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Protein
Submitted name:

T-lymphoma invasion and metastasis-inducing protein 1

Gene

Tiam1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-3928665 EPH-ephrin mediated repulsion of cells
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
T-lymphoma invasion and metastasis-inducing protein 1Imported
Gene namesi
Name:Tiam1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:103306 Tiam1

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiE9Q1R7
PeptideAtlasiE9Q1R7
PRIDEiE9Q1R7

Expressioni

Gene expression databases

BgeeiENSMUSG00000002489
ExpressionAtlasiE9Q1R7 baseline and differential
GenevisibleiE9Q1R7 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9Q1R7
SMRiE9Q1R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 265DHInterPro annotationAdd BLAST195

Phylogenomic databases

eggNOGiENOG410ITS1 Eukaryota
ENOG410XPCM LUCA
GeneTreeiENSGT00900000140796
TreeFamiTF319686

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR033360 TIAM1
PANTHERiPTHR22826:SF88 PTHR22826:SF88, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q1R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLWKIKRK PRVESDRAGD SLYRTLHLST EQVAAFCRSL HEMSPSDSSP
60 70 80 90 100
SPQDATSPQL ATTRQLSDAD KLRKVICELL ETERTYVKDL NCLMERYLKP
110 120 130 140 150
LQKETFLTQD ELDVLFGNLT EMVEFQVEFL KTLEDGVRLV PDLEKLEKVD
160 170 180 190 200
QFKKVLFSLG GSFLYYADRF KLYSAFCASH TKVPKVLVKA KTDTAFKAFL
210 220 230 240 250
DAQNPRQQHS STLESYLIKP IQRVLKYPLL LRELFALTDA ESEEHYHLDV
260 270 280 290 300
AIKTMNKVAS HINEMQKIHE EFGAVFDQLI AEQTGEKKEV ADLSMGDLLL
310 320 330 340 350
HTSVIWLNPP ASLGKWKKEP ELAAFVFKTA VVLVYKDGSK QKKKLVGSHR
360 370 380 390 400
LSIYEEWDPF RFRHMIPTEA LQVRALPSAD AEANAVCEIV HVKSESEGRP
410 420 430 440 450
ERVFHLCCSS PESRKDFLKS VHSILRDKHR RQLLKTESLP SAQQYVPFGG
460 470 480 490 500
KRLCALKGAR PAMSRAVSAP SKSLGRRRRR LARNRFTIDS DAISASSPEK
510 520 530 540 550
EPQQPAGGGD TDRWVEEQFD LAQYEEQDDI KETDILSDDD EFCESLKGAS
560 570 580 590 600
VDRDLQEQLQ AASISQRARG RRTLDSHASR MTQLKKQAAL SGINGGLESA
610 620
SEEVIWVRRE DFAPSRKLNT EI
Length:622
Mass (Da):70,648
Last modified:April 5, 2011 - v1
Checksum:i20549BC068A55E80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087840 Genomic DNA No translation available.
AC102908 Genomic DNA No translation available.
AC122218 Genomic DNA No translation available.
RefSeqiNP_001139359.1, NM_001145887.1
UniGeneiMm.310902

Genome annotation databases

EnsembliENSMUST00000164263; ENSMUSP00000126020; ENSMUSG00000002489
GeneIDi21844
UCSCiuc007zvs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiE9Q1R7_MOUSE
AccessioniPrimary (citable) accession number: E9Q1R7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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