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E9PYG6

- E9PYG6_MOUSE

UniProt

E9PYG6 - E9PYG6_MOUSE

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Protein
Submitted name:

Protein Rasa1

Gene

Rasa1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. Ras GTPase activator activity Source: RefGenome

GO - Biological processi

  1. negative regulation of cell-matrix adhesion Source: Ensembl
  2. negative regulation of Ras protein signal transduction Source: RefGenome
  3. positive regulation of Ras GTPase activity Source: RefGenome
  4. regulation of actin filament polymerization Source: Ensembl
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_230639. Downstream signal transduction.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_257656. EPHB-mediated forward signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Rasa1Imported
Gene namesi
Name:Rasa1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:97860. Rasa1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
  3. plasma membrane Source: MGI
  4. ruffle Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Proteomic databases

MaxQBiE9PYG6.
PRIDEiE9PYG6.

Expressioni

Gene expression databases

BgeeiE9PYG6.
ExpressionAtlasiE9PYG6. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiE9PYG6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliE9PYG6.
SMRiE9PYG6. Positions 137-437, 466-564, 584-686, 709-1032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains PH domain.SAAS annotation

Keywords - Domaini

SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119092.
InParanoidiE9PYG6.
KOiK04352.
OMAiQAQDWMK.
OrthoDBiEOG7HTHG8.
TreeFamiTF105301.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PYG6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMAAEAGSEE GGPATAGPGG GAATGSSAYS AACRVKLPAA LPVAAAPCPG
60 70 80 90 100
LADADLVAAL GGGAASGSGF LGTGPVAGVL GGAALTGSAA AGVAGAAAAG
110 120 130 140 150
PAGDVAFTKG TLSLPAETLG PGGGFPPLPP PPQLPPLGSG LGTVDEGDSL
160 170 180 190 200
DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT IAEERLRQAG KSGSYLIRES
210 220 230 240 250
DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV
260 270 280 290 300
SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV
310 320 330 340 350
HNELEDGWMW VTNLRTDEQG LIVEDLVEEV GREEDPHEGK IWFHGKISKQ
360 370 380 390 400
EAYNLLMTVG QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF
410 420 430 440 450
MMGGRYYNSI GDIIDHYRKE QIVEGYYLKE PVPMQDQGQV LNDTVDGKEI
460 470 480 490 500
YNTIRRKTKD AFYKNIVKKG YLLKKGKGKR WKNLYFILEG SDAQLIYFES
510 520 530 540 550
EKRATKPKGL IDLSVCSVYV VHDSLFGRPN CFQIVVQHFS EEHYIFYFAG
560 570 580 590 600
ETPEQAEDWM KGLQAFCSLR KSSPGTSNKR LRQVSSLVLH IEEAHKLPVK
610 620 630 640 650
HFTNPYCNIY LNSVQVAKTH AREGQNPVWS EEFVFDDLPP DINRFEITLS
660 670 680 690 700
NKTKKSKDPD ILFMRCQLSR LQKGHATDEW FLLSSHIPLK GIEPGSLRVR
710 720 730 740 750
ARYSMEKIMP EEEYSEFKEL ILQKELHVVY ALSHVCGQDR TLLASILLKI
760 770 780 790 800
FLHEKLESLL LCTLNDREIS MEDEATTLFR ATTLASTLME QYMKATATQF
810 820 830 840 850
VHHALKDSIL KIMESKQSCE LSPSKLEKNE DVNTNLAHLL SILSELVEKI
860 870 880 890 900
FMASEILPPT LRYIYGCLQK SVQHKWPTNN TMRTRVVSGF VFLRLICPAI
910 920 930 940 950
LNPRMFNIIS DSPSPIAART LTLVAKSVQN LANLVEFGAK EPYMEGVNPF
960 970 980 990 1000
IKSNKHRMIM FLDELGNVPE LPDTTEHSRT DLSRDLAALH EICVAHSDEL
1010 1020 1030
RTLSNERGVQ QHVLKKLLAI TELLQQKQNQ YTKTNDIR
Length:1,038
Mass (Da):115,429
Last modified:April 5, 2011 - v1
Checksum:iB6F56F0489252685
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127316 Genomic DNA. No translation available.
AC154271 Genomic DNA. No translation available.
RefSeqiNP_663427.2. NM_145452.3.
UniGeneiMm.259653.

Genome annotation databases

EnsembliENSMUST00000109552; ENSMUSP00000105179; ENSMUSG00000021549.
GeneIDi218397.
KEGGimmu:218397.
UCSCiuc007rix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127316 Genomic DNA. No translation available.
AC154271 Genomic DNA. No translation available.
RefSeqi NP_663427.2. NM_145452.3.
UniGenei Mm.259653.

3D structure databases

ProteinModelPortali E9PYG6.
SMRi E9PYG6. Positions 137-437, 466-564, 584-686, 709-1032.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi E9PYG6. 1 interaction.

Proteomic databases

MaxQBi E9PYG6.
PRIDEi E9PYG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109552 ; ENSMUSP00000105179 ; ENSMUSG00000021549 .
GeneIDi 218397.
KEGGi mmu:218397.
UCSCi uc007rix.2. mouse.

Organism-specific databases

CTDi 5921.
MGIi MGI:97860. Rasa1.

Phylogenomic databases

GeneTreei ENSGT00760000119092.
InParanoidi E9PYG6.
KOi K04352.
OMAi QAQDWMK.
OrthoDBi EOG7HTHG8.
TreeFami TF105301.

Enzyme and pathway databases

Reactomei REACT_230639. Downstream signal transduction.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_257656. EPHB-mediated forward signaling.

Miscellaneous databases

NextBioi 376276.
PROi E9PYG6.
SOURCEi Search...

Gene expression databases

Bgeei E9PYG6.
ExpressionAtlasi E9PYG6. baseline and differential.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProi IPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PYG6_MOUSE
AccessioniPrimary (citable) accession number: E9PYG6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3