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Protein
Submitted name:

Transcription factor E2-alpha

Gene

Tcf3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. bHLH transcription factor binding Source: MGI
  2. chromatin binding Source: MGI
  3. DNA binding Source: MGI
  4. E-box binding Source: MGI
  5. mitogen-activated protein kinase kinase kinase binding Source: MGI
  6. protein heterodimerization activity Source: MGI
  7. protein homodimerization activity Source: MGI
  8. repressing transcription factor binding Source: MGI
  9. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  10. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  11. sequence-specific DNA binding Source: MGI
  12. sequence-specific DNA binding transcription factor activity Source: MGI
  13. transcription coactivator activity Source: MGI
  14. transcription factor binding Source: MGI
  15. vitamin D response element binding Source: MGI

GO - Biological processi

  1. B cell lineage commitment Source: MGI
  2. cell development Source: MGI
  3. histone H3 acetylation Source: MGI
  4. histone H4 acetylation Source: MGI
  5. immunoglobulin V(D)J recombination Source: MGI
  6. lymphocyte differentiation Source: MGI
  7. natural killer cell differentiation Source: MGI
  8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  9. Peyer's patch development Source: MGI
  10. positive regulation of B cell proliferation Source: MGI
  11. positive regulation of cell cycle Source: MGI
  12. positive regulation of gene expression Source: MGI
  13. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  14. positive regulation of transcription, DNA-templated Source: MGI
  15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  16. protein stabilization Source: MGI
  17. regulation of G1/S transition of mitotic cell cycle Source: MGI
  18. regulation of transcription, DNA-templated Source: MGI
  19. regulation of transcription from RNA polymerase II promoter Source: MGI
  20. response to drug Source: MGI
  21. response to lipopolysaccharide Source: MGI
  22. T cell differentiation in thymus Source: MGI
  23. transcription, DNA-templated Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor E2-alphaImported
Gene namesi
Name:Tcf3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:98510. Tcf3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear chromatin Source: MGI
  3. nuclear nucleosome Source: MGI
  4. nucleus Source: MGI
  5. protein complex Source: MGI
  6. transcription factor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PVV1.
ExpressionAtlasiE9PVV1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PVV1.
SMRiE9PVV1. Positions 538-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00510000046438.
KOiK09063.
OMAiSGASEIN.
OrthoDBiEOG72G16Q.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PVV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG
60 70 80 90 100
LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG
110 120 130 140 150
GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY
160 170 180 190 200
YPSFPSNPRR RAADGGLADT QPKKVRKVPP GLPSSVYPPS SGDSYSRDAA
210 220 230 240 250
AYPSAKTPSS AYPSPFYVAD GSLHPSAELW STPSQVGFGP MLGDGSSPLP
260 270 280 290 300
LAPGSSSVGS GTFGGLQQQD RMGYQLHGSE VNGSLPAVSS FSAAPGTYSG
310 320 330 340 350
TSGHTPPVSG AAAESLLGTR GTTASSSGDA LGKALASIYS PDHSSNNFSP
360 370 380 390 400
SPSTPVGSPQ GLPGTSQWPR AGAPSALSPN YDAGLHGLQS KMEDRLDEAI
410 420 430 440 450
HVLRSHAVGT ASDLHGLLPG HGALTTSFTG PMSLGGRHAG LVGGSHPEEG
460 470 480 490 500
LTSGASLLHN HASLPSQPSS LPDLSQRPPD SYSGLGRAGT TAGASEIKRE
510 520 530 540 550
EKEDEEIASV ADAEEDKKDL KVPRTRTSST DEVLSLEEKD LRDRERRMAN
560 570 580 590 600
NARERVRVRD INEAFRELGR MCQLHLKSDK AQTKLLILQQ AVQVILGLEQ
610 620 630 640 650
QVRERNLNPK AACLKRREEE KVSGVVGDPQ LALSAAHPGL GEAHNPAGHL
Length:650
Mass (Da):67,617
Last modified:April 5, 2011 - v1
Checksum:iE81DB3BF42D48BAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152062 Genomic DNA. No translation available.
RefSeqiNP_001157622.1. NM_001164150.1.
UniGeneiMm.3406.

Genome annotation databases

EnsembliENSMUST00000105344; ENSMUSP00000100981; ENSMUSG00000020167.
GeneIDi21423.
KEGGimmu:21423.
UCSCiuc007gdj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC152062 Genomic DNA. No translation available.
RefSeqiNP_001157622.1. NM_001164150.1.
UniGeneiMm.3406.

3D structure databases

ProteinModelPortaliE9PVV1.
SMRiE9PVV1. Positions 538-610.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105344; ENSMUSP00000100981; ENSMUSG00000020167.
GeneIDi21423.
KEGGimmu:21423.
UCSCiuc007gdj.2. mouse.

Organism-specific databases

CTDi6929.
MGIiMGI:98510. Tcf3.

Phylogenomic databases

GeneTreeiENSGT00510000046438.
KOiK09063.
OMAiSGASEIN.
OrthoDBiEOG72G16Q.

Miscellaneous databases

ChiTaRSiTcf3. mouse.
NextBioi300742.
SOURCEiSearch...

Gene expression databases

BgeeiE9PVV1.
ExpressionAtlasiE9PVV1. baseline and differential.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PVV1_MOUSE
AccessioniPrimary (citable) accession number: E9PVV1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.