UniProtKB - E9PZ97 (E9PZ97_MOUSE)
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Protein
Submitted name:
Bloom syndrome protein homolog
Gene
Blm
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- 8-hydroxy-2'-deoxyguanosine DNA binding Source: Ensembl
- annealing helicase activity Source: Ensembl
- ATP binding Source: Ensembl
- ATP-dependent 3'-5' DNA helicase activity Source: InterPro
- bubble DNA binding Source: Ensembl
- forked DNA-dependent helicase activity Source: Ensembl
- four-way junction DNA binding Source: Ensembl
- four-way junction helicase activity Source: Ensembl
- G-quadruplex DNA binding Source: Ensembl
- p53 binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- single-stranded DNA binding Source: Ensembl
- telomeric D-loop binding Source: Ensembl
- Y-form DNA binding Source: Ensembl
- zinc ion binding Source: Ensembl
GO - Biological processi
- cellular response to camptothecin Source: Ensembl
- cellular response to hydroxyurea Source: Ensembl
- cellular response to ionizing radiation Source: Ensembl
- DNA double-strand break processing Source: Ensembl
- DNA recombination Source: InterPro
- G-quadruplex DNA unwinding Source: Ensembl
- mitotic G2 DNA damage checkpoint Source: Ensembl
- negative regulation of cell division Source: Ensembl
- negative regulation of DNA recombination Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- protein complex oligomerization Source: Ensembl
- protein homooligomerization Source: Ensembl
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
- regulation of DNA-dependent DNA replication Source: Ensembl
- replication fork processing Source: Ensembl
- response to X-ray Source: Ensembl
- telomeric D-loop disassembly Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Bloom syndrome protein homologImported |
Gene namesi | Name:BlmImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1328362. Blm. |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030528. |
ExpressionAtlasi | E9PZ97. baseline and differential. |
Genevisiblei | E9PZ97. MM. |
Interactioni
GO - Molecular functioni
- p53 binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
Structurei
3D structure databases
ProteinModelPortali | E9PZ97. |
SMRi | E9PZ97. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 687 – 862 | Helicase ATP-bindingInterPro annotationAdd BLAST | 176 | |
Domaini | 888 – 1035 | Helicase C-terminalInterPro annotationAdd BLAST | 148 | |
Domaini | 1220 – 1300 | HRDCInterPro annotationAdd BLAST | 81 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 216 – 236 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0351. Eukaryota. COG0514. LUCA. |
GeneTreei | ENSGT00550000074520. |
OMAi | CENITEC. |
OrthoDBi | EOG091G021X. |
TreeFami | TF317801. |
Family and domain databases
CDDi | cd00079. HELICc. 1 hit. |
Gene3Di | 1.10.10.10. 1 hit. |
InterProi | View protein in InterPro IPR012532. BDHCT. IPR032439. BDHCT_assoc. IPR032437. BLM_N. IPR011545. DEAD/DEAH_box_helicase_dom. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR004589. DNA_helicase_ATP-dep_RecQ. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR010997. HRDC-like_sf. IPR002121. HRDC_dom. IPR027417. P-loop_NTPase. IPR032284. RecQ_Zn-bd. IPR018982. RQC_domain. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf. |
Pfami | View protein in Pfam PF08072. BDHCT. 1 hit. PF16204. BDHCT_assoc. 1 hit. PF16202. BLM_N. 1 hit. PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. PF00570. HRDC. 1 hit. PF16124. RecQ_Zn_bind. 1 hit. PF09382. RQC. 1 hit. |
SMARTi | View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. SM00341. HRDC. 1 hit. SM00956. RQC. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. SSF47819. SSF47819. 1 hit. SSF52540. SSF52540. 3 hits. |
TIGRFAMsi | TIGR00614. recQ_fam. 1 hit. |
PROSITEi | View protein in PROSITE PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50967. HRDC. 1 hit. |
i Sequence
Sequence statusi: Complete.
