SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E9Q1R7

- E9Q1R7_MOUSE

UniProt

E9Q1R7 - E9Q1R7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

T-lymphoma invasion and metastasis-inducing protein 1

Gene
Tiam1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ephrin receptor binding Source: MGI
  2. guanyl-nucleotide exchange factor activity Source: MGI
  3. phospholipid binding Source: MGI
  4. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. ephrin receptor signaling pathway Source: MGI
  2. positive regulation of axonogenesis Source: MGI
  3. regulation of GTPase activity Source: GOC
  4. small GTPase mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
T-lymphoma invasion and metastasis-inducing protein 1Imported
Gene namesi
Name:Tiam1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:103306. Tiam1.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiE9Q1R7.
BgeeiE9Q1R7.

Structurei

3D structure databases

ProteinModelPortaliE9Q1R7.
SMRiE9Q1R7. Positions 65-432.

Family & Domainsi

Sequence similaritiesi

Contains DH (DBL-homology) domain.SAAS annotations
Contains PH domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000114955.
KOiK05731.
TreeFamiTF319686.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q1R7-1 [UniParc]FASTAAdd to Basket

« Hide

MSSLWKIKRK PRVESDRAGD SLYRTLHLST EQVAAFCRSL HEMSPSDSSP    50
SPQDATSPQL ATTRQLSDAD KLRKVICELL ETERTYVKDL NCLMERYLKP 100
LQKETFLTQD ELDVLFGNLT EMVEFQVEFL KTLEDGVRLV PDLEKLEKVD 150
QFKKVLFSLG GSFLYYADRF KLYSAFCASH TKVPKVLVKA KTDTAFKAFL 200
DAQNPRQQHS STLESYLIKP IQRVLKYPLL LRELFALTDA ESEEHYHLDV 250
AIKTMNKVAS HINEMQKIHE EFGAVFDQLI AEQTGEKKEV ADLSMGDLLL 300
HTSVIWLNPP ASLGKWKKEP ELAAFVFKTA VVLVYKDGSK QKKKLVGSHR 350
LSIYEEWDPF RFRHMIPTEA LQVRALPSAD AEANAVCEIV HVKSESEGRP 400
ERVFHLCCSS PESRKDFLKS VHSILRDKHR RQLLKTESLP SAQQYVPFGG 450
KRLCALKGAR PAMSRAVSAP SKSLGRRRRR LARNRFTIDS DAISASSPEK 500
EPQQPAGGGD TDRWVEEQFD LAQYEEQDDI KETDILSDDD EFCESLKGAS 550
VDRDLQEQLQ AASISQRARG RRTLDSHASR MTQLKKQAAL SGINGGLESA 600
SEEVIWVRRE DFAPSRKLNT EI 622
Length:622
Mass (Da):70,648
Last modified:April 5, 2011 - v1
Checksum:i20549BC068A55E80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC087840 Genomic DNA. No translation available.
AC102908 Genomic DNA. No translation available.
AC122218 Genomic DNA. No translation available.
RefSeqiNP_001139359.1. NM_001145887.1.
UniGeneiMm.310902.

Genome annotation databases

EnsembliENSMUST00000164263; ENSMUSP00000126020; ENSMUSG00000002489.
GeneIDi21844.
KEGGimmu:21844.
UCSCiuc007zvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC087840 Genomic DNA. No translation available.
AC102908 Genomic DNA. No translation available.
AC122218 Genomic DNA. No translation available.
RefSeqi NP_001139359.1. NM_001145887.1.
UniGenei Mm.310902.

3D structure databases

ProteinModelPortali E9Q1R7.
SMRi E9Q1R7. Positions 65-432.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000164263 ; ENSMUSP00000126020 ; ENSMUSG00000002489 .
GeneIDi 21844.
KEGGi mmu:21844.
UCSCi uc007zvs.2. mouse.

Organism-specific databases

CTDi 7074.
MGIi MGI:103306. Tiam1.

Phylogenomic databases

GeneTreei ENSGT00740000114955.
KOi K05731.
TreeFami TF319686.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Miscellaneous databases

NextBioi 301314.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9Q1R7.
Bgeei E9Q1R7.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
PROSITEi PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q1R7_MOUSE
AccessioniPrimary (citable) accession number: E9Q1R7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi