Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E9PX67 (E9PX67_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length813 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000628 SAAS SAAS013098

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. PIRNR PIRNR000628

Contains protein kinase domain. SAAS SAAS013098

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000112623

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain SAAS SAAS008266
Repeat SAAS SAAS013098
Transmembrane
Transmembrane helix SAAS SAAS013098
   LigandATP-binding PIRNR PIRNR000628 SAAS SAAS013098
Nucleotide-binding
   Molecular functionKinase
Receptor PIRNR PIRNR000628 SAAS SAAS013098
Transferase
Tyrosine-protein kinase PIRNR PIRNR000628 SAAS SAAS013098
   PTMPhosphoprotein SAAS SAAS008266
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from genetic interaction PubMed 16778080. Source: MGI

axonogenesis

Inferred from mutant phenotype PubMed 17951031. Source: MGI

bone development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

bone mineralization

Inferred from mutant phenotype PubMed 12756187. Source: MGI

bone morphogenesis

Inferred from mutant phenotype PubMed 10518547. Source: MGI

branch elongation involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 15972105. Source: MGI

branching involved in labyrinthine layer morphogenesis

Inferred from mutant phenotype PubMed 9435295. Source: MGI

branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 12666202PubMed 17215304. Source: MGI

branching involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 11731698. Source: MGI

branching morphogenesis of a nerve

Inferred from mutant phenotype PubMed 17951031. Source: MGI

bud elongation involved in lung branching

Inferred from mutant phenotype PubMed 16989802. Source: MGI

cell fate commitment

Inferred from direct assay PubMed 15509736. Source: MGI

cell-cell signaling

Inferred from mutant phenotype PubMed 15199404. Source: MGI

coronal suture morphogenesis

Inferred from mutant phenotype PubMed 19389359. Source: MGI

digestive tract development

Inferred from mutant phenotype PubMed 15234214. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from electronic annotation. Source: InterPro

embryonic digestive tract morphogenesis

Inferred from mutant phenotype PubMed 16618415PubMed 21550054. Source: MGI

embryonic organ development

Inferred from mutant phenotype PubMed 9435295. Source: MGI

embryonic organ morphogenesis

Inferred from mutant phenotype PubMed 15843416. Source: MGI

embryonic pattern specification

Inferred from mutant phenotype PubMed 16618415. Source: MGI

endodermal digestive tract morphogenesis

Inferred from mutant phenotype PubMed 21550054. Source: MGI

epidermis morphogenesis

Inferred from mutant phenotype PubMed 14530295. Source: MGI

epithelial cell differentiation

Inferred from mutant phenotype PubMed 16618415. Source: MGI

epithelial cell proliferation

Inferred from mutant phenotype PubMed 11312155PubMed 15843416. Source: MGI

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 15972105. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 9435295. Source: MGI

fibroblast growth factor receptor signaling pathway involved in mammary gland specification

Inferred from mutant phenotype PubMed 16720875. Source: MGI

gland morphogenesis

Inferred from mutant phenotype PubMed 17202188. Source: MGI

hair follicle morphogenesis

Inferred from mutant phenotype PubMed 14530295. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 9435295. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 10934262. Source: MGI

lacrimal gland development

Inferred from mutant phenotype PubMed 10821755. Source: MGI

lateral sprouting from an epithelium

Inferred from mutant phenotype PubMed 12666202. Source: MGI

lens fiber cell development

Inferred from mutant phenotype PubMed 23136392. Source: MGI

limb bud formation

Inferred from mutant phenotype PubMed 10518547PubMed 9435295. Source: MGI

lung alveolus development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

lung development

Inferred from mutant phenotype PubMed 10518547. Source: MGI

lung lobe morphogenesis

Inferred from mutant phenotype PubMed 16989802. Source: MGI

lung-associated mesenchyme development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

mammary gland bud formation

Inferred from mutant phenotype PubMed 11782400. Source: MGI

membranous septum morphogenesis

Inferred from mutant phenotype PubMed 16687131. Source: MGI

mesenchymal cell differentiation

Inferred from genetic interaction PubMed 16442091. Source: MGI

mesenchymal cell differentiation involved in lung development

Inferred from genetic interaction PubMed 16989802. Source: MGI

mesenchymal cell proliferation involved in lung development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

midbrain development

Inferred from genetic interaction PubMed 17687036. Source: MGI

morphogenesis of embryonic epithelium

Inferred from mutant phenotype PubMed 15843416. Source: MGI

multicellular organism growth

Inferred from mutant phenotype PubMed 16989802. Source: MGI

negative regulation of cell proliferation

Inferred from genetic interaction PubMed 18455718. Source: MGI

negative regulation of mitosis

Inferred from genetic interaction PubMed 18455718. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 16989802. Source: MGI

neuromuscular junction development

Inferred from mutant phenotype PubMed 17418794. Source: MGI

odontogenesis

Inferred from mutant phenotype PubMed 17951031. Source: MGI

organ growth

Inferred from mutant phenotype PubMed 16618415. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 12666202. Source: MGI

otic vesicle formation

Inferred from mutant phenotype PubMed 9435295. Source: MGI

outflow tract septum morphogenesis

Inferred from mutant phenotype PubMed 16687131. Source: MGI

positive regulation of ERK1 and ERK2 cascade

Inferred from genetic interaction PubMed 17202188. Source: MGI

positive regulation of Wnt signaling pathway

Inferred from mutant phenotype PubMed 16989802. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 16720875. Source: MGI

positive regulation of cardiac muscle cell proliferation

Inferred from genetic interaction PubMed 15621532. Source: MGI

positive regulation of cell division

Inferred from mutant phenotype PubMed 14530295. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 14530295PubMed 15199404. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from genetic interaction PubMed 15972105. Source: MGI

