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Protein
Submitted name:

Desmoplakin

Gene

Dsp

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: MGI
  2. protein binding, bridging Source: MGI
  3. protein kinase C binding Source: MGI
  4. scaffold protein binding Source: MGI
  5. structural molecule activity Source: MGI

GO - Biological processi

  1. adherens junction organization Source: MGI
  2. bundle of His cell to Purkinje myocyte communication Source: MGI
  3. desmosome organization Source: MGI
  4. intermediate filament cytoskeleton organization Source: MGI
  5. keratinocyte differentiation Source: MGI
  6. peptide cross-linking Source: MGI
  7. regulation of heart rate by cardiac conduction Source: MGI
  8. single organismal cell-cell adhesion Source: MGI
  9. skin development Source: MGI
  10. ventricular cardiac muscle cell action potential Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
DesmoplakinImported
Gene namesi
Name:DspImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:109611. Dsp.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. cell-cell junction Source: MGI
  3. cornified envelope Source: MGI
  4. cytoskeleton Source: InterPro
  5. desmosome Source: MGI
  6. extracellular vesicular exosome Source: MGI
  7. intercalated disc Source: MGI
  8. membrane Source: MGI
  9. mitochondrion Source: MGI
  10. nucleus Source: MGI
  11. plasma membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PZW0.

Expressioni

Gene expression databases

BgeeiE9PZW0.
ExpressionAtlasiE9PZW0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PZW0.
SMRiE9PZW0. Positions 190-639, 1622-1861, 2026-2221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119163.
KOiK10381.
OrthoDBiEOG7TQTZV.

Family and domain databases

Gene3Di3.90.1290.10. 5 hits.
InterProiIPR028462. Desmoplakin.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR11915:SF234. PTHR11915:SF234. 1 hit.
PfamiPF00681. Plectin. 8 hits.
[Graphical view]
SMARTiSM00250. PLEC. 18 hits.
SM00150. SPEC. 2 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 5 hits.

Sequencei

Sequence statusi: Complete.

