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E9PWE4

- E9PWE4_MOUSE

UniProt

E9PWE4 - E9PWE4_MOUSE

Protein
Submitted name:

Transcription factor E2-alpha

Gene

Tcf3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: MGI
    4. protein heterodimerization activity Source: MGI
    5. protein homodimerization activity Source: MGI
    6. sequence-specific DNA binding Source: MGI
    7. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cell development Source: MGI
    2. histone H3 acetylation Source: MGI
    3. histone H4 acetylation Source: MGI
    4. immunoglobulin V(D)J recombination Source: MGI
    5. lymphocyte differentiation Source: MGI
    6. natural killer cell differentiation Source: MGI
    7. Peyer's patch development Source: MGI
    8. positive regulation of gene expression Source: MGI
    9. positive regulation of transcription, DNA-templated Source: MGI
    10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    11. protein stabilization Source: MGI
    12. regulation of transcription, DNA-templated Source: MGI
    13. regulation of transcription from RNA polymerase II promoter Source: MGI
    14. response to drug Source: MGI
    15. response to lipopolysaccharide Source: MGI
    16. T cell differentiation in thymus Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Transcription factor E2-alphaImported
    Gene namesi
    Name:Tcf3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:98510. Tcf3.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear nucleosome Source: MGI
    2. nucleus Source: MGI
    3. transcription factor complex Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiE9PWE4.
    BgeeiE9PWE4.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PWE4.
    SMRiE9PWE4. Positions 536-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00510000046438.
    KOiK09063.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PWE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG    50
    LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG 100
    GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY 150
    YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA 200
    YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL 250
    APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT 300
    SGHTPPVSGA AAESLLGTRG TTASSSGDAL GKALASIYSP DHSSNNFSPS 350
    PSTPVGSPQG LPGTSQWPRA GAPSALSPNY DAGLHGLQSK MEDRLDEAIH 400
    VLRSHAVGTA SDLHGLLPGH GALTTSFTGP MSLGGRHAGL VGGSHPEEGL 450
    TSGASLLHNH ASLPSQPSSL PDLSQRPPDS YSGLGRAGTT AGASEIKREE 500
    KEDEEIASVA DAEEDKKDLK VPRTRTSTDE VLSLEEKDLR DRERRMANNA 550
    RERVRVRDIN EAFRELGRMC QLHLKSDKAQ TKLLILQQAV QVILGLEQQV 600
    RERNLNPKAA CLKRREEEKV SGVVGDPQLA LSAAHPGLGE AHNPAGHL 648
    Length:648
    Mass (Da):67,458
    Last modified:April 5, 2011 - v1
    Checksum:i601A68FD940D7506
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152062 Genomic DNA. No translation available.
    RefSeqiNP_001157625.1. NM_001164153.1.
    UniGeneiMm.3406.

    Genome annotation databases

    EnsembliENSMUST00000105340; ENSMUSP00000100977; ENSMUSG00000020167.
    GeneIDi21423.
    KEGGimmu:21423.
    UCSCiuc007gdl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC152062 Genomic DNA. No translation available.
    RefSeqi NP_001157625.1. NM_001164153.1.
    UniGenei Mm.3406.

    3D structure databases

    ProteinModelPortali E9PWE4.
    SMRi E9PWE4. Positions 536-608.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105340 ; ENSMUSP00000100977 ; ENSMUSG00000020167 .
    GeneIDi 21423.
    KEGGi mmu:21423.
    UCSCi uc007gdl.2. mouse.

    Organism-specific databases

    CTDi 6929.
    MGIi MGI:98510. Tcf3.

    Phylogenomic databases

    GeneTreei ENSGT00510000046438.
    KOi K09063.

    Miscellaneous databases

    ChiTaRSi TCF3. mouse.
    NextBioi 300742.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9PWE4.
    Bgeei E9PWE4.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9PWE4_MOUSE
    AccessioniPrimary (citable) accession number: E9PWE4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3