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Protein
Submitted name:

Protein Col6a3

Gene

Col6a3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-186797. Signaling by PDGF.
R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-419037. NCAM1 interactions.

Protein family/group databases

MEROPSiI02.968.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Col6a3Imported
Gene namesi
Name:Col6a3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88461. Col6a3.

Subcellular locationi

  • Secretedextracellular space SAAS annotation

GO - Cellular componenti

  • collagen trimer Source: MGI
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • extracellular space Source: MGI
  • extracellular vesicle Source: MGI
  • proteinaceous extracellular matrix Source: MGI
  • sarcolemma Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 32843259Sequence analysisPRO_5003245642Add
BLAST

Proteomic databases

MaxQBiE9PWQ3.
PeptideAtlasiE9PWQ3.

Expressioni

Gene expression databases

ExpressionAtlasiE9PWQ3. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-60655N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IGIX-ray1.20A1022-1224[»]
4IHKX-ray1.20A1022-1224[»]
ProteinModelPortaliE9PWQ3.
SMRiE9PWQ3. Positions 37-1607, 1634-1821, 2225-2250, 3225-3279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 212175VWFAInterPro annotationAdd
BLAST
Domaini241 – 414174VWFAInterPro annotationAdd
BLAST
Domaini444 – 619176VWFAInterPro annotationAdd
BLAST
Domaini638 – 811174VWFAInterPro annotationAdd
BLAST
Domaini836 – 1008173VWFAInterPro annotationAdd
BLAST
Domaini1026 – 1202177VWFAInterPro annotationAdd
BLAST
Domaini1230 – 1401172VWFAInterPro annotationAdd
BLAST
Domaini1433 – 1606174VWFAInterPro annotationAdd
BLAST
Domaini1636 – 1813178VWFAInterPro annotationAdd
BLAST
Domaini1835 – 2021187VWFAInterPro annotationAdd
BLAST
Domaini2399 – 2578180VWFAInterPro annotationAdd
BLAST
Domaini2616 – 2812197VWFAInterPro annotationAdd
BLAST
Domaini3107 – 319892Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini3228 – 327851BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119000.
InParanoidiE9PWQ3.
OMAiSWRPSFR.
TreeFamiTF337483.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.410. 12 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 11 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 12 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF53300. SSF53300. 12 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 1 hit.
PS50234. VWFA. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PWQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKHRHLPLV AVFSLLLSGI ATTHAQQHGD VKNGAAADIV FLVDSSWSAG
60 70 80 90 100
KDRFLLVQEF LSDVVESLAV GDNDFHFALV RLNGNPHTEF LLNTYHSKQE
110 120 130 140 150
VLSHIVNMSY IGGSNQTGKG LEYVIHSHLT EASGSRAADG VPQVIIVLTD
160 170 180 190 200
GQSEDGFALP SAELKSADVN VFAVGVEGAD ERALGEVASE PLSMHVFNLE
210 220 230 240 250
NVTSLHGLVG NLVSCIHSSV NPERAGDKES LKDITAQDSA DIIFLIDGSQ
260 270 280 290 300
NTGNANFDVI RDFLVNVLER LSVGNQQVQV GVVQYSEEPI TMFSLNSYPS
310 320 330 340 350
KAAVLDAVKG LSLVGGESAN IGQALDFVVE NHFTRAGGSR VEEGVPQVLV
360 370 380 390 400
LISAGPSSDE IRDSVVALKQ ASVFSFGLGA QAASRAELQH IATDDSLVFT
410 420 430 440 450
VPEFRSFGDL QEQILPYLVG VAQRHIVLQP PAIVTQVMEV NKRDIVFLVD
460 470 480 490 500
GSSSLGPSNF NAIRDFVTRV IQRLEIGQDL VQVSVAQYAD TVKPEFYLNS
510 520 530 540 550
YTNKRDAITA VRKMRALNGS ALYTGSSLDF VRNNLFTSSA GHRAAEGVPK
560 570 580 590 600
LLVLITGGKS LDEVSQPAQE LKRGSIMALA VGSKAADEDE LKEIAFDSSL
610 620 630 640 650
VFIPAEFRPA PLQNMLPSLM APLRTLTGTT EVHVNKRDII FLLDGSDNVG
660 670 680 690 700
KNNFPYVRDF VTNLVNSLDV GSDNIRVGLV QFSDTPVTEF SLDTYQTKSE
710 720 730 740 750
LLAHLRRLQL KGGSGLNAGS ALSYIHANHF TEAGGSRTRE HVPQLLLLLM
760 770 780 790 800
AGPSEDAYLQ AANALVRSGV LTFCVGTNRA DKAELEHIAF NPSLVYLMDD
810 820 830 840 850
FRSLPSLPQQ LIQPLTTYVS GGVQEVPLSQ PESKRDILFL FDGSVNVLGQ
860 870 880 890 900
FPAVRDFLYR IIEELDVKPD GTRVAIAQFS DDVRLESRFS EHQTKAEILN
910 920 930 940 950
LVKKMKLKTG KALNLGYALD YALRNIFVRS AGSRIEDNVQ QFLVLLVAGR
960 970 980 990 1000
SSDAVAGPAS SLKQRGVVPF IFQAKNANPS ELEQIVLSPA FILAAESLPK
1010 1020 1030 1040 1050
IGDLQSQIVS LLKAEQGSGP VSGEKDVVFL IDGSEGVRSG FPLLKDFVQR
1060 1070 1080 1090 1100
VVESLDVGPD RVRVALVQYS DRTRPEFYLN SHMDQQGVIS AIRRLTLLGG
1110 1120 1130 1140 1150
