Bloom syndrome protein homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 8-hydroxy-2'-deoxyguanosine DNA binding Source: Ensembl
• annealing helicase activity Source: Ensembl
• ATP binding Source: Ensembl
• ATP-dependent 3'-5' DNA helicase activity Source: InterPro
• bubble DNA binding Source: Ensembl
• forked DNA-dependent helicase activity Source: Ensembl
• four-way junction DNA binding Source: Ensembl
• four-way junction helicase activity Source: Ensembl
• G-quadruplex DNA binding Source: Ensembl
• p53 binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• single-stranded DNA binding Source: Ensembl
• telomeric D-loop binding Source: Ensembl
• Y-form DNA binding Source: Ensembl
• zinc ion binding Source: Ensembl

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cellular response to camptothecin Source: Ensembl
• cellular response to hydroxyurea Source: Ensembl
• cellular response to ionizing radiation Source: Ensembl
• DNA double-strand break processing Source: Ensembl
• DNA recombination Source: InterPro
• G-quadruplex DNA unwinding Source: Ensembl
• mitotic G2 DNA damage checkpoint Source: Ensembl
• negative regulation of cell division Source: Ensembl
• negative regulation of DNA recombination Source: Ensembl
• positive regulation of transcription, DNA-templated Source: Ensembl
• protein complex oligomerization Source: Ensembl
• protein homooligomerization Source: Ensembl
• regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
• regulation of DNA-dependent DNA replication Source: Ensembl
• replication fork processing Source: Ensembl
• response to X-ray Source: Ensembl
• telomeric D-loop disassembly Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• p53 binding Source: Ensembl
• protein homodimerization activity Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MRIMAAVPLN NLQEQLQRHS ARKLNNQPSL SKPKSLGFTF KKKTSEGDVS 
        60         70         80         90        100
VTSVSVVKTP ALSDKDVNVS EAFSFTESPL HKPKQQAKIE GFFKHFPGRQ 
       110        120        130        140        150
QSKGTCSEPS LPATVQTAQD TLCTTPKTPT AKKLPVAVFK KLEFSSSADS 
       160        170        180        190        200
LSDWADMDDF DMSASDAFAS LAKNPATRVS TAQKMKKTKR NFFKPPPRKA 
       210        220        230        240        250
NAVKTDLTPP SPECLQVDLT KESEEEEEEE EEAEGADCLS RDVICIDNDS 
       260        270        280        290        300
ASEELTEKDT QESQSLKAHL GAERGDSEKK SHEDEAVFHS VQNTEYFEHN 
       310        320        330        340        350
DNDYDIDFVP PSPEEIISTA SSSLKCSSML KDLDDSDKEK GILSTSEELL 
       360        370        380        390        400
SKPEEMTTHK SDAGTSKDCD AQQIRIQQQL IHVMEHICKL VDTVPTDELE 
       410        420        430        440        450
ALNCGTELLQ QRNIRRKLLA EAGFNGNDVR LLGSLWRHRP DSLDNTVQGD 
       460        470        480        490        500
SCPVGHPNKE LNSPYLLSHS PSTEECLPTT TPGKTGFSAT PKNLFERPLL 
       510        520        530        540        550
NSHLQKSFVS SNWAETPRME NRNESTDFPG SVLTSTTVKA QSKQAASGWN 
       560        570        580        590        600
VERHGQASYD IDNFNIDDFD DDDDDDDWEN IMHNFPASKS STATYPPIKE 
       610        620        630        640        650
GGPVKSLSER ISSAKAKFLP VVSTAQNTNL SESIQNCSDK LAQNLSSKNP 
       660        670        680        690        700
KHEHFQSLNF PHTKEMMKIF HKKFGLHNFR TNQLEAINAA LLGEDCFILM 
       710        720        730        740        750
PTGGGKSLCY QLPACVSPGV TIVISPLRSL IVDQVQKLTS FDIPATYLTG 
       760        770        780        790        800
DKTDSEAANI YLQLSKKDPI IKLLYVTPEK VCASNRLIST LENLYERKLL 
       810        820        830        840        850
ARFVIDEAHC VSQWGHDFRQ DYKRMNMLRQ KFPSVPVMAL TATANPRVQK 
       860        870        880        890        900
DILTQLKILR PQVFSMSFNR HNLKYYVLPK KPKKVAFDCL EWIRKHHPYD 
       910        920        930        940        950
SGIIYCLSRR ECDTMADTLQ REGLAALAYH AGLSDSARDE VQHKWINQDN 
       960        970        980        990       1000
CQVICATIAF GMGIDKPDVR FVIHASLPKS MEGYYQESGR AGRDGEISHC 
      1010       1020       1030       1040       1050
VLFYTYHDVT RLKRLIMMEK DGNYHTKETH VNNLYSMVHY CENITECRRI 
      1060       1070       1080       1090       1100
QLLAYFGEKG FNPDFCKKYP DVSCDNCCKT KDYKTKDVTD DVKNIIRFVQ 
      1110       1120       1130       1140       1150
EHSSSPGTRN IGPAGRFTLN MLVDIFLGSK SAKVKSGIFG KGTTYSRHNA 
      1160       1170       1180       1190       1200
ERLFKKLILD KILDEDLYIN ANDQPIAYVM LGTKAHSVLS GHLKVDFMET 
      1210       1220       1230       1240       1250
ENSSSIKKQK ALVAKVSQRE EVVKKCLGEL TEVCKLLGKV FGVHYFNIFN 
      1260       1270       1280       1290       1300
TATLKKLAES LSSDPEVLLQ IDGVTEDKLE KYGAEVIPVL QKYSEWTVPA 
      1310       1320       1330       1340       1350
EDGSPGARGA PEDTEEEEEE APVSSHYFAN QTRNERKRKK MSATHKPKRR 
      1360       1370       1380       1390       1400
RTSYGGFRAK GGSTTCRKTT SKSKFYGVTG SRSASCASQA TSSASRKLGI 
      1410 
MAPPKPVNRT FLRPSYAFS                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