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E9PVX6

- E9PVX6_MOUSE

UniProt

E9PVX6 - E9PVX6_MOUSE

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Protein
Submitted name:

Protein Mki67

Gene

Mki67

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. cell proliferation Source: MGI
  2. cellular response to heat Source: Ensembl
  3. DNA metabolic process Source: Ensembl
  4. hyaluronan metabolic process Source: Ensembl
  5. meiotic nuclear division Source: MGI
  6. organ regeneration Source: Ensembl
  7. response to organic cyclic compound Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Mki67Imported
Gene namesi
Name:Mki67Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:106035. Mki67.

Subcellular locationi

GO - Cellular componenti

  1. chromosome, centromeric region Source: MGI
  2. condensed chromosome Source: MGI
  3. cytoplasm Source: MGI
  4. membrane Source: Ensembl
  5. nucleolus Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9PVX6.
PRIDEiE9PVX6.

PTM databases

PhosphoSiteiE9PVX6.

Expressioni

Gene expression databases

BgeeiE9PVX6.
ExpressionAtlasiE9PVX6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PVX6.
SMRiE9PVX6. Positions 7-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000064425.
InParanoidiE9PVX6.
KOiK17582.
OMAiPGKALQT.
OrthoDBiEOG76QFGJ.
TreeFamiTF336000.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR012568. K167R.
IPR029334. PP1-bd.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF08065. K167R. 16 hits.
PF15276. PP1_bind. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PVX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSAHLVTI KRSGDDGAHF PLSLSSCLFG RSIECDIRIQ LPVVSKRHCK
60 70 80 90 100
IEVKEQEAIL YNFSSTNPTQ VNGVTIDEPV RLRHGDIITI IDRSFRYEDG
110 120 130 140 150
NHEDGSKPTE FPGKSLGKEP SRRASRDSFC ADPDGEGQDT KASKMTASRR
160 170 180 190 200
SFVYAKGLSA DSPASDGSKN SVSQDSSGHV EQHTGRNIVE PTSGDLFKKS
210 220 230 240 250
RSTGSSYREP KSSPTQSLSN SNEKESPFEK LYQSMKEELD VKSQKSCRKS
260 270 280 290 300
EPQPDRAAEE SRETQLLVSG RARAKSSGST PVTAASSPKV GKIWTERWRG
310 320 330 340 350
GMVPVQTSTE TAKMKTPVRH SQQLKDEDSR VTGRRHSVNL DEGESAQAVH
360 370 380 390 400
KTVTPGKLAT RNQAAVEAGD VASPADTPEH SSSKKRSIPA KVEAPSAETQ
410 420 430 440 450
KRLSLTQRLV PGEKKTPKGS FSKPEKLATA AEQTCSGLPG LSSVDISNFG
460 470 480 490 500
DSINKSEGMP MKRRRVSFGG HLRPELFDEN LPPNTPLKRG ETPTKRKSLG
510 520 530 540 550
THSPAVLKTI IKERPQSPGK QESPGITPPR TNDQRRRSGR TSSGSKFLCE
560 570 580 590 600
TDIPKKAGRK SGNLPAKRAS ISRSQHGILQ MICSKRRSGA SEANLIVAKS
610 620 630 640 650
WADVVKLGVK QTQTKVAKHV PQKQTSKRQR RPSTPKKPTS NLHNQFTTGH
660 670 680 690 700
ANSPCTIVVG RAQIEKVSVP ARPYKMLNNL MLNRKVDFSE DLSGLTEMFK
710 720 730 740 750
TPVKEKQQQM SDTGSVLSNS ANLSERQLQV TNSGDIPEPI TTEILGEKVL
760 770 780 790 800
SSTRNAAKQQ SDRYSASPTL RRRSIKHENT VQTPKNVHNI TDLEKKTPVS
810 820 830 840 850
ETEPLKTASS VSKLRRSREL RHTLVETMNE KTEAVLAENT TARHLRGTFR
860 870 880 890 900
EQKVDQQVQD NENAPQRCKE SGELSEGSEK TSARRSSARK QKPTKDLLGS
910 920 930 940 950
QMVTQTADYA EELLSQGQGT IQNLEESMHM QNTSISEDQG ITEKKVNIIV
960 970 980 990 1000
YATKEKHSPK TPGKKAQPLE GPAGLKEHFE TPNPKDKPIT EDRTRVLCKS
1010 1020 1030 1040 1050
PQVTTENITT NTKPQTSTSG KKVDMKEESS ALTKRIHMPG ESRHNPKILK
1060 1070 1080 1090 1100
LECEDIKALK QSENEMLTST VNGSKRTLEK SKKKAQPLED LTCFQELFIS
1110 1120 1130 1140 1150
PVPTNIIKKI PSKSPHTQPV RTPASTKRLS KTGLSKVDVR QEPSTLGKRT
1160 1170 1180 1190 1200
KSPGRAPGTP APVQEENDST AFMETPKQKL DFAGNSSGSK RRSRTSKNRS