PTPNTGAALE FVLRNILTSS TGSRIAEGVP QLLIVLTAEP SGDDVRGPSV
1160 1170 1180 1190 1200
VLKQGGAVPI GIGIGNADIS EMQTISFIPD FAVAIPTFRE LGTIQQVISE
1210 1220 1230 1240 1250
RVIQLNREEL SSLKPILTPS TGAGVGSKKD VVFLIDGSRN AGPEFQYIRT
1260 1270 1280 1290 1300
LIERIVEYLD IGFDTTRVAV IQFSEDSKME FPLNAHFSKD EVQNAVRRLR
1310 1320 1330 1340 1350
PKGGSQVYIG NALEYVLKNI FQRPLGSRIE EGVPQFLVLI SSGKSDDEVD
1360 1370 1380 1390 1400
DSAVELKQFG VAPLTIARHT DQEELVKISL SPEYVYSVST FRELPRLEQK
1410 1420 1430 1440 1450
LLTPITTLTS QQIHQILAST RYPPSVVESD AADIVFLIDS SDAVKPDGIA
1460 1470 1480 1490 1500
HIRDFVSRIV RRLNIGPSKV RIGVVQFSND VFPEFYLKTH KSQSSVLEAI
1510 1520 1530 1540 1550
RRLRFKGGSP LNTGRALEFV ARNLFVKSAG SRIEDGVPQH LVLFLGGKSQ
1560 1570 1580 1590 1600
DDVARHAQVI SSSGIVSLGI GDRNIDRTDL QTITNDPRLV FTVREFRELP
1610 1620 1630 1640 1650
NIEERVMLSF GPSGATPQPP GVDLPSPSRP EKKKADIVFL LDGSINFRRD
1660 1670 1680 1690 1700
SFQEVLRFAS EIVDTVYEDG DSIRVGLVQY NSDPTDEFFL RDFSTKRQII
1710 1720 1730 1740 1750
DAINKVVYKG GRHANTRVGI EHLLRNHFVP EAGSRLDERV PQIAFVITGG
1760 1770 1780 1790 1800
KSVEDAQDVS LALTQKGVKV FAVGVRNIDS EEVGKIASNS ATAFRVGSVQ
1810 1820 1830 1840 1850
ELSELSETVL ETLHDAMHET LCPGVTDVSK ACNLEVILGF DGSRDQNVFV
1860 1870 1880 1890 1900
SQKGLESKVD IILNRISQIQ RISCSGNQLP TVRVSVMANT PSGPVEAFDF
1910 1920 1930 1940 1950
AEYQPELFEK FRNMRSQRPY VLTADTLKLY QNKFRQSSPD TVKVVIHFTD
1960 1970 1980 1990 2000
GADGDMADLY RASEELRQAG AQALILVGLE RVANLERLMH LEFGRGFMYD
2010 2020 2030 2040 2050
RPLRLNLLDL DYELAEQLDN IAEKACCGVP CKCSGERGDR GPIGSIGPKG
2060 2070 2080 2090 2100
ISGEDGYRGY PGDEGGPGER GPPGVNGTQG FQGCPGQRGV KGSRGFPGEK
2110 2120 2130 2140 2150
GELGEIGLDG LDGEEGDKGL PGSSGEKGSP GRRGDKGPKG DKGERGDVGI
2160 2170 2180 2190 2200
RGDPGDSGRD SQQRGPKGET GDIGPMGLPG RDGIPGSPGD PGKDGGSGRR
2210 2220 2230 2240 2250
GPAGAKGNRG GPGQPGFEGE QGTRGSQGPP GPIGPPGLIG EQGIPGPRGG
2260 2270 2280 2290 2300
GGTAGAPGER GRTGPLGRKG EPGEPGPKGS IGNRGPRGET GDDGRDGVGS
2310 2320 2330 2340 2350
EGRRGKKGER GFPGYPGPKG TPGEPGADGP PGPKGIRGRR GNSGPPGATG
2360 2370 2380 2390 2400
QKGDPGYPGP SGHKGNRGDS VDQCALIQSI RDKCPCCYGP LECPVFPTEL
2410 2420 2430 2440 2450
AFALDTSEGV TQDTFSRMRE VLLGIVGDLT IAESNCPRGA RVAVVTYNNE
2460 2470 2480 2490 2500
VTTEIRFADS KKKSALLDSI QNLQVALTSK QQSLETAMSF VARNTFKRVR
2510 2520 2530 2540 2550
SGFLMRKVAV FFSNKPTRAS PQLREAVLKL SDAGITPLFL TSQEDRQLIN
2560 2570 2580 2590 2600
ALQINNTAVG HALVLPARRD LTDFLKNVLT CHVCLDICNI DPSCGFGSWR
2610 2620 2630 2640 2650
PSFRDRRAAG SDVDIDLAFI LDSSEATTLF QFNEMKKYIG YVIRQLDLSP
2660 2670 2680 2690 2700
DPKASQHFAR VAVVQQSTYE SVDNASVPPV KVEFSLTDYG AKEKLLDFLS
2710 2720 2730 2740 2750
RRMTQLQGTM GLGNAIEYTI ENIFESAPNP RDLKIMVLML TGDMQRQQLE
2760 2770 2780 2790 2800
EAQRAILQAK CKGYFFVVLG IGRKVNIKEV YSFASEPNDV FFKFVDKSTE
2810 2820 2830 2840 2850
LNEEPLMRFG RLLPSFVSSE NAFYLPPDLR KQCDWFQGDQ PVKNGVKFGH
2860 2870 2880 2890 2900
KQINPPHTAN SSLTSKVVTT MKPVTTTKPT AIVNLPPAKP APARPAPAQP
2910 2920 2930 2940 2950
VLAKPDPAKP AQARPAPAKP ASAKLVPPQP VHVQPAPAQT ASVRPAPAKP
2960 2970 2980 2990 3000
APPQPAAAKP VPAKPAVPAQ PAPPQPAAAK PVPAKPAVPA QPAPPQPAAA
3010 3020 3030 3040 3050
KPVPAKPAVP AQPAAAQPMP AQPVLTKSAA VKPASANKPV AAKPVATNTA
3060 3070 3080 3090 3100
TATARPALAA KPAAAKPAAT RPLAAAIRPV ATKPEAPRQQ AKPAATKPAT
3110 3120 3130 3140 3150
TKPLARVSRE VQVSEVTENS ARLHWERPEP SSSFFYDLTV TSAHDQSLVL
3160 3170 3180 3190 3200
RQNLTVTDRV IGGLLAGQLY HVVVVSYLQS QVRAIYQGSF NTKKTQPPPL
3210 3220 3230 3240 3250
QAAHRASSST INLMVNTEPL FLTKTDICKL SRDAGTCVDF KLLWHYDLES
3260 3270 3280
KSCKRFWYGG CGGNENRFHS QEECEKMCSP DLLV
Length:3,284
Mass (Da):353,932
Last modified:October 3, 2012 - v2
Checksum:i0C05EA0C7105B0F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110895 Genomic DNA. No translation available.
AC158773 Genomic DNA. No translation available.
FQ976558 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000056925; ENSMUSP00000057131; ENSMUSG00000048126.
UCSCiuc011wpc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110895 Genomic DNA. No translation available.
AC158773 Genomic DNA. No translation available.
FQ976558 Genomic DNA. No translation available.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IGIX-ray1.20A1022-1224[»]
4IHKX-ray1.20A1022-1224[»]
ProteinModelPortaliE9PWQ3.
SMRiE9PWQ3. Positions 37-1607, 1634-1821, 2225-2250, 3225-3279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60655N.

