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Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: MGI
  • cellular response to steroid hormone stimulus Source: MGI
  • glucocorticoid metabolic process Source: MGI
  • glucocorticoid receptor signaling pathway Source: MGI
  • mammary gland duct morphogenesis Source: MGI
  • maternal behavior Source: MGI
  • negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  • positive regulation of neuron apoptotic process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of glucocorticoid biosynthetic process Source: MGI
  • regulation of gluconeogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiE9PYV1.

Expressioni

Gene expression databases

BgeeiE9PYV1.
ExpressionAtlasiE9PYV1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025300.

Structurei

3D structure databases

ProteinModelPortaliE9PYV1.
SMRiE9PYV1. Positions 436-792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118887.
KOiK05771.
OMAiQSTFDIL.
TreeFamiTF106510.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PYV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA
60 70 80 90 100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV
110 120 130 140 150
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS
160 170 180 190 200
TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK
210 220 230 240 250
LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD
260 270 280 290 300
PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF
310 320 330 340 350
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH
360 370 380 390 400
YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF
410 420 430 440 450
AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG
460 470 480 490 500
VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC IIDKIRRKNC PACRYRKCLQ
510 520 530 540 550
AGMNLEARKT KKKIKGIQQA TAGVSQDTSE NANKTIVPAA LPQLTPTLVS
560 570 580 590 600
LLEVIEPEVL YAGYDSSVPD SAWRIMTTLN MLGGRQVIAA VKWAKAIPGF
610 620 630 640 650
RNLHLDDQMT LLQYSWMFLM AFALGWRSYR QASGNLLCFA PDLIINEQRM
660 670 680 690 700
TLPCMYDQCK HMLFISTELQ RLQVSYEEYL CMKTLLLLSS VPKEGLKSQE
710 720 730 740 750
LFDEIRMTYI KELGKAIVKR EGNSSQNWQR FYQLTKLLDS MHDVVENLLS
760 770 780 790
YCFQTFLDKS MSIEFPEMLA EIITNQIPKY SNGNIKKLLF HQK
Length:793
Mass (Da):87,320
Last modified:April 5, 2011 - v1
Checksum:iFC18E0D14CE98EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqiXP_006525721.1. XM_006525658.1.
XP_006525722.1. XM_006525659.2.
XP_006525723.1. XM_006525660.1.
XP_006525724.1. XM_006525661.2.
XP_006525725.1. XM_006525662.1.
XP_006525726.1. XM_006525663.2.
XP_006525727.1. XM_006525664.1.
XP_006525728.1. XM_006525665.2.
UniGeneiMm.129481.

Genome annotation databases

EnsembliENSMUST00000097592; ENSMUSP00000095199; ENSMUSG00000024431.
GeneIDi14815.
KEGGimmu:14815.
UCSCiuc008esy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqiXP_006525721.1. XM_006525658.1.
XP_006525722.1. XM_006525659.2.
XP_006525723.1. XM_006525660.1.
XP_006525724.1. XM_006525661.2.
XP_006525725.1. XM_006525662.1.
XP_006525726.1. XM_006525663.2.
XP_006525727.1. XM_006525664.1.
XP_006525728.1. XM_006525665.2.
UniGeneiMm.129481.

3D structure databases

ProteinModelPortaliE9PYV1.
SMRiE9PYV1. Positions 436-792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025300.

Proteomic databases

PRIDEiE9PYV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097592; ENSMUSP00000095199; ENSMUSG00000024431.
GeneIDi14815.
KEGGimmu:14815.
UCSCiuc008esy.1. mouse.

Organism-specific databases

CTDi2908.
MGIiMGI:95824. Nr3c1.

Phylogenomic databases

GeneTreeiENSGT00760000118887.
KOiK05771.
OMAiQSTFDIL.
TreeFamiTF106510.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiNr3c1. mouse.
NextBioi35554344.
SOURCEiSearch...

Gene expression databases

BgeeiE9PYV1.
ExpressionAtlasiE9PYV1. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PYV1_MOUSE
AccessioniPrimary (citable) accession number: E9PYV1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.