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Protein
Submitted name:

Protein Tns1

Gene

Tns1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: MGI
  • poly(A) RNA binding Source: MGI

GO - Biological processi

  • cell-substrate junction assembly Source: MGI
  • fibroblast migration Source: MGI
  • intracellular signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Tns1Imported
Gene namesi
Name:Tns1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104552. Tns1.

Subcellular locationi

GO - Cellular componenti

  • cell-substrate junction Source: MGI
  • focal adhesion Source: MGI
  • intracellular Source: GOC
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9Q0S6.
MaxQBiE9Q0S6.
PaxDbiE9Q0S6.
PeptideAtlasiE9Q0S6.
PRIDEiE9Q0S6.

PTM databases

iPTMnetiE9Q0S6.

Expressioni

Gene expression databases

BgeeiE9Q0S6.
ExpressionAtlasiE9Q0S6. baseline and differential.
GenevisibleiE9Q0S6. MM.

Interactioni

GO - Molecular functioni

  • actin binding Source: MGI

Protein-protein interaction databases

IntActiE9Q0S6. 1 interaction.
STRINGi10090.ENSMUSP00000127715.

Structurei

3D structure databases

ProteinModelPortaliE9Q0S6.
SMRiE9Q0S6. Positions 1611-1727, 1750-1882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 10848Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini175 – 347173Phosphatase tensin-typeInterPro annotationAdd
BLAST
Domaini352 – 478127C2 tensin-typeInterPro annotationAdd
BLAST
Domaini1616 – 1725110SH2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains SH2 domain.SAAS annotation

