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Protein
Submitted name:

Bloom syndrome protein homolog

Gene

Blm

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bloom syndrome protein homologImported
Gene namesi
Name:BlmImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1328362. Blm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiE9PZ97.
PeptideAtlasiE9PZ97.
PRIDEiE9PZ97.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030528.
ExpressionAtlasiE9PZ97. baseline and differential.
GenevisibleiE9PZ97. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127995.

Structurei

3D structure databases

ProteinModelPortaliE9PZ97.
SMRiE9PZ97. Positions 651-1302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini687 – 862176Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini888 – 1035148Helicase C-terminalInterPro annotationAdd
BLAST
Domaini1220 – 130081HRDCInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0351. Eukaryota.
COG0514. LUCA.
GeneTreeiENSGT00550000074520.
OMAiCENITEC.
OrthoDBiEOG091G021X.
TreeFamiTF317801.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.80. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012532. BDHCT.
IPR032439. BDHCT_assoc.
IPR032437. BLM_N.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR010997. HRDC-like.
IPR002121. HRDC_dom.
IPR027417. P-loop_NTPase.
IPR032284. RecQ_Zn-bd.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF08072. BDHCT. 1 hit.
PF16204. BDHCT_assoc. 1 hit.
PF16202. BLM_N. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00570. HRDC. 1 hit.
PF16124. RecQ_Zn_bind. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00341. HRDC. 1 hit.
SM00956. RQC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47819. SSF47819. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50967. HRDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PZ97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIMAAVPLN NLQEQLQRHS ARKLNNQPSL SKPKSLGFTF KKKTSEGDVS
60 70 80 90 100
VTSVSVVKTP ALSDKDVNVS EAFSFTESPL HKPKQQAKIE GFFKHFPGRQ
110 120 130 140 150
QSKGTCSEPS LPATVQTAQD TLCTTPKTPT AKKLPVAVFK KLEFSSSADS
160 170 180 190 200
LSDWADMDDF DMSASDAFAS LAKNPATRVS TAQKMKKTKR NFFKPPPRKA
210 220 230 240 250
NAVKTDLTPP SPECLQVDLT KESEEEEEEE EEAEGADCLS RDVICIDNDS
260 270 280 290 300
ASEELTEKDT QESQSLKAHL GAERGDSEKK SHEDEAVFHS VQNTEYFEHN
310 320 330 340 350
DNDYDIDFVP PSPEEIISTA SSSLKCSSML KDLDDSDKEK GILSTSEELL
360 370 380 390 400
SKPEEMTTHK SDAGTSKDCD AQQIRIQQQL IHVMEHICKL VDTVPTDELE
410 420 430 440 450
ALNCGTELLQ QRNIRRKLLA EAGFNGNDVR LLGSLWRHRP DSLDNTVQGD
460 470 480 490 500
SCPVGHPNKE LNSPYLLSHS PSTEECLPTT TPGKTGFSAT PKNLFERPLL
510 520 530 540 550
NSHLQKSFVS SNWAETPRME NRNESTDFPG SVLTSTTVKA QSKQAASGWN
560 570 580 590 600
VERHGQASYD IDNFNIDDFD DDDDDDDWEN IMHNFPASKS STATYPPIKE
610 620 630 640 650
GGPVKSLSER ISSAKAKFLP VVSTAQNTNL SESIQNCSDK LAQNLSSKNP
660 670 680 690 700
KHEHFQSLNF PHTKEMMKIF HKKFGLHNFR TNQLEAINAA LLGEDCFILM
710 720 730 740 750
PTGGGKSLCY QLPACVSPGV TIVISPLRSL IVDQVQKLTS FDIPATYLTG
760 770 780 790 800
DKTDSEAANI YLQLSKKDPI IKLLYVTPEK VCASNRLIST LENLYERKLL
810 820 830 840 850
ARFVIDEAHC VSQWGHDFRQ DYKRMNMLRQ KFPSVPVMAL TATANPRVQK
860 870 880 890 900
DILTQLKILR PQVFSMSFNR HNLKYYVLPK KPKKVAFDCL EWIRKHHPYD
910 920 930 940 950
SGIIYCLSRR ECDTMADTLQ REGLAALAYH AGLSDSARDE VQHKWINQDN
960 970 980 990 1000
CQVICATIAF GMGIDKPDVR FVIHASLPKS MEGYYQESGR AGRDGEISHC
1010 1020 1030 1040 1050
VLFYTYHDVT RLKRLIMMEK DGNYHTKETH VNNLYSMVHY CENITECRRI
1060 1070 1080 1090 1100
QLLAYFGEKG FNPDFCKKYP DVSCDNCCKT KDYKTKDVTD DVKNIIRFVQ
1110 1120 1130 1140 1150
EHSSSPGTRN IGPAGRFTLN MLVDIFLGSK SAKVKSGIFG KGTTYSRHNA
1160 1170 1180 1190 1200
ERLFKKLILD KILDEDLYIN ANDQPIAYVM LGTKAHSVLS GHLKVDFMET
1210 1220 1230 1240 1250
ENSSSIKKQK ALVAKVSQRE EVVKKCLGEL TEVCKLLGKV FGVHYFNIFN
1260 1270 1280 1290 1300
TATLKKLAES LSSDPEVLLQ IDGVTEDKLE KYGAEVIPVL QKYSEWTVPA
1310 1320 1330 1340 1350
EDGSPGARGA PEDTEEEEEE APVSSHYFAN QTRNERKRKK MSATHKPKRR
1360 1370 1380 1390 1400
RTSYGGFRAK GGSTTCRKTT SKSKFYGVTG SRSASCASQA TSSASRKLGI
1410
MAPPKPVNRT FLRPSYAFS
Length:1,419
Mass (Da):158,766
Last modified:April 5, 2011 - v1
Checksum:iF6BD6CBC6498AC3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110907 Genomic DNA. No translation available.
RefSeqiNP_031576.4. NM_007550.4.
UniGeneiMm.12932.

