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Protein
Submitted name:

Protein Rasa1

Gene

Rasa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_278498. Downstream signal transduction.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_313804. EPHB-mediated forward signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Rasa1Imported
Gene namesi
Name:Rasa1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97860. Rasa1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • intrinsic component of the cytoplasmic side of the plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
  • ruffle Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Proteomic databases

MaxQBiE9PYG6.
PRIDEiE9PYG6.

Expressioni

Gene expression databases

BgeeiE9PYG6.
ExpressionAtlasiE9PYG6. baseline and differential.
GenevisibleiE9PYG6. MM.

Interactioni

Protein-protein interaction databases

IntActiE9PYG6. 1 interaction.
STRINGi10090.ENSMUSP00000105179.

Structurei

3D structure databases

ProteinModelPortaliE9PYG6.
SMRiE9PYG6. Positions 272-437, 709-1032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119092.
InParanoidiE9PYG6.
KOiK04352.
OMAiDPHEGKI.
OrthoDBiEOG7HTHG8.
TreeFamiTF105301.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PYG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAEAGSEE GGPATAGPGG GAATGSSAYS AACRVKLPAA LPVAAAPCPG
60 70 80 90 100
LADADLVAAL GGGAASGSGF LGTGPVAGVL GGAALTGSAA AGVAGAAAAG
110 120 130 140 150
PAGDVAFTKG TLSLPAETLG PGGGFPPLPP PPQLPPLGSG LGTVDEGDSL
160 170 180 190 200
DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT IAEERLRQAG KSGSYLIRES
210 220 230 240 250
DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV
260 270 280 290 300
SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV
310 320 330 340 350
HNELEDGWMW VTNLRTDEQG LIVEDLVEEV GREEDPHEGK IWFHGKISKQ
360 370 380 390 400
EAYNLLMTVG QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF
410 420 430 440 450
MMGGRYYNSI GDIIDHYRKE QIVEGYYLKE PVPMQDQGQV LNDTVDGKEI
460 470 480 490 500
YNTIRRKTKD AFYKNIVKKG YLLKKGKGKR WKNLYFILEG SDAQLIYFES
510 520 530 540 550
EKRATKPKGL IDLSVCSVYV VHDSLFGRPN CFQIVVQHFS EEHYIFYFAG
560 570 580 590 600
ETPEQAEDWM KGLQAFCSLR KSSPGTSNKR LRQVSSLVLH IEEAHKLPVK
610 620 630 640 650
HFTNPYCNIY LNSVQVAKTH AREGQNPVWS EEFVFDDLPP DINRFEITLS
660 670 680 690 700
NKTKKSKDPD ILFMRCQLSR LQKGHATDEW FLLSSHIPLK GIEPGSLRVR
710 720 730 740 750
ARYSMEKIMP EEEYSEFKEL ILQKELHVVY ALSHVCGQDR TLLASILLKI
760 770 780 790 800
FLHEKLESLL LCTLNDREIS MEDEATTLFR ATTLASTLME QYMKATATQF
810 820 830 840 850
VHHALKDSIL KIMESKQSCE LSPSKLEKNE DVNTNLAHLL SILSELVEKI
860 870 880 890 900
FMASEILPPT LRYIYGCLQK SVQHKWPTNN TMRTRVVSGF VFLRLICPAI
910 920 930 940 950
LNPRMFNIIS DSPSPIAART LTLVAKSVQN LANLVEFGAK EPYMEGVNPF
960 970 980 990 1000
IKSNKHRMIM FLDELGNVPE LPDTTEHSRT DLSRDLAALH EICVAHSDEL
1010 1020 1030
RTLSNERGVQ QHVLKKLLAI TELLQQKQNQ YTKTNDIR
Length:1,038
Mass (Da):115,429
Last modified:April 5, 2011 - v1
Checksum:iB6F56F0489252685
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127316 Genomic DNA. No translation available.
AC154271 Genomic DNA. No translation available.
RefSeqiNP_663427.2. NM_145452.3.
UniGeneiMm.259653.

Genome annotation databases

EnsembliENSMUST00000109552; ENSMUSP00000105179; ENSMUSG00000021549.
GeneIDi218397.
KEGGimmu:218397.
UCSCiuc007rix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127316 Genomic DNA. No translation available.
AC154271 Genomic DNA. No translation available.
RefSeqiNP_663427.2. NM_145452.3.
UniGeneiMm.259653.

3D structure databases

ProteinModelPortaliE9PYG6.
SMRiE9PYG6. Positions 272-437, 709-1032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9PYG6. 1 interaction.
STRINGi10090.ENSMUSP00000105179.

Proteomic databases

MaxQBiE9PYG6.
PRIDEiE9PYG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109552; ENSMUSP00000105179; ENSMUSG00000021549.
GeneIDi218397.
KEGGimmu:218397.
UCSCiuc007rix.2. mouse.

Organism-specific databases

CTDi5921.
MGIiMGI:97860. Rasa1.

Phylogenomic databases

GeneTreeiENSGT00760000119092.
InParanoidiE9PYG6.
KOiK04352.
OMAiDPHEGKI.
OrthoDBiEOG7HTHG8.
TreeFamiTF105301.

Enzyme and pathway databases

ReactomeiREACT_278498. Downstream signal transduction.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_313804. EPHB-mediated forward signaling.

Miscellaneous databases

NextBioi376276.
PROiE9PYG6.
SOURCEiSearch...

Gene expression databases

BgeeiE9PYG6.
ExpressionAtlasiE9PYG6. baseline and differential.
GenevisibleiE9PYG6. MM.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PYG6_MOUSE
AccessioniPrimary (citable) accession number: E9PYG6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 22, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.