E9PZ97-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRIMAAVPLN NLQEQLQRHS ARKLNNQPSL SKPKSLGFTF KKKTSEGDVS
60 70 80 90 100
VTSVSVVKTP ALSDKDVNVS EAFSFTESPL HKPKQQAKIE GFFKHFPGRQ
110 120 130 140 150
QSKGTCSEPS LPATVQTAQD TLCTTPKTPT AKKLPVAVFK KLEFSSSADS
160 170 180 190 200
LSDWADMDDF DMSASDAFAS LAKNPATRVS TAQKMKKTKR NFFKPPPRKA
210 220 230 240 250
NAVKTDLTPP SPECLQVDLT KESEEEEEEE EEAEGADCLS RDVICIDNDS
260 270 280 290 300
ASEELTEKDT QESQSLKAHL GAERGDSEKK SHEDEAVFHS VQNTEYFEHN
310 320 330 340 350
DNDYDIDFVP PSPEEIISTA SSSLKCSSML KDLDDSDKEK GILSTSEELL
360 370 380 390 400
SKPEEMTTHK SDAGTSKDCD AQQIRIQQQL IHVMEHICKL VDTVPTDELE
410 420 430 440 450
ALNCGTELLQ QRNIRRKLLA EAGFNGNDVR LLGSLWRHRP DSLDNTVQGD
460 470 480 490 500
SCPVGHPNKE LNSPYLLSHS PSTEECLPTT TPGKTGFSAT PKNLFERPLL
510 520 530 540 550
NSHLQKSFVS SNWAETPRME NRNESTDFPG SVLTSTTVKA QSKQAASGWN
560 570 580 590 600
VERHGQASYD IDNFNIDDFD DDDDDDDWEN IMHNFPASKS STATYPPIKE
610 620 630 640 650
GGPVKSLSER ISSAKAKFLP VVSTAQNTNL SESIQNCSDK LAQNLSSKNP
660 670 680 690 700
KHEHFQSLNF PHTKEMMKIF HKKFGLHNFR TNQLEAINAA LLGEDCFILM
710 720 730 740 750
PTGGGKSLCY QLPACVSPGV TIVISPLRSL IVDQVQKLTS FDIPATYLTG
760 770 780 790 800
DKTDSEAANI YLQLSKKDPI IKLLYVTPEK VCASNRLIST LENLYERKLL
810 820 830 840 850
ARFVIDEAHC VSQWGHDFRQ DYKRMNMLRQ KFPSVPVMAL TATANPRVQK
860 870 880 890 900
DILTQLKILR PQVFSMSFNR HNLKYYVLPK KPKKVAFDCL EWIRKHHPYD
910 920 930 940 950
SGIIYCLSRR ECDTMADTLQ REGLAALAYH AGLSDSARDE VQHKWINQDN
960 970 980 990 1000
CQVICATIAF GMGIDKPDVR FVIHASLPKS MEGYYQESGR AGRDGEISHC
1010 1020 1030 1040 1050
VLFYTYHDVT RLKRLIMMEK DGNYHTKETH VNNLYSMVHY CENITECRRI
1060 1070 1080 1090 1100
QLLAYFGEKG FNPDFCKKYP DVSCDNCCKT KDYKTKDVTD DVKNIIRFVQ
1110 1120 1130 1140 1150
EHSSSPGTRN IGPAGRFTLN MLVDIFLGSK SAKVKSGIFG KGTTYSRHNA
1160 1170 1180 1190 1200
ERLFKKLILD KILDEDLYIN ANDQPIAYVM LGTKAHSVLS GHLKVDFMET
1210 1220 1230 1240 1250
ENSSSIKKQK ALVAKVSQRE EVVKKCLGEL TEVCKLLGKV FGVHYFNIFN
1260 1270 1280 1290 1300
TATLKKLAES LSSDPEVLLQ IDGVTEDKLE KYGAEVIPVL QKYSEWTVPA
1310 1320 1330 1340 1350
EDGSPGARGA PEDTEEEEEE APVSSHYFAN QTRNERKRKK MSATHKPKRR
1360 1370 1380 1390 1400
RTSYGGFRAK GGSTTCRKTT SKSKFYGVTG SRSASCASQA TSSASRKLGI
1410
MAPPKPVNRT FLRPSYAFS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC110907 Genomic DNA. No translation available. |
RefSeqi | NP_031576.4. NM_007550.4. |
UniGenei | Mm.12932. |
Genome annotation databases
Ensembli | ENSMUST00000170315; ENSMUSP00000127995; ENSMUSG00000030528. |
GeneIDi | 12144. |
UCSCi | uc009iaw.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | E9PZ97_MOUSE | |
Accessioni | E9PZ97Primary (citable) accession number: E9PZ97 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | March 28, 2018 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |