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Protein
Submitted name:

Disks large homolog 4

Gene

Dlg4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. guanylate kinase activity Source: GO_Central
  2. kinase binding Source: MGI
  3. protein C-terminus binding Source: MGI

GO - Biological processi

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Source: GO_Central
  2. dendritic spine morphogenesis Source: Ensembl
  3. establishment of protein localization Source: MGI
  4. negative regulation of receptor internalization Source: Ensembl
  5. nucleotide phosphorylation Source: GOC
  6. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  7. positive regulation of excitatory postsynaptic membrane potential Source: Ensembl
  8. positive regulation of synaptic transmission Source: Ensembl
  9. protein complex assembly Source: MGI
  10. protein localization to synapse Source: MGI
  11. receptor localization to synapse Source: GO_Central
  12. regulation of long-term neuronal synaptic plasticity Source: MGI
  13. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
  14. signal transduction Source: GO_Central
  15. synaptic vesicle maturation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Disks large homolog 4Imported
Gene namesi
Name:Dlg4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1277959. Dlg4.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
  2. cell junction Source: MGI
  3. cerebellar mossy fiber Source: MGI
  4. cortical cytoskeleton Source: MGI
  5. cytoplasm Source: MGI
  6. dendrite Source: MGI
  7. dendrite cytoplasm Source: Ensembl
  8. endoplasmic reticulum Source: MGI
  9. excitatory synapse Source: MGI
  10. extrinsic component of cytoplasmic side of plasma membrane Source: MGI
  11. juxtaparanode region of axon Source: MGI
  12. membrane Source: MGI
  13. neuronal postsynaptic density Source: MGI
  14. neuron projection terminus Source: MGI
  15. neuron spine Source: MGI
  16. plasma membrane Source: MGI
  17. postsynaptic density Source: MGI
  18. postsynaptic membrane Source: MGI
  19. synapse Source: MGI
  20. synaptic membrane Source: MGI
  21. synaptic vesicle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PXG2.
ExpressionAtlasiE9PXG2. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118866.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR016313. DLG1.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PXG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR
60 70 80 90 100
LRVNDSILFV NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKIIE

IKLIKG
Length:106
Mass (Da):11,487
Last modified:February 4, 2015 - v4
Checksum:i3CC3E525C15E5688
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei106 – 1061Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596185 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000133140; ENSMUSP00000126707; ENSMUSG00000020886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596185 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133140; ENSMUSP00000126707; ENSMUSG00000020886.

Organism-specific databases

MGIiMGI:1277959. Dlg4.

Phylogenomic databases

GeneTreeiENSGT00760000118866.

Miscellaneous databases

ChiTaRSiDlg4. mouse.
NextBioi35554155.
SOURCEiSearch...

Gene expression databases

BgeeiE9PXG2.
ExpressionAtlasiE9PXG2. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR016313. DLG1.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PXG2_MOUSE
AccessioniPrimary (citable) accession number: E9PXG2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: February 4, 2015
Last modified: March 4, 2015
This is version 34 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.