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Protein

Receptor protein-tyrosine kinase

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei627 – 6271Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • axonogenesis Source: MGI
  • bone development Source: MGI
  • bone mineralization Source: MGI
  • bone morphogenesis Source: MGI
  • branch elongation involved in salivary gland morphogenesis Source: MGI
  • branching involved in labyrinthine layer morphogenesis Source: MGI
  • branching involved in prostate gland morphogenesis Source: MGI
  • branching involved in salivary gland morphogenesis Source: MGI
  • branching morphogenesis of a nerve Source: MGI
  • bud elongation involved in lung branching Source: MGI
  • cell-cell signaling Source: MGI
  • cell fate commitment Source: MGI
  • coronal suture morphogenesis Source: MGI
  • digestive tract development Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic digestive tract morphogenesis Source: MGI
  • embryonic organ development Source: MGI
  • embryonic organ morphogenesis Source: MGI
  • embryonic pattern specification Source: MGI
  • endodermal digestive tract morphogenesis Source: MGI
  • epidermis morphogenesis Source: MGI
  • epithelial cell differentiation Source: MGI
  • epithelial cell proliferation Source: MGI
  • epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  • gland morphogenesis Source: MGI
  • hair follicle morphogenesis Source: MGI
  • inner ear morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • lacrimal gland development Source: MGI
  • lateral sprouting from an epithelium Source: MGI
  • lens fiber cell development Source: MGI
  • limb bud formation Source: MGI
  • lung alveolus development Source: MGI
  • lung-associated mesenchyme development Source: MGI
  • lung development Source: MGI
  • lung lobe morphogenesis Source: MGI
  • mammary gland bud formation Source: MGI
  • membranous septum morphogenesis Source: MGI
  • mesenchymal cell differentiation Source: MGI
  • mesenchymal cell differentiation involved in lung development Source: MGI
  • mesenchymal cell proliferation involved in lung development Source: MGI
  • midbrain development Source: MGI
  • morphogenesis of embryonic epithelium Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of mitotic nuclear division Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neuromuscular junction development Source: MGI
  • odontogenesis Source: MGI
  • organ growth Source: MGI
  • organ morphogenesis Source: MGI
  • otic vesicle formation Source: MGI
  • outflow tract septum morphogenesis Source: MGI
  • peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cardiac muscle cell proliferation Source: MGI
  • positive regulation of cell division Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of phospholipase activity Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of Wnt signaling pathway Source: MGI
  • post-embryonic development Source: MGI
  • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  • prostate epithelial cord elongation Source: MGI
  • prostate gland morphogenesis Source: MGI
  • protein autophosphorylation Source: MGI
  • regulation of branching involved in prostate gland morphogenesis Source: MGI
  • regulation of cell fate commitment Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of epithelial cell proliferation Source: MGI
  • regulation of ERK1 and ERK2 cascade Source: MGI
  • regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  • regulation of morphogenesis of a branching structure Source: MGI
  • regulation of multicellular organism growth Source: MGI
  • regulation of smoothened signaling pathway Source: MGI
  • regulation of smooth muscle cell differentiation Source: MGI
  • reproductive structure development Source: MGI
  • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
  • synaptic vesicle transport Source: MGI
  • ureteric bud development Source: MGI
  • ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_297015. FGFR2b ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_361588. SHC-mediated cascade:FGFR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: MGI
  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • extracellular region Source: MGI
  • integral component of plasma membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiE9PX67.

Expressioni

Gene expression databases

BgeeiE9PX67.
ExpressionAtlasiE9PX67. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112430.

Structurei

3D structure databases

ProteinModelPortaliE9PX67.
SMRiE9PX67. Positions 5-361, 468-796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PX67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEAY
60 70 80 90 100
VVAPGESLEL QCMLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR
110 120 130 140 150
DSGLYACTAA RTVDSETWYF MVNVTDAISS GDDEDDTDSS EDVVSENRSN
160 170 180 190 200
QRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPTPTMR WLKNGKEFKQ
210 220 230 240 250
EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI NHTYHLDVVE
260 270 280 290 300
RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK
310 320 330 340 350
YGPDGLPYLK VLKHSGINSS NAEVLALFNV TEMDAGEYIC KVSNYIGQAN
360 370 380 390 400
QSAWLTVLPK QQAPVREKEI TASPDYLEIA IYCIGVFLIA CMVVTVIFCR
410 420 430 440 450
MKTTTKKPDF SSQPAVHKLT KRIPLRRQVT VSAESSSSMN SNTPLVRITT
460 470 480 490 500
RLSSTADTPM LAGVSEYELP EDPKWEFPRD KLTLGKPLGE GCFGQVVMAE
510 520 530 540 550
AVGIDKDKPK EAVTVAVKML KDDATEKDLS DLVSEMEMMK MIGKHKNIIN
560 570 580 590 600
LLGACTQDGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT
610 620 630 640 650
FKDLVSCTYQ LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR
660 670 680 690 700
DINNIDYYKK TTNGRLPVKW MAPEALFDRV YTHQSDVWSF GVLMWEIFTL
710 720 730 740 750
GGSPYPGIPV EELFKLLKEG HRMDKPTNCT NELYMMMRDC WHAVPSQRPT
760 770 780 790 800
FKQLVEDLDR ILTLTTNERN TWTSVSLSNR IHLVILTQGE IKRLSSLLAG
810
ILGSHPASRT VFS
Length:813
Mass (Da):91,188
Last modified:April 5, 2011 - v1
Checksum:i2C7AC1FFED57F518
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC099609 Genomic DNA. No translation available.
AC099627 Genomic DNA. No translation available.
AC100735 Genomic DNA. No translation available.
AC101690 Genomic DNA. No translation available.
AC101762 Genomic DNA. No translation available.
AC105062 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC119806 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC126688 Genomic DNA. No translation available.
AC138624 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC156606 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC158314 Genomic DNA. No translation available.
AC159994 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
AC238818 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000117858; ENSMUSP00000112623; ENSMUSG00000030849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC099609 Genomic DNA. No translation available.
AC099627 Genomic DNA. No translation available.
AC100735 Genomic DNA. No translation available.
AC101690 Genomic DNA. No translation available.
AC101762 Genomic DNA. No translation available.
AC105062 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC119806 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC126688 Genomic DNA. No translation available.
AC138624 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC156606 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC158314 Genomic DNA. No translation available.
AC159994 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
AC238818 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PX67.
SMRiE9PX67. Positions 5-361, 468-796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112430.

Proteomic databases

PRIDEiE9PX67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117858; ENSMUSP00000112623; ENSMUSG00000030849.

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Phylogenomic databases

GeneTreeiENSGT00760000118923.

Enzyme and pathway databases

ReactomeiREACT_297015. FGFR2b ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_361588. SHC-mediated cascade:FGFR2.

Miscellaneous databases

ChiTaRSiFgfr2. mouse.
NextBioi35554116.
SOURCEiSearch...

Gene expression databases

BgeeiE9PX67.
ExpressionAtlasiE9PX67. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PX67_MOUSE
AccessioniPrimary (citable) accession number: E9PX67
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.