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E9PXG2

- E9PXG2_MOUSE

UniProt

E9PXG2 - E9PXG2_MOUSE

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Protein
Submitted name: Disks large homolog 4
Gene
Dlg4
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Source: Ensembl
  2. dendritic spine morphogenesis Source: Ensembl
  3. establishment of protein localization Source: Ensembl
  4. negative regulation of receptor internalization Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  6. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
  7. positive regulation of synaptic transmission Source: Ensembl
  8. protein complex assembly Source: Ensembl
  9. protein localization to synapse Source: MGI
  10. receptor localization to synapse Source: Ensembl
  11. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
  12. regulation of long-term neuronal synaptic plasticity Source: MGI
  13. synaptic vesicle maturation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Disks large homolog 4Imported
Gene namesi
Name:Dlg4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1277959. Dlg4.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
  2. cell junction Source: MGI
  3. cerebellar mossy fiber Source: MGI
  4. cortical cytoskeleton Source: Ensembl
  5. cytoplasm Source: MGI
  6. dendrite Source: MGI
  7. dendrite cytoplasm Source: Ensembl
  8. endoplasmic reticulum Source: MGI
  9. excitatory synapse Source: MGI
  10. extrinsic component of cytoplasmic side of plasma membrane Source: MGI
  11. juxtaparanode region of axon Source: MGI
  12. membrane Source: MGI
  13. neuron projection terminus Source: MGI
  14. neuron spine Source: MGI
  15. neuronal postsynaptic density Source: MGI
  16. plasma membrane Source: MGI
  17. postsynaptic density Source: MGI
  18. postsynaptic membrane Source: Ensembl
  19. synapse Source: MGI
  20. synaptic vesicle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiE9PXG2.
BgeeiE9PXG2.

Structurei

3D structure databases

ProteinModelPortaliE9PXG2.

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00660000095130.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR016313. DLG1.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PXG2-1 [UniParc]FASTAAdd to Basket

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MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR    50
LRVNDSILFV NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKIIE 100
IKLIKG 106
Length:106
Mass (Da):11,487
Last modified:May 14, 2014 - v2
Checksum:i3CC3E525C15E5688
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei106 – 1061Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596185 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000133140; ENSMUSP00000126707; ENSMUSG00000020886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596185 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PXG2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000133140 ; ENSMUSP00000126707 ; ENSMUSG00000020886 .

Organism-specific databases

MGIi MGI:1277959. Dlg4.

Phylogenomic databases

GeneTreei ENSGT00660000095130.

Miscellaneous databases

ChiTaRSi DLG4. mouse.
NextBioi 35554155.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9PXG2.
Bgeei E9PXG2.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR016313. DLG1.
IPR001478. PDZ.
[Graphical view ]
PANTHERi PTHR23119. PTHR23119. 1 hit.
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PXG2_MOUSE
AccessioniPrimary (citable) accession number: E9PXG2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: May 14, 2014
Last modified: September 3, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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