ID   E9PXG5_MOUSE            Unreviewed;       233 AA.
AC   E9PXG5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Clusterin {ECO:0000313|Ensembl:ENSMUSP00000114720.2};
DE   Flags: Fragment;
GN   Name=Clu {ECO:0000313|Ensembl:ENSMUSP00000114720.2,
GN   ECO:0000313|MGI:MGI:88423};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000114720.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000114720.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114720.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000114720.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114720.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000256|ARBA:ARBA00004556}. Microsome
CC       {ECO:0000256|ARBA:ARBA00004144}. Mitochondrion membrane
CC       {ECO:0000256|ARBA:ARBA00004325}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the clusterin family.
CC       {ECO:0000256|ARBA:ARBA00010069}.
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DR   AlphaFoldDB; E9PXG5; -.
DR   SMR; E9PXG5; -.
DR   jPOST; E9PXG5; -.
DR   MaxQB; E9PXG5; -.
DR   ProteomicsDB; 320473; -.
DR   Antibodypedia; 631; 1388 antibodies from 52 providers.
DR   Ensembl; ENSMUST00000127387.8; ENSMUSP00000114720.2; ENSMUSG00000022037.16.
DR   AGR; MGI:88423; -.
DR   MGI; MGI:88423; Clu.
DR   VEuPathDB; HostDB:ENSMUSG00000022037; -.
DR   GeneTree; ENSGT00530000063668; -.
DR   OMA; QGSKYIN; -.
DR   ChiTaRS; Clu; mouse.
DR   Proteomes; UP000000589; Chromosome 14.
DR   Bgee; ENSMUSG00000022037; Expressed in iris and 298 other cell types or tissues.
DR   ExpressionAtlas; E9PXG5; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR033986; Clusterin_CS.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; CLUSTERIN; 1.
DR   PANTHER; PTHR10970:SF1; CLUSTERIN; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00030; CLb; 1.
DR   PROSITE; PS00492; CLUSTERIN_1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Proteomics identification {ECO:0007829|EPD:E9PXG5,
KW   ECO:0007829|MaxQB:E9PXG5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..233
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003243016"
FT   DOMAIN          22..226
FT                   /note="Clusterin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00030"
FT   COILED          59..93
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         233
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000114720.2"
SQ   SEQUENCE   233 AA;  26937 MW;  E3A062E85A3E3FA0 CRC64;
     MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ GVKHIKTLIE
     KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV CNETMMALWE ECKPCLKHTC
     MKFYARVCRS GSGLVGQQLE EFLNQSSPFY FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA
     RASGIIDTLF QDRFFARELH DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSH
//