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E9PYV1

- E9PYV1_MOUSE

UniProt

E9PYV1 - E9PYV1_MOUSE

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Protein
Submitted name: Glucocorticoid receptor
Gene
Nr3c1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. glucocorticoid receptor activity Source: MGI
  3. protein binding Source: MGI
  4. protein dimerization activity Source: MGI
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding transcription factor activity Source: InterPro
  7. steroid binding Source: InterPro
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. glucocorticoid metabolic process Source: MGI
  3. glucocorticoid receptor signaling pathway Source: MGI
  4. mammary gland duct morphogenesis Source: MGI
  5. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  6. positive regulation of neuron apoptotic process Source: MGI
  7. regulation of glucocorticoid biosynthetic process Source: MGI
  8. regulation of gluconeogenesis Source: MGI
  9. regulation of transcription, DNA-templated Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. intracellular Source: MGI
  4. membrane Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiE9PYV1.

Expressioni

Gene expression databases

ArrayExpressiE9PYV1.
BgeeiE9PYV1.

Structurei

3D structure databases

ProteinModelPortaliE9PYV1.
SMRiE9PYV1. Positions 433-792.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00730000110451.
KOiK05771.
OMAiQSTFDIL.
TreeFamiTF106510.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PYV1-1 [UniParc]FASTAAdd to Basket

« Hide

MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA    50
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV 100
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS 150
TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK 200
LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD 250
PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 300
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH 350
YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF 400
AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG 450
VLTCGSCKVF FKRAVEGRQH NYLCAGRNDC IIDKIRRKNC PACRYRKCLQ 500
AGMNLEARKT KKKIKGIQQA TAGVSQDTSE NANKTIVPAA LPQLTPTLVS 550
LLEVIEPEVL YAGYDSSVPD SAWRIMTTLN MLGGRQVIAA VKWAKAIPGF 600
RNLHLDDQMT LLQYSWMFLM AFALGWRSYR QASGNLLCFA PDLIINEQRM 650
TLPCMYDQCK HMLFISTELQ RLQVSYEEYL CMKTLLLLSS VPKEGLKSQE 700
LFDEIRMTYI KELGKAIVKR EGNSSQNWQR FYQLTKLLDS MHDVVENLLS 750
YCFQTFLDKS MSIEFPEMLA EIITNQIPKY SNGNIKKLLF HQK 793
Length:793
Mass (Da):87,320
Last modified:April 5, 2011 - v1
Checksum:iFC18E0D14CE98EF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqiXP_006525721.1. XM_006525658.1.
XP_006525722.1. XM_006525659.1.
XP_006525723.1. XM_006525660.1.
XP_006525724.1. XM_006525661.1.
XP_006525725.1. XM_006525662.1.
XP_006525726.1. XM_006525663.1.
XP_006525727.1. XM_006525664.1.
XP_006525728.1. XM_006525665.1.
UniGeneiMm.129481.

Genome annotation databases

EnsembliENSMUST00000097592; ENSMUSP00000095199; ENSMUSG00000024431.
GeneIDi14815.
KEGGimmu:14815.
UCSCiuc008esy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqi XP_006525721.1. XM_006525658.1.
XP_006525722.1. XM_006525659.1.
XP_006525723.1. XM_006525660.1.
XP_006525724.1. XM_006525661.1.
XP_006525725.1. XM_006525662.1.
XP_006525726.1. XM_006525663.1.
XP_006525727.1. XM_006525664.1.
XP_006525728.1. XM_006525665.1.
UniGenei Mm.129481.

3D structure databases

ProteinModelPortali E9PYV1.
SMRi E9PYV1. Positions 433-792.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9PYV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097592 ; ENSMUSP00000095199 ; ENSMUSG00000024431 .
GeneIDi 14815.
KEGGi mmu:14815.
UCSCi uc008esy.1. mouse.

Organism-specific databases

CTDi 2908.
MGIi MGI:95824. Nr3c1.

Phylogenomic databases

GeneTreei ENSGT00730000110451.
KOi K05771.
OMAi QSTFDIL.
TreeFami TF106510.

Miscellaneous databases

ChiTaRSi NR3C1. mouse.
NextBioi 35554344.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9PYV1.
Bgeei E9PYV1.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PYV1_MOUSE
AccessioniPrimary (citable) accession number: E9PYV1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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