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Protein
Submitted name:

Intersectin-1

Gene

Itsn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Intersectin-1Imported
Gene namesi
Name:Itsn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1338069. Itsn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9Q0N0.
MaxQBiE9Q0N0.
PaxDbiE9Q0N0.

Expressioni

Gene expression databases

BgeeiE9Q0N0.
ExpressionAtlasiE9Q0N0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109635.

Structurei

3D structure databases

ProteinModelPortaliE9Q0N0.
SMRiE9Q0N0. Positions 1-111, 210-312, 914-967, 1003-1058, 1068-1579, 1593-1716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10080EHInterPro annotationAdd
BLAST
Domaini53 – 8836EF-handInterPro annotationAdd
BLAST
Domaini221 – 31090EHInterPro annotationAdd
BLAST
Domaini254 – 28936EF-handInterPro annotationAdd
BLAST
Domaini738 – 80467SH3InterPro annotationAdd
BLAST
Domaini911 – 96959SH3InterPro annotationAdd
BLAST
Domaini1000 – 105859SH3InterPro annotationAdd
BLAST
Domaini1072 – 113665SH3InterPro annotationAdd
BLAST
Domaini1153 – 121260SH3InterPro annotationAdd
BLAST
Domaini1235 – 1421187DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini1460 – 1569110PHInterPro annotationAdd
BLAST
Domaini1595 – 167783C2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili354 – 44693Sequence analysisAdd
BLAST
Coiled coili474 – 51542Sequence analysisAdd
BLAST
Coiled coili564 – 60542Sequence analysisAdd
BLAST
Coiled coili615 – 65844Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 5 SH3 domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
OMAiVMVKGEW.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF14604. SH3_9. 3 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q0N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFPTPFGG SLDVWAITVE ERAKHDQQFL SLKPIAGFIT GDQARNFFFQ
60 70 80 90 100
SGLPQPVLAQ IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSTLPP
110 120 130 140 150
VMKQQPVAIS SAPAFGIGGI ASMPPLTAVA PVPMGSIPVV GMSPPLVSSV
160 170 180 190 200
PPAAVPPLAN GAPPVIQPLP AFAHPAATLP KSSSFSRSGP GSQLNTKLQK
210 220 230 240 250
AQSFDVASAP PAAEWAVPQS SRLKYRQLFN SHDKTMSGHL TGPQARTILM
260 270 280 290 300
QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
310 320 330 340 350
PEYIPPSFRR VRSGSGMSVI SSSSVDQRLP EEPSSEDEQQ PEKKLPVTFE
360 370 380 390 400
DKKRENFERG SVELEKRRQA LLEQQRKEQE RLAQLERAEQ ERKERERQEQ
410 420 430 440 450
ERKRQLELEK QLEKQRELER QREEERRKEI ERREAAKREL ERQRQLEWER
460 470 480 490 500
NRRQELLNQR NKEQEGTVVL KARRKTLEFE LEALNDKKHQ LEGKLQDIRC
510 520 530 540 550
RLATQRQEIE STNKSRELRI AEITHLQQQL QESQQMLGRL IPEKQILSDQ
560 570 580 590 600
LKQVQQNSLH RDSLLTLKRA LEAKELARQQ LREQLDEVER ETRSKLQEID
610 620 630 640 650
VFNNQLKELR EIHSKQQLQK QRSLEAARLK QKEQERKSLE LEKQKEDAQR
660 670 680 690 700
RVQERDKQWL EHVQQEEQPR PRKPHEEDRL KREDSVRKKE AEERAKPEMQ
710 720 730 740 750
DKQSRLFHPH QEPAKLATQA PWSTTEKGPL TISAQESVKV VYYRALYPFE
760 770 780 790 800
SRSHDEITIQ PGDIVMVKGE WVDESQTGEP GWLGGELKGK TGWFPANYAE
810 820 830 840 850
KIPENEVPTP AKPVTDLTSA PAPKLALRET PAPLPVTSSE PSTTPNNWAD
