Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase

Gene

Setd1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • chromatin-mediated maintenance of transcription Source: BHF-UCL
  • histone H3-K4 methylation Source: BHF-UCL
  • positive regulation of neural precursor cell proliferation Source: MGI
  • positive regulation of stem cell proliferation Source: MGI
  • stem cell maintenance Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_278269. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:Setd1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2446244. Setd1a.

Subcellular locationi

GO - Cellular componenti

  • histone methyltransferase complex Source: BHF-UCL
  • nuclear euchromatin Source: BHF-UCL
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • Set1C/COMPASS complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037600.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119228.
KOiK11422.
OMAiGYLRLTY.
TreeFamiTF106436.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PYH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQEGGGDGQ KAPSFQWRNY KLIVDPALDP ALRRPSQKVY RYDGVHFSVS
60 70 80 90 100
DSKYTPVEDL QDPRCHVRSK ARDFSLPVPK FKLDEFYIGQ IPLKEVTFAR
110 120 130 140 150
LNDNVRETFL KDMCRKYGEV EEVEILLHPR TRKHLGLARV LFTSTRGAKE
160 170 180 190 200
TVKNLHLTSV MGNIIHAQLD IKGQQRMKYY ELIVNGSYTP QTVPTGGKAL
210 220 230 240 250
SEKFQGSGAA AETTEARRRS SSDTAAYPAG TTVGGTPGNG TPCSQDTNFS
260 270 280 290 300
SSRQDTPSSF GQFTPQSSQG TPYTSRGSTP YSQDSAYSSS TTSTSFKPRR
310 320 330 340 350
SENSYQDSFS RRHFSTSSAP ATTATATSAT AAATAASSSS SSSSSSSSSS
360 370 380 390 400
SSSSSASQFR GSDSSYPAYY ESWNRYQRHT SYPPRRATRE DPSGASFAEN
410 420 430 440 450
TAERFPPSYT SYLAPEPNRS TDQDYRPPAS EAPPPEPPEP GGGGGGSGGG
460 470 480 490 500
GGGGGGGGGG APSPEREEAR TPPRPASPAR SGSPAPETTN ESVPFAQHSS
510 520 530 540 550
LDSRIEMLLK EQRSKFSFLA SDTEEEEENS SAGPGARDAG AEVPSGAGHG
560 570 580 590 600
PCTPPPAPAN FEDVAPTGSG EPGAARESPK ANGQNQASPC SSGEDMEISD
610 620 630 640 650
DDRGGSPPPA PTPPQQPPPP PPPPPPPPPP YLASLPLGYP PHQPAYLLPP
660 670 680 690 700
RPDGPPPPEY PPPPPPPPPH IYDFVNSLEL MDRLGAQWGG MPMSFQMQTQ
710 720 730 740 750
MLTRLHQLRQ GKGLTAASAG PPGGAFGEAF LPFPPPQEAA YGLPYALYTQ
760 770 780 790 800
GQEGRGSYSR EAYHLPLPMA AEPLPSSSVS GEEARLPHRE EAEIAESKVL
810 820 830 840 850
PSAGTVGRVL ATLVQEMKSI MQRDLNRKMV ENVAFGAFDQ WWESKEEKAK
860 870 880 890 900
PFQNAAKQQA KEEDKEKMKL KEPGMLSLVD WAKSGGITGI EAFAFGSGLR
910 920 930 940 950
GALRLPSFKV KRKEPSEISE ASEEKRPRPS TPAEEDEDDP EREKEAGEPG
960 970 980 990 1000
RPGTKPPKRD EERGKTQGKH RKSFTLDSEG EEASQESSSE KDEDDDDEDE
1010 1020 1030 1040 1050
EDEEQEEAVD ATKKEAEASD GEDEDSDSSS QCSLYADSDG ENGSTSDSES
1060 1070 1080 1090 1100
GSSSSSSSSS SSSSSSSSSE SSSEEEEQSA VIPSASPPRE VPEPLPAPDE
1110 1120 1130 1140 1150
KPETDGLVDS PVMPLSEKET LPTQPAGPAE EPPPSVPQPP AEPPAGPPDA
1160 1170 1180 1190 1200
APRLDERPSS PIPLLPPPKK RRKTVSFSAA EEAPVPEPST AAPLQAKSSG
1210 1220 1230 1240 1250
PVSRKVPRVV ERTIRNLPLD HASLVKSWPE EVARGGRNRA GGRVRSTEEE
1260 1270 1280 1290 1300
EATESGTEVD LAVLADLALT PARRGLATLP TGDDSEATET SDEAERPSPL
1310 1320 1330 1340 1350
LSHILLEHNY ALAIKPPPTT PAPRPLEPAP ALAALFSSPA DEVLEAPEVV
1360 1370 1380 1390 1400
VAEAEEPKQQ LQQQHPEQEG EEEEEDEEEE SESSESSSSS SSDEEGAIRR
1410 1420 1430 1440 1450
RSLRSHTRRR RPPLPPPPPP PPSFEPRSEF EQMTILYDIW NSGLDLEDMS
1460 1470 1480 1490 1500
YLRLTYERLL QQTSGADWLN DTHWVQHTIT NLSTPKRKRR PQDGPREHQT
1510 1520 1530 1540 1550
GSARSEGYYP ISKKEKDKYL DVCPVSARQL EGGDTQGTNR VLSERRSEQR
1560 1570 1580 1590 1600
RLLSAIGTSA IMDSDLLKLN QLKFRKKKLR FGRSRIHEWG LFAMEPIAAD
1610 1620 1630 1640 1650
EMVIEYVGQN IRQMVADMRE KRYVQEGIGS SYLFRVDHDT IIDATKCGNL
1660 1670 1680 1690 1700
ARFINHCCTP NCYAKVITIE SQKKIVIYSK QPIGVDEEIT YDYKFPLEDN
1710
KIPCLCGTES CRGSLN
Length:1,716
Mass (Da):186,060
Last modified:April 5, 2011 - v1
Checksum:iF578D5A2276F2D73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149222 Genomic DNA. No translation available.
RefSeqiNP_821172.2. NM_178029.3.
UniGeneiMm.435494.

Genome annotation databases

EnsembliENSMUST00000047075; ENSMUSP00000047672; ENSMUSG00000042308.
ENSMUST00000047157; ENSMUSP00000037600; ENSMUSG00000042308.
GeneIDi233904.
KEGGimmu:233904.
UCSCiuc009jwt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149222 Genomic DNA. No translation available.
RefSeqiNP_821172.2. NM_178029.3.
UniGeneiMm.435494.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037600.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047075; ENSMUSP00000047672; ENSMUSG00000042308.
ENSMUST00000047157; ENSMUSP00000037600; ENSMUSG00000042308.
GeneIDi233904.
KEGGimmu:233904.
UCSCiuc009jwt.1. mouse.

Organism-specific databases

CTDi9739.
MGIiMGI:2446244. Setd1a.

Phylogenomic databases

GeneTreeiENSGT00760000119228.
KOiK11422.
OMAiGYLRLTY.
TreeFamiTF106436.

Enzyme and pathway databases

ReactomeiREACT_278269. PKMTs methylate histone lysines.

Miscellaneous databases

NextBioi381943.
PROiE9PYH6.
SOURCEiSearch...

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PYH6_MOUSE
AccessioniPrimary (citable) accession number: E9PYH6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.