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Protein

Poly [ADP-ribose] polymerase

Gene

Parp4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-197264 Nicotinamide salvaging

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
Short name:
PARPUniRule annotation
Gene namesi
Name:Parp4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2685589 Parp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9PYK3
PaxDbiE9PYK3
PeptideAtlasiE9PYK3
PRIDEiE9PYK3

PTM databases

iPTMnetiE9PYK3
PhosphoSitePlusiE9PYK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000054509
GenevisibleiE9PYK3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124258

Structurei

3D structure databases

SMRiE9PYK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94BRCTInterPro annotationAdd BLAST94
Domaini235 – 363PARP alpha-helicalInterPro annotationAdd BLAST129
Domaini362 – 566PARP catalyticInterPro annotationAdd BLAST205
Domaini600 – 728VITInterPro annotationAdd BLAST129
Domaini869 – 1039VWFAInterPro annotationAdd BLAST171

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili672 – 692Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
GeneTreeiENSGT00530000063006
InParanoidiE9PYK3
KOiK10798
OMAiFHPHENT
OrthoDBiEOG091G03L8
TreeFamiTF329720

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.40.50.10190, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR009408 Formin_homology_1
IPR031273 PARP4
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR10338:SF127 PTHR10338:SF127, 1 hit
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF06346 Drf_FH1, 1 hit
PF00644 PARP, 1 hit
PF08487 VIT, 1 hit
PF13768 VWA_3, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF47587 SSF47587, 1 hit
SSF52113 SSF52113, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

