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E9PVX6

- E9PVX6_MOUSE

UniProt

E9PVX6 - E9PVX6_MOUSE

Protein
Submitted name:

Protein Mki67

Gene

Mki67

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell proliferation Source: MGI
    2. cellular response to heat Source: Ensembl
    3. DNA metabolic process Source: Ensembl
    4. hyaluronan metabolic process Source: Ensembl
    5. meiotic nuclear division Source: MGI
    6. organ regeneration Source: Ensembl
    7. response to organic cyclic compound Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Mki67Imported
    Gene namesi
    Name:Mki67Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:106035. Mki67.

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome, centromeric region Source: MGI
    2. condensed chromosome Source: MGI
    3. cytoplasm Source: MGI
    4. intracellular Source: MGI
    5. nucleolus Source: MGI
    6. nucleus Source: MGI

    PTM / Processingi

    Proteomic databases

    MaxQBiE9PVX6.
    PRIDEiE9PVX6.

    PTM databases

    PhosphoSiteiE9PVX6.

    Expressioni

    Gene expression databases

    ArrayExpressiE9PVX6.
    BgeeiE9PVX6.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PVX6.
    SMRiE9PVX6. Positions 7-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000064425.
    KOiK17582.
    OMAiPGKALQT.
    OrthoDBiEOG76QFGJ.
    TreeFamiTF336000.

