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Protein
Submitted name:

Regulatory-associated protein of mTOR

Gene

Rptor

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 14-3-3 protein binding Source: MGI
  2. protein complex binding Source: MGI
  3. protein kinase binding Source: MGI
  4. RNA polymerase III type 1 promoter DNA binding Source: MGI
  5. RNA polymerase III type 2 promoter DNA binding Source: MGI
  6. RNA polymerase III type 3 promoter DNA binding Source: MGI
  7. TFIIIC-class transcription factor binding Source: MGI

GO - Biological processi

  1. cell growth Source: MGI
  2. cellular response to amino acid stimulus Source: MGI
  3. cellular response to nutrient levels Source: MGI
  4. positive regulation of protein serine/threonine kinase activity Source: MGI
  5. positive regulation of TOR signaling Source: MGI
  6. positive regulation of transcription from RNA polymerase III promoter Source: MGI
  7. regulation of cell size Source: MGI
  8. TOR signaling Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Names & Taxonomyi

Protein namesi
Submitted name:
Regulatory-associated protein of mTORImported
Gene namesi
Name:RptorImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1921620. Rptor.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. intracellular membrane-bounded organelle Source: MGI
  3. lysosomal membrane Source: MGI
  4. lysosome Source: MGI
  5. nucleoplasm Source: MGI
  6. TORC1 complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PXZ5.
ExpressionAtlasiE9PXZ5. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00640000091541.

Family and domain databases

InterProiIPR004083. Raptor.
IPR029347. Raptor_N.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PXZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEMLQSPL MGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR
60 70 80 90 100
MKDRMKTVSV ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE
110 120 130 140 150
TIGANLQKQY ENWQPRARYK QSLDPTVDEV KKLCTSLRRN AKEERVLFHY
160 170 180 190 200
NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY DLQTWMGSPS IFVYDCSNAG
210 220 230 240 250
LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC IQLAACEAHE
260 270 280 290 300
LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG
310 320 330 340 350
RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF
360 370 380
LLAERIMRSY NCTPVSSPRL PPTYMHAMCT AHSLPSS
Length:387
Mass (Da):44,008
Last modified:April 5, 2011 - v1
Checksum:i5820C9A329E8128F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669881 Genomic DNA. No translation available.
AL928989 Genomic DNA. No translation available.
AL929234 Genomic DNA. No translation available.
BX248132 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000147781; ENSMUSP00000124366; ENSMUSG00000025583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669881 Genomic DNA. No translation available.
AL928989 Genomic DNA. No translation available.
AL929234 Genomic DNA. No translation available.
BX248132 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000147781; ENSMUSP00000124366; ENSMUSG00000025583.

Organism-specific databases

MGIiMGI:1921620. Rptor.

Phylogenomic databases

GeneTreeiENSGT00640000091541.

Enzyme and pathway databases

ReactomeiREACT_213550. HSF1-dependent transactivation.
REACT_220701. Regulation of AMPK activity via LKB1.
REACT_241655. Release of eIF4E.
REACT_255725. mTOR signalling.
REACT_260675. S6K1-mediated signalling.

Miscellaneous databases

ChiTaRSiRptor. mouse.
NextBioi35554222.
SOURCEiSearch...

Gene expression databases

BgeeiE9PXZ5.
ExpressionAtlasiE9PXZ5. baseline and differential.

Family and domain databases

InterProiIPR004083. Raptor.
IPR029347. Raptor_N.
[Graphical view]
PANTHERiPTHR12848. PTHR12848. 1 hit.
PfamiPF14538. Raptor_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PXZ5_MOUSE
AccessioniPrimary (citable) accession number: E9PXZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.