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E9PWE4 (E9PWE4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000100977

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processPeyer's patch development

Inferred from genetic interaction PubMed 17452521. Source: MGI

T cell differentiation in thymus

Inferred from mutant phenotype PubMed 18958875. Source: MGI

cell development

Inferred from genetic interaction PubMed 17452521. Source: MGI

histone H3 acetylation

Inferred from mutant phenotype PubMed 16428437. Source: MGI

histone H4 acetylation

Inferred from mutant phenotype PubMed 16428437. Source: MGI

immunoglobulin V(D)J recombination

Inferred from mutant phenotype PubMed 16428437. Source: MGI

lymphocyte differentiation

Inferred from mutant phenotype PubMed 18958875. Source: MGI

natural killer cell differentiation

Inferred from genetic interaction PubMed 17452521. Source: MGI

positive regulation of gene expression

Inferred from mutant phenotype PubMed 18958875. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16428437PubMed 8760303. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from genetic interaction PubMed 12070084. Source: MGI

protein stabilization

Inferred from direct assay PubMed 15322112. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19796622. Source: MGI

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12200424PubMed 15351717PubMed 15520228. Source: MGI

response to drug

Inferred from mutant phenotype PubMed 2160325. Source: MGI

response to lipopolysaccharide

Inferred from mutant phenotype PubMed 16428437. Source: MGI

   Cellular_componentnuclear nucleosome

Inferred from direct assay PubMed 16428437. Source: MGI

nucleus

Inferred from direct assay PubMed 12200424PubMed 14573534PubMed 15322112PubMed 19011221PubMed 19796622. Source: MGI

transcription factor complex

Inferred from direct assay PubMed 12200424PubMed 17938243PubMed 8760303. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 14757642PubMed 15509787PubMed 16140986PubMed 17430895. Source: MGI

chromatin binding

Inferred from direct assay PubMed 18550854PubMed 19011221. Source: MGI

protein heterodimerization activity

Inferred from physical interaction PubMed 11439353PubMed 15314159PubMed 15509787PubMed 17430895PubMed 18388149. Source: MGI

protein homodimerization activity

Inferred from direct assay PubMed 14757642. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 16428437PubMed 17938243PubMed 18388149. Source: MGI

sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 8001124. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E9PWE4 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 601A68FD940D7506

FASTA64867,458
        10         20         30         40         50         60 
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG LEDRPSSGSW 

        70         80         90        100        110        120 
GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG GKGSERNAYA TFGRDTSVGT 

       130        140        150        160        170        180 
LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG 

       190        200        210        220        230        240 
LPSSVYPPSS GDSYSRDAAA YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM 

       250        260        270        280        290        300 
LGDGSSPLPL APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT 

       310        320        330        340        350        360 
SGHTPPVSGA AAESLLGTRG TTASSSGDAL GKALASIYSP DHSSNNFSPS PSTPVGSPQG 

       370        380        390        400        410        420 
LPGTSQWPRA GAPSALSPNY DAGLHGLQSK MEDRLDEAIH VLRSHAVGTA SDLHGLLPGH 

       430        440        450        460        470        480 
GALTTSFTGP MSLGGRHAGL VGGSHPEEGL TSGASLLHNH ASLPSQPSSL PDLSQRPPDS 

       490        500        510        520        530        540 
YSGLGRAGTT AGASEIKREE KEDEEIASVA DAEEDKKDLK VPRTRTSTDE VLSLEEKDLR 

       550        560        570        580        590        600 
DRERRMANNA RERVRVRDIN EAFRELGRMC QLHLKSDKAQ TKLLILQQAV QVILGLEQQV 

       610        620        630        640 
RERNLNPKAA CLKRREEEKV SGVVGDPQLA LSAAHPGLGE AHNPAGHL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC152062 Genomic DNA. No translation available.
RefSeqNP_001157625.1. NM_001164153.1.
UniGeneMm.3406.

3D structure databases

ProteinModelPortalE9PWE4.
SMRE9PWE4. Positions 536-608.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105340; ENSMUSP00000100977; ENSMUSG00000020167.
GeneID21423.
KEGGmmu:21423.
UCSCuc007gdl.2. mouse.

Organism-specific databases

CTD6929.
MGIMGI:98510. Tcf3.

Phylogenomic databases

GeneTreeENSGT00510000046438.
KOK09063.

Gene expression databases

ArrayExpressE9PWE4.
BgeeE9PWE4.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTCF3. mouse.
NextBio300742.
SOURCESearch...

Entry information

Entry nameE9PWE4_MOUSE
AccessionPrimary (citable) accession number: E9PWE4
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)