    Family and domain databases

    Gene3Di2.60.200.20. 1 hit.
    InterProiIPR000253. FHA_dom.
    IPR012568. K167R.
    IPR029334. PP1-bd.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PfamiPF00498. FHA. 1 hit.
    PF08065. K167R. 16 hits.
    PF15276. PP1_bind. 1 hit.
    [Graphical view]
    SMARTiSM00240. FHA. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    PROSITEiPS50006. FHA_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PVX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSAHLVTI KRSGDDGAHF PLSLSSCLFG RSIECDIRIQ LPVVSKRHCK     50
    IEVKEQEAIL YNFSSTNPTQ VNGVTIDEPV RLRHGDIITI IDRSFRYEDG 100
    NHEDGSKPTE FPGKSLGKEP SRRASRDSFC ADPDGEGQDT KASKMTASRR 150
    SFVYAKGLSA DSPASDGSKN SVSQDSSGHV EQHTGRNIVE PTSGDLFKKS 200
    RSTGSSYREP KSSPTQSLSN SNEKESPFEK LYQSMKEELD VKSQKSCRKS 250
    EPQPDRAAEE SRETQLLVSG RARAKSSGST PVTAASSPKV GKIWTERWRG 300
    GMVPVQTSTE TAKMKTPVRH SQQLKDEDSR VTGRRHSVNL DEGESAQAVH 350
    KTVTPGKLAT RNQAAVEAGD VASPADTPEH SSSKKRSIPA KVEAPSAETQ 400
    KRLSLTQRLV PGEKKTPKGS FSKPEKLATA AEQTCSGLPG LSSVDISNFG 450
    DSINKSEGMP MKRRRVSFGG HLRPELFDEN LPPNTPLKRG ETPTKRKSLG 500
    THSPAVLKTI IKERPQSPGK QESPGITPPR TNDQRRRSGR TSSGSKFLCE 550
    TDIPKKAGRK SGNLPAKRAS ISRSQHGILQ MICSKRRSGA SEANLIVAKS 600
    WADVVKLGVK QTQTKVAKHV PQKQTSKRQR RPSTPKKPTS NLHNQFTTGH 650
    ANSPCTIVVG RAQIEKVSVP ARPYKMLNNL MLNRKVDFSE DLSGLTEMFK 700
    TPVKEKQQQM SDTGSVLSNS ANLSERQLQV TNSGDIPEPI TTEILGEKVL 750
    SSTRNAAKQQ SDRYSASPTL RRRSIKHENT VQTPKNVHNI TDLEKKTPVS 800
    ETEPLKTASS VSKLRRSREL RHTLVETMNE KTEAVLAENT TARHLRGTFR 850
    EQKVDQQVQD NENAPQRCKE SGELSEGSEK TSARRSSARK QKPTKDLLGS 900
    QMVTQTADYA EELLSQGQGT IQNLEESMHM QNTSISEDQG ITEKKVNIIV 950
    YATKEKHSPK TPGKKAQPLE GPAGLKEHFE TPNPKDKPIT EDRTRVLCKS 1000
    PQVTTENITT NTKPQTSTSG KKVDMKEESS ALTKRIHMPG ESRHNPKILK 1050
    LECEDIKALK QSENEMLTST VNGSKRTLEK SKKKAQPLED LTCFQELFIS 1100
    PVPTNIIKKI PSKSPHTQPV RTPASTKRLS KTGLSKVDVR QEPSTLGKRT 1150
    KSPGRAPGTP APVQEENDST AFMETPKQKL DFAGNSSGSK RRSRTSKNRS 1200
    QPLEDLDGFQ ELFQTPAGAS DSVTVEESAK ISLESSQAEP VKTPASTKRR 1250
    SKMSLMKVDM KELSILEKQT QSRGRDAGTP APMQEGNGTT AIMETPKQKL 1300
    DFTGNSTGHK RRPRTPKIRA QPLEDLDGFQ ELFQTPAGAN DSVTVEESAK 1350
    MSLESSQAEP VKTPASTKRL SKTDLSKVDV REDPSILGKK TKSPGRAPGT 1400
    PAPVQEENDC TAYMETPKQK LESIENLTGL RKQSRTPKDI TGFQDSFQIP 1450
    DHANGPLVVV KTKKMFFNSP QPESAITRKS RERQSRASIS KIDVKEELLE 1500
    SEEHLQLGEG VDTFQVSTNK VIRSSRKPAK RKLDSTAGMP NSKRMRCSSK 1550
    DNTPCLEDLN GFQELFQMPG YANDSLTTGI STMLARSPQL GPVRTQINKK 1600
    SLPKIILRKM DVTEEISGLW KQSLGRVHTT QEQEDNAIKA IMEIPKETLQ 1650
    TAADGTRLTR QPQTPKEKVQ PLEDHSVFQE LFQTSRYCSD PLIGNKQTRM 1700
    SLRSPQPGFV RTPRTSKRLA KTSVGNIAVR EKISPVSLPQ CATGEVVHIP 1750
    IGPEDDTENK GVKESTPQTL DSSASRTVSK RQQGAHEERP QFSGDLFHPQ 1800
    ELFQTPASGK DPVTVDETTK IALQSPQPGH IINPASMKRQ SNMSLRKDMR 1850
    EFSILEKQTQ SRGRDAGTPA PMQEENGTTA IMETPKQKLD FIGNSTGHKR 1900
    RPRTPKNRAQ PLEDLDGFQE LFQTPAGASD PVSVEESAKI SLASSQAEPV 1950
    RTPASTKRRS KTGLSKVDVR QEPSTLGKRM KSLGRAPGTP APVQEENDST 2000
    AFMETPKQKL DFTGNSSGHK RRPQTPKIRA QPLEDLDGFQ ELFQTPAGAN 2050
    DSVTVEESVK MSLESSQAEP VKTPASTKRL SKTGLSKVDV REDPSILEKK 2100
    TKSPGTPAPV QEENDCTAFM ETPKQKLDFT GNSSGHKRRP RTPKIRAQPL 2150
    EDLDGFQELF QTPAGASDSV TVEESAKMSL ESSQAKPVKT PASTKRLSKT 2200
    GLSKVDVRED PSTLGKKTKS PGRAPGTPAP VQEENDSTAF METPKQKLDF 2250
    AENSSGSKRR SRTSKNRSQP LEDLDGFQEL FQTPAGASNP VSVEESAKIS 2300
    LESSQAEPVR TRASTKRLSK TGLNKMDVRE GHSPLSKSSC ASQKVMQTLT 2350
    LGEDHGRETK DGKVLLAQKL EPAIYVTRGK RQQRSCKKRS QSPEDLSGVQ 2400
    EVFQTSGHNK DSVTVDNLAK LPSSSPPLEP TDTSVTSRRQ ARTGLRKVHV 2450
    KNELSGGIMH PQISGEIVDL PREPEGEGKV IKTRKQSVKR KLDTEVNVPR 2500
    SKRQRITRAE KTLEDLPGFQ ELCQAPSLVM DSVIVEKTPK MPDKSPEPVD 2550
    TTSETQARRR LRRLVVTEEP IPQRKTTRVV RQTRNTQKEP ISDNQGMEEF 2600
    KESSVQKQDP SVSLTGRRNQ PRTVKEKTQP LEELTSFQEE TAKRISSKSP 2650
    QPEEKETLAG LKRQLRIQLI NDGVKEEPTA QRKQPSRETR NTLKEPVGDS 2700
    INVEEVKKST KQKIDPVASV PVSKRPRRVP KEKAQALELA GLKGPIQTLG 2750
    HTDESASDKG PTQMPCNSLQ PEQVDSFQSS PRRPRTRRGK VEADEEPSAV 2800
    RKTVSTSRQT MRSRKVPEIG NNGTQVSKAS IKQTLDTVAK VTGSRRQLRT 2850
    HKDGVQPLEV LGDSKEITQI SDHSEKLAHD TSILKSTQQQ KPDSVKPLRT 2900
    CRRVLRASKE DPKEVLVDTR DHATLQSKSN PLLSPKRKSA RDGSIVRTRA 2950
    LRSLAPKQEA TDEKPVPEKK RAASSKRHVS PEPVKMKHLK IVSNKLESVE 3000
    EQVSTVMKTE EMEAKRENPV TPDQNSRYRK KTNVKQPRPK FDASAENVGI 3050
    KKNEKTMKTA SQETELQNPD DGAKKSTSRG QVSGKRTCLR SRGTTEMPQP 3100
    CEAEEKTSKP AAEILIKPQE EKGVSGESDV RCLRSRKTRV ALDSEPKPRV 3150
    TRGTKKDAKT LKEDEDIVCT KKLRTRS 3177
    Length:3,177
    Mass (Da):350,864
    Last modified:April 5, 2011 - v1
    Checksum:i969A3BE300D755B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123047 Genomic DNA. No translation available.
    RefSeqiNP_001074586.2. NM_001081117.2.
    UniGeneiMm.4078.