1210 1220 1230 1240 1250
QPLEDLDGFQ ELFQTPAGAS DSVTVEESAK ISLESSQAEP VKTPASTKRR
1260 1270 1280 1290 1300
SKMSLMKVDM KELSILEKQT QSRGRDAGTP APMQEGNGTT AIMETPKQKL
1310 1320 1330 1340 1350
DFTGNSTGHK RRPRTPKIRA QPLEDLDGFQ ELFQTPAGAN DSVTVEESAK
1360 1370 1380 1390 1400
MSLESSQAEP VKTPASTKRL SKTDLSKVDV REDPSILGKK TKSPGRAPGT
1410 1420 1430 1440 1450
PAPVQEENDC TAYMETPKQK LESIENLTGL RKQSRTPKDI TGFQDSFQIP
1460 1470 1480 1490 1500
DHANGPLVVV KTKKMFFNSP QPESAITRKS RERQSRASIS KIDVKEELLE
1510 1520 1530 1540 1550
SEEHLQLGEG VDTFQVSTNK VIRSSRKPAK RKLDSTAGMP NSKRMRCSSK
1560 1570 1580 1590 1600
DNTPCLEDLN GFQELFQMPG YANDSLTTGI STMLARSPQL GPVRTQINKK
1610 1620 1630 1640 1650
SLPKIILRKM DVTEEISGLW KQSLGRVHTT QEQEDNAIKA IMEIPKETLQ
1660 1670 1680 1690 1700
TAADGTRLTR QPQTPKEKVQ PLEDHSVFQE LFQTSRYCSD PLIGNKQTRM
1710 1720 1730 1740 1750
SLRSPQPGFV RTPRTSKRLA KTSVGNIAVR EKISPVSLPQ CATGEVVHIP
1760 1770 1780 1790 1800
IGPEDDTENK GVKESTPQTL DSSASRTVSK RQQGAHEERP QFSGDLFHPQ
1810 1820 1830 1840 1850
ELFQTPASGK DPVTVDETTK IALQSPQPGH IINPASMKRQ SNMSLRKDMR
1860 1870 1880 1890 1900
EFSILEKQTQ SRGRDAGTPA PMQEENGTTA IMETPKQKLD FIGNSTGHKR
1910 1920 1930 1940 1950
RPRTPKNRAQ PLEDLDGFQE LFQTPAGASD PVSVEESAKI SLASSQAEPV
1960 1970 1980 1990 2000
RTPASTKRRS KTGLSKVDVR QEPSTLGKRM KSLGRAPGTP APVQEENDST
2010 2020 2030 2040 2050
AFMETPKQKL DFTGNSSGHK RRPQTPKIRA QPLEDLDGFQ ELFQTPAGAN
2060 2070 2080 2090 2100
DSVTVEESVK MSLESSQAEP VKTPASTKRL SKTGLSKVDV REDPSILEKK
2110 2120 2130 2140 2150
TKSPGTPAPV QEENDCTAFM ETPKQKLDFT GNSSGHKRRP RTPKIRAQPL
2160 2170 2180 2190 2200
EDLDGFQELF QTPAGASDSV TVEESAKMSL ESSQAKPVKT PASTKRLSKT
2210 2220 2230 2240 2250
GLSKVDVRED PSTLGKKTKS PGRAPGTPAP VQEENDSTAF METPKQKLDF
2260 2270 2280 2290 2300
AENSSGSKRR SRTSKNRSQP LEDLDGFQEL FQTPAGASNP VSVEESAKIS
2310 2320 2330 2340 2350
LESSQAEPVR TRASTKRLSK TGLNKMDVRE GHSPLSKSSC ASQKVMQTLT
2360 2370 2380 2390 2400
LGEDHGRETK DGKVLLAQKL EPAIYVTRGK RQQRSCKKRS QSPEDLSGVQ
2410 2420 2430 2440 2450
EVFQTSGHNK DSVTVDNLAK LPSSSPPLEP TDTSVTSRRQ ARTGLRKVHV
2460 2470 2480 2490 2500
KNELSGGIMH PQISGEIVDL PREPEGEGKV IKTRKQSVKR KLDTEVNVPR
2510 2520 2530 2540 2550
SKRQRITRAE KTLEDLPGFQ ELCQAPSLVM DSVIVEKTPK MPDKSPEPVD
2560 2570 2580 2590 2600
TTSETQARRR LRRLVVTEEP IPQRKTTRVV RQTRNTQKEP ISDNQGMEEF
2610 2620 2630 2640 2650
KESSVQKQDP SVSLTGRRNQ PRTVKEKTQP LEELTSFQEE TAKRISSKSP
2660 2670 2680 2690 2700
QPEEKETLAG LKRQLRIQLI NDGVKEEPTA QRKQPSRETR NTLKEPVGDS
2710 2720 2730 2740 2750
INVEEVKKST KQKIDPVASV PVSKRPRRVP KEKAQALELA GLKGPIQTLG
2760 2770 2780 2790 2800
HTDESASDKG PTQMPCNSLQ PEQVDSFQSS PRRPRTRRGK VEADEEPSAV
2810 2820 2830 2840 2850
RKTVSTSRQT MRSRKVPEIG NNGTQVSKAS IKQTLDTVAK VTGSRRQLRT
2860 2870 2880 2890 2900
HKDGVQPLEV LGDSKEITQI SDHSEKLAHD TSILKSTQQQ KPDSVKPLRT
2910 2920 2930 2940 2950
CRRVLRASKE DPKEVLVDTR DHATLQSKSN PLLSPKRKSA RDGSIVRTRA
2960 2970 2980 2990 3000
LRSLAPKQEA TDEKPVPEKK RAASSKRHVS PEPVKMKHLK IVSNKLESVE
3010 3020 3030 3040 3050
EQVSTVMKTE EMEAKRENPV TPDQNSRYRK KTNVKQPRPK FDASAENVGI
3060 3070 3080 3090 3100
KKNEKTMKTA SQETELQNPD DGAKKSTSRG QVSGKRTCLR SRGTTEMPQP
3110 3120 3130 3140 3150
CEAEEKTSKP AAEILIKPQE EKGVSGESDV RCLRSRKTRV ALDSEPKPRV
3160 3170
TRGTKKDAKT LKEDEDIVCT KKLRTRS
Length:3,177
Mass (Da):350,864
Last modified:April 5, 2011 - v1
Checksum:i969A3BE300D755B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123047 Genomic DNA. No translation available.
RefSeqiNP_001074586.2. NM_001081117.2.
UniGeneiMm.4078.

