ID   E9Q1C5_MOUSE            Unreviewed;       250 AA.
AC   E9Q1C5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=Interferon, alpha-inducible protein 27 {ECO:0000313|Ensembl:ENSMUSP00000078275.6};
GN   Name=Ifi27 {ECO:0000313|Ensembl:ENSMUSP00000078275.6,
GN   ECO:0000313|MGI:MGI:1277180};
GN   Synonyms=Ifi27l1 {ECO:0000313|MGI:MGI:1277180};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000078275.6, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000078275.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078275.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000078275.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000078275.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the IFI6/IFI27 family.
CC       {ECO:0000256|ARBA:ARBA00007262}.
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DR   RefSeq; NP_919042.2; NM_194066.2.
DR   AlphaFoldDB; E9Q1C5; -.
DR   ProteomicsDB; 365259; -.
DR   DNASU; 52668; -.
DR   Ensembl; ENSMUST00000079294.12; ENSMUSP00000078275.6; ENSMUSG00000064215.14.
DR   GeneID; 52668; -.
DR   UCSC; uc007ovr.2; mouse.
DR   AGR; MGI:1277180; -.
DR   CTD; 3429; -.
DR   MGI; MGI:1277180; Ifi27.
DR   VEuPathDB; HostDB:ENSMUSG00000064215; -.
DR   GeneTree; ENSGT00940000155018; -.
DR   OrthoDB; 4850256at2759; -.
DR   BioGRID-ORCS; 52668; 2 hits in 78 CRISPR screens.
DR   ChiTaRS; Ifi27; mouse.
DR   Proteomes; UP000000589; Chromosome 12.
DR   Bgee; ENSMUSG00000064215; Expressed in choroid plexus of fourth ventricle and 233 other cell types or tissues.
DR   ExpressionAtlas; E9Q1C5; baseline and differential.
DR   GO; GO:0031966; C:mitochondrial membrane; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR   GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR   GO; GO:0005637; C:nuclear inner membrane; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0005521; F:lamin binding; ISO:MGI.
DR   GO; GO:0060090; F:molecular adaptor activity; ISO:MGI.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0046825; P:regulation of protein export from nucleus; IMP:MGI.
DR   Gene3D; 6.10.110.10; -; 1.
DR   InterPro; IPR009311; IFI6/IFI27-like.
DR   InterPro; IPR038213; IFI6/IFI27-like_sf.
DR   PANTHER; PTHR16932; INTERFERON ALPHA-INDUCIBLE PROTEIN 27; 1.
DR   PANTHER; PTHR16932:SF30; INTERFERON, ALPHA-INDUCIBLE PROTEIN 27; 1.
DR   Pfam; PF06140; Ifi-6-16; 1.
DR   Genevisible; E9Q1C5; MM.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:E9Q1C5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ   SEQUENCE   250 AA;  24676 MW;  04BA97C3BF4A690E CRC64;
     MAFSGTGTLV ASIVSKMTSS AAMVKAGGAV SGTILAGSKG LILLTQSALG SATSALGALK
     VGTILSGFSA STLAASPIGE EPALVGREKK SDFRFSFPAA GKAARRQRKE GQSKIYLKGF
     EFSRAMTVAA VPPALSAVGF TASGIAASSL AAKMMSLSAI ANGGGVPAGG LVAILQSAGA
     AGLSVPSTVI VGSAGSAVVA SVMNICESFY PFLMGSEVAD MATEVADMAI EVADISTEEA
     LPNLSNTEKD
//