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Protein

Poly [ADP-ribose] polymerase

Gene

Parp4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
Short name:
PARPUniRule annotation
Gene namesi
Name:Parp4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2685589. Parp4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • membrane Source: MGI
  • nucleus Source: MGI
  • spindle Source: MGI
  • spindle microtubule Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9PYK3.
MaxQBiE9PYK3.
PaxDbiE9PYK3.

PTM databases

iPTMnetiE9PYK3.
PhosphoSiteiE9PYK3.

Expressioni

Gene expression databases

BgeeiE9PYK3.
GenevisibleiE9PYK3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124258.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9494BRCTInterPro annotationAdd
BLAST
Domaini235 – 363129PARP alpha-helicalInterPro annotationAdd
BLAST
Domaini362 – 566205PARP catalyticInterPro annotationAdd
BLAST
Domaini600 – 728129VITInterPro annotationAdd
BLAST
Domaini869 – 1039171VWFAInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BRCT domain.UniRule annotation
Contains 1 PARP alpha-helical domain.UniRule annotation
Contains 1 PARP catalytic domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1037. Eukaryota.
ENOG410XP18. LUCA.
GeneTreeiENSGT00530000063006.
InParanoidiE9PYK3.
KOiK10798.
OrthoDBiEOG75F4CF.
TreeFamiTF329720.

Family and domain databases

Gene3Di1.20.142.10. 1 hit.
3.40.50.10190. 1 hit.
3.40.50.410. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR009408. Formin_homology_1.
IPR031273. PARP4.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10338:SF112. PTHR10338:SF112. 3 hits.
PfamiPF16589. BRCT_2. 1 hit.
PF06346. Drf_FH1. 1 hit.
PF00644. PARP. 1 hit.
PF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
SM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF47587. SSF47587. 1 hit.
SSF52113. SSF52113. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
PS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGIFANCI FCLKVKYLPR QQKKKLQTDI KENGGKFSFL LNPQCTHVIV
60 70 80 90 100
DSADVLSRCH LNSIQKNDVQ IANPAFIQDS VRQRRLLDVR NYDPLSPAPA
110 120 130 140 150
APPAERSRSE VQSEYLPSDN TPEKENTEVT EVSAENVEIP PFLQDFEVVK
160 170 180 190 200
YNILEKVGGP ETVVVELQSS QDPESCPFVI TAHFLLADQK TRRESTGKQT
210 220 230 240 250
SEGAIEYYES YVEDLKRQGF LLQEHFTAEA TQLASEKLQA LLLEEVISSG
260 270 280 290 300
ALSQEVSDLL EVIWTEALGH LENTLLKPVN SMSLNDVSKA EGILLLVKTA
310 320 330 340 350
LKNGDSPGQL QKTMAEFYRL LPHRHPASEE VNLRLLAQKE DLCQLVRDMV
360 370 380 390 400
NVCETNLSKP NPPSLAKYRA LRCKIEHVDQ NTEEFSRVRK EVLQNNRSEQ
410 420 430 440 450
PVDILQIFRV GRVNEATEFL SKLGNVRLLF HGSPVRNILG ILSRGLLLPK
460 470 480 490 500
VAEDRGVQRT DVGNLGSGIY FSDSLSTSIK YAHAGETDGS RLLVVCDVAL
510 520 530 540 550
GKCVNLFKKD FSLTEAPPGY DSVHGVSETT SVPTDFQDDE FVVYKTNQVK
560 570 580 590 600
MKYIVKFCTP GDQIKEFHPH ENTEVEEQRA EPSSVPEAGD FQLPDIKPFT
610 620 630 640 650
NIKAGLQDAS ANPVPLDSVH IKGRVIDFVA QVIVFQTYTN QSHVPIEAKY
660 670 680 690 700
IFPLDDKAAV CGFEAFINGK HIVGEIKEKE EARQEYREAV SQGHGAYLMD
710 720 730 740 750
QDTPDVFTVS VGNLPPRAKV LIKITYITEL SIQSPVAIFF IPGTVAPWQQ
760 770 780 790 800
DKALNENLQD TVETIRIKEI GAEQSFSLAM SIEMPYMIEF ISSDTHELRQ
810 820 830 840 850
KSTDCKAVVS TVEGSSLDSG GFSLHIGLRD AYLPRMWVEK HPEKESEACM
860 870 880 890 900
LVFQPELADV LPDLRGKNEV IICLDCSSSM EGVTFTQAKQ VALYALSLLG
910 920 930 940 950
EEQKVNIMQF GTGYKELFSY PKCITDSKMA TEFIMSAAPS MGNTDFWKVL
960 970 980 990 1000
RYLSLLYPSE GFRNILLISD GHLQSESLTL QLVKRNIQHT RVFTCAVGST
1010 1020 1030 1040 1050
ANRHILRTLS QCGAGVFEYF NSKSKHSWKK QIEAQMTRIR SPSCHSVSVK
1060 1070 1080 1090 1100
WQQLSRDAPE PLQAPAWVPS LFHNDRLLVY GFIPHCTQAT LQAFIQEKEF
1110 1120 1130 1140 1150
CTMVSTTELQ KTTGTMIHKL AARALIRDYE DGILHDDETN HEMKKNIMKS
1160 1170 1180 1190 1200
LIIELSKENS LITQFTSFVA VEKRDVNEIP FANVPNISEL VAKEDVDFLP
1210 1220 1230 1240 1250
YVSWQEKQPE ASISQTEIDS SRLKHNKLSD GHGVLQPVSV SSEVNEKPSL
1260 1270 1280 1290 1300
LLAAKKRKIK TIKKCSLDIS EDFEDRTAVA QSPATAQSLN FHLPLSVRPQ
1310 1320 1330 1340 1350
LKAVEQQLHG NRLEPKQRGG FRKLLMAKKC RNVPDSLVSS APAVTAEFSY
1360 1370 1380 1390 1400
LSACSSSSAF LSPLCDIPSS LPPHPLGGTH PPPPLPLPDG THLPSPLFGS
1410 1420 1430 1440 1450
THPPPPLFGG TLIPPPSSLF GGTHLPPPPP LPGGTHIPPP PPIPGGTLIP
1460 1470 1480 1490 1500
PSSSLFGGTH LPPPPLLSAG THIPPPPLLS AGTHLPPPPL LPAGTHIPPP
1510 1520 1530 1540 1550
PPITGSTHPP PPSSLFGGTH LPPPPPLPGG THIPPPPPIP GGTLIPSPSS
1560 1570 1580 1590 1600
LFGGTHLPPP PLLPAGTHIP PPPPITGSTH PPPPSSLFGG THLPPPPPAG
1610 1620 1630 1640 1650
TQFSLSPIGF IPPKLGPPKL SHSHKLVGDT NIHDSEPPLL GFKDLCSRDM
1660 1670 1680 1690 1700
GFSCGTAFSG SFASSKDFDP GKFSQGPNNI SFSPKAPEMG VLHQSPFCSP
1710 1720 1730 1740 1750
PKPPSAPPLV TNVLCSEAPQ SYFLNLQSAA VHQSPNNRVS EIIMESVESS
1760 1770 1780 1790 1800
LPSDYSSRDA SSYLALEGAE DSLLGGSSFE TDTDEAAAFI ANDLLTSIET
1810 1820 1830 1840 1850
SSDEECAFCD EDQESPVPWA SLFALQTENG FWKLTPELGL ILNLNVNALL
1860 1870 1880 1890 1900
TSLEEKGIRS LGTKGRERLL DLIATLLVLQ FLYTKLEQEG MVAKSLIKMD
1910 1920 1930 1940 1950
DAFISRNIPW AFENIKKARE WARKTEGQYP SICQRLELGK DWESATKQLL
1960
GIQPQANTSL HRILYYSQG
Length:1,969
Mass (Da):216,133
Last modified:April 5, 2011 - v1
Checksum:iB1EDC5481653F93A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154731 Genomic DNA. No translation available.
AC154837 Genomic DNA. No translation available.
RefSeqiNP_001139450.2. NM_001145978.2.
UniGeneiMm.379357.