Keywords - Domaini

SH2 domainSAAS annotation

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
InParanoidiE9Q0S6.
OMAiMDHLENG.
OrthoDBiEOG7QG43J.
TreeFamiTF315996.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q0S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCTVSLVCC EALEPLPSCG PQPPGTPPGP ARPERCEPGG AAPDPRRRLL
60 70 80 90 100
LQPEDLEAPK THHFKVKAFK KVKPCGICRQ AITREGCVCK VCSFSCHRKC
110 120 130 140 150
QAKVAAPCVP PSSHELVPIT TETVPKNVVD VGEGDCRVGS SPKNLEEGGS
160 170 180 190 200
MRVSPSIQPQ PQSQPTSLSR NTSVSRAMED SCELDLVYVT ERIIAVSFPS
210 220 230 240 250
TANEENFRSN LREVAQMLKS KHGGNYLLFN LSEQRPDITK LHAKVLEFGW
260 270 280 290 300
PDLHTPALEK ICSVCKAMDT WLNADPHNVV VLHNKGNRGR IGVVIAAYLH
310 320 330 340 350
YSNISASADQ ALDRFAMKRF YEDKIVPIGQ PSQRRYVHYF SGLLSGSIKM
360 370 380 390 400
NNKPLFLHHV IMHGIPNFES KGGCRPFLRI YQAMQPVYTS GIYNIPGDSQ
410 420 430 440 450
ASICITIEPG LLLKGDILLK CYHKKFRSPA RDVIFRVQFH TCAIHDLGVV
460 470 480 490 500
FGKEDLDEAF KDDRFPDYGK VEFVFSYGPE KIQGMEHLEN GPSVSVDYNT
510 520 530 540 550
SDPLIRWDSY DNFSGHREDG MEEVVGHTQG PLDGSLYAKV KKKDSLNGSS
560 570 580 590 600
GPVTTARPAL SATPNHVEHT LSVSSDSGNS TASTKTDKTD EPVSGATTAP
610 620 630 640 650
AALSPQEKKE LDRLLSGFGV DREKQGAMYR AQQLRSHPGG GPTVPSPGRH
660 670 680 690 700
IVPAQVHVNG GALASERETD ILDDELPIQD GQSGGSMGTL SSLDGVTNTS
710 720 730 740 750
ESGYPETLSP LTNGLDKPYS TEPVLNGGGY PYEAANRVIP VHSSHSAPIR
760 770 780 790 800
PSYSAQEGLA GYQREGPHPA WSQQVTSAHC GCDPSGLFRS QSFPDVEPQL
810 820 830 840 850
PQAPTRGGSS REAVQRGLNS WQQQQPHPPP RQQERSPLQS LARSKPSPQL
860 870 880 890 900
SAETPVAALP EFPRAASQQE IEQSIETLNM LMLDLEPASA AAPLHKSQSV
910 920 930 940 950
PGAWPGASPL SSQPLLGSSR QSHPLTQSRS GYIPSGHSLG TPELVSSGRP
960 970 980 990 1000
YSPYDYQLHP AGSNQSFHPK SPASSTFLPS PHSSAGPQEP PASLPGLIAQ
1010 1020 1030 1040 1050
PQLPPKETTS DPSRTPEEEP LNLEGLVAHR VAGVQARERQ PAEPPGPLRR
1060 1070 1080 1090 1100
RAASDGQYEN QSPEATSPRS PGVRSPVQCV SPELALTIAL NPGGRPKEPH
1110 1120 1130 1140 1150
LHSYKEAFEE MEGTSPSSPP HSVARSPPGL AKTPLSALGL KPHNPADILL
1160 1170 1180 1190 1200
HPTGVARRLI QPEEDEGEEV TKPPEEPRSY VESVARTAVA GPRAQDVEPK
1210 1220 1230 1240 1250
SFSAPAAHAY GHETPLRNGT PGGSFVSPSP LSTSSPILSA DSTSVGSFPS
1260 1270 1280 1290 1300
VVSSDQGPRT PFQPMLDSSI RSGSLGQPSP AALSYQSSSP VPVGGSSYNS
1310 1320 1330 1340 1350
PDYSLQPFSS SPESQGQPQY SAASVHMVPG SPQARHRTVG TNTPPSPGFG
1360 1370 1380 1390 1400
RRAVNPTMAA PGSPSLSHRQ VMGPSGPGFH GNVVSGHPAS AATTPGSPSL
1410 1420 1430 1440 1450
GRHPVGSHQV PGLHSSVVTT PGSPSLGRHP GAHQGNLASS LHSNAVISPG
1460 1470 1480 1490 1500
SPSLGRHLGG SGSVVPGSPS LDRHAAYGGY STPEDRRPTL SRQSSASGYQ
1510 1520 1530 1540 1550
APSTPSFPVS PAYYPGLSSP ATSPSPDSAA FRQGSPTPAL PEKRRMSVGD
1560 1570 1580 1590 1600
RAGSLPNYAT INGKVSSSPV ANGMASGSST VSFSHTLPDF SKYSMPDNSP
1610 1620 1630 1640 1650
ETRAKVKFVQ DTSKYWYKPE ISREQAIALL KDQEPGAFII RDSHSFRGAY
1660 1670 1680 1690 1700
GLAMKVSSPP PTITQQGKKG DMTHELVRHF LIETGPRGVK LKGCPNEPNF
1710 1720 1730 1740 1750
GSLSALVYQH SVIPLALPCK LVIPSRDPTD ESKDSSGPAN STTDLLKQGA
1760 1770 1780 1790 1800
ACNVLFVNSV DMESLTGPQA ISKATSETLA ADPTPAATIV HFKVSAQGIT
1810 1820 1830 1840 1850
LTDNQRKLFF RRHYPLNTVT FCDLDPQERK WMKTEGGAPA KLFGFVARKQ
1860 1870 1880
GSTTDNACHL FAELDPNQPA SAIVNFVSKV MLSAGQKR
Length:1,888
Mass (Da):201,383
Last modified:April 5, 2011 - v1
Checksum:i8143843A1BFC2494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116419 Genomic DNA. No translation available.
AC117757 Genomic DNA. No translation available.
RefSeqiNP_082160.3. NM_027884.3.
UniGeneiMm.309975.

Genome annotation databases

EnsembliENSMUST00000169786; ENSMUSP00000127715; ENSMUSG00000055322.
GeneIDi21961.
UCSCiuc011wmx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116419 Genomic DNA. No translation available.
AC117757 Genomic DNA. No translation available.
RefSeqiNP_082160.3. NM_027884.3.
UniGeneiMm.309975.

3D structure databases

ProteinModelPortaliE9Q0S6.
SMRiE9Q0S6. Positions 1611-1727, 1750-1882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q0S6. 1 interaction.
STRINGi10090.ENSMUSP00000127715.

PTM databases

iPTMnetiE9Q0S6.

Proteomic databases

EPDiE9Q0S6.
MaxQBiE9Q0S6.
PaxDbiE9Q0S6.
PeptideAtlasiE9Q0S6.
PRIDEiE9Q0S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169786; ENSMUSP00000127715; ENSMUSG00000055322.
GeneIDi21961.
UCSCiuc011wmx.2. mouse.

Organism-specific databases

CTDi7145.
MGIiMGI:104552. Tns1.

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
InParanoidiE9Q0S6.
OMAiMDHLENG.
OrthoDBiEOG7QG43J.
TreeFamiTF315996.

Miscellaneous databases

ChiTaRSiTns1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q0S6.
ExpressionAtlasiE9Q0S6. baseline and differential.
GenevisibleiE9Q0S6. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q0S6_MOUSE
AccessioniPrimary (citable) accession number: E9Q0S6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.