E9PYH6 (E9PYH6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Setd1a Ensembl ENSMUSP00000047672 Ensembl ENSMUSP00000037600

Gene names

Name:

Setd1a Ensembl ENSMUSP00000047672 Ensembl ENSMUSP00000037600 MGI 2446244

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000047672

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1716 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214
Sequence similarities	Contains 1 SET domain. SAAS SAAS001214 RuleBase RU004538 Contains 1 post-SET domain. SAAS SAAS001214 RuleBase RU004541
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000047672 Ensembl ENSMUSP00000037600

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Molecular function	Methyltransferase SAAS SAAS001214 RuleBase RU004541 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Set1C/COMPASS complex Inferred from electronic annotation. Source: Compara histone methyltransferase complex Inferred from sequence orthology PubMed 17500065. Source: MGI
Molecular_function	histone methyltransferase activity (H3-K4 specific) Inferred from electronic annotation. Source: Compara nucleic acid binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9PYH6 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: F578D5A2276F2D73	FASTA	1,716	186,060
	10 20 30 40 50 60 MDQEGGGDGQ KAPSFQWRNY KLIVDPALDP ALRRPSQKVY RYDGVHFSVS DSKYTPVEDL 70 80 90 100 110 120 QDPRCHVRSK ARDFSLPVPK FKLDEFYIGQ IPLKEVTFAR LNDNVRETFL KDMCRKYGEV 130 140 150 160 170 180 EEVEILLHPR TRKHLGLARV LFTSTRGAKE TVKNLHLTSV MGNIIHAQLD IKGQQRMKYY 190 200 210 220 230 240 ELIVNGSYTP QTVPTGGKAL SEKFQGSGAA AETTEARRRS SSDTAAYPAG TTVGGTPGNG 250 260 270 280 290 300 TPCSQDTNFS SSRQDTPSSF GQFTPQSSQG TPYTSRGSTP YSQDSAYSSS TTSTSFKPRR 310 320 330 340 350 360 SENSYQDSFS RRHFSTSSAP ATTATATSAT AAATAASSSS SSSSSSSSSS SSSSSASQFR 370 380 390 400 410 420 GSDSSYPAYY ESWNRYQRHT SYPPRRATRE DPSGASFAEN TAERFPPSYT SYLAPEPNRS 430 440 450 460 470 480 TDQDYRPPAS EAPPPEPPEP GGGGGGSGGG GGGGGGGGGG APSPEREEAR TPPRPASPAR 490 500 510 520 530 540 SGSPAPETTN ESVPFAQHSS LDSRIEMLLK EQRSKFSFLA SDTEEEEENS SAGPGARDAG 550 560 570 580 590 600 AEVPSGAGHG PCTPPPAPAN FEDVAPTGSG EPGAARESPK ANGQNQASPC SSGEDMEISD 610 620 630 640 650 660 DDRGGSPPPA PTPPQQPPPP PPPPPPPPPP YLASLPLGYP PHQPAYLLPP RPDGPPPPEY 670 680 690 700 710 720 PPPPPPPPPH IYDFVNSLEL MDRLGAQWGG MPMSFQMQTQ MLTRLHQLRQ GKGLTAASAG 730 740 750 760 770 780 PPGGAFGEAF LPFPPPQEAA YGLPYALYTQ GQEGRGSYSR EAYHLPLPMA AEPLPSSSVS 790 800 810 820 830 840 GEEARLPHRE EAEIAESKVL PSAGTVGRVL ATLVQEMKSI MQRDLNRKMV ENVAFGAFDQ 850 860 870 880 890 900 WWESKEEKAK PFQNAAKQQA KEEDKEKMKL KEPGMLSLVD WAKSGGITGI EAFAFGSGLR 910 920 930 940 950 960 GALRLPSFKV KRKEPSEISE ASEEKRPRPS TPAEEDEDDP EREKEAGEPG RPGTKPPKRD 970 980 990 1000 1010 1020 EERGKTQGKH RKSFTLDSEG EEASQESSSE KDEDDDDEDE EDEEQEEAVD ATKKEAEASD 1030 1040 1050 1060 1070 1080 GEDEDSDSSS QCSLYADSDG ENGSTSDSES GSSSSSSSSS SSSSSSSSSE SSSEEEEQSA 1090 1100 1110 1120 1130 1140 VIPSASPPRE VPEPLPAPDE KPETDGLVDS PVMPLSEKET LPTQPAGPAE EPPPSVPQPP 1150 1160 1170 1180 1190 1200 AEPPAGPPDA APRLDERPSS PIPLLPPPKK RRKTVSFSAA EEAPVPEPST AAPLQAKSSG 1210 1220 1230 1240 1250 1260 PVSRKVPRVV ERTIRNLPLD HASLVKSWPE EVARGGRNRA GGRVRSTEEE EATESGTEVD 1270 1280 1290 1300 1310 1320 LAVLADLALT PARRGLATLP TGDDSEATET SDEAERPSPL LSHILLEHNY ALAIKPPPTT 1330 1340 1350 1360 1370 1380 PAPRPLEPAP ALAALFSSPA DEVLEAPEVV VAEAEEPKQQ LQQQHPEQEG EEEEEDEEEE 1390 1400 1410 1420 1430 1440 SESSESSSSS SSDEEGAIRR RSLRSHTRRR RPPLPPPPPP PPSFEPRSEF EQMTILYDIW 1450 1460 1470 1480 1490 1500 NSGLDLEDMS YLRLTYERLL QQTSGADWLN DTHWVQHTIT NLSTPKRKRR PQDGPREHQT 1510 1520 1530 1540 1550 1560 GSARSEGYYP ISKKEKDKYL DVCPVSARQL EGGDTQGTNR VLSERRSEQR RLLSAIGTSA 1570 1580 1590 1600 1610 1620 IMDSDLLKLN QLKFRKKKLR FGRSRIHEWG LFAMEPIAAD EMVIEYVGQN IRQMVADMRE 1630 1640 1650 1660 1670 1680 KRYVQEGIGS SYLFRVDHDT IIDATKCGNL ARFINHCCTP NCYAKVITIE SQKKIVIYSK 1690 1700 1710 QPIGVDEEIT YDYKFPLEDN KIPCLCGTES CRGSLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000047672 Ensembl ENSMUSP00000037600.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000047672.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000037600.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC149222 Genomic DNA. No translation available.
IPI	IPI00323238.
RefSeq	NP_821172.2. NM_178029.3.
UniGene	Mm.435494.
3D structure databases
SMR	E9PYH6. Positions 89-195.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000047075; ENSMUSP00000047672; ENSMUSG00000042308. ENSMUST00000047157; ENSMUSP00000037600; ENSMUSG00000042308.
GeneID	233904.
KEGG	mmu:233904.
Organism-specific databases
CTD	9739.
MGI	MGI:2446244. Setd1a.
Phylogenomic databases
GeneTree	ENSGT00700000104213.
KO	K11422.
OMA	NGQNQAS.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR024657. COMPASS_Set1_N-SET. IPR015722. Histone-lysine_MeTfrase. IPR012677. Nucleotide-bd_a/b_plait. IPR003616. Post-SET_dom. IPR000504. RRM_dom. IPR001214. SET_dom. [Graphical view]
PANTHER	PTHR22884:SF10. PTHR22884:SF10. 1 hit.
Pfam	PF11764. N-SET. 1 hit. PF00076. RRM_1. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00508. PostSET. 1 hit. SM00360. RRM. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50102. RRM. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	381943.
SOURCE	Search...

Entry information

Entry name

E9PYH6_MOUSE

Accession

Primary (citable) accession number: E9PYH6

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)