Transcription factor E2-alpha - Mus musculus (Mouse)

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E9PVV2 (E9PVV2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 22. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Transcription factor E2-alpha Ensembl ENSMUSP00000100980

Gene names

Name:

Tcf3 Ensembl ENSMUSP00000100980 MGI 98510

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000100980

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	649 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000100980

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Peyer's patch development Inferred from genetic interaction PubMed 17452521. Source: MGI T cell differentiation in thymus Inferred from mutant phenotype PubMed 18958875. Source: MGI cell development Inferred from genetic interaction PubMed 17452521. Source: MGI histone H3 acetylation Inferred from mutant phenotype PubMed 16428437. Source: MGI histone H4 acetylation Inferred from mutant phenotype PubMed 16428437. Source: MGI immunoglobulin V(D)J recombination Inferred from mutant phenotype PubMed 16428437. Source: MGI natural killer cell differentiation Inferred from genetic interaction PubMed 17452521. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16428437 PubMed 8760303. Source: MGI protein stabilization Inferred from direct assay PubMed 15322112. Source: MGI response to drug Inferred from mutant phenotype PubMed 2160325. Source: MGI response to lipopolysaccharide Inferred from mutant phenotype PubMed 16428437. Source: MGI
Cellular_component	nuclear nucleosome Inferred from direct assay PubMed 16428437. Source: MGI transcription factor complex Inferred from direct assay PubMed 12200424 PubMed 17938243 PubMed 8760303. Source: MGI
Molecular_function	chromatin binding Inferred from direct assay PubMed 18550854 PubMed 19011221. Source: MGI protein heterodimerization activity Inferred from sequence orthology PubMed 19323994. Source: MGI protein homodimerization activity Inferred from direct assay PubMed 14757642. Source: MGI sequence-specific DNA binding Inferred from direct assay PubMed 16428437 PubMed 17938243 PubMed 18388149. Source: MGI sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 8001124. Source: MGI
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

E9PVV2 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 423F3E6EB1579453
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FASTA

649

67,488

        10         20         30         40         50         60 
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG LEDRPSSGSW 

        70         80         90        100        110        120 
GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG GKGSERNAYA TFGRDTSVGT 

       130        140        150        160        170        180 
LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY YPSFPSNPRR RAADGGLADT QPKKVRKVPP 

       190        200        210        220        230        240 
GLPSSVYPPS SGDSYSRDAA AYPSAKTPSS AYPSPFYVAD GSLHPSAELW STPSQVGFGP 

       250        260        270        280        290        300 
MLGDGSSPLP LAPGSSSVGS GTFGGLQQQD RMGYQLHGSE VNGSLPAVSS FSAAPGTYSG 

       310        320        330        340        350        360 
TSGHTPPVSG AAAESLLGTR GTTASSSGDA LGKALASIYS PDHSSNNFSP SPSTPVGSPQ 

       370        380        390        400        410        420 
GLPGTSQWPR AGAPSALSPN YDAGLHGLSK MEDRLDEAIH VLRSHAVGTA SDLHGLLPGH 

       430        440        450        460        470        480 
GALTTSFTGP MSLGGRHAGL VGGSHPEEGL TSGASLLHNH ASLPSQPSSL PDLSQRPPDS 

       490        500        510        520        530        540 
YSGLGRAGTT AGASEIKREE KEDEEIASVA DAEEDKKDLK VPRTRTSSTD EVLSLEEKDL 

       550        560        570        580        590        600 
RDRERRMANN ARERVRVRDI NEAFRELGRM CQLHLKSDKA QTKLLILQQA VQVILGLEQQ 

       610        620        630        640 
VRERNLNPKA ACLKRREEEK VSGVVGDPQL ALSAAHPGLG EAHNPAGHL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000100980.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000100980.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC152062 Genomic DNA. No translation available.
IPI	IPI00830212.
RefSeq	NP_001157624.1. NM_001164152.1.
UniGene	Mm.3406.
3D structure databases
ProteinModelPortal	E9PVV2.
SMR	E9PVV2. Positions 545-604.
ModBase	Search...
Proteomic databases
PRIDE	E9PVV2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000105343; ENSMUSP00000100980; ENSMUSG00000020167.
GeneID	21423.
KEGG	mmu:21423.
UCSC	uc007gdm.2. mouse.
Organism-specific databases
CTD	6929.
MGI	MGI:98510. Tcf3.
Phylogenomic databases
GeneTree	ENSGT00510000046438.
KO	K09063.
Gene expression databases
ArrayExpress	E9PVV2.
Bgee	E9PVV2.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TCF3. mouse.
NextBio	300742.
SOURCE	Search...

Entry information

Entry name

E9PVV2_MOUSE

Accession

Primary (citable) accession number: E9PVV2

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 29, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information