Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

E9PXG2

- E9PXG2_MOUSE

UniProt

E9PXG2 - E9PXG2_MOUSE

Protein
Submitted name:

Disks large homolog 4

Gene

Dlg4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Source: Ensembl
    2. dendritic spine morphogenesis Source: Ensembl
    3. establishment of protein localization Source: Ensembl
    4. negative regulation of receptor internalization Source: Ensembl
    5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    6. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
    7. positive regulation of synaptic transmission Source: Ensembl
    8. protein complex assembly Source: Ensembl
    9. protein localization to synapse Source: MGI
    10. receptor localization to synapse Source: Ensembl
    11. regulation of long-term neuronal synaptic plasticity Source: MGI
    12. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
    13. synaptic vesicle maturation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Disks large homolog 4Imported
    Gene namesi
    Name:Dlg4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1277959. Dlg4.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
    2. cell junction Source: MGI
    3. cerebellar mossy fiber Source: MGI
    4. cortical cytoskeleton Source: Ensembl
    5. cytoplasm Source: MGI
    6. dendrite Source: MGI
    7. dendrite cytoplasm Source: Ensembl
    8. endoplasmic reticulum Source: MGI
    9. excitatory synapse Source: MGI
    10. extrinsic component of cytoplasmic side of plasma membrane Source: MGI
    11. juxtaparanode region of axon Source: MGI
    12. membrane Source: MGI
    13. neuronal postsynaptic density Source: MGI
    14. neuron projection terminus Source: MGI
    15. neuron spine Source: MGI
    16. plasma membrane Source: MGI
    17. postsynaptic density Source: MGI
    18. postsynaptic membrane Source: Ensembl
    19. synapse Source: MGI
    20. synaptic vesicle Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiE9PXG2.
    BgeeiE9PXG2.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PXG2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00660000095130.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR016313. DLG1.
    IPR001478. PDZ.
    [Graphical view]
    PANTHERiPTHR23119. PTHR23119. 1 hit.
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    E9PXG2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR    50
    LRVNDSILFV NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKIIE 100
    IKLIKG 106
    Length:106
    Mass (Da):11,487
    Last modified:May 14, 2014 - v2
    Checksum:i3CC3E525C15E5688
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei106 – 1061Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596185 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000133140; ENSMUSP00000126707; ENSMUSG00000020886.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596185 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9PXG2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000133140 ; ENSMUSP00000126707 ; ENSMUSG00000020886 .

    Organism-specific databases

    MGIi MGI:1277959. Dlg4.

    Phylogenomic databases

    GeneTreei ENSGT00660000095130.

    Miscellaneous databases

    ChiTaRSi DLG4. mouse.
    NextBioi 35554155.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9PXG2.
    Bgeei E9PXG2.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR016313. DLG1.
    IPR001478. PDZ.
    [Graphical view ]
    PANTHERi PTHR23119. PTHR23119. 1 hit.
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9PXG2_MOUSE
    AccessioniPrimary (citable) accession number: E9PXG2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 29 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3