860 870 880 890 900
FSSTWPSSSN EKPETDNWDT WAAQPSLTVP SAGQLRQRSA FTPATATGSS
910 920 930 940 950
PSPVLGQGEK VEGLQAQALY PWRAKKDNHL NFNKSDVITV LEQQDMWWFG
960 970 980 990 1000
EVQGQKGWFP KSYVKLISGP VRKSTSIDTG PTESPASLKR VASPAAKPAI
1010 1020 1030 1040 1050
PGEEFIAMYT YESSEQGDLT FQQGDVIVVT KKDGDWWTGT VGDKSGVFPS
1060 1070 1080 1090 1100
NYVRLKDSEG SGTAGKTGSL GKKPEIAQVI ASYAATGPEQ LTLAPGQLIL
1110 1120 1130 1140 1150
IRKKNPGGWW EGELQARGKK RQIGWFPANY VKLLSPGTSK ITPTELPKTA
1160 1170 1180 1190 1200
VQPAVCQVIG MYDYTAQNDD ELAFSKGQII NVLNKEDPDW WKGEVSGQVG
1210 1220 1230 1240 1250
LFPSNYVKLT TDMDPSQQWC SDLHLLDMLT PTERKRQGYI HELIVTEENY
1260 1270 1280 1290 1300
VNDLQLVTEI FQKPLTESEL LTEKEVAMIF VNWKELIMCN IKLLKALRVR
1310 1320 1330 1340 1350
KKMSGEKMPV KMIGDILSAQ LPHMQPYIRF CSCQLNGAAL IQQKTDEAPD
1360 1370 1380 1390 1400
FKEFVKRLAM DPRCKGMPLS SFILKPMQRV TRYPLIIKNI LENTPENHPD
1410 1420 1430 1440 1450
HSHLKHALEK AEELCSQVNE GVREKENSDR LEWIQAHVQC EGLSEQLVFN
1460 1470 1480 1490 1500
SVTNCLGPRK FLHSGKLYKA KSNKELYGFL FNDFLLLTQI TKPLGSSGTD
1510 1520 1530 1540 1550
KVFSPKSNLQ YKMYKTPIFL NEVLVKLPTD PSGDEPIFHI SHIDRVYTLR
1560 1570 1580 1590 1600
AESINERTAW VQKIKAASEL YIETEKKKRE KAYLVRSQRA TGIGRLMVNV
1610 1620 1630 1640 1650
VEGIELKPCR SHGKSNPYCE VTMGSQCHIT KTIQDTLNPK WNSNCQFFIR
1660 1670 1680 1690 1700
DLEQEVLCIT VFERDQFSPD DFLGRTEIRV ADIKKDQGSK GPVTKCLLLH
1710
EVPTGEIVVR LDLQLFDEP
Length:1,719
Mass (Da):194,897
Last modified:April 5, 2011 - v1
Checksum:iB59C3A9BFC702EF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126053 Genomic DNA. No translation available.
AC131691 Genomic DNA. No translation available.
AC134837 Genomic DNA. No translation available.
RefSeqiXP_006522997.1. XM_006522934.2.
UniGeneiMm.40546.

Genome annotation databases

EnsembliENSMUST00000064797; ENSMUSP00000066361; ENSMUSG00000022957.
GeneIDi16443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126053 Genomic DNA. No translation available.
AC131691 Genomic DNA. No translation available.
AC134837 Genomic DNA. No translation available.
RefSeqiXP_006522997.1. XM_006522934.2.
UniGeneiMm.40546.

3D structure databases

ProteinModelPortaliE9Q0N0.
SMRiE9Q0N0. Positions 1-111, 210-312, 914-967, 1003-1058, 1068-1579, 1593-1716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109635.

Proteomic databases

EPDiE9Q0N0.
MaxQBiE9Q0N0.
PaxDbiE9Q0N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064797; ENSMUSP00000066361; ENSMUSG00000022957.
GeneIDi16443.

Organism-specific databases

CTDi6453.
MGIiMGI:1338069. Itsn1.

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
GeneTreeiENSGT00760000118985.
OMAiVMVKGEW.

Miscellaneous databases

ChiTaRSiItsn1. mouse.
NextBioi35554595.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q0N0.
ExpressionAtlasiE9Q0N0. baseline and differential.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF14604. SH3_9. 3 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q0N0_MOUSE
AccessioniPrimary (citable) accession number: E9Q0N0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.