Blm

Functionⁱ

GO - Molecular functionⁱ

8-hydroxy-2'-deoxyguanosine DNA binding Source: Ensembl
annealing helicase activity Source: Ensembl
ATP binding Source: Ensembl
ATP-dependent 3'-5' DNA helicase activity Source: InterPro
bubble DNA binding Source: Ensembl
forked DNA-dependent helicase activity Source: Ensembl
four-way junction DNA binding Source: Ensembl
four-way junction helicase activity Source: Ensembl
G-quadruplex DNA binding Source: Ensembl
p53 binding Source: Ensembl
single-stranded DNA binding Source: Ensembl
telomeric D-loop binding Source: Ensembl
Y-form DNA binding Source: Ensembl

GO - Biological processⁱ

cellular response to camptothecin Source: Ensembl
cellular response to hydroxyurea Source: Ensembl
cellular response to ionizing radiation Source: Ensembl
DNA double-strand break processing Source: Ensembl
DNA recombination Source: InterPro
G-quadruplex DNA unwinding Source: Ensembl
mitotic G2 DNA damage checkpoint Source: Ensembl
negative regulation of cell division Source: Ensembl
negative regulation of DNA recombination Source: Ensembl
positive regulation of transcription, DNA-templated Source: Ensembl
protein oligomerization Source: Ensembl
regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
replication fork processing Source: Ensembl
response to X-ray Source: Ensembl
telomeric D-loop disassembly Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Bloom syndrome protein homologImported
Gene namesⁱ	Name:BlmImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1328362. Blm.

Subcellular locationⁱ

GO - Cellular componentⁱ

chromosome, telomeric region Source: Ensembl
cytosol Source: Ensembl
lateral element Source: Ensembl
nuclear matrix Source: Ensembl
nucleolus Source: Ensembl
PML body Source: Ensembl

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E9PZ97.
PaxDbⁱ	E9PZ97.
PeptideAtlas More...PeptideAtlasⁱ	E9PZ97.
PRIDEⁱ	E9PZ97.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030528.
ExpressionAtlasⁱ	E9PZ97. baseline and differential.
Genevisibleⁱ	E9PZ97. MM.

Interactionⁱ

GO - Molecular functionⁱ

p53 binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000127995.

STRINGⁱ

10090.ENSMUSP00000127995.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E9PZ97.
SMRⁱ	E9PZ97.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	687 – 862	Helicase ATP-bindingInterPro annotationAdd BLAST	176
Domainⁱ	888 – 1035	Helicase C-terminalInterPro annotationAdd BLAST	148
Domainⁱ	1220 – 1300	HRDCInterPro annotationAdd BLAST	81

Phylogenomic databases

eggNOGⁱ	KOG0351. Eukaryota. COG0514. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074520.
OMAⁱ	CENITEC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G021X.
TreeFamⁱ	TF317801.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR012532. BDHCT. IPR032439. BDHCT_assoc. IPR032437. BLM_N. IPR011545. DEAD/DEAH_box_helicase_dom. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR004589. DNA_helicase_ATP-dep_RecQ. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR010997. HRDC-like. IPR002121. HRDC_dom. IPR027417. P-loop_NTPase. IPR032284. RecQ_Zn-bd. IPR018982. RQC_domain. IPR011991. WHTH_DNA-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08072. BDHCT. 1 hit. PF16204. BDHCT_assoc. 1 hit. PF16202. BLM_N. 1 hit. PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. PF00570. HRDC. 1 hit. PF16124. RecQ_Zn_bind. 1 hit. PF09382. RQC. 1 hit.
SMARTⁱ	View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00341. HRDC. 1 hit. SM00956. RQC. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit. SSF47819. SSF47819. 1 hit. SSF52540. SSF52540. 3 hits.
TIGRFAMsⁱ	TIGR00614. recQ_fam. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50967. HRDC. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

