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Protein
Submitted name:

T-lymphoma invasion and metastasis-inducing protein 1

Gene

Tiam1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ephrin receptor binding Source: MGI
  2. guanyl-nucleotide exchange factor activity Source: MGI
  3. phospholipid binding Source: MGI
  4. Rac guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  1. cell-matrix adhesion Source: MGI
  2. cell migration Source: MGI
  3. ephrin receptor signaling pathway Source: MGI
  4. positive regulation of axonogenesis Source: MGI
  5. positive regulation of Rac GTPase activity Source: MGI
  6. Rac protein signal transduction Source: MGI
  7. small GTPase mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.
REACT_243590. EPH-ephrin mediated repulsion of cells.
REACT_257656. EPHB-mediated forward signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
T-lymphoma invasion and metastasis-inducing protein 1Imported
Gene namesi
Name:Tiam1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:103306. Tiam1.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell contact zone Source: MGI
  2. cell-cell junction Source: MGI
  3. extrinsic component of cytoplasmic side of plasma membrane Source: MGI
  4. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q1R7.
ExpressionAtlasiE9Q1R7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q1R7.
SMRiE9Q1R7. Positions 65-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains DH (DBL-homology) domain.SAAS annotation
Contains PH domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118925.
KOiK05731.
TreeFamiTF319686.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q1R7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLWKIKRK PRVESDRAGD SLYRTLHLST EQVAAFCRSL HEMSPSDSSP
60 70 80 90 100
SPQDATSPQL ATTRQLSDAD KLRKVICELL ETERTYVKDL NCLMERYLKP
110 120 130 140 150
LQKETFLTQD ELDVLFGNLT EMVEFQVEFL KTLEDGVRLV PDLEKLEKVD
160 170 180 190 200
QFKKVLFSLG GSFLYYADRF KLYSAFCASH TKVPKVLVKA KTDTAFKAFL
210 220 230 240 250
DAQNPRQQHS STLESYLIKP IQRVLKYPLL LRELFALTDA ESEEHYHLDV
260 270 280 290 300
AIKTMNKVAS HINEMQKIHE EFGAVFDQLI AEQTGEKKEV ADLSMGDLLL
310 320 330 340 350
HTSVIWLNPP ASLGKWKKEP ELAAFVFKTA VVLVYKDGSK QKKKLVGSHR
360 370 380 390 400
LSIYEEWDPF RFRHMIPTEA LQVRALPSAD AEANAVCEIV HVKSESEGRP
410 420 430 440 450
ERVFHLCCSS PESRKDFLKS VHSILRDKHR RQLLKTESLP SAQQYVPFGG
460 470 480 490 500
KRLCALKGAR PAMSRAVSAP SKSLGRRRRR LARNRFTIDS DAISASSPEK
510 520 530 540 550
EPQQPAGGGD TDRWVEEQFD LAQYEEQDDI KETDILSDDD EFCESLKGAS
560 570 580 590 600
VDRDLQEQLQ AASISQRARG RRTLDSHASR MTQLKKQAAL SGINGGLESA
610 620
SEEVIWVRRE DFAPSRKLNT EI
Length:622
Mass (Da):70,648
Last modified:April 5, 2011 - v1
Checksum:i20549BC068A55E80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087840 Genomic DNA. No translation available.
AC102908 Genomic DNA. No translation available.
AC122218 Genomic DNA. No translation available.
RefSeqiNP_001139359.1. NM_001145887.1.
UniGeneiMm.310902.

Genome annotation databases

EnsembliENSMUST00000164263; ENSMUSP00000126020; ENSMUSG00000002489.
GeneIDi21844.
KEGGimmu:21844.
UCSCiuc007zvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087840 Genomic DNA. No translation available.
AC102908 Genomic DNA. No translation available.
AC122218 Genomic DNA. No translation available.
RefSeqiNP_001139359.1. NM_001145887.1.
UniGeneiMm.310902.

3D structure databases

ProteinModelPortaliE9Q1R7.
SMRiE9Q1R7. Positions 65-432.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164263; ENSMUSP00000126020; ENSMUSG00000002489.
GeneIDi21844.
KEGGimmu:21844.
UCSCiuc007zvs.2. mouse.

Organism-specific databases

CTDi7074.
MGIiMGI:103306. Tiam1.

Phylogenomic databases

GeneTreeiENSGT00760000118925.
KOiK05731.
TreeFamiTF319686.

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.
REACT_243590. EPH-ephrin mediated repulsion of cells.
REACT_257656. EPHB-mediated forward signaling.

Miscellaneous databases

ChiTaRSiTiam1. mouse.
NextBioi301314.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q1R7.
ExpressionAtlasiE9Q1R7. baseline and differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q1R7_MOUSE
AccessioniPrimary (citable) accession number: E9Q1R7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.