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Protein
Submitted name:

Protein Sptbn4

Gene

Sptbn4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: MGI
  • ankyrin binding Source: MGI
  • phosphatase binding Source: MGI
  • phospholipid binding Source: InterPro
  • spectrin binding Source: MGI

GO - Biological processi

  • adult behavior Source: MGI
  • adult walking behavior Source: MGI
  • axonogenesis Source: MGI
  • cardiac conduction Source: MGI
  • cellular protein localization Source: MGI
  • central nervous system projection neuron axonogenesis Source: MGI
  • clustering of voltage-gated sodium channels Source: MGI
  • fertilization Source: MGI
  • negative regulation of heart rate Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • regulation of peptidyl-serine phosphorylation Source: MGI
  • regulation of sodium ion transport Source: MGI
  • reproductive process Source: MGI
  • sensory perception of sound Source: MGI
  • transmission of nerve impulse Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Sptbn4Imported
Gene namesi
Name:Sptbn4Imported
Synonyms:Spnb4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1890574. Sptbn4.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • axon hillock Source: MGI
  • axon initial segment Source: MGI
  • cell body fiber Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • membrane Source: MGI
  • neuronal cell body Source: MGI
  • nuclear matrix Source: MGI
  • paranode region of axon Source: MGI
  • PML body Source: MGI
  • spectrin Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiE9PZC2.

Interactioni

GO - Molecular functioni

  • actin binding Source: MGI
  • ankyrin binding Source: MGI
  • phosphatase binding Source: MGI
  • spectrin binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011895.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1095 – 1204110PHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili121 – 14828Sequence analysisAdd
BLAST
Coiled coili339 – 36628Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
KOiK06115.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00435. Spectrin. 8 hits.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00150. SPEC. 8 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PZC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMARDGTRE DSHKLHKRWL RHQAFMAELA QNKEWLEKIE REGQQLMQEK
60 70 80 90 100
PELAASVRKK LGEIRQCWAE LESTTQAKAR QLFEASKADQ LVQSFAELDK
110 120 130 140 150
RLLHMESQLQ DVDPGGDLAT VNSQLKKLQS MESQVEEWCR EVGELQAQTA
160 170 180 190 200
ALPLEQASKE LVGERQSAVG ERLVRLLEPL QERRRLLLAS KELHQVAHDL
210 220 230 240 250
DDELAWVQER LPLAMQTERG TGLQAVQQHI KKNQGLRREI QAHGPRLEEV
260 270 280 290 300
LERAGVLASL RSPEAEAVRR GQEQLQSAWT GLREAAERRQ QTLDAAFQVE
310 320 330 340 350
QYYFDVAEVE AWLGEQELLM MSEDKGKDEQ STLQLLKKHL QLEQGVENYE
360 370 380 390 400
ESIAQLSRQC RALLEMGHPD SEQISRRQSQ VDRLYVALKE LGEERRVSLE
410 420 430 440 450
QQYWLYQLSR QVDELEHWIA EKEVVAGSPE LGQDFEHVSV LQEKFSEFAS
460 470 480 490 500
ETGTAGRERL AAVNQMVDEL IECGHTAAAT MAEWKDGLNE AWAELLELMG
510 520 530 540 550
TRAQLLAASR ELHKFFSDAR ELQGQIEEKR RRLPRLTAPP EPRPSASSMQ
560 570 580 590 600
RTLRAFEHDL QLLVSQVRQL QEGAAQLRTV YAGEHAEAIA SREQEVLQGW
610 620 630 640 650
KELLAACEDA RLHVSSTADA LRFHSQARDL LSWMDGIAGQ IGAADKPRDV
660 670 680 690 700
SSVEVLMNYH QGLKTELEAR VPELATCQEL GRSLLLNKSA MADEIQAQLD
710 720 730 740 750
KLGSRKEEVS EKWDRHWEWL QQMLEVHQFA QEAVVADAWL TAQEPLLQSR
760 770 780 790 800
ELGSSVDEVE QLIRRHEAFR KAAAAWEERF SSLRRLTTIE KLKAEQSKQP
810 820 830 840 850
PTPLLGRKFF GDPTELAAKA APLLRPGGYD RGLEPLARRA SDTLSAEVRT
860 870 880 890 900
RVGYVRQELK PERLQPRIDR LPETSGKVEP AAPTAAALDT TDTPGTPAAT
910 920 930 940 950
ELVRPRSERQ ELADRAEELP RRRRSERQES VDQPEETARR RRPERQESAD
960 970 980 990 1000
HEGPHSLTLG RYEQMERRRE RRERRIERQE SSEQETPTRG ELVKGKATLA
1010 1020 1030 1040 1050
DIVEQLQEKE AGPGIPAGVP SLPQPRELPP GRLPNGLEPP ERTPRPDRPR
1060 1070 1080 1090 1100
ARDRPKPRRR PRPREGGEGG GSRRSRSAPA QGGSAPAPPP PPTHTVQHEG
1110 1120 1130 1140 1150
FLLRKRELDA NRKSSNRSWV SLYCVLSKGE LGFYKDSKGP ASGGTHGGEP
1160 1170 1180 1190 1200
LLSLHKATSE VASDYKKKKH VFKLQTQDGS EFLLQAKDEE EMNGWLEAVA
1210 1220 1230 1240
NSVAEHAEIA RWGQTLPTTS STDEGNPKRE GGERRASGRR K
Length:1,241
Mass (Da):140,574
Last modified:April 5, 2011 - v1
Checksum:iBAB3AC56F3074235
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157561 Genomic DNA. No translation available.
AC158304 Genomic DNA. No translation available.
RefSeqiNP_001186163.1. NM_001199234.1.
NP_001186164.1. NM_001199235.1.
NP_001186165.1. NM_001199236.1.
UniGeneiMm.459123.

Genome annotation databases

EnsembliENSMUST00000108362; ENSMUSP00000103999; ENSMUSG00000011751.
ENSMUST00000108363; ENSMUSP00000104000; ENSMUSG00000011751.
ENSMUST00000108364; ENSMUSP00000104001; ENSMUSG00000011751.
GeneIDi80297.
KEGGimmu:80297.
UCSCiuc009fvz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157561 Genomic DNA. No translation available.
AC158304 Genomic DNA. No translation available.
RefSeqiNP_001186163.1. NM_001199234.1.
NP_001186164.1. NM_001199235.1.
NP_001186165.1. NM_001199236.1.
UniGeneiMm.459123.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000011895.

Proteomic databases

PeptideAtlasiE9PZC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108362; ENSMUSP00000103999; ENSMUSG00000011751.
ENSMUST00000108363; ENSMUSP00000104000; ENSMUSG00000011751.
ENSMUST00000108364; ENSMUSP00000104001; ENSMUSG00000011751.
GeneIDi80297.
KEGGimmu:80297.
UCSCiuc009fvz.1. mouse.

Organism-specific databases

CTDi57731.
MGIiMGI:1890574. Sptbn4.

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
KOiK06115.

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00435. Spectrin. 8 hits.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00150. SPEC. 8 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PZC2_MOUSE
AccessioniPrimary (citable) accession number: E9PZC2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.