    Genome annotation databases

    EnsembliENSMUST00000033310; ENSMUSP00000033310; ENSMUSG00000031004.
    GeneIDi17345.
    KEGGimmu:17345.
    UCSCiuc009kem.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC123047 Genomic DNA. No translation available.
    RefSeqi NP_001074586.2. NM_001081117.2.
    UniGenei Mm.4078.

    3D structure databases

    ProteinModelPortali E9PVX6.
    SMRi E9PVX6. Positions 7-99.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei E9PVX6.

    Proteomic databases

    MaxQBi E9PVX6.
    PRIDEi E9PVX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033310 ; ENSMUSP00000033310 ; ENSMUSG00000031004 .
    GeneIDi 17345.
    KEGGi mmu:17345.
    UCSCi uc009kem.2. mouse.

    Organism-specific databases

    CTDi 4288.
    MGIi MGI:106035. Mki67.

    Phylogenomic databases

    GeneTreei ENSGT00530000064425.
    KOi K17582.
    OMAi PGKALQT.
    OrthoDBi EOG76QFGJ.
    TreeFami TF336000.

    Miscellaneous databases

    ChiTaRSi MKI67. mouse.
    NextBioi 291926.
    PROi E9PVX6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9PVX6.
    Bgeei E9PVX6.

    Family and domain databases

    Gene3Di 2.60.200.20. 1 hit.
    InterProi IPR000253. FHA_dom.
    IPR012568. K167R.
    IPR029334. PP1-bd.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    Pfami PF00498. FHA. 1 hit.
    PF08065. K167R. 16 hits.
    PF15276. PP1_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00240. FHA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    PROSITEi PS50006. FHA_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiE9PVX6_MOUSE
    AccessioniPrimary (citable) accession number: E9PVX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3