E9PZ97-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRIMAAVPLN NLQEQLQRHS ARKLNNQPSL SKPKSLGFTF KKKTSEGDVS 
        60         70         80         90        100
VTSVSVVKTP ALSDKDVNVS EAFSFTESPL HKPKQQAKIE GFFKHFPGRQ 
       110        120        130        140        150
QSKGTCSEPS LPATVQTAQD TLCTTPKTPT AKKLPVAVFK KLEFSSSADS 
       160        170        180        190        200
LSDWADMDDF DMSASDAFAS LAKNPATRVS TAQKMKKTKR NFFKPPPRKA 
       210        220        230        240        250
NAVKTDLTPP SPECLQVDLT KESEEEEEEE EEAEGADCLS RDVICIDNDS 
       260        270        280        290        300
ASEELTEKDT QESQSLKAHL GAERGDSEKK SHEDEAVFHS VQNTEYFEHN 
       310        320        330        340        350
DNDYDIDFVP PSPEEIISTA SSSLKCSSML KDLDDSDKEK GILSTSEELL 
       360        370        380        390        400
SKPEEMTTHK SDAGTSKDCD AQQIRIQQQL IHVMEHICKL VDTVPTDELE 
       410        420        430        440        450
ALNCGTELLQ QRNIRRKLLA EAGFNGNDVR LLGSLWRHRP DSLDNTVQGD 
       460        470        480        490        500
SCPVGHPNKE LNSPYLLSHS PSTEECLPTT TPGKTGFSAT PKNLFERPLL 
       510        520        530        540        550
NSHLQKSFVS SNWAETPRME NRNESTDFPG SVLTSTTVKA QSKQAASGWN 
       560        570        580        590        600
VERHGQASYD IDNFNIDDFD DDDDDDDWEN IMHNFPASKS STATYPPIKE 
       610        620        630        640        650
GGPVKSLSER ISSAKAKFLP VVSTAQNTNL SESIQNCSDK LAQNLSSKNP 
       660        670        680        690        700
KHEHFQSLNF PHTKEMMKIF HKKFGLHNFR TNQLEAINAA LLGEDCFILM 
       710        720        730        740        750
PTGGGKSLCY QLPACVSPGV TIVISPLRSL IVDQVQKLTS FDIPATYLTG 
       760        770        780        790        800
DKTDSEAANI YLQLSKKDPI IKLLYVTPEK VCASNRLIST LENLYERKLL 
       810        820        830        840        850
ARFVIDEAHC VSQWGHDFRQ DYKRMNMLRQ KFPSVPVMAL TATANPRVQK 
       860        870        880        890        900
DILTQLKILR PQVFSMSFNR HNLKYYVLPK KPKKVAFDCL EWIRKHHPYD 
       910        920        930        940        950
SGIIYCLSRR ECDTMADTLQ REGLAALAYH AGLSDSARDE VQHKWINQDN 
       960        970        980        990       1000
CQVICATIAF GMGIDKPDVR FVIHASLPKS MEGYYQESGR AGRDGEISHC 
      1010       1020       1030       1040       1050
VLFYTYHDVT RLKRLIMMEK DGNYHTKETH VNNLYSMVHY CENITECRRI 
      1060       1070       1080       1090       1100
QLLAYFGEKG FNPDFCKKYP DVSCDNCCKT KDYKTKDVTD DVKNIIRFVQ 
      1110       1120       1130       1140       1150
EHSSSPGTRN IGPAGRFTLN MLVDIFLGSK SAKVKSGIFG KGTTYSRHNA 
      1160       1170       1180       1190       1200
ERLFKKLILD KILDEDLYIN ANDQPIAYVM LGTKAHSVLS GHLKVDFMET 
      1210       1220       1230       1240       1250
ENSSSIKKQK ALVAKVSQRE EVVKKCLGEL TEVCKLLGKV FGVHYFNIFN 
      1260       1270       1280       1290       1300
TATLKKLAES LSSDPEVLLQ IDGVTEDKLE KYGAEVIPVL QKYSEWTVPA 
      1310       1320       1330       1340       1350
EDGSPGARGA PEDTEEEEEE APVSSHYFAN QTRNERKRKK MSATHKPKRR 
      1360       1370       1380       1390       1400
RTSYGGFRAK GGSTTCRKTT SKSKFYGVTG SRSASCASQA TSSASRKLGI 
      1410 
MAPPKPVNRT FLRPSYAFS

Length:1,419

Mass (Da):158,766

Last modified:April 5, 2011 - v1

Checksum:ⁱF6BD6CBC6498AC3E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC110907 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_031576.4. NM_007550.4.
UniGeneⁱ	Mm.12932.

Genome annotation databases

Ensemblⁱ	ENSMUST00000170315; ENSMUSP00000127995; ENSMUSG00000030528.
GeneIDⁱ	12144.
UCSC genome browser More...UCSCⁱ	uc009iaw.2. mouse.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC110907 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_031576.4. NM_007550.4.
UniGeneⁱ	Mm.12932.

3D structure databases

ProteinModelPortalⁱ	E9PZ97.
SMRⁱ	E9PZ97.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000127995.

STRINGⁱ

10090.ENSMUSP00000127995.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E9PZ97.
PaxDbⁱ	E9PZ97.
PeptideAtlas More...PeptideAtlasⁱ	E9PZ97.
PRIDEⁱ	E9PZ97.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	12144.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000170315; ENSMUSP00000127995; ENSMUSG00000030528.
GeneIDⁱ	12144.
UCSC genome browser More...UCSCⁱ	uc009iaw.2. mouse.

Organism-specific databases

CTDⁱ	641.
MGIⁱ	MGI:1328362. Blm.

Phylogenomic databases

eggNOGⁱ	KOG0351. Eukaryota. COG0514. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074520.
OMAⁱ	CENITEC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G021X.
TreeFamⁱ	TF317801.

Miscellaneous databases

ChiTaRSⁱ	Blm. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030528.
ExpressionAtlasⁱ	E9PZ97. baseline and differential.
Genevisibleⁱ	E9PZ97. MM.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR012532. BDHCT. IPR032439. BDHCT_assoc. IPR032437. BLM_N. IPR011545. DEAD/DEAH_box_helicase_dom. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR004589. DNA_helicase_ATP-dep_RecQ. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR010997. HRDC-like. IPR002121. HRDC_dom. IPR027417. P-loop_NTPase. IPR032284. RecQ_Zn-bd. IPR018982. RQC_domain. IPR011991. WHTH_DNA-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08072. BDHCT. 1 hit. PF16204. BDHCT_assoc. 1 hit. PF16202. BLM_N. 1 hit. PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. PF00570. HRDC. 1 hit. PF16124. RecQ_Zn_bind. 1 hit. PF09382. RQC. 1 hit.
SMARTⁱ	View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00341. HRDC. 1 hit. SM00956. RQC. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit. SSF47819. SSF47819. 1 hit. SSF52540. SSF52540. 3 hits.
TIGRFAMsⁱ	TIGR00614. recQ_fam. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50967. HRDC. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9PZ97_MOUSE
Accessionⁱ	E9PZ97Primary (citable) accession number: E9PZ97
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	April 5, 2011
	Last modified:	June 7, 2017
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E9PZ97 (E9PZ97_MOUSE)

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Bloom syndrome protein homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