Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

E9Q1R7

- E9Q1R7_MOUSE

UniProt

E9Q1R7 - E9Q1R7_MOUSE

Protein
Submitted name:

T-lymphoma invasion and metastasis-inducing protein 1

Gene

Tiam1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. ephrin receptor binding Source: MGI
    2. guanyl-nucleotide exchange factor activity Source: MGI
    3. phospholipid binding Source: MGI
    4. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. ephrin receptor signaling pathway Source: MGI
    2. positive regulation of axonogenesis Source: MGI
    3. positive regulation of GTPase activity Source: GOC
    4. small GTPase mediated signal transduction Source: MGI

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factorSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_204733. G alpha (12/13) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    T-lymphoma invasion and metastasis-inducing protein 1Imported
    Gene namesi
    Name:Tiam1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:103306. Tiam1.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q1R7.
    BgeeiE9Q1R7.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q1R7.
    SMRiE9Q1R7. Positions 65-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains DH (DBL-homology) domain.SAAS annotation
    Contains PH domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114955.
    KOiK05731.
    TreeFamiTF319686.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q1R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLWKIKRK PRVESDRAGD SLYRTLHLST EQVAAFCRSL HEMSPSDSSP    50
    SPQDATSPQL ATTRQLSDAD KLRKVICELL ETERTYVKDL NCLMERYLKP 100
    LQKETFLTQD ELDVLFGNLT EMVEFQVEFL KTLEDGVRLV PDLEKLEKVD 150
    QFKKVLFSLG GSFLYYADRF KLYSAFCASH TKVPKVLVKA KTDTAFKAFL 200
    DAQNPRQQHS STLESYLIKP IQRVLKYPLL LRELFALTDA ESEEHYHLDV 250
    AIKTMNKVAS HINEMQKIHE EFGAVFDQLI AEQTGEKKEV ADLSMGDLLL 300
    HTSVIWLNPP ASLGKWKKEP ELAAFVFKTA VVLVYKDGSK QKKKLVGSHR 350
    LSIYEEWDPF RFRHMIPTEA LQVRALPSAD AEANAVCEIV HVKSESEGRP 400
    ERVFHLCCSS PESRKDFLKS VHSILRDKHR RQLLKTESLP SAQQYVPFGG 450
    KRLCALKGAR PAMSRAVSAP SKSLGRRRRR LARNRFTIDS DAISASSPEK 500
    EPQQPAGGGD TDRWVEEQFD LAQYEEQDDI KETDILSDDD EFCESLKGAS 550
    VDRDLQEQLQ AASISQRARG RRTLDSHASR MTQLKKQAAL SGINGGLESA 600
    SEEVIWVRRE DFAPSRKLNT EI 622
    Length:622
    Mass (Da):70,648
    Last modified:April 5, 2011 - v1
    Checksum:i20549BC068A55E80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087840 Genomic DNA. No translation available.
    AC102908 Genomic DNA. No translation available.
    AC122218 Genomic DNA. No translation available.
    RefSeqiNP_001139359.1. NM_001145887.1.
    UniGeneiMm.310902.

    Genome annotation databases

    EnsembliENSMUST00000164263; ENSMUSP00000126020; ENSMUSG00000002489.
    GeneIDi21844.
    KEGGimmu:21844.
    UCSCiuc007zvs.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087840 Genomic DNA. No translation available.
    AC102908 Genomic DNA. No translation available.
    AC122218 Genomic DNA. No translation available.
    RefSeqi NP_001139359.1. NM_001145887.1.
    UniGenei Mm.310902.

    3D structure databases

    ProteinModelPortali E9Q1R7.
    SMRi E9Q1R7. Positions 65-432.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000164263 ; ENSMUSP00000126020 ; ENSMUSG00000002489 .
    GeneIDi 21844.
    KEGGi mmu:21844.
    UCSCi uc007zvs.2. mouse.

    Organism-specific databases

    CTDi 7074.
    MGIi MGI:103306. Tiam1.

    Phylogenomic databases

    GeneTreei ENSGT00740000114955.
    KOi K05731.
    TreeFami TF319686.

    Enzyme and pathway databases

    Reactomei REACT_204733. G alpha (12/13) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    NextBioi 301314.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q1R7.
    Bgeei E9Q1R7.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q1R7_MOUSE
    AccessioniPrimary (citable) accession number: E9Q1R7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3