Genome annotation databases

EnsembliENSMUST00000161553; ENSMUSP00000124258; ENSMUSG00000054509.
GeneIDi328417.
KEGGimmu:328417.
UCSCiuc007ucd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154731 Genomic DNA. No translation available.
AC154837 Genomic DNA. No translation available.
RefSeqiNP_001139450.2. NM_001145978.2.
UniGeneiMm.379357.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124258.

PTM databases

iPTMnetiE9PYK3.
PhosphoSiteiE9PYK3.

Proteomic databases

EPDiE9PYK3.
MaxQBiE9PYK3.
PaxDbiE9PYK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161553; ENSMUSP00000124258; ENSMUSG00000054509.
GeneIDi328417.
KEGGimmu:328417.
UCSCiuc007ucd.2. mouse.

Organism-specific databases

CTDi143.
MGIiMGI:2685589. Parp4.

Phylogenomic databases

eggNOGiKOG1037. Eukaryota.
ENOG410XP18. LUCA.
GeneTreeiENSGT00530000063006.
InParanoidiE9PYK3.
KOiK10798.
OrthoDBiEOG75F4CF.
TreeFamiTF329720.

Miscellaneous databases

ChiTaRSiParp4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9PYK3.
GenevisibleiE9PYK3. MM.

Family and domain databases

Gene3Di1.20.142.10. 1 hit.
3.40.50.10190. 1 hit.
3.40.50.410. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR009408. Formin_homology_1.
IPR031273. PARP4.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10338:SF112. PTHR10338:SF112. 3 hits.
PfamiPF16589. BRCT_2. 1 hit.
PF06346. Drf_FH1. 1 hit.
PF00644. PARP. 1 hit.
PF08487. VIT. 1 hit.
PF13768. VWA_3. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
SM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF47587. SSF47587. 1 hit.
SSF52113. SSF52113. 1 hit.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
PS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PYK3_MOUSE
AccessioniPrimary (citable) accession number: E9PYK3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.