Genome annotation databases

EnsembliENSMUST00000170315; ENSMUSP00000127995; ENSMUSG00000030528.
GeneIDi12144.
UCSCiuc009iaw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110907 Genomic DNA. No translation available.
RefSeqiNP_031576.4. NM_007550.4.
UniGeneiMm.12932.

3D structure databases

ProteinModelPortaliE9PZ97.
SMRiE9PZ97. Positions 651-1302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127995.

Proteomic databases

PaxDbiE9PZ97.
PeptideAtlasiE9PZ97.
PRIDEiE9PZ97.

Protocols and materials databases

DNASUi12144.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170315; ENSMUSP00000127995; ENSMUSG00000030528.
GeneIDi12144.
UCSCiuc009iaw.2. mouse.

Organism-specific databases

CTDi641.
MGIiMGI:1328362. Blm.

Phylogenomic databases

eggNOGiKOG0351. Eukaryota.
COG0514. LUCA.
GeneTreeiENSGT00550000074520.
OMAiCENITEC.
OrthoDBiEOG091G021X.
TreeFamiTF317801.

Miscellaneous databases

ChiTaRSiBlm. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030528.
ExpressionAtlasiE9PZ97. baseline and differential.
GenevisibleiE9PZ97. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.80. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012532. BDHCT.
IPR032439. BDHCT_assoc.
IPR032437. BLM_N.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR010997. HRDC-like.
IPR002121. HRDC_dom.
IPR027417. P-loop_NTPase.
IPR032284. RecQ_Zn-bd.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF08072. BDHCT. 1 hit.
PF16204. BDHCT_assoc. 1 hit.
PF16202. BLM_N. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00570. HRDC. 1 hit.
PF16124. RecQ_Zn_bind. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00341. HRDC. 1 hit.
SM00956. RQC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47819. SSF47819. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50967. HRDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PZ97_MOUSE
AccessioniPrimary (citable) accession number: E9PZ97
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.