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E9PWE2

- E9PWE2_MOUSE

UniProt

E9PWE2 - E9PWE2_MOUSE

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Protein
Submitted name:

Transcription factor E2-alpha

Gene

Tcf3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. E-box binding Source: Ensembl
  4. protein heterodimerization activity Source: MGI
  5. protein homodimerization activity Source: MGI
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  7. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  8. sequence-specific DNA binding Source: MGI
  9. sequence-specific DNA binding transcription factor activity Source: MGI
  10. transcription coactivator activity Source: Ensembl
  11. vitamin D response element binding Source: Ensembl

GO - Biological processi

  1. cell development Source: MGI
  2. histone H3 acetylation Source: MGI
  3. histone H4 acetylation Source: MGI
  4. immunoglobulin V(D)J recombination Source: MGI
  5. lymphocyte differentiation Source: MGI
  6. natural killer cell differentiation Source: MGI
  7. Peyer's patch development Source: MGI
  8. positive regulation of B cell proliferation Source: Ensembl
  9. positive regulation of cell cycle Source: Ensembl
  10. positive regulation of gene expression Source: MGI
  11. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  12. positive regulation of transcription, DNA-templated Source: MGI
  13. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  14. protein stabilization Source: MGI
  15. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  16. regulation of transcription, DNA-templated Source: MGI
  17. regulation of transcription from RNA polymerase II promoter Source: MGI
  18. response to drug Source: MGI
  19. response to lipopolysaccharide Source: MGI
  20. T cell differentiation in thymus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor E2-alphaImported
Gene namesi
Name:Tcf3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:98510. Tcf3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nuclear nucleosome Source: MGI
  3. nucleus Source: MGI
  4. transcription factor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PWE2.
ExpressionAtlasiE9PWE2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PWE2.
SMRiE9PWE2. Positions 549-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00510000046438.
KOiK09063.
OMAiAYPAPFY.
TreeFamiTF321672.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PWE2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG
60 70 80 90 100
LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG
110 120 130 140 150
GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY
160 170 180 190 200
YPSFPSNPRR RAADGGLADT QPKKVRKVPP GLPSSVYPPS SGDSYSRDAA
210 220 230 240 250
AYPSAKTPSS AYPSPFYVAD GSLHPSAELW STPSQVGFGP MLGDGSSPLP
260 270 280 290 300
LAPGSSSVGS GTFGGLQQQD RMGYQLHGSE VNGSLPAVSS FSAAPGTYSG
310 320 330 340 350
TSGHTPPVSG AAAESLLGTR GTTASSSGDA LGKALASIYS PDHSSNNFSP
360 370 380 390 400
SPSTPVGSPQ GLPGTSQWPR AGAPSALSPN YDAGLHGLQS KMEDRLDEAI
410 420 430 440 450
HVLRSHAVGT ASDLHGLLPG HGALTTSFTG PMSLGGRHAG LVGGSHPEEG
460 470 480 490 500
LTSGASLLHN HASLPSQPSS LPDLSQRPPD SYSGLGRAGT TAGASEIKRE
510 520 530 540 550
EKEDEEIASV ADAEEDKKDL KVPRTRTSPD EDEDDLLPPE QKAEREKERR
560 570 580 590 600
VANNARERLR VRDINEAFKE LGRMCQLHLS SEKPQTKLLI LHQAVAVILS
610 620 630 640 650
LEQQVRERNL NPKAACLKRR EEEKVSGVVG DPQLALSAAH PGLGEAHNPA

GHL
Length:653
Mass (Da):67,900
Last modified:April 5, 2011 - v1
Checksum:iEAC10EC77D565B36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC152062 Genomic DNA. No translation available.
RefSeqiNP_001157619.1. NM_001164147.1.
UniGeneiMm.3406.

Genome annotation databases

EnsembliENSMUST00000105342; ENSMUSP00000100979; ENSMUSG00000020167.
GeneIDi21423.
KEGGimmu:21423.
UCSCiuc007gdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC152062 Genomic DNA. No translation available.
RefSeqi NP_001157619.1. NM_001164147.1.
UniGenei Mm.3406.

3D structure databases

ProteinModelPortali E9PWE2.
SMRi E9PWE2. Positions 549-608.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105342 ; ENSMUSP00000100979 ; ENSMUSG00000020167 .
GeneIDi 21423.
KEGGi mmu:21423.
UCSCi uc007gdf.2. mouse.

Organism-specific databases

CTDi 6929.
MGIi MGI:98510. Tcf3.

Phylogenomic databases

GeneTreei ENSGT00510000046438.
KOi K09063.
OMAi AYPAPFY.
TreeFami TF321672.

Miscellaneous databases

ChiTaRSi TCF3. mouse.
NextBioi 300742.
SOURCEi Search...

Gene expression databases

Bgeei E9PWE2.
ExpressionAtlasi E9PWE2. baseline and differential.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PWE2_MOUSE
AccessioniPrimary (citable) accession number: E9PWE2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3