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E9PX58

- E9PX58_MOUSE

UniProt

E9PX58 - E9PX58_MOUSE

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Protein

Interleukin

Gene

Il21

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. cytokine receptor binding Source: MGI

GO - Biological processi

  1. immune response Source: InterPro
  2. positive regulation of interferon-gamma biosynthetic process Source: MGI
  3. positive regulation of interleukin-10 production Source: MGI
  4. positive regulation of natural killer cell cytokine production Source: MGI
  5. positive regulation of natural killer cell differentiation Source: MGI
  6. positive regulation of natural killer cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
InterleukinUniRule annotation
Gene namesi
Name:Il21Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1890474. Il21.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PX58.
ExpressionAtlasiE9PX58. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PX58.
SMRiE9PX58. Positions 23-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010494.
KOiK05434.
OMAiEQSAFSC.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PX58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERTLVCLVV IFLGTVAHKS SPQGPDRLLI RLRHLIDIVE QLKIYENDLD
60 70 80 90 100
PELLSAPQDV KGHCEHAAFA CFQKAKLKPS NPGNNKTFII DLVAQLRRRL
110 120 130 140 150
PARRGGKKQK HIAKCPSCDS YEKRTPKEFL ERLKWLLQKV CTLNAFLSLP
160
CCVRVPPVPS DS
Length:162
Mass (Da):18,364
Last modified:April 5, 2011 - v1
Checksum:iC1B64A6EE7D95074
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662823 Genomic DNA. No translation available.
RefSeqiNP_001277970.1. NM_001291041.1.
UniGeneiMm.157689.

Genome annotation databases

EnsembliENSMUST00000161015; ENSMUSP00000124668; ENSMUSG00000027718.
GeneIDi60505.
KEGGimmu:60505.
UCSCiuc008pak.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662823 Genomic DNA. No translation available.
RefSeqi NP_001277970.1. NM_001291041.1.
UniGenei Mm.157689.

3D structure databases

ProteinModelPortali E9PX58.
SMRi E9PX58. Positions 23-140.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000161015 ; ENSMUSP00000124668 ; ENSMUSG00000027718 .
GeneIDi 60505.
KEGGi mmu:60505.
UCSCi uc008pak.1. mouse.

Organism-specific databases

CTDi 59067.
MGIi MGI:1890474. Il21.

Phylogenomic databases

GeneTreei ENSGT00390000010494.
KOi K05434.
OMAi EQSAFSC.

Miscellaneous databases

NextBioi 35554109.
SOURCEi Search...

Gene expression databases

Bgeei E9PX58.
ExpressionAtlasi E9PX58. baseline and differential.

Family and domain databases

InterProi IPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view ]
PANTHERi PTHR14356. PTHR14356. 1 hit.
Pfami PF02372. IL15. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PX58_MOUSE
AccessioniPrimary (citable) accession number: E9PX58
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3