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Protein

Sodium channel protein

Gene

Scn9a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • behavioral response to pain Source: MGI
  • inflammatory response Source: MGI
  • membrane depolarization during action potential Source: GO_Central
  • neuronal action potential Source: GO_Central
  • post-embryonic development Source: MGI
  • response to toxic substance Source: MGI
  • sodium ion transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn9aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107636. Scn9a.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei122 – 14524HelicalUniRule annotationAdd
BLAST
Transmembranei190 – 20920HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24222HelicalUniRule annotationAdd
BLAST
Transmembranei248 – 26821HelicalUniRule annotationAdd
BLAST
Transmembranei378 – 40528HelicalUniRule annotationAdd
BLAST
Transmembranei725 – 75127HelicalUniRule annotationAdd
BLAST
Transmembranei763 – 78119HelicalUniRule annotationAdd
BLAST
Transmembranei801 – 82222HelicalUniRule annotationAdd
BLAST
Transmembranei843 – 87129HelicalUniRule annotationAdd
BLAST
Transmembranei933 – 95624HelicalUniRule annotationAdd
BLAST
Transmembranei1180 – 119819HelicalUniRule annotationAdd
BLAST
Transmembranei1219 – 123517HelicalUniRule annotationAdd
BLAST
Transmembranei1247 – 126721HelicalUniRule annotationAdd
BLAST
Transmembranei1296 – 132227HelicalUniRule annotationAdd
BLAST
Transmembranei1421 – 144424HelicalUniRule annotationAdd
BLAST
Transmembranei1503 – 152119HelicalUniRule annotationAdd
BLAST
Transmembranei1533 – 155119HelicalUniRule annotationAdd
BLAST
Transmembranei1563 – 158321HelicalUniRule annotationAdd
BLAST
Transmembranei1620 – 164829HelicalUniRule annotationAdd
BLAST
Transmembranei1724 – 174724HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiE9PW82.
ExpressionAtlasiE9PW82. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097641.

Structurei

3D structure databases

ProteinModelPortaliE9PW82.
SMRiE9PW82. Positions 1748-1900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118827.
KOiK04841.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PW82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS
60 70 80 90 100
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF
110 120 130 140 150
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD
160 170 180 190 200
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY
210 220 230 240 250
VTEFVDLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI
260 270 280 290 300
LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK
310 320 330 340 350
RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA
360 370 380 390 400
FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV
410 420 430 440 450
VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL
460 470 480 490 500
GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKLSSG EEKGDDEKLS
510 520 530 540 550
KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG SLFSARRSSR
560 570 580 590 600
TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN
610 620 630 640 650
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEGTTN
660 670 680 690 700
QMRKKRLSSS YFLSEDMLND PHLRQRAMSR ASILTNTVEE LEESRQKCPP
710 720 730 740 750
WWYRFAHTFL IWNCSPYWIK FKKFIYFIVM DPFVDLAITI CIVLNTLFMA
760 770 780 790 800
MEHHPMTDEF KNVLAVGNLV FTGIFAAEMV LKLIAMDPYE YFQVGWNIFD
810 820 830 840 850
SLIVTLSLVE LFLADVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS
860 870 880 890 900
VGALGNLTLV LAIIVFIFAV VGMQLFGKSY KECVCKINEN CKLPRWHMND
910 920 930 940 950
FFHSFLIVFR VLCGEWIETM WDCMEVAGQT MCLIVYMMVM VIGNLVVLNL
960 970 980 990 1000
FLALLLSSFS SDNLTAIEED TDANNLQIAV ARIKRGINYV KQTLREFILK
1010 1020 1030 1040 1050
SFSKKPKGSK DTKRTADPNN KRENYISNRT LAEISKDHNF LKEKDKISGF
1060 1070 1080 1090 1100
SSSLDKSFMD ENDYQSFIHN PSLTVTVPIA PGESDLENMN TEELSSDSDS
1110 1120 1130 1140 1150
DYSKERRNRS SSSECSTVDN PLPGEEEAEA EPINADEPEA CFTDGCVRRF
1160 1170 1180 1190 1200
PCCQVNIDSG KGKVWWTIRK TCYRIVEHSW FESFIVLMIL LSSGALAFED
1210 1220 1230 1240 1250
IYIEKKKTIK IILEYADKIF TYIFILEMLL KWVAYGYKTY FTNAWCWLDF
1260 1270 1280 1290 1300
LIVDVSLVTL VANTLGYSDL GPIKSLRTLR ALRPLRALSR FEGMRVVVNA
1310 1320 1330 1340 1350
LIGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFYECVNT TDGSRFSVSQ
1360 1370 1380 1390 1400
VANRSECFAL MNVSGNVRWK NLKVNFDNVG LGYLSLLQVA TFKGWMDIMY
1410 1420 1430 1440 1450
AAVDSVNVNA QPIYEYNLYM YIYFVIFIIF GSFFTLNLFI GVIIDNFNQQ
1460 1470 1480 1490 1500
KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPGNK FQGCIFDLVT
1510 1520 1530 1540 1550
NQAFDITIMV LICLNMVTMM VEKEGQTDYM SFVLYWINVV FIILFTGECV
1560 1570 1580 1590 1600
LKLISLRHYY FTVGWNIFDF VVVILSIVGM FLAEMIEKYF VSPTLFRVIR
1610 1620 1630 1640 1650
LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM
1660 1670 1680 1690 1700
SNFAYVKKEA GINDMFNFET FGNSMICLFQ ITTSAGWDGL LAPILNSAPP
1710 1720 1730 1740 1750
DCDPKKVHPG SSVEGDCGNP SVGIFYFVSY IIISFLVVVN MYIAVILENF
1760 1770 1780 1790 1800
SVATEESTEP LSEDDFEMFY EVWEKFDPDA TQFIEFCKLS DFAAALDPPL
1810 1820 1830 1840 1850
LIAKPNKVQL IAMDLPMVSG DRIHCLDILF AFTKRVLGES GEMDSLRSQM
1860 1870 1880 1890 1900
EERFMSANPS KVSYEPITTT LKRKQEDVSA TIIQRAYRRY RLRQNVKNIS
1910 1920 1930 1940 1950
SIYIKDGDRD DDLPNKEDIV FDNVNENSSP EKTDATASTI SPPSYDSVTK
1960 1970
PDQEKYETDK TEKEDKEKDE SRK
Length:1,973
Mass (Da):224,654
Last modified:April 5, 2011 - v1
Checksum:iA1E5422E899449E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqiNP_001277604.1. NM_001290675.1.
UniGeneiMm.440889.

Genome annotation databases

EnsembliENSMUST00000169900; ENSMUSP00000131711; ENSMUSG00000075316.
GeneIDi20274.
KEGGimmu:20274.
UCSCiuc012bwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqiNP_001277604.1. NM_001290675.1.
UniGeneiMm.440889.

3D structure databases

ProteinModelPortaliE9PW82.
SMRiE9PW82. Positions 1748-1900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169900; ENSMUSP00000131711; ENSMUSG00000075316.
GeneIDi20274.
KEGGimmu:20274.
UCSCiuc012bwi.1. mouse.

Organism-specific databases

CTDi6335.
MGIiMGI:107636. Scn9a.

Phylogenomic databases

GeneTreeiENSGT00760000118827.
KOiK04841.

Miscellaneous databases

ChiTaRSiScn9a. mouse.
NextBioi35553976.
SOURCEiSearch...

Gene expression databases

BgeeiE9PW82.
ExpressionAtlasiE9PW82. baseline and differential.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PW82_MOUSE
AccessioniPrimary (citable) accession number: E9PW82
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.