ID E9PVJ6_MOUSE Unreviewed; 405 AA. AC E9PVJ6; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 27-MAR-2024, entry version 95. DE SubName: Full=Protein tyrosine phosphatase, receptor type, O {ECO:0000313|Ensembl:ENSMUSP00000131764.2}; GN Name=Ptpro {ECO:0000313|Ensembl:ENSMUSP00000131764.2, GN ECO:0000313|MGI:MGI:1097152}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000131764.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0007829|PubMed:19144319} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000131764.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131764.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000131764.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131764.2}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001157874.1; NM_001164402.1. DR AlphaFoldDB; E9PVJ6; -. DR SMR; E9PVJ6; -. DR jPOST; E9PVJ6; -. DR MaxQB; E9PVJ6; -. DR PeptideAtlas; E9PVJ6; -. DR ProteomicsDB; 371521; -. DR Antibodypedia; 23718; 116 antibodies from 22 providers. DR DNASU; 19277; -. DR Ensembl; ENSMUST00000167002.4; ENSMUSP00000131764.2; ENSMUSG00000030223.15. DR GeneID; 19277; -. DR UCSC; uc009emx.2; mouse. DR AGR; MGI:1097152; -. DR CTD; 5800; -. DR MGI; MGI:1097152; Ptpro. DR VEuPathDB; HostDB:ENSMUSG00000030223; -. DR GeneTree; ENSGT00940000154814; -. DR HOGENOM; CLU_001645_9_1_1; -. DR OrthoDB; 5395787at2759; -. DR BioGRID-ORCS; 19277; 2 hits in 72 CRISPR screens. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000030223; Expressed in cortical plate and 190 other cell types or tissues. DR ExpressionAtlas; E9PVJ6; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro. DR CDD; cd14614; R-PTPc-O; 1. DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1. DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like. DR InterPro; IPR000242; PTP_cat. DR InterPro; IPR042996; PTPRO. DR InterPro; IPR016130; Tyr_Pase_AS. DR InterPro; IPR003595; Tyr_Pase_cat. DR InterPro; IPR000387; Tyr_Pase_dom. DR PANTHER; PTHR47028; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1. DR PANTHER; PTHR47028:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1. DR Pfam; PF00102; Y_phosphatase; 1. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00194; PTPc; 1. DR SMART; SM00404; PTPc_motif; 1. DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1. DR Genevisible; E9PVJ6; MM. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|MaxQB:E9PVJ6, KW ECO:0007829|ProteomicsDB:E9PVJ6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 12..33 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 69..90 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 127..384 FT /note="Tyrosine-protein phosphatase" FT /evidence="ECO:0000259|PROSITE:PS50055" FT DOMAIN 301..375 FT /note="Tyrosine specific protein phosphatases" FT /evidence="ECO:0000259|PROSITE:PS50056" SQ SEQUENCE 405 AA; 46962 MW; FDA781061EB370FF CRC64; MVTEVNPNVV VISVLAILST LLIGLLLVTL VILRKKHLQM ARECGAGTFV NFASLEREGK LPYSWRRSVF ALLTLLPSCL WTDYLLAFYI NPWSKNGLKK RKLTNPVQLD DFDSYIKDMA KDSDYKFSLQ FEELKLIGLD IPHFAADLPL NRCKNRYTNI LPYDFSRVRL VSMNEEEGAD YINANYIPGY NSPQEYIATQ GPLPETRNDF WKMVLQQKSH IIVMLTQCNE KRRVKCDHYW PFTEEPIAYG DITVEMVSEE EEEDWASRHF RINYADEAQD VMHFNYTAWP DHGVPPANAA ESILQFVFTV RQQAAKSKGP MIIHCSAGVG RTGTFIALDR LLQHIRDHEF VDILGLVSEM RSYRMSMVQT EEQYIFIHQC VQLMWLRKKQ QFCISDVIYE NVSKS //