E9PZW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TYSGGGGGGG GGGGGGTSRT
60 70 80 90 100
FYSHSRRCTV NDQNSDGYCQ TGTMSRHQNQ NTIQEMLQNC SDCLMRAELI
110 120 130 140 150
AQPELKFGEG MQLAWNRELD EYFTQANDQM EIIDGLIREM RQMGQPCDAY
160 170 180 190 200
QKRLLQLQEQ MRALYKAISV PRVRRASSKG AGGYTCQSGS GWDEFTKRLT
210 220 230 240 250
GECLGWMRQQ REEMDLMAWG VDAGSVEQHI NSHRSIHNTI GDYRWQLDKI
260 270 280 290 300
KADLREKSAI YQLEEEYENL LKASFERMDH LRQLQNIIQA TSREIMWIND
310 320 330 340 350
CEEEELLYDW SDKNTNIAQK QEAFSIRMSQ LEVKEKELNK LKQESDQLVL
360 370 380 390 400
NQHPASDKIE AYMDTLQTQW SWILQITKCI DVHLKENAAY FQFFEEAQST
410 420 430 440 450
EAYLKGLQDS IRKKYPCDKN MPLQHLLEQI KELEKEREKI IEYKRQVQNL
460 470 480 490 500
VNKSKKIVQL KPRNPDYRSN KPIILRALCD YKQDQKIVHK GDECILKDNN
510 520 530 540 550
ERSKWYVTGP GGVDMLVPSV GLIIPPPNPL AVDLSCKIEQ YYEAILALWN
560 570 580 590 600
QLYINMKSLV SWHYCMIDIE KIRAMTIAKL KTMRQEDYMK TIEDLELHYQ
610 620 630 640 650
DFIKNSQGSE MFGDDDKRRM QSQFTDAQKH YQTLVIQLPG HPQHQTVTKT
660 670 680 690 700
EITHLGTCQD VNHNKVIETN RENDKQETWL LMELQKIRRQ MEHCEARMTL
710 720 730 740 750
KNLLLAEQGS THHITVKINE LKSVQNDSQA LAEVLNQLKD MLANFRGSEK
760 770 780 790 800
YCYLQNEIFG LFQKLENING VSDGYLNSLC SVRALLQAIL QTEDMLKVYE
810 820 830 840 850
ARLTEEETVC LDLDKVEAYR CGLKKIKNDL NLKKSLLATM KTELQKAQQI
860 870 880 890 900
HSQSSQQYPL YDLDLGKFTE KVTQLTDRWQ KIDKQIDFRL WDLEKQIKQL
910 920 930 940 950
RNYRDNYQSF CKWLYDAKRR QDSLESMKFG DSNTVMRFLN EQKNLHSEIS
960 970 980 990 1000
GKRDKSEEVH KIAELCANSI KDYELQLASY TSGLETLLNI PIKRTMVQSP
1010 1020 1030 1040 1050
SGVILQEAAD IHARYIELLT RSGDYYRFLS EMLKSLEDLK LKNTKIEVLE
1060 1070 1080 1090 1100
EELRLARDAN SENCNKNKFL DQNLQKYQAE CSQFKAKLVS LEELKRQAEL
1110 1120 1130 1140 1150
DGKSAKQNLD KCYGQIKELN EKITRLTYEI EDEKRRRKTV EDRFDQQKND
1160 1170 1180 1190 1200
YDQLQKARQC EKENLSWQKL ESEKAIKEKE YEIERLRVLL QEEGARKREY
1210 1220 1230 1240 1250
ENELAKASNR IQESKSQCTQ VVQERESLLV KIKVLEQDKA RLQRLEDELN
1260 1270 1280 1290 1300
RAKATLEAES RVKQRLECEK QQIQNDLNQW KTQYSRKEET IRKIESEREK
1310 1320 1330 1340 1350
SEREKNSLRS EIERLQAEIK RIEERCRRKL EDSSRETQSQ LESERCRLQK
1360 1370 1380 1390 1400
EIEKLRQRPY GSHRETQTEY EWTVDSSKLV FDGLRKKVTA MQLYECQLID
1410 1420 1430 1440 1450
KTTLDKLLKG KKSVEEVASE IQPFLRGAGA IAGASASPKE KYSLVEAKRK
1460 1470 1480 1490 1500
KFITPESTVM LLEAQAATGG IIDPHRNEKL TVDNAVARDL IDFDDRQQIY
1510 1520 1530 1540 1550
TAEKAITGFD DPFSGKTVSV SEAIKKNLID RETGMRLLEA QLASGGVVDP
1560 1570 1580 1590 1600
VNSVFLPKDV ALARGLIDRD LYRSLNDPRD SQKNFVDPIT KKKVSYMQLR
1610 1620 1630 1640 1650
ERCRIEPHTG LLLLSVQKRS MSFQGIRQPV TVTELVDSGI LRPSTVNELE
1660 1670 1680 1690 1700
SGQISYDEVG ERIKDFLQGS SCIAGIYNET TKQKLGIYEA MKIGLVRPGT
1710 1720 1730 1740 1750
ALELLEAQAA TGFIVDPVSN LRLPVEEAYK RGLVGIEFKE KLLSAERAVT
1760 1770 1780 1790 1800
GYNDPETGNI ISLFQAMNKE LIEKGHGIRL LEAQIATGGI IDPKESHRLP
1810 1820 1830 1840 1850
VDMAYKRGYF NEELSEILSD PSDDTKGFFD PNTEENLTYL QLKERCIKDE
1860 1870 1880 1890 1900
ETGLCLLPLK EKKKQVQTSQ KNTLRKRRVV IVDPETNKEM SVQEAYKKGL
1910 1920 1930 1940 1950
IDYDTFKELC EQECEWEEIT ITGSDGSTRV VLVDRKTGSQ YDIQDAIDKG
1960 1970 1980 1990 2000
LVDRKFFDQY RSGSLSLTQF ADMISLKNGV GNSSGLGGSV NDDVFSSSRH
2010 2020 2030 2040 2050
DSVSKISTIS SVRNLTIRSS SLSDPLEESS PIAAIFDTEN LEKISIAEGI
2060 2070 2080 2090 2100
ERGIVDSITG QRLLEAQACT GGIIHPTTGQ KLSLQDAVNQ GLIDQDMATR
2110 2120 2130 2140 2150
LKPAQKAFIG FEGVKGKKKM SAAEAVKEKW LPYEAGQRFL EFQFLTGGLV
2160 2170 2180 2190 2200
DPEVHGRIST EEAIRKGFID GRAAQRLQDI SSYAKILTCP KTKLKISYKD
2210 2220 2230 2240 2250
AMNRSMVEDI TGLRLLEAAS VSSKGLPSPY NMSAPGSRSG SRSGSRSGSR
2260 2270 2280
SGSRSGSRRG SFDATGNSSY SYSYSFSSSS IGGY
Length:2,284
Mass (Da):261,420
Last modified:April 5, 2011 - v1
Checksum:i8C5DB16985159434
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140331 Genomic DNA. No translation available.
RefSeqiXP_006516595.1. XM_006516532.1.
UniGeneiMm.355327.

Genome annotation databases

EnsembliENSMUST00000127906; ENSMUSP00000117252; ENSMUSG00000054889.
GeneIDi109620.
KEGGimmu:109620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140331 Genomic DNA. No translation available.
RefSeqiXP_006516595.1. XM_006516532.1.
UniGeneiMm.355327.

3D structure databases

ProteinModelPortaliE9PZW0.
SMRiE9PZW0. Positions 190-639, 1622-1861, 2026-2221.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9PZW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000127906; ENSMUSP00000117252; ENSMUSG00000054889.
GeneIDi109620.
KEGGimmu:109620.

Organism-specific databases

CTDi1832.
MGIiMGI:109611. Dsp.

Phylogenomic databases

GeneTreeiENSGT00760000119163.
KOiK10381.
OrthoDBiEOG7TQTZV.

Miscellaneous databases

ChiTaRSiDsp. mouse.
NextBioi35554491.
SOURCEiSearch...

Gene expression databases

BgeeiE9PZW0.
ExpressionAtlasiE9PZW0. baseline and differential.

Family and domain databases

Gene3Di3.90.1290.10. 5 hits.
InterProiIPR028462. Desmoplakin.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR11915:SF234. PTHR11915:SF234. 1 hit.
PfamiPF00681. Plectin. 8 hits.
[Graphical view]
SMARTiSM00250. PLEC. 18 hits.
SM00150. SPEC. 2 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 5 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PZW0_MOUSE
AccessioniPrimary (citable) accession number: E9PZW0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.