Genome annotation databases

EnsembliENSMUST00000033310; ENSMUSP00000033310; ENSMUSG00000031004.
GeneIDi17345.
KEGGimmu:17345.
UCSCiuc009kem.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123047 Genomic DNA. No translation available.
RefSeqi NP_001074586.2. NM_001081117.2.
UniGenei Mm.4078.

3D structure databases

ProteinModelPortali E9PVX6.
SMRi E9PVX6. Positions 7-99.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei E9PVX6.

Proteomic databases

MaxQBi E9PVX6.
PRIDEi E9PVX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033310 ; ENSMUSP00000033310 ; ENSMUSG00000031004 .
GeneIDi 17345.
KEGGi mmu:17345.
UCSCi uc009kem.2. mouse.

Organism-specific databases

CTDi 4288.
MGIi MGI:106035. Mki67.

Phylogenomic databases

GeneTreei ENSGT00530000064425.
InParanoidi E9PVX6.
KOi K17582.
OMAi PGKALQT.
OrthoDBi EOG76QFGJ.
TreeFami TF336000.

Miscellaneous databases

ChiTaRSi Mki67. mouse.
NextBioi 291926.
PROi E9PVX6.
SOURCEi Search...

Gene expression databases

Bgeei E9PVX6.
ExpressionAtlasi E9PVX6. baseline and differential.

Family and domain databases

Gene3Di 2.60.200.20. 1 hit.
InterProi IPR000253. FHA_dom.
IPR012568. K167R.
IPR029334. PP1-bd.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
Pfami PF00498. FHA. 1 hit.
PF08065. K167R. 16 hits.
PF15276. PP1_bind. 1 hit.
[Graphical view ]
SMARTi SM00240. FHA. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
PROSITEi PS50006. FHA_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PVX6_MOUSE
AccessioniPrimary (citable) accession number: E9PVX6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3