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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase O

Gene

Ptpro

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei325Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase OImported
Gene namesi
Name:PtproImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097152. Ptpro.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 33HelicalSequence analysisAdd BLAST22
Transmembranei69 – 90HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiE9PVJ6.
PaxDbiE9PVJ6.
PeptideAtlasiE9PVJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030223.
ExpressionAtlasiE9PVJ6. baseline and differential.
GenevisibleiE9PVJ6. MM.

Structurei

3D structure databases

ProteinModelPortaliE9PVJ6.
SMRiE9PVJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 384Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini301 – 375TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0791. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140785.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEVNPNVV VISVLAILST LLIGLLLVTL VILRKKHLQM ARECGAGTFV
60 70 80 90 100
NFASLEREGK LPYSWRRSVF ALLTLLPSCL WTDYLLAFYI NPWSKNGLKK
110 120 130 140 150
RKLTNPVQLD DFDSYIKDMA KDSDYKFSLQ FEELKLIGLD IPHFAADLPL
160 170 180 190 200
NRCKNRYTNI LPYDFSRVRL VSMNEEEGAD YINANYIPGY NSPQEYIATQ
210 220 230 240 250
GPLPETRNDF WKMVLQQKSH IIVMLTQCNE KRRVKCDHYW PFTEEPIAYG
260 270 280 290 300
DITVEMVSEE EEEDWASRHF RINYADEAQD VMHFNYTAWP DHGVPPANAA
310 320 330 340 350
ESILQFVFTV RQQAAKSKGP MIIHCSAGVG RTGTFIALDR LLQHIRDHEF
360 370 380 390 400
VDILGLVSEM RSYRMSMVQT EEQYIFIHQC VQLMWLRKKQ QFCISDVIYE

NVSKS
Length:405
Mass (Da):46,962
Last modified:April 5, 2011 - v1
Checksum:iFDA781061EB370FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
RefSeqiNP_001157874.1. NM_001164402.1.
UniGeneiMm.186361.
Mm.491536.

Genome annotation databases

EnsembliENSMUST00000167002; ENSMUSP00000131764; ENSMUSG00000030223.
GeneIDi19277.
UCSCiuc009emx.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiE9PVJ6_MOUSE
AccessioniPrimary (citable) accession number: E9PVJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported