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E9PYG6

- E9PYG6_MOUSE

UniProt

E9PYG6 - E9PYG6_MOUSE

Protein
Submitted name:

Protein Rasa1

Gene

Rasa1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. Ras GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of cell-matrix adhesion Source: Ensembl
    2. negative regulation of Ras protein signal transduction Source: RefGenome
    3. positive regulation of Ras GTPase activity Source: RefGenome
    4. regulation of actin filament polymerization Source: Ensembl
    5. signal transduction Source: Ensembl

    Keywords - Molecular functioni

    GTPase activationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Rasa1Imported
    Gene namesi
    Name:Rasa1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:97860. Rasa1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
    3. plasma membrane Source: MGI
    4. ruffle Source: MGI

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Proteomic databases

    MaxQBiE9PYG6.
    PRIDEiE9PYG6.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PYG6.
    BgeeiE9PYG6.

    Interactioni

    Protein-protein interaction databases

    IntActiE9PYG6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PYG6.
    SMRiE9PYG6. Positions 137-437, 466-564, 709-1032.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains 1 PH domain.UniRule annotation
    Contains 1 SH3 domain.
    Contains PH domain.SAAS annotation

    Keywords - Domaini

    SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00600000084217.
    KOiK04352.
    OMAiQAQDWMK.
    OrthoDBiEOG7HTHG8.
    TreeFamiTF105301.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.30.505.10. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF00169. PH. 1 hit.
    PF00616. RasGAP. 1 hit.
    PF00017. SH2. 2 hits.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PYG6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMAAEAGSEE GGPATAGPGG GAATGSSAYS AACRVKLPAA LPVAAAPCPG     50
    LADADLVAAL GGGAASGSGF LGTGPVAGVL GGAALTGSAA AGVAGAAAAG 100
    PAGDVAFTKG TLSLPAETLG PGGGFPPLPP PPQLPPLGSG LGTVDEGDSL 150
    DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT IAEERLRQAG KSGSYLIRES 200
    DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV 250
    SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV 300
    HNELEDGWMW VTNLRTDEQG LIVEDLVEEV GREEDPHEGK IWFHGKISKQ 350
    EAYNLLMTVG QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF 400
    MMGGRYYNSI GDIIDHYRKE QIVEGYYLKE PVPMQDQGQV LNDTVDGKEI 450
    YNTIRRKTKD AFYKNIVKKG YLLKKGKGKR WKNLYFILEG SDAQLIYFES 500
    EKRATKPKGL IDLSVCSVYV VHDSLFGRPN CFQIVVQHFS EEHYIFYFAG 550
    ETPEQAEDWM KGLQAFCSLR KSSPGTSNKR LRQVSSLVLH IEEAHKLPVK 600
    HFTNPYCNIY LNSVQVAKTH AREGQNPVWS EEFVFDDLPP DINRFEITLS 650
    NKTKKSKDPD ILFMRCQLSR LQKGHATDEW FLLSSHIPLK GIEPGSLRVR 700
    ARYSMEKIMP EEEYSEFKEL ILQKELHVVY ALSHVCGQDR TLLASILLKI 750
    FLHEKLESLL LCTLNDREIS MEDEATTLFR ATTLASTLME QYMKATATQF 800
    VHHALKDSIL KIMESKQSCE LSPSKLEKNE DVNTNLAHLL SILSELVEKI 850
    FMASEILPPT LRYIYGCLQK SVQHKWPTNN TMRTRVVSGF VFLRLICPAI 900
    LNPRMFNIIS DSPSPIAART LTLVAKSVQN LANLVEFGAK EPYMEGVNPF 950
    IKSNKHRMIM FLDELGNVPE LPDTTEHSRT DLSRDLAALH EICVAHSDEL 1000
    RTLSNERGVQ QHVLKKLLAI TELLQQKQNQ YTKTNDIR 1038
    Length:1,038
    Mass (Da):115,429
    Last modified:April 5, 2011 - v1
    Checksum:iB6F56F0489252685
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127316 Genomic DNA. No translation available.
    AC154271 Genomic DNA. No translation available.
    RefSeqiNP_663427.2. NM_145452.3.
    UniGeneiMm.259653.

    Genome annotation databases

    EnsembliENSMUST00000109552; ENSMUSP00000105179; ENSMUSG00000021549.
    GeneIDi218397.
    KEGGimmu:218397.
    UCSCiuc007rix.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127316 Genomic DNA. No translation available.
    AC154271 Genomic DNA. No translation available.
    RefSeqi NP_663427.2. NM_145452.3.
    UniGenei Mm.259653.

    3D structure databases

    ProteinModelPortali E9PYG6.
    SMRi E9PYG6. Positions 137-437, 466-564, 709-1032.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi E9PYG6. 1 interaction.

    Proteomic databases

    MaxQBi E9PYG6.
    PRIDEi E9PYG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109552 ; ENSMUSP00000105179 ; ENSMUSG00000021549 .
    GeneIDi 218397.
    KEGGi mmu:218397.
    UCSCi uc007rix.2. mouse.

    Organism-specific databases

    CTDi 5921.
    MGIi MGI:97860. Rasa1.

    Phylogenomic databases

    GeneTreei ENSGT00600000084217.
    KOi K04352.
    OMAi QAQDWMK.
    OrthoDBi EOG7HTHG8.
    TreeFami TF105301.

    Miscellaneous databases

    NextBioi 376276.
    PROi E9PYG6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9PYG6.
    Bgeei E9PYG6.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.30.505.10. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF00169. PH. 1 hit.
    PF00616. RasGAP. 1 hit.
    PF00017. SH2. 2 hits.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9PYG6_MOUSE
    AccessioniPrimary (citable) accession number: E9PYG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3