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E9PYG6

- E9PYG6_MOUSE

UniProt

E9PYG6 - E9PYG6_MOUSE

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Protein
Submitted name:

Protein Rasa1

Gene
Rasa1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI
  2. Ras GTPase activator activity Source: RefGenome

GO - Biological processi

  1. negative regulation of cell-matrix adhesion Source: Ensembl
  2. negative regulation of Ras protein signal transduction Source: RefGenome
  3. positive regulation of Ras GTPase activity Source: RefGenome
  4. regulation of actin filament polymerization Source: Ensembl
  5. signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Rasa1Imported
Gene namesi
Name:Rasa1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:97860. Rasa1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
  3. plasma membrane Source: MGI
  4. ruffle Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotations

Proteomic databases

MaxQBiE9PYG6.
PRIDEiE9PYG6.

Expressioni

Gene expression databases

ArrayExpressiE9PYG6.
BgeeiE9PYG6.

Interactioni

Protein-protein interaction databases

IntActiE9PYG6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliE9PYG6.
SMRiE9PYG6. Positions 137-437, 466-564, 584-704, 709-1032.

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 SH3 domain.
Contains PH domain.SAAS annotations

Keywords - Domaini

SH2 domainSAAS annotations, SH3 domainUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00600000084217.
KOiK04352.
OMAiQAQDWMK.
OrthoDBiEOG7HTHG8.
TreeFamiTF105301.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PYG6-1 [UniParc]FASTAAdd to Basket

« Hide

MMAAEAGSEE GGPATAGPGG GAATGSSAYS AACRVKLPAA LPVAAAPCPG     50
LADADLVAAL GGGAASGSGF LGTGPVAGVL GGAALTGSAA AGVAGAAAAG 100
PAGDVAFTKG TLSLPAETLG PGGGFPPLPP PPQLPPLGSG LGTVDEGDSL 150
DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT IAEERLRQAG KSGSYLIRES 200
DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV 250
SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV 300
HNELEDGWMW VTNLRTDEQG LIVEDLVEEV GREEDPHEGK IWFHGKISKQ 350
EAYNLLMTVG QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF 400
MMGGRYYNSI GDIIDHYRKE QIVEGYYLKE PVPMQDQGQV LNDTVDGKEI 450
YNTIRRKTKD AFYKNIVKKG YLLKKGKGKR WKNLYFILEG SDAQLIYFES 500
EKRATKPKGL IDLSVCSVYV VHDSLFGRPN CFQIVVQHFS EEHYIFYFAG 550
ETPEQAEDWM KGLQAFCSLR KSSPGTSNKR LRQVSSLVLH IEEAHKLPVK 600
HFTNPYCNIY LNSVQVAKTH AREGQNPVWS EEFVFDDLPP DINRFEITLS 650
NKTKKSKDPD ILFMRCQLSR LQKGHATDEW FLLSSHIPLK GIEPGSLRVR 700
ARYSMEKIMP EEEYSEFKEL ILQKELHVVY ALSHVCGQDR TLLASILLKI 750
FLHEKLESLL LCTLNDREIS MEDEATTLFR ATTLASTLME QYMKATATQF 800
VHHALKDSIL KIMESKQSCE LSPSKLEKNE DVNTNLAHLL SILSELVEKI 850
FMASEILPPT LRYIYGCLQK SVQHKWPTNN TMRTRVVSGF VFLRLICPAI 900
LNPRMFNIIS DSPSPIAART LTLVAKSVQN LANLVEFGAK EPYMEGVNPF 950
IKSNKHRMIM FLDELGNVPE LPDTTEHSRT DLSRDLAALH EICVAHSDEL 1000
RTLSNERGVQ QHVLKKLLAI TELLQQKQNQ YTKTNDIR 1038
Length:1,038
Mass (Da):115,429
Last modified:April 5, 2011 - v1
Checksum:iB6F56F0489252685
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC127316 Genomic DNA. No translation available.
AC154271 Genomic DNA. No translation available.
RefSeqiNP_663427.2. NM_145452.3.
UniGeneiMm.259653.

Genome annotation databases

EnsembliENSMUST00000109552; ENSMUSP00000105179; ENSMUSG00000021549.
GeneIDi218397.
KEGGimmu:218397.
UCSCiuc007rix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC127316 Genomic DNA. No translation available.
AC154271 Genomic DNA. No translation available.
RefSeqi NP_663427.2. NM_145452.3.
UniGenei Mm.259653.

3D structure databases

ProteinModelPortali E9PYG6.
SMRi E9PYG6. Positions 137-437, 466-564, 584-704, 709-1032.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi E9PYG6. 1 interaction.

Proteomic databases

MaxQBi E9PYG6.
PRIDEi E9PYG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000109552 ; ENSMUSP00000105179 ; ENSMUSG00000021549 .
GeneIDi 218397.
KEGGi mmu:218397.
UCSCi uc007rix.2. mouse.

Organism-specific databases

CTDi 5921.
MGIi MGI:97860. Rasa1.

Phylogenomic databases

GeneTreei ENSGT00600000084217.
KOi K04352.
OMAi QAQDWMK.
OrthoDBi EOG7HTHG8.
TreeFami TF105301.

Miscellaneous databases

NextBioi 376276.
PROi E9PYG6.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9PYG6.
Bgeei E9PYG6.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProi IPR000008. C2_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PYG6_MOUSE
AccessioniPrimary (citable) accession number: E9PYG6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi