Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

E3 ubiquitin-protein ligase NEDD4-like

Gene

Nedd4l

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-2672351. Stimuli-sensing channels.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase NEDD4-likeImported
Gene namesi
Name:Nedd4lImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1933754. Nedd4l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9PXB7.
MaxQBiE9PXB7.
PaxDbiE9PXB7.
PeptideAtlasiE9PXB7.

Expressioni

Gene expression databases

BgeeiE9PXB7.
ExpressionAtlasiE9PXB7. baseline and differential.
GenevisibleiE9PXB7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132838.

Structurei

3D structure databases

ProteinModelPortaliE9PXB7.
SMRiE9PXB7. Positions 6-154, 193-226, 387-421, 497-967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 109103C2InterPro annotationAdd
BLAST
Domaini193 – 22634WWInterPro annotationAdd
BLAST
Domaini386 – 41934WWInterPro annotationAdd
BLAST
Domaini498 – 53134WWInterPro annotationAdd
BLAST
Domaini549 – 58234WWInterPro annotationAdd
BLAST
Domaini641 – 975335HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains HECT (E6AP-type E3 ubiquitin-protein ligase) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.
KOiK13305.
OMAiFDENRLX.
OrthoDBiEOG7RFTGT.
TreeFamiTF323658.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 4 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 4 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 4 hits.
PS50020. WW_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PXB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGLGEPVY GLSEEEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY
60 70 80 90 100
VADENRELAL VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT
110 120 130 140 150
RDDFLGQVDV PLSHLPTEDP TMERPYTFKD FLLRPRSHKS RVKGFLRLKM
160 170 180 190 200
AYMPKNGGQD EENSEQRDDM EHGWEVVDSN DSASQHQEEL PPPPLPPGWE
210 220 230 240 250
EKVDNLGRTY YVNHNNRSTQ WHRPSLMDVS SESDNNIRQI NQEAAHRRFR
260 270 280 290 300
SRRHISEDLE PEASEGGGEG PEPWETISEE MNMAGDSLSL ALPPPPASPV
310 320 330 340 350
SRTSPQELSE EVSRRLQITP DSNGEQFSSL IQREPSSRLR SCSVTDTVAE
360 370 380 390 400
QAHLPPPSTP TRRARSSTVT GGEESTPSVA YVHTTPGLPS GWEERKDAKG
410 420 430 440 450
RTYYVNHNNR TTTWTRPIMQ LAEDGASGSA TNSNNHLVEP QIRRPRSLSS
460 470 480 490 500
PTVTLSAPLE GAKDSPIRRA VKDTLSNPQS PQPSPYNSPK PQHKVTQSFL
510 520 530 540 550
PPGWEMRIAP NGRPFFIDHN TKTTTWEDPR LKFPVHMRSK ASLNPNDLGP
560 570 580 590 600
LPPGWEERIH LDGRTFYIDH NSKITQWEDP RLQNPAITGP AVPYSREFKQ
610 620 630 640 650
KYDYFRKKLK KPADIPNRFE MKLHRNNIFE ESYRRIMSVK RPDVLKARLW
660 670 680 690 700
IEFESEKGLD YGGVAREWFF LLSKEMFNPY YGLFEYSATD NYTLQINPNS
710 720 730 740 750
GLCNEDHLSY FTFIGRVAGL AVFHGKLLDG FFIRPFYKMM LGKQITLNDM
760 770 780 790 800
ESVDSEYYNS LKWILENDPT ELDLMFCIDE ENFGQTYQVD LKPNGSEIMV
810 820 830 840 850
TNENKREYID LVIQWRFVNR VQKQMNAFLE GFTELLPIDL IKIFDENELE
860 870 880 890 900
LLMCGLGDVD VNDWRQHSIY KNGYCPNHPV IQWFWKAVLL MDAEKRIRLL
910 920 930 940 950
QFVTGTSRVP MNGFAELYGS NGPQLFTIEQ WGSPEKLPRA HTCFNRLDLP
960 970
PYETFEDLRE KLLMAVENAQ GFEGVD
Length:976
Mass (Da):112,220
Last modified:April 5, 2011 - v1
Checksum:i9FFA5EFBF06FED64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102288 Genomic DNA. No translation available.
AC102333 Genomic DNA. No translation available.
AC131709 Genomic DNA. No translation available.
AC161175 Genomic DNA. No translation available.
RefSeqiNP_001107858.1. NM_001114386.1.
UniGeneiMm.98668.

Genome annotation databases

EnsembliENSMUST00000163516; ENSMUSP00000132838; ENSMUSG00000024589.
GeneIDi83814.
KEGGimmu:83814.
UCSCiuc012beb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102288 Genomic DNA. No translation available.
AC102333 Genomic DNA. No translation available.
AC131709 Genomic DNA. No translation available.
AC161175 Genomic DNA. No translation available.
RefSeqiNP_001107858.1. NM_001114386.1.
UniGeneiMm.98668.

3D structure databases

ProteinModelPortaliE9PXB7.
SMRiE9PXB7. Positions 6-154, 193-226, 387-421, 497-967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132838.

Proteomic databases

EPDiE9PXB7.
MaxQBiE9PXB7.
PaxDbiE9PXB7.
PeptideAtlasiE9PXB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163516; ENSMUSP00000132838; ENSMUSG00000024589.
GeneIDi83814.
KEGGimmu:83814.
UCSCiuc012beb.1. mouse.

Organism-specific databases

CTDi23327.
MGIiMGI:1933754. Nedd4l.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.
KOiK13305.
OMAiFDENRLX.
OrthoDBiEOG7RFTGT.
TreeFamiTF323658.

Enzyme and pathway databases

ReactomeiR-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-2672351. Stimuli-sensing channels.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiNedd4l. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9PXB7.
ExpressionAtlasiE9PXB7. baseline and differential.
GenevisibleiE9PXB7. MM.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 4 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 4 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 4 hits.
PS50020. WW_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PXB7_MOUSE
AccessioniPrimary (citable) accession number: E9PXB7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.