237 PTHR24223:SF237, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

E9Q236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVHTEVKP NPLQDANLCS RVFFWWLNPL FKTGHKRRLE EDDMFSVLPE
60 70 80 90 100
DRSKHLGEEL QRYWDKELLR AKKDSRKPSL TKAIIKCYWK SYLILGIFTL
110 120 130 140 150
IEEGTRVVQP LFLGKIIEYF EKYDPDDSVA LHTAYGYAAV LSMCTLILAI
160 170 180 190 200
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNSAMGKTT TGQIVNLLSN
210 220 230 240 250
DVNKFDQVTI FLHFLWAGPL QAIAVTVLLW VEIGISCLAG LAVLVILLPL
260 270 280 290 300
QSCIGKLFSS LRSKTAAFTD ARIRTMNEVI TGMRIIKMYA WEKSFADLIA
310 320 330 340 350
NLRKKEISKI LGSSYLRGMN MASFFIANKV ILFVTFTSYV LLGNEITASH
360 370 380 390 400
VFVAMTLYGA VRLTVTLFFP SAIERGSEAI VSIRRIKNFL LLDELPQRKA
410 420 430 440 450
HVPSDGKAIV HVQDFTAFWD KALDSPTLQG LSFIARPGEL LAVVGPVGAG
460 470 480 490 500
KSSLLSAVLG ELPPASGLVS VHGRIAYVSQ QPWVFSGTVR SNILFGKKYE
510 520 530 540 550
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGATLSGGQK ARVNLARAVY
560 570 580 590 600
QDADIYLLDD PLSAVDAEVG KHLFQLCICQ ALHEKITILV THQLQYLKAA
610 620 630 640 650
SHILILKDGE MVQKGTYTEF LKSGVDFGSL LKKENEEAEP STAPGTPTLR
660 670 680 690 700
KRTFSEASIW SQQSSRPSLK DGAPEGQDAE NTQAVQPEES RSEGRIGFKA
710 720 730 740 750
YKNYFSAGAS WFFIIFLVLL NMVGQVFYVL QDWWLSHWAN KQGALNNTRN
760 770 780 790 800
ANGNITETLD LSWYLGIYAG LTAVTVLFGI ARSLLVFYIL VNASQTLHNR
810 820 830 840 850
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HMDDLLPLTF LDFIQTLLLV
860 870 880 890 900
VSVIAVAAAV IPWILIPLVP LSVVFLVLRR YFLETSRDVK RLESTTRSPV
910 920 930 940 950
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV
960 970 980 990 1000
RLDAICAIFV IVVAFGSLVL AKTLNAGQVG LALSYALTLM GMFQWSVRQS
1010 1020 1030 1040 1050
AEVENMMISV ERVIEYTDLE KEAPWECKKR PPPGWPHEGV IVFDNVNFTY
1060 1070 1080 1090 1100
SLDGPLVLKH LTALIKSREK VGIVGRTGAG KSSLISALFR LSEPEGKIWI
1110 1120 1130 1140 1150
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWRAL
1160 1170 1180 1190 1200
EEVQLKEAIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILKNNRILII
1210 1220 1230 1240 1250
DEATANVDPR TDELIQQKIR EKFAQCTVLT IAHRLNTIID SDKIMVLDSG
1260 1270 1280 1290 1300
RLKEYDEPYV LLQNPESLFY KMVQQLGKGE AAALTETAKQ VYFRRNYPDI
1310 1320
TFTSPAVMNT SNGQPSALTI FETAL
Length:1,325
Mass (Da):148,888
Last modified:April 5, 2011 - v1
Checksum:i3F1469648CBE9699
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154419 Genomic DNA No translation available.
AC167668 Genomic DNA No translation available.
CT025694 Genomic DNA No translation available.
RefSeqiNP_001028508.2, NM_001033336.3
UniGeneiMm.40537

Genome annotation databases

EnsembliENSMUST00000036554; ENSMUSP00000042186; ENSMUSG00000032849
GeneIDi239273
KEGGimmu:239273
UCSCiuc007uyv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiE9Q236_MOUSE
AccessioniPrimary (citable) accession number: E9Q236
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health