E9PYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGIFANCI FCLKVKYLPR QQKKKLQTDI KENGGKFSFL LNPQCTHVIV
60 70 80 90 100
DSADVLSRCH LNSIQKNDVQ IANPAFIQDS VRQRRLLDVR NYDPLSPAPA
110 120 130 140 150
APPAERSRSE VQSEYLPSDN TPEKENTEVT EVSAENVEIP PFLQDFEVVK
160 170 180 190 200
YNILEKVGGP ETVVVELQSS QDPESCPFVI TAHFLLADQK TRRESTGKQT
210 220 230 240 250
SEGAIEYYES YVEDLKRQGF LLQEHFTAEA TQLASEKLQA LLLEEVISSG
260 270 280 290 300
ALSQEVSDLL EVIWTEALGH LENTLLKPVN SMSLNDVSKA EGILLLVKTA
310 320 330 340 350
LKNGDSPGQL QKTMAEFYRL LPHRHPASEE VNLRLLAQKE DLCQLVRDMV
360 370 380 390 400
NVCETNLSKP NPPSLAKYRA LRCKIEHVDQ NTEEFSRVRK EVLQNNRSEQ
410 420 430 440 450
PVDILQIFRV GRVNEATEFL SKLGNVRLLF HGSPVRNILG ILSRGLLLPK
460 470 480 490 500
VAEDRGVQRT DVGNLGSGIY FSDSLSTSIK YAHAGETDGS RLLVVCDVAL
510 520 530 540 550
GKCVNLFKKD FSLTEAPPGY DSVHGVSETT SVPTDFQDDE FVVYKTNQVK
560 570 580 590 600
MKYIVKFCTP GDQIKEFHPH ENTEVEEQRA EPSSVPEAGD FQLPDIKPFT
610 620 630 640 650
NIKAGLQDAS ANPVPLDSVH IKGRVIDFVA QVIVFQTYTN QSHVPIEAKY
660 670 680 690 700
IFPLDDKAAV CGFEAFINGK HIVGEIKEKE EARQEYREAV SQGHGAYLMD
710 720 730 740 750
QDTPDVFTVS VGNLPPRAKV LIKITYITEL SIQSPVAIFF IPGTVAPWQQ
760 770 780 790 800
DKALNENLQD TVETIRIKEI GAEQSFSLAM SIEMPYMIEF ISSDTHELRQ
810 820 830 840 850
KSTDCKAVVS TVEGSSLDSG GFSLHIGLRD AYLPRMWVEK HPEKESEACM
860 870 880 890 900
LVFQPELADV LPDLRGKNEV IICLDCSSSM EGVTFTQAKQ VALYALSLLG
910 920 930 940 950
EEQKVNIMQF GTGYKELFSY PKCITDSKMA TEFIMSAAPS MGNTDFWKVL
960 970 980 990 1000
RYLSLLYPSE GFRNILLISD GHLQSESLTL QLVKRNIQHT RVFTCAVGST
1010 1020 1030 1040 1050
ANRHILRTLS QCGAGVFEYF NSKSKHSWKK QIEAQMTRIR SPSCHSVSVK
1060 1070 1080 1090 1100
WQQLSRDAPE PLQAPAWVPS LFHNDRLLVY GFIPHCTQAT LQAFIQEKEF
1110 1120 1130 1140 1150
CTMVSTTELQ KTTGTMIHKL AARALIRDYE DGILHDDETN HEMKKNIMKS
1160 1170 1180 1190 1200
LIIELSKENS LITQFTSFVA VEKRDVNEIP FANVPNISEL VAKEDVDFLP
1210 1220 1230 1240 1250
YVSWQEKQPE ASISQTEIDS SRLKHNKLSD GHGVLQPVSV SSEVNEKPSL
1260 1270 1280 1290 1300
LLAAKKRKIK TIKKCSLDIS EDFEDRTAVA QSPATAQSLN FHLPLSVRPQ
1310 1320 1330 1340 1350
LKAVEQQLHG NRLEPKQRGG FRKLLMAKKC RNVPDSLVSS APAVTAEFSY
1360 1370 1380 1390 1400
LSACSSSSAF LSPLCDIPSS LPPHPLGGTH PPPPLPLPDG THLPSPLFGS
1410 1420 1430 1440 1450
THPPPPLFGG TLIPPPSSLF GGTHLPPPPP LPGGTHIPPP PPIPGGTLIP
1460 1470 1480 1490 1500
PSSSLFGGTH LPPPPLLSAG THIPPPPLLS AGTHLPPPPL LPAGTHIPPP
1510 1520 1530 1540 1550
PPITGSTHPP PPSSLFGGTH LPPPPPLPGG THIPPPPPIP GGTLIPSPSS
1560 1570 1580 1590 1600
LFGGTHLPPP PLLPAGTHIP PPPPITGSTH PPPPSSLFGG THLPPPPPAG
1610 1620 1630 1640 1650
TQFSLSPIGF IPPKLGPPKL SHSHKLVGDT NIHDSEPPLL GFKDLCSRDM
1660 1670 1680 1690 1700
GFSCGTAFSG SFASSKDFDP GKFSQGPNNI SFSPKAPEMG VLHQSPFCSP
1710 1720 1730 1740 1750
PKPPSAPPLV TNVLCSEAPQ SYFLNLQSAA VHQSPNNRVS EIIMESVESS
1760 1770 1780 1790 1800
LPSDYSSRDA SSYLALEGAE DSLLGGSSFE TDTDEAAAFI ANDLLTSIET
1810 1820 1830 1840 1850
SSDEECAFCD EDQESPVPWA SLFALQTENG FWKLTPELGL ILNLNVNALL
1860 1870 1880 1890 1900
TSLEEKGIRS LGTKGRERLL DLIATLLVLQ FLYTKLEQEG MVAKSLIKMD
1910 1920 1930 1940 1950
DAFISRNIPW AFENIKKARE WARKTEGQYP SICQRLELGK DWESATKQLL
1960
GIQPQANTSL HRILYYSQG
Length:1,969
Mass (Da):216,133
Last modified:April 5, 2011 - v1
Checksum:iB1EDC5481653F93A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154731 Genomic DNA No translation available.
AC154837 Genomic DNA No translation available.
RefSeqiNP_001139450.2, NM_001145978.2
UniGeneiMm.379357

Genome annotation databases

EnsembliENSMUST00000161553; ENSMUSP00000124258; ENSMUSG00000054509
GeneIDi328417
KEGGimmu:328417
UCSCiuc007ucd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiE9PYK3_MOUSE
AccessioniPrimary (citable) accession number: E9PYK3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health