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E9PYH6

- E9PYH6_MOUSE

UniProt

E9PYH6 - E9PYH6_MOUSE

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Protein
Submitted name: Protein Setd1a
Gene
Setd1a
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotations

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K4 specific) Source: Ensembl
  2. nucleic acid binding Source: InterPro
  3. nucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotations, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineSAAS annotations

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Setd1aImported
    Gene namesi
    Name:Setd1aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2446244. Setd1a.

    Subcellular locationi

    GO - Cellular componenti

    1. Set1C/COMPASS complex Source: Ensembl
    2. histone methyltransferase complex Source: MGI
    3. nucleus Source: MGI
    Complete GO annotation...

    Keywords - Cellular componenti

    NucleusSAAS annotations

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotations
    Contains post-SET domain.SAAS annotations

    Phylogenomic databases

    GeneTreeiENSGT00740000115089.
    KOiK11422.
    OMAiGYLRLTY.
    TreeFamiTF106436.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PYH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQEGGGDGQ KAPSFQWRNY KLIVDPALDP ALRRPSQKVY RYDGVHFSVS     50
    DSKYTPVEDL QDPRCHVRSK ARDFSLPVPK FKLDEFYIGQ IPLKEVTFAR 100
    LNDNVRETFL KDMCRKYGEV EEVEILLHPR TRKHLGLARV LFTSTRGAKE 150
    TVKNLHLTSV MGNIIHAQLD IKGQQRMKYY ELIVNGSYTP QTVPTGGKAL 200
    SEKFQGSGAA AETTEARRRS SSDTAAYPAG TTVGGTPGNG TPCSQDTNFS 250
    SSRQDTPSSF GQFTPQSSQG TPYTSRGSTP YSQDSAYSSS TTSTSFKPRR 300
    SENSYQDSFS RRHFSTSSAP ATTATATSAT AAATAASSSS SSSSSSSSSS 350
    SSSSSASQFR GSDSSYPAYY ESWNRYQRHT SYPPRRATRE DPSGASFAEN 400
    TAERFPPSYT SYLAPEPNRS TDQDYRPPAS EAPPPEPPEP GGGGGGSGGG 450
    GGGGGGGGGG APSPEREEAR TPPRPASPAR SGSPAPETTN ESVPFAQHSS 500
    LDSRIEMLLK EQRSKFSFLA SDTEEEEENS SAGPGARDAG AEVPSGAGHG 550
    PCTPPPAPAN FEDVAPTGSG EPGAARESPK ANGQNQASPC SSGEDMEISD 600
    DDRGGSPPPA PTPPQQPPPP PPPPPPPPPP YLASLPLGYP PHQPAYLLPP 650
    RPDGPPPPEY PPPPPPPPPH IYDFVNSLEL MDRLGAQWGG MPMSFQMQTQ 700
    MLTRLHQLRQ GKGLTAASAG PPGGAFGEAF LPFPPPQEAA YGLPYALYTQ 750
    GQEGRGSYSR EAYHLPLPMA AEPLPSSSVS GEEARLPHRE EAEIAESKVL 800
    PSAGTVGRVL ATLVQEMKSI MQRDLNRKMV ENVAFGAFDQ WWESKEEKAK 850
    PFQNAAKQQA KEEDKEKMKL KEPGMLSLVD WAKSGGITGI EAFAFGSGLR 900
    GALRLPSFKV KRKEPSEISE ASEEKRPRPS TPAEEDEDDP EREKEAGEPG 950
    RPGTKPPKRD EERGKTQGKH RKSFTLDSEG EEASQESSSE KDEDDDDEDE 1000
    EDEEQEEAVD ATKKEAEASD GEDEDSDSSS QCSLYADSDG ENGSTSDSES 1050
    GSSSSSSSSS SSSSSSSSSE SSSEEEEQSA VIPSASPPRE VPEPLPAPDE 1100
    KPETDGLVDS PVMPLSEKET LPTQPAGPAE EPPPSVPQPP AEPPAGPPDA 1150
    APRLDERPSS PIPLLPPPKK RRKTVSFSAA EEAPVPEPST AAPLQAKSSG 1200
    PVSRKVPRVV ERTIRNLPLD HASLVKSWPE EVARGGRNRA GGRVRSTEEE 1250
    EATESGTEVD LAVLADLALT PARRGLATLP TGDDSEATET SDEAERPSPL 1300
    LSHILLEHNY ALAIKPPPTT PAPRPLEPAP ALAALFSSPA DEVLEAPEVV 1350
    VAEAEEPKQQ LQQQHPEQEG EEEEEDEEEE SESSESSSSS SSDEEGAIRR 1400
    RSLRSHTRRR RPPLPPPPPP PPSFEPRSEF EQMTILYDIW NSGLDLEDMS 1450
    YLRLTYERLL QQTSGADWLN DTHWVQHTIT NLSTPKRKRR PQDGPREHQT 1500
    GSARSEGYYP ISKKEKDKYL DVCPVSARQL EGGDTQGTNR VLSERRSEQR 1550
    RLLSAIGTSA IMDSDLLKLN QLKFRKKKLR FGRSRIHEWG LFAMEPIAAD 1600
    EMVIEYVGQN IRQMVADMRE KRYVQEGIGS SYLFRVDHDT IIDATKCGNL 1650
    ARFINHCCTP NCYAKVITIE SQKKIVIYSK QPIGVDEEIT YDYKFPLEDN 1700
    KIPCLCGTES CRGSLN 1716
    Length:1,716
    Mass (Da):186,060
    Last modified:April 5, 2011 - v1
    Checksum:iF578D5A2276F2D73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149222 Genomic DNA. No translation available.
    RefSeqiNP_821172.2. NM_178029.3.
    UniGeneiMm.435494.

    Genome annotation databases

    EnsembliENSMUST00000047075; ENSMUSP00000047672; ENSMUSG00000042308.
    ENSMUST00000047157; ENSMUSP00000037600; ENSMUSG00000042308.
    GeneIDi233904.
    KEGGimmu:233904.
    UCSCiuc009jwt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149222 Genomic DNA. No translation available.
    RefSeqi NP_821172.2. NM_178029.3.
    UniGenei Mm.435494.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047075 ; ENSMUSP00000047672 ; ENSMUSG00000042308 .
    ENSMUST00000047157 ; ENSMUSP00000037600 ; ENSMUSG00000042308 .
    GeneIDi 233904.
    KEGGi mmu:233904.
    UCSCi uc009jwt.1. mouse.

    Organism-specific databases

    CTDi 9739.
    MGIi MGI:2446244. Setd1a.

    Phylogenomic databases

    GeneTreei ENSGT00740000115089.
    KOi K11422.
    OMAi GYLRLTY.
    TreeFami TF106436.

    Miscellaneous databases

    NextBioi 381943.
    PROi E9PYH6.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9PYH6_MOUSE
    AccessioniPrimary (citable) accession number: E9PYH6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: May 14, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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