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E9Q236

- E9Q236_MOUSE

UniProt

E9Q236 - E9Q236_MOUSE

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Protein
Submitted name:

Protein Abcc4

Gene

Abcc4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. drug transmembrane transporter activity Source: MGI

GO - Biological processi

  1. drug transmembrane transport Source: MGI
  2. positive regulation of smooth muscle cell proliferation Source: Ensembl
  3. response to organic cyclic compound Source: Ensembl
  4. response to organonitrogen compound Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Abcc4Imported
Gene namesi
Name:Abcc4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2443111. Abcc4.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: InterPro
  3. platelet dense granule membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9Q236.
PRIDEiE9Q236.

Expressioni

Gene expression databases

BgeeiE9Q236.
ExpressionAtlasiE9Q236. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q236.
SMRiE9Q236. Positions 110-689, 761-1280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation
Contains ABC transmembrane type-1 domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119056.
InParanoidiE9Q236.
KOiK05673.
OMAiCAMFVII.
OrthoDBiEOG7MWGW0.
PhylomeDBiE9Q236.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q236 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPVHTEVKP NPLQDANLCS RVFFWWLNPL FKTGHKRRLE EDDMFSVLPE
60 70 80 90 100
DRSKHLGEEL QRYWDKELLR AKKDSRKPSL TKAIIKCYWK SYLILGIFTL
110 120 130 140 150
IEEGTRVVQP LFLGKIIEYF EKYDPDDSVA LHTAYGYAAV LSMCTLILAI
160 170 180 190 200
LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR LSNSAMGKTT TGQIVNLLSN
210 220 230 240 250
DVNKFDQVTI FLHFLWAGPL QAIAVTVLLW VEIGISCLAG LAVLVILLPL
260 270 280 290 300
QSCIGKLFSS LRSKTAAFTD ARIRTMNEVI TGMRIIKMYA WEKSFADLIA
310 320 330 340 350
NLRKKEISKI LGSSYLRGMN MASFFIANKV ILFVTFTSYV LLGNEITASH
360 370 380 390 400
VFVAMTLYGA VRLTVTLFFP SAIERGSEAI VSIRRIKNFL LLDELPQRKA
410 420 430 440 450
HVPSDGKAIV HVQDFTAFWD KALDSPTLQG LSFIARPGEL LAVVGPVGAG
460 470 480 490 500
KSSLLSAVLG ELPPASGLVS VHGRIAYVSQ QPWVFSGTVR SNILFGKKYE
510 520 530 540 550
KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGATLSGGQK ARVNLARAVY
560 570 580 590 600
QDADIYLLDD PLSAVDAEVG KHLFQLCICQ ALHEKITILV THQLQYLKAA
610 620 630 640 650
SHILILKDGE MVQKGTYTEF LKSGVDFGSL LKKENEEAEP STAPGTPTLR
660 670 680 690 700
KRTFSEASIW SQQSSRPSLK DGAPEGQDAE NTQAVQPEES RSEGRIGFKA
710 720 730 740 750
YKNYFSAGAS WFFIIFLVLL NMVGQVFYVL QDWWLSHWAN KQGALNNTRN
760 770 780 790 800
ANGNITETLD LSWYLGIYAG LTAVTVLFGI ARSLLVFYIL VNASQTLHNR
810 820 830 840 850
MFESILKAPV LFFDRNPIGR ILNRFSKDIG HMDDLLPLTF LDFIQTLLLV
860 870 880 890 900
VSVIAVAAAV IPWILIPLVP LSVVFLVLRR YFLETSRDVK RLESTTRSPV
910 920 930 940 950
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV
960 970 980 990 1000
RLDAICAIFV IVVAFGSLVL AKTLNAGQVG LALSYALTLM GMFQWSVRQS
1010 1020 1030 1040 1050
AEVENMMISV ERVIEYTDLE KEAPWECKKR PPPGWPHEGV IVFDNVNFTY
1060 1070 1080 1090 1100
SLDGPLVLKH LTALIKSREK VGIVGRTGAG KSSLISALFR LSEPEGKIWI
1110 1120 1130 1140 1150
DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE HTDEELWRAL
1160 1170 1180 1190 1200
EEVQLKEAIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILKNNRILII
1210 1220 1230 1240 1250
DEATANVDPR TDELIQQKIR EKFAQCTVLT IAHRLNTIID SDKIMVLDSG
1260 1270 1280 1290 1300
RLKEYDEPYV LLQNPESLFY KMVQQLGKGE AAALTETAKQ VYFRRNYPDI
1310 1320
TFTSPAVMNT SNGQPSALTI FETAL
Length:1,325
Mass (Da):148,888
Last modified:April 5, 2011 - v1
Checksum:i3F1469648CBE9699
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154419 Genomic DNA. No translation available.
AC167668 Genomic DNA. No translation available.
CT025694 Genomic DNA. No translation available.
RefSeqiNP_001028508.2. NM_001033336.3.
UniGeneiMm.40537.

Genome annotation databases

EnsembliENSMUST00000036554; ENSMUSP00000042186; ENSMUSG00000032849.
GeneIDi239273.
KEGGimmu:239273.
UCSCiuc007uyv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154419 Genomic DNA. No translation available.
AC167668 Genomic DNA. No translation available.
CT025694 Genomic DNA. No translation available.
RefSeqi NP_001028508.2. NM_001033336.3.
UniGenei Mm.40537.

3D structure databases

ProteinModelPortali E9Q236.
SMRi E9Q236. Positions 110-689, 761-1280.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi E9Q236.
PRIDEi E9Q236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036554 ; ENSMUSP00000042186 ; ENSMUSG00000032849 .
GeneIDi 239273.
KEGGi mmu:239273.
UCSCi uc007uyv.2. mouse.

Organism-specific databases

CTDi 10257.
MGIi MGI:2443111. Abcc4.

Phylogenomic databases

GeneTreei ENSGT00760000119056.
InParanoidi E9Q236.
KOi K05673.
OMAi CAMFVII.
OrthoDBi EOG7MWGW0.
PhylomeDBi E9Q236.
TreeFami TF105202.

Miscellaneous databases

NextBioi 384052.
PROi E9Q236.
SOURCEi Search...

Gene expression databases

Bgeei E9Q236.
ExpressionAtlasi E9Q236. baseline and differential.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q236_MOUSE
AccessioniPrimary (citable) accession number: E9Q236
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3