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Protein
Submitted name:

SET domain-containing 1A

Gene

Setd1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • chromatin-mediated maintenance of transcription Source: BHF-UCL
  • histone H3-K4 methylation Source: MGI
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • positive regulation of neural precursor cell proliferation Source: MGI
  • positive regulation of stem cell proliferation Source: MGI
  • regulation of chromatin organization Source: ParkinsonsUK-UCL
  • regulation of erythrocyte differentiation Source: ParkinsonsUK-UCL
  • regulation of hematopoietic stem cell differentiation Source: MGI
  • stem cell population maintenance Source: MGI

Keywordsi

Molecular functionMethyltransferaseSAAS annotation, RNA-bindingPROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methionineSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-3214841 PKMTs methylate histone lysines
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Names & Taxonomyi

Protein namesi
Submitted name:
SET domain-containing 1AImported
Gene namesi
Name:Setd1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2446244 Setd1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000042308

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037600

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 172RRMInterPro annotationAdd BLAST89
Domaini1577 – 1694SETInterPro annotationAdd BLAST118
Domaini1700 – 1716Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1358 – 1378Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1080 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00760000119228
KOiK11422
OMAiQNQASPC
OrthoDBiEOG091G00IV
TreeFamiTF106436

Family and domain databases

CDDicd12548 RRM_Set1A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR024657 COMPASS_Set1_N-SET
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR003616 Post-SET_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034467 Set1A_RRM
IPR001214 SET_dom
IPR037841 SETD1A
PANTHERiPTHR22884:SF295 PTHR22884:SF295, 1 hit
PfamiView protein in Pfam
PF11764 N-SET, 1 hit
PF00076 RRM_1, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM01291 N-SET, 1 hit
SM00508 PostSET, 1 hit
SM00360 RRM, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50102 RRM, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