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Inferred from mutant phenotype PubMed 16989802. Source: MGI

positive regulation of mesenchymal cell proliferation

Inferred from genetic interaction PubMed 16540513. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 16989802. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

Inferred from mutant phenotype PubMed 17215304. Source: MGI

prostate epithelial cord elongation

Inferred from mutant phenotype PubMed 17215304. Source: MGI

prostate gland morphogenesis

Inferred from mutant phenotype PubMed 18184727. Source: MGI

regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 17202188. Source: MGI

regulation of cell fate commitment

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of cell proliferation

Inferred from mutant phenotype PubMed 12756187. Source: MGI

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 17215304PubMed 18184727. Source: MGI

regulation of fibroblast growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of morphogenesis of a branching structure

Inferred from mutant phenotype PubMed 17202188. Source: MGI

regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 9435295. Source: MGI

regulation of smooth muscle cell differentiation

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 16618415. Source: MGI

reproductive structure development

Inferred from mutant phenotype PubMed 12666202. Source: MGI

squamous basal epithelial stem cell differentiation involved in prostate gland acinus development

Inferred from mutant phenotype PubMed 17215304. Source: MGI

synaptic vesicle transport

Inferred from mutant phenotype PubMed 17418794. Source: MGI

ureteric bud development

Inferred from genetic interaction PubMed 16442091. Source: MGI

ventricular cardiac muscle tissue morphogenesis

Inferred from mutant phenotype PubMed 16687131. Source: MGI

   Cellular_componentextracellular region

Traceable author statement PubMed 12024206. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from direct assay PubMed 15229180PubMed 15944199. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

fibroblast growth factor binding

Inferred from direct assay PubMed 9435295. Source: MGI

fibroblast growth factor-activated receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site6271Proton acceptor By similarity PIRSR PIRSR000628-1

Experimental info

Non-terminal residue11 Ensembl ENSMUSP00000112623

Sequences

Sequence LengthMass (Da)Tools
E9PX67 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 2C7AC1FFED57F518

FASTA81391,188
        10         20         30         40         50         60 
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEAY VVAPGESLEL 

        70         80         90        100        110        120 
QCMLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR DSGLYACTAA RTVDSETWYF 

       130        140        150        160        170        180 
MVNVTDAISS GDDEDDTDSS EDVVSENRSN QRAPYWTNTE KMEKRLHAVP AANTVKFRCP 

       190        200        210        220        230        240 
AGGNPTPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI 

       250        260        270        280        290        300 
NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK 

       310        320        330        340        350        360 
YGPDGLPYLK VLKHSGINSS NAEVLALFNV TEMDAGEYIC KVSNYIGQAN QSAWLTVLPK 

       370        380        390        400        410        420 
QQAPVREKEI TASPDYLEIA IYCIGVFLIA CMVVTVIFCR MKTTTKKPDF SSQPAVHKLT 

       430        440        450        460        470        480 
KRIPLRRQVT VSAESSSSMN SNTPLVRITT RLSSTADTPM LAGVSEYELP EDPKWEFPRD 

       490        500        510        520        530        540 
KLTLGKPLGE GCFGQVVMAE AVGIDKDKPK EAVTVAVKML KDDATEKDLS DLVSEMEMMK 

       550        560        570        580        590        600 
MIGKHKNIIN LLGACTQDGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT 

       610        620        630        640        650        660 
FKDLVSCTYQ LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK 

       670        680        690        700        710        720 
TTNGRLPVKW MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG 

       730        740        750        760        770        780 
HRMDKPTNCT NELYMMMRDC WHAVPSQRPT FKQLVEDLDR ILTLTTNERN TWTSVSLSNR 

       790        800        810 
IHLVILTQGE IKRLSSLLAG ILGSHPASRT VFS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC087063 Genomic DNA. No translation available.
AC099609 Genomic DNA. No translation available.
AC099627 Genomic DNA. No translation available.
AC100735 Genomic DNA. No translation available.
AC101690 Genomic DNA. No translation available.
AC101762 Genomic DNA. No translation available.
AC105062 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC119806 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC126688 Genomic DNA. No translation available.
AC138624 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC156606 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC158314 Genomic DNA. No translation available.
AC159994 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
AC238818 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalE9PX67.
SMRE9PX67. Positions 5-361, 468-796.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEE9PX67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000117858; ENSMUSP00000112623; ENSMUSG00000030849.

Organism-specific databases

MGIMGI:95523. Fgfr2.

Phylogenomic databases

GeneTreeENSGT00670000097694.

Gene expression databases

ArrayExpressE9PX67.
BgeeE9PX67.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000628. FGFR. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFGFR2. mouse.
NextBio35554116.
SOURCESearch...

Entry information

Entry nameE9PX67_MOUSE
AccessionPrimary (citable) accession number: E9PX67
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)