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Protein

Tyrosine-protein kinase

Gene

Syk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei373ATPUniRule annotation1
Active sitei465Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi348 – 356ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:SykImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:99515. Syk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9PWE9.
PaxDbiE9PWE9.
PeptideAtlasiE9PWE9.
PRIDEiE9PWE9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021457.
ExpressionAtlasiE9PWE9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060828.

Structurei

3D structure databases

ProteinModelPortaliE9PWE9.
SMRiE9PWE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 106SH2InterPro annotationAdd BLAST93
Domaini167 – 258SH2InterPro annotationAdd BLAST92
Domaini342 – 583Protein kinaseInterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IH0T. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118799.

Family and domain databases

Gene3Di1.10.930.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR023420. Kinase_SYK/ZAP-70_inter-SH2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR012234. Tyr_kinase_non-rcpt_SYK/ZAP70.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PIRSFiPIRSF000604. TyrPK_SYK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PWE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSAVDSAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF
60 70 80 90 100
ALSVAHNRKA HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPDGLIC
110 120 130 140 150
LLKKPFNRPP GVQPKTGPFE DLKENLIREY VKQTWNLQGQ ALEQAIISQK
160 170 180 190 200
PQLEKLIATT AHEKMPWFHG NISRDESEQT VLIGSKTNGK FLIRARDNSG
210 220 230 240 250
SYALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV EHYSYKPDGL
260 270 280 290 300
LRVLTVPCQK IGAQMGHPGS PNAHPVPAPP QGSRPESTVS FNPYEPTGGP
310 320 330 340 350
WGPDRGLQRE ALPMDTEVYE SPYADPEEIR PKEVYLDRSL LTLEDNELGS
360 370 380 390 400
GNFGTVKKGY YQMKKVVKTV AVKILKNEAN DPALKDELLA EANVMQQLDN
410 420 430 440 450
PYIVRMIGIC EAESWMLVME MAELGPLNKY LQQNRHIKDK NIIELVHQVS
460 470 480 490 500
MGMKYLEESN FVHRDLAARN VLLVTQHYAK ISDFGLSKAL RADENYYKAQ
510 520 530 540 550
THGKWPVKWY APECINYYKF SSKSDVWSFG VLMWEAFSYG QKPYRGMKGS
560 570 580
EVTAMLEKGE RMGCPAGCPR EMYDLMNLCW TYE
Length:583
Mass (Da):66,066
Last modified:April 5, 2011 - v1
Checksum:i7A4EAB9B347DA5F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159192 Genomic DNA. No translation available.
AC160765 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000118756; ENSMUSP00000112914; ENSMUSG00000021457.
UCSCiuc007qmy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159192 Genomic DNA. No translation available.
AC160765 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PWE9.
SMRiE9PWE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060828.

Proteomic databases

MaxQBiE9PWE9.
PaxDbiE9PWE9.
PeptideAtlasiE9PWE9.
PRIDEiE9PWE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118756; ENSMUSP00000112914; ENSMUSG00000021457.
UCSCiuc007qmy.1. mouse.

Organism-specific databases

MGIiMGI:99515. Syk.

Phylogenomic databases

eggNOGiENOG410IH0T. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118799.

Miscellaneous databases

ChiTaRSiSyk. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021457.
ExpressionAtlasiE9PWE9. baseline and differential.

Family and domain databases

Gene3Di1.10.930.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR023420. Kinase_SYK/ZAP-70_inter-SH2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR012234. Tyr_kinase_non-rcpt_SYK/ZAP70.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 2 hits.
[Graphical view]
PIRSFiPIRSF000604. TyrPK_SYK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PWE9_MOUSE
AccessioniPrimary (citable) accession number: E9PWE9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.