Protein family/group databases

MEROPSiI02.968.

Proteomic databases

MaxQBiE9PWQ3.
PeptideAtlasiE9PWQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056925; ENSMUSP00000057131; ENSMUSG00000048126.
UCSCiuc011wpc.2. mouse.

Organism-specific databases

MGIiMGI:88461. Col6a3.

Phylogenomic databases

GeneTreeiENSGT00760000119000.
InParanoidiE9PWQ3.
OMAiSWRPSFR.
TreeFamiTF337483.

Enzyme and pathway databases

ReactomeiR-MMU-1442490. Collagen degradation.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-186797. Signaling by PDGF.
R-MMU-2022090. Assembly of collagen fibrils and other multimeric structures.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-419037. NCAM1 interactions.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

ExpressionAtlasiE9PWQ3. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.410. 12 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 3 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 11 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 12 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF53300. SSF53300. 12 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 1 hit.
PS50234. VWFA. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  4. "Crystal structure of the Collagen VI alpha3 N5 domain R1061Q."
    Mikolajek H., Becker A.K.A., Paulsson M., Wagener R., Werner J.M.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 1022-1224.
  5. "Crystal structure of the Collagen VI alpha3 N5 domain."
    Mikolajek H., Becker A.K.A., Paulsson M., Wagener R., Werner J.M.
    Submitted (DEC-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 1022-1224.

Entry informationi

Entry nameiE9PWQ3_MOUSE
AccessioniPrimary (citable) accession number: E9PWQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: October 3, 2012
Last modified: July 6, 2016
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.