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Protein
Submitted name:

Transcription factor E2-alpha

Gene

Tcf3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • B cell lineage commitment Source: MGI
  • cell development Source: MGI
  • histone H3 acetylation Source: MGI
  • histone H4 acetylation Source: MGI
  • immunoglobulin V(D)J recombination Source: MGI
  • lymphocyte differentiation Source: MGI
  • natural killer cell differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • Peyer's patch development Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of cell cycle Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein stabilization Source: MGI
  • regulation of G1/S transition of mitotic cell cycle Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to drug Source: MGI
  • response to lipopolysaccharide Source: MGI
  • T cell differentiation in thymus Source: MGI
  • transcription, DNA-templated Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor E2-alphaImported
Gene namesi
Name:Tcf3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:98510. Tcf3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear chromatin Source: MGI
  • nuclear nucleosome Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
  • RNA polymerase II transcription factor complex Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PWE4.
ExpressionAtlasiE9PWE4. baseline and differential.
GenevisibleiE9PWE4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100979.

Structurei

3D structure databases

ProteinModelPortaliE9PWE4.
SMRiE9PWE4. Positions 2-38, 536-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00510000046438.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PWE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG
60 70 80 90 100
LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG
110 120 130 140 150
GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY
160 170 180 190 200
YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA
210 220 230 240 250
YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL
260 270 280 290 300
APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT
310 320 330 340 350
SGHTPPVSGA AAESLLGTRG TTASSSGDAL GKALASIYSP DHSSNNFSPS
360 370 380 390 400
PSTPVGSPQG LPGTSQWPRA GAPSALSPNY DAGLHGLQSK MEDRLDEAIH
410 420 430 440 450
VLRSHAVGTA SDLHGLLPGH GALTTSFTGP MSLGGRHAGL VGGSHPEEGL
460 470 480 490 500
TSGASLLHNH ASLPSQPSSL PDLSQRPPDS YSGLGRAGTT AGASEIKREE
510 520 530 540 550
KEDEEIASVA DAEEDKKDLK VPRTRTSTDE VLSLEEKDLR DRERRMANNA
560 570 580 590 600
RERVRVRDIN EAFRELGRMC QLHLKSDKAQ TKLLILQQAV QVILGLEQQV
610 620 630 640
RERNLNPKAA CLKRREEEKV SGVVGDPQLA LSAAHPGLGE AHNPAGHL
Length:648
Mass (Da):67,458
Last modified:April 5, 2011 - v1
Checksum:i601A68FD940D7506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152062 Genomic DNA. No translation available.
RefSeqiNP_001157625.1. NM_001164153.1.
UniGeneiMm.3406.

Genome annotation databases

EnsembliENSMUST00000105340; ENSMUSP00000100977; ENSMUSG00000020167.
GeneIDi21423.
UCSCiuc007gdl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152062 Genomic DNA. No translation available.
RefSeqiNP_001157625.1. NM_001164153.1.
UniGeneiMm.3406.

3D structure databases

ProteinModelPortaliE9PWE4.
SMRiE9PWE4. Positions 2-38, 536-608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105340; ENSMUSP00000100977; ENSMUSG00000020167.
GeneIDi21423.
UCSCiuc007gdl.2. mouse.

Organism-specific databases

CTDi6929.
MGIiMGI:98510. Tcf3.

Phylogenomic databases

GeneTreeiENSGT00510000046438.

Miscellaneous databases

ChiTaRSiTcf3. mouse.
NextBioi300742.
SOURCEiSearch...

Gene expression databases

BgeeiE9PWE4.
ExpressionAtlasiE9PWE4. baseline and differential.
GenevisibleiE9PWE4. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PWE4_MOUSE
AccessioniPrimary (citable) accession number: E9PWE4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 22, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.