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Protein

Receptor protein-tyrosine kinase

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei538Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-190377 FGFR2b ligand binding and activation
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95523 Fgfr2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500324302122 – 724Receptor protein-tyrosine kinaseSequence analysisAdd BLAST703

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9PXV8

Expressioni

Gene expression databases

BgeeiENSMUSG00000030849
ExpressionAtlasiE9PXV8 baseline and differential

Structurei

3D structure databases

SMRiE9PXV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 158Ig-likeInterPro annotationAdd BLAST94
Domaini167 – 267Ig-likeInterPro annotationAdd BLAST101
Domaini393 – 673Protein kinaseInterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
OMAiILCRMKT

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Fragment.

E9PXV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEDAIS SGDDEDDTDS
60 70 80 90 100
SEDVVSENRS NQRAPYWTNT EKMEKRLHAV PAANTVKFRC PAGGNPTPTM
110 120 130 140 150
RWLKNGKEFK QEHRIGGYKV RNQHWSLIME SVVPSDKGNY TCLVENEYGS
160 170 180 190 200
INHTYHLDVV ERSPHRPILQ AGLPANASTV VGGDVEFVCK VYSDAQPHIQ
210 220 230 240 250
WIKHVEKNGS KYGPDGLPYL KVLKHSGINS SNAEVLALFN VTEMDAGEYI
260 270 280 290 300
CKVSNYIGQA NQSAWLTVLP KQQAPVREKE ITASPDYLEI AIYCIGVFLI
310 320 330 340 350
ACMVVTVIFC RMKTTTKKPD FSSQPAVHKL TKRIPLRRQV TVSAESSSSM
360 370 380 390 400
NSNTPLVRIT TRLSSTADTP MLAGVSEYEL PEDPKWEFPR DKLTLGKPLG
410 420 430 440 450
EGCFGQVVMA EAVGIDKDKP KEAVTVAVKM LKDDATEKDL SDLVSEMEMM
460 470 480 490 500
KMIGKHKNII NLLGACTQDG PLYVIVEYAS KGNLREYLRA RRPPGMEYSY
510 520 530 540 550
DINRVPEEQM TFKDLVSCTY QLARGMEYLA SQKCIHRDLA ARNVLVTENN
560 570 580 590 600
VMKIADFGLA RDINNIDYYK KTTNGRLPVK WMAPEALFDR VYTHQSDVWS
610 620 630 640 650
FGVLMWEIFT LGGSPYPGIP VEELFKLLKE GHRMDKPTNC TNELYMMMRD
660 670 680 690 700
CWHAVPSQRP TFKQLVEDLD RILTLTTNER NTWTSVSLSN RIHLVILTQG
710 720
EIKRLSSLLA GILGSHPASR TVFS
Length:724
Mass (Da):81,400
Last modified:April 5, 2011 - v1
Checksum:iC8928C5C3743C53F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA No translation available.
AC110885 Genomic DNA No translation available.
AC111058 Genomic DNA No translation available.
AC115697 Genomic DNA No translation available.
AC122258 Genomic DNA No translation available.
AC145294 Genomic DNA No translation available.
AC149596 Genomic DNA No translation available.
AC157606 Genomic DNA No translation available.
AC158113 Genomic DNA No translation available.
AC175034 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000118296; ENSMUSP00000112471; ENSMUSG00000030849

Similar proteinsi

Entry informationi

Entry nameiE9PXV8_MOUSE
AccessioniPrimary (citable) accession number: E9PXV8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health