E9PYH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQEGGGDGQ KAPSFQWRNY KLIVDPALDP ALRRPSQKVY RYDGVHFSVS
60 70 80 90 100
DSKYTPVEDL QDPRCHVRSK ARDFSLPVPK FKLDEFYIGQ IPLKEVTFAR
110 120 130 140 150
LNDNVRETFL KDMCRKYGEV EEVEILLHPR TRKHLGLARV LFTSTRGAKE
160 170 180 190 200
TVKNLHLTSV MGNIIHAQLD IKGQQRMKYY ELIVNGSYTP QTVPTGGKAL
210 220 230 240 250
SEKFQGSGAA AETTEARRRS SSDTAAYPAG TTVGGTPGNG TPCSQDTNFS
260 270 280 290 300
SSRQDTPSSF GQFTPQSSQG TPYTSRGSTP YSQDSAYSSS TTSTSFKPRR
310 320 330 340 350
SENSYQDSFS RRHFSTSSAP ATTATATSAT AAATAASSSS SSSSSSSSSS
360 370 380 390 400
SSSSSASQFR GSDSSYPAYY ESWNRYQRHT SYPPRRATRE DPSGASFAEN
410 420 430 440 450
TAERFPPSYT SYLAPEPNRS TDQDYRPPAS EAPPPEPPEP GGGGGGSGGG
460 470 480 490 500
GGGGGGGGGG APSPEREEAR TPPRPASPAR SGSPAPETTN ESVPFAQHSS
510 520 530 540 550
LDSRIEMLLK EQRSKFSFLA SDTEEEEENS SAGPGARDAG AEVPSGAGHG
560 570 580 590 600
PCTPPPAPAN FEDVAPTGSG EPGAARESPK ANGQNQASPC SSGEDMEISD
610 620 630 640 650
DDRGGSPPPA PTPPQQPPPP PPPPPPPPPP YLASLPLGYP PHQPAYLLPP
660 670 680 690 700
RPDGPPPPEY PPPPPPPPPH IYDFVNSLEL MDRLGAQWGG MPMSFQMQTQ
710 720 730 740 750
MLTRLHQLRQ GKGLTAASAG PPGGAFGEAF LPFPPPQEAA YGLPYALYTQ
760 770 780 790 800
GQEGRGSYSR EAYHLPLPMA AEPLPSSSVS GEEARLPHRE EAEIAESKVL
810 820 830 840 850
PSAGTVGRVL ATLVQEMKSI MQRDLNRKMV ENVAFGAFDQ WWESKEEKAK
860 870 880 890 900
PFQNAAKQQA KEEDKEKMKL KEPGMLSLVD WAKSGGITGI EAFAFGSGLR
910 920 930 940 950
GALRLPSFKV KRKEPSEISE ASEEKRPRPS TPAEEDEDDP EREKEAGEPG
960 970 980 990 1000
RPGTKPPKRD EERGKTQGKH RKSFTLDSEG EEASQESSSE KDEDDDDEDE
1010 1020 1030 1040 1050
EDEEQEEAVD ATKKEAEASD GEDEDSDSSS QCSLYADSDG ENGSTSDSES
1060 1070 1080 1090 1100
GSSSSSSSSS SSSSSSSSSE SSSEEEEQSA VIPSASPPRE VPEPLPAPDE
1110 1120 1130 1140 1150
KPETDGLVDS PVMPLSEKET LPTQPAGPAE EPPPSVPQPP AEPPAGPPDA
1160 1170 1180 1190 1200
APRLDERPSS PIPLLPPPKK RRKTVSFSAA EEAPVPEPST AAPLQAKSSG
1210 1220 1230 1240 1250
PVSRKVPRVV ERTIRNLPLD HASLVKSWPE EVARGGRNRA GGRVRSTEEE
1260 1270 1280 1290 1300
EATESGTEVD LAVLADLALT PARRGLATLP TGDDSEATET SDEAERPSPL
1310 1320 1330 1340 1350
LSHILLEHNY ALAIKPPPTT PAPRPLEPAP ALAALFSSPA DEVLEAPEVV
1360 1370 1380 1390 1400
VAEAEEPKQQ LQQQHPEQEG EEEEEDEEEE SESSESSSSS SSDEEGAIRR
1410 1420 1430 1440 1450
RSLRSHTRRR RPPLPPPPPP PPSFEPRSEF EQMTILYDIW NSGLDLEDMS
1460 1470 1480 1490 1500
YLRLTYERLL QQTSGADWLN DTHWVQHTIT NLSTPKRKRR PQDGPREHQT
1510 1520 1530 1540 1550
GSARSEGYYP ISKKEKDKYL DVCPVSARQL EGGDTQGTNR VLSERRSEQR
1560 1570 1580 1590 1600
RLLSAIGTSA IMDSDLLKLN QLKFRKKKLR FGRSRIHEWG LFAMEPIAAD
1610 1620 1630 1640 1650
EMVIEYVGQN IRQMVADMRE KRYVQEGIGS SYLFRVDHDT IIDATKCGNL
1660 1670 1680 1690 1700
ARFINHCCTP NCYAKVITIE SQKKIVIYSK QPIGVDEEIT YDYKFPLEDN
1710
KIPCLCGTES CRGSLN
Length:1,716
Mass (Da):186,060
Last modified:April 5, 2011 - v1
Checksum:iF578D5A2276F2D73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149222 Genomic DNA No translation available.
RefSeqiNP_821172.2, NM_178029.3
XP_017177700.1, XM_017322211.1
XP_017177701.1, XM_017322212.1
XP_017177702.1, XM_017322213.1
XP_017177703.1, XM_017322214.1
UniGeneiMm.435494

Genome annotation databases

EnsembliENSMUST00000047075; ENSMUSP00000047672; ENSMUSG00000042308
ENSMUST00000047157; ENSMUSP00000037600; ENSMUSG00000042308
GeneIDi233904
KEGGimmu:233904
UCSCiuc009jwt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9PYH6_MOUSE
AccessioniPrimary (citable) accession number: E9PYH6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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