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Protein

Sodium/nucleoside cotransporter

Gene

Slc28a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_339322. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporterUniRule annotation
Gene namesi
Name:Slc28a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3605073. Slc28a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei110 – 12819HelicalUniRule annotationAdd
BLAST
Transmembranei148 – 16720HelicalUniRule annotationAdd
BLAST
Transmembranei179 – 19517HelicalUniRule annotationAdd
BLAST
Transmembranei202 – 22221HelicalUniRule annotationAdd
BLAST
Transmembranei262 – 28322HelicalUniRule annotationAdd
BLAST
Transmembranei338 – 36023HelicalUniRule annotationAdd
BLAST
Transmembranei424 – 44623HelicalUniRule annotationAdd
BLAST
Transmembranei533 – 55624HelicalUniRule annotationAdd
BLAST
Transmembranei568 – 59225HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026820.

Family & Domainsi

Sequence similaritiesi

Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016025.
KOiK11536.
OMAiGFIQWFI.
OrthoDBiEOG7RV9FR.
TreeFamiTF314131.

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030212. CNT1/CNT2.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF12. PTHR10590:SF12. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PXX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDTPRQRE SISLTPVAHG LENMGAEFLE IMEEGQLPHR HSSLPEGGGS
60 70 80 90 100
RSKAVWKPFS RWRSLQPTVQ ARSLCREHWQ LFEWISKGLL STAYIGFLIV
110 120 130 140 150
ACLLDFPRAL ALFVITCVVL VFLAYNLLKR LLGSKLKKCV KFQGHSCLSL
160 170 180 190 200
WLKRGLALAA GLGVILWLSL DTAQRPEQLV SFAGICVFLV LLFAGSKHHR
210 220 230 240 250
AVSWRAVSWG LGLQFVLGLF VIRTEPGFVA FQWLGDQIRV FLSYTEAGSS
260 270 280 290 300
FVFGEALVKD VFAFQVLPII VFFSCVMSVL YYLGLMQWVI LKIAWLMQVT
310 320 330 340 350
MGTSATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA
360 370 380 390 400
GSLLGAYISF GIDASSLIAA SVMAAPCALA LSKLVYPEVE ESKFRSEEGV
410 420 430 440 450
KLTYGDAQNL VEAASAGAAI SVKVVANIAA NLIAFLAVLA FINAALSWLG
460 470 480 490 500
DMVDIQGLSF QLICSYVLRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA
510 520 530 540 550
YQELSQYKQR RLAGAEEWLG DKKQWISVRA EILTTYALCG FANFSSIGIM
560 570 580 590 600
LGGLTSMVPQ RRSDFSQIVL RALITGAFVS LVNACVAGIL YVPRGVEVDC
610 620 630 640
MSLLNQTVSS SSFEVYLCCR QVFQNTSLEF GQEALHNCCR FYNHTVCT
Length:648
Mass (Da):71,174
Last modified:April 5, 2011 - v1
Checksum:iC32DCEA9133147E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109220 Genomic DNA. No translation available.
RefSeqiNP_001004184.2. NM_001004184.3.
XP_006541039.1. XM_006540976.2.
XP_006541040.1. XM_006540977.2.
XP_006541041.1. XM_006540978.2.
XP_006541042.1. XM_006540979.2.
UniGeneiMm.389909.

Genome annotation databases

EnsembliENSMUST00000026820; ENSMUSP00000026820; ENSMUSG00000025726.
ENSMUST00000119083; ENSMUSP00000112421; ENSMUSG00000025726.
GeneIDi434203.
KEGGimmu:434203.
UCSCiuc009ibs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109220 Genomic DNA. No translation available.
RefSeqiNP_001004184.2. NM_001004184.3.
XP_006541039.1. XM_006540976.2.
XP_006541040.1. XM_006540977.2.
XP_006541041.1. XM_006540978.2.
XP_006541042.1. XM_006540979.2.
UniGeneiMm.389909.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026820; ENSMUSP00000026820; ENSMUSG00000025726.
ENSMUST00000119083; ENSMUSP00000112421; ENSMUSG00000025726.
GeneIDi434203.
KEGGimmu:434203.
UCSCiuc009ibs.1. mouse.

Organism-specific databases

CTDi9154.
MGIiMGI:3605073. Slc28a1.

Phylogenomic databases

GeneTreeiENSGT00390000016025.
KOiK11536.
OMAiGFIQWFI.
OrthoDBiEOG7RV9FR.
TreeFamiTF314131.

Enzyme and pathway databases

ReactomeiREACT_339322. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

NextBioi409408.
PROiE9PXX9.
SOURCEiSearch...

Family and domain databases

InterProiIPR008276. C_nuclsd_transpt.
IPR018270. C_nuclsd_transpt_met_bac.
IPR030212. CNT1/CNT2.
IPR011657. CNT_C_dom.
IPR002668. CNT_N_dom.
IPR011642. Nucleoside_recog_Gate.
[Graphical view]
PANTHERiPTHR10590. PTHR10590. 1 hit.
PTHR10590:SF12. PTHR10590:SF12. 1 hit.
PfamiPF07670. Gate. 1 hit.
PF07662. Nucleos_tra2_C. 1 hit.
PF01773. Nucleos_tra2_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00804. nupC. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PXX9_MOUSE
AccessioniPrimary (citable) accession number: E9PXX9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.