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Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi434 – 510Nuclear receptorPROSITE-ProRule annotationAdd BLAST77

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-MMU-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

MaxQBiE9PYV1.
PaxDbiE9PYV1.
PeptideAtlasiE9PYV1.
PRIDEiE9PYV1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024431.
ExpressionAtlasiE9PYV1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PYV1.
SMRiE9PYV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini434 – 510Nuclear receptor DNA-bindingInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
OMAiQSTFDIL.
OrthoDBiEOG091G02FB.
TreeFamiTF106510.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR001409. Glcrtcd_rcpt.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF02155. GCR. 2 hits.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PYV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA
60 70 80 90 100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV
110 120 130 140 150
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS
160 170 180 190 200
TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK
210 220 230 240 250
LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD
260 270 280 290 300
PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF
310 320 330 340 350
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH
360 370 380 390 400
YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF
410 420 430 440 450
AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG
460 470 480 490 500
VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC IIDKIRRKNC PACRYRKCLQ
510 520 530 540 550
AGMNLEARKT KKKIKGIQQA TAGVSQDTSE NANKTIVPAA LPQLTPTLVS
560 570 580 590 600
LLEVIEPEVL YAGYDSSVPD SAWRIMTTLN MLGGRQVIAA VKWAKAIPGF
610 620 630 640 650
RNLHLDDQMT LLQYSWMFLM AFALGWRSYR QASGNLLCFA PDLIINEQRM
660 670 680 690 700
TLPCMYDQCK HMLFISTELQ RLQVSYEEYL CMKTLLLLSS VPKEGLKSQE
710 720 730 740 750
LFDEIRMTYI KELGKAIVKR EGNSSQNWQR FYQLTKLLDS MHDVVENLLS
760 770 780 790
YCFQTFLDKS MSIEFPEMLA EIITNQIPKY SNGNIKKLLF HQK
Length:793
Mass (Da):87,320
Last modified:April 5, 2011 - v1
Checksum:iFC18E0D14CE98EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqiXP_006525721.1. XM_006525658.1.
XP_006525722.1. XM_006525659.3.
XP_006525723.1. XM_006525660.2.
XP_006525724.1. XM_006525661.2.
XP_006525725.1. XM_006525662.1.
XP_006525726.1. XM_006525663.3.
XP_006525727.1. XM_006525664.1.
XP_006525728.1. XM_006525665.3.
UniGeneiMm.129481.

Genome annotation databases

EnsembliENSMUST00000097592; ENSMUSP00000095199; ENSMUSG00000024431.
GeneIDi14815.
UCSCiuc008esy.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE9PYV1_MOUSE
AccessioniPrimary (citable) accession number: E9PYV1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 5, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported