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Protein

Sodium/nucleoside cotransporter

Gene

Slc28a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/nucleoside cotransporterUniRule annotation
Gene namesi
Name:Slc28a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3605073 Slc28a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Transmembranei110 – 128HelicalUniRule annotationAdd BLAST19
Transmembranei148 – 167HelicalUniRule annotationAdd BLAST20
Transmembranei179 – 195HelicalUniRule annotationAdd BLAST17
Transmembranei202 – 222HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 283HelicalUniRule annotationAdd BLAST22
Transmembranei338 – 360HelicalUniRule annotationAdd BLAST23
Transmembranei424 – 446HelicalUniRule annotationAdd BLAST23
Transmembranei533 – 556HelicalUniRule annotationAdd BLAST24
Transmembranei568 – 592HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000025726

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026820

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 255Nucleos_tra2_NInterPro annotationAdd BLAST72
Domaini264 – 360GateInterPro annotationAdd BLAST97
Domaini367 – 590Nucleos_tra2_CInterPro annotationAdd BLAST224

Sequence similaritiesi

Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3747 Eukaryota
COG1972 LUCA
GeneTreeiENSGT00390000016025
KOiK11536
OMAiHRWIVQT
OrthoDBiEOG091G05D5
TreeFamiTF314131

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PTHR10590:SF16 PTHR10590:SF16, 1 hit
PfamiView protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit

Sequencei

Sequence statusi: Complete.

E9PXX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDTPRQRE SISLTPVAHG LENMGAEFLE IMEEGQLPHR HSSLPEGGGS
60 70 80 90 100
RSKAVWKPFS RWRSLQPTVQ ARSLCREHWQ LFEWISKGLL STAYIGFLIV
110 120 130 140 150
ACLLDFPRAL ALFVITCVVL VFLAYNLLKR LLGSKLKKCV KFQGHSCLSL
160 170 180 190 200
WLKRGLALAA GLGVILWLSL DTAQRPEQLV SFAGICVFLV LLFAGSKHHR
210 220 230 240 250
AVSWRAVSWG LGLQFVLGLF VIRTEPGFVA FQWLGDQIRV FLSYTEAGSS
260 270 280 290 300
FVFGEALVKD VFAFQVLPII VFFSCVMSVL YYLGLMQWVI LKIAWLMQVT
310 320 330 340 350
MGTSATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA
360 370 380 390 400
GSLLGAYISF GIDASSLIAA SVMAAPCALA LSKLVYPEVE ESKFRSEEGV
410 420 430 440 450
KLTYGDAQNL VEAASAGAAI SVKVVANIAA NLIAFLAVLA FINAALSWLG
460 470 480 490 500
DMVDIQGLSF QLICSYVLRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA
510 520 530 540 550
YQELSQYKQR RLAGAEEWLG DKKQWISVRA EILTTYALCG FANFSSIGIM
560 570 580 590 600
LGGLTSMVPQ RRSDFSQIVL RALITGAFVS LVNACVAGIL YVPRGVEVDC
610 620 630 640
MSLLNQTVSS SSFEVYLCCR QVFQNTSLEF GQEALHNCCR FYNHTVCT
Length:648
Mass (Da):71,174
Last modified:April 5, 2011 - v1
Checksum:iC32DCEA9133147E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109220 Genomic DNA No translation available.
RefSeqiNP_001004184.2, NM_001004184.3
XP_006541039.1, XM_006540976.3
XP_006541040.1, XM_006540977.3
XP_006541041.1, XM_006540978.3
XP_006541042.1, XM_006540979.3
UniGeneiMm.389909

Genome annotation databases

EnsembliENSMUST00000026820; ENSMUSP00000026820; ENSMUSG00000025726
ENSMUST00000119083; ENSMUSP00000112421; ENSMUSG00000025726
GeneIDi434203
KEGGimmu:434203
UCSCiuc009ibs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9PXX9_MOUSE
AccessioniPrimary (citable) accession number: E9PXX9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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