Ptpro

Functionⁱ

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	325	Phosphocysteine intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

protein tyrosine phosphatase activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphataseUniRule annotationSAAS annotation

Molecular function

Hydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesⁱ	Name:PtproImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:1097152. Ptpro.

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	12 – 33	HelicalSequence analysisAdd BLAST		22
Transmembraneⁱ	69 – 90	HelicalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E9PVJ6.
PeptideAtlas More...PeptideAtlasⁱ	E9PVJ6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030223.
ExpressionAtlasⁱ	E9PVJ6. baseline and differential.
Genevisibleⁱ	E9PVJ6. MM.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E9PVJ6.
SMRⁱ	E9PVJ6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	127 – 384	Tyrosine-protein phosphataseInterPro annotationAdd BLAST		258
Domainⁱ	301 – 375	TYR_PHOSPHATASE_2InterPro annotationAdd BLAST		75

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0791. Eukaryota. COG5599. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140785.

Family and domain databases

Gene3Dⁱ	3.90.190.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029021. Prot-tyrosine_phosphatase-like. IPR000242. PTPase_domain. IPR016130. Tyr_Pase_AS. IPR003595. Tyr_Pase_cat. IPR000387. TYR_PHOSPHATASE_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00102. Y_phosphatase. 1 hit.
PRINTSⁱ	PR00700. PRTYPHPHTASE.
SMARTⁱ	View protein in SMART SM00194. PTPc. 1 hit. SM00404. PTPc_motif. 1 hit.
SUPFAMⁱ	SSF52799. SSF52799. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

E9PVJ6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVTEVNPNVV VISVLAILST LLIGLLLVTL VILRKKHLQM ARECGAGTFV 
        60         70         80         90        100
NFASLEREGK LPYSWRRSVF ALLTLLPSCL WTDYLLAFYI NPWSKNGLKK 
       110        120        130        140        150
RKLTNPVQLD DFDSYIKDMA KDSDYKFSLQ FEELKLIGLD IPHFAADLPL 
       160        170        180        190        200
NRCKNRYTNI LPYDFSRVRL VSMNEEEGAD YINANYIPGY NSPQEYIATQ 
       210        220        230        240        250
GPLPETRNDF WKMVLQQKSH IIVMLTQCNE KRRVKCDHYW PFTEEPIAYG 
       260        270        280        290        300
DITVEMVSEE EEEDWASRHF RINYADEAQD VMHFNYTAWP DHGVPPANAA 
       310        320        330        340        350
ESILQFVFTV RQQAAKSKGP MIIHCSAGVG RTGTFIALDR LLQHIRDHEF 
       360        370        380        390        400
VDILGLVSEM RSYRMSMVQT EEQYIFIHQC VQLMWLRKKQ QFCISDVIYE 

NVSKS

Length:405

Mass (Da):46,962

Last modified:April 5, 2011 - v1

Checksum:ⁱFDA781061EB370FF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC093120 Genomic DNA. No translation available. AC144767 Genomic DNA. No translation available. AC163627 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157874.1. NM_001164402.1.
UniGeneⁱ	Mm.186361. Mm.491536.

Genome annotation databases

Ensemblⁱ	ENSMUST00000167002; ENSMUSP00000131764; ENSMUSG00000030223.
GeneIDⁱ	19277.
UCSC genome browser More...UCSCⁱ	uc009emx.2. mouse.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
E9PVJ6	E9Q612 Q80W11 Q6P4T4 Q68FL5 Q80UH9	Mus musculus (Mouse)	1,226	UniRef100_E9Q612	Cluster: Receptor-type tyrosine-protein phosphatase O	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
E9PVJ6	E9Q612 Q80W11 Q6P4T4 Q68FL5 Q80UH9 UPI00022F4418 UPI000454A0CA Q9ERM5 UPI000A316C4E UPI000A3154A9 +5	Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mus caroli (Ryukyu mouse) (Ricefield mouse) Rattus norvegicus (Rat) Microtus ochrogaster (Prairie vole)	1,226	UniRef90_E9Q612	Cluster: Receptor-type tyrosine-protein phosphatase O	16

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
E9PVJ6	E9Q612 Q80W11 Q6P4T4 Q68FL5 Q80UH9 UPI00022F4418 UPI000454A0CA UPI000A316C4E UPI000A3154A9 Q9ERM5 +175	Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mus caroli (Ryukyu mouse) (Ricefield mouse) Rattus norvegicus (Rat) Microtus ochrogaster (Prairie vole) Gallus gallus (Chicken) Lonchura striata domestica (Bengalese finch) Castor canadensis (Beaver) Poecilia reticulata (Guppy) (Acanthophacelus reticulatus) Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) And more	1,226	UniRef50_E9Q612	Cluster: Receptor-type tyrosine-protein phosphatase O	186

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC093120 Genomic DNA. No translation available. AC144767 Genomic DNA. No translation available. AC163627 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157874.1. NM_001164402.1.
UniGeneⁱ	Mm.186361. Mm.491536.

3D structure databases

ProteinModelPortalⁱ	E9PVJ6.
SMRⁱ	E9PVJ6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E9PVJ6.
PeptideAtlas More...PeptideAtlasⁱ	E9PVJ6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000167002; ENSMUSP00000131764; ENSMUSG00000030223.
GeneIDⁱ	19277.
UCSC genome browser More...UCSCⁱ	uc009emx.2. mouse.

Organism-specific databases

CTDⁱ	5800.
MGIⁱ	MGI:1097152. Ptpro.

Phylogenomic databases

eggNOGⁱ	KOG0791. Eukaryota. COG5599. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140785.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030223.
ExpressionAtlasⁱ	E9PVJ6. baseline and differential.
Genevisibleⁱ	E9PVJ6. MM.

Family and domain databases

Gene3Dⁱ	3.90.190.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029021. Prot-tyrosine_phosphatase-like. IPR000242. PTPase_domain. IPR016130. Tyr_Pase_AS. IPR003595. Tyr_Pase_cat. IPR000387. TYR_PHOSPHATASE_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00102. Y_phosphatase. 1 hit.
PRINTSⁱ	PR00700. PRTYPHPHTASE.
SMARTⁱ	View protein in SMART SM00194. PTPc. 1 hit. SM00404. PTPc_motif. 1 hit.
SUPFAMⁱ	SSF52799. SSF52799. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9PVJ6_MOUSE
Accessionⁱ	E9PVJ6Primary (citable) accession number: E9PVJ6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	April 5, 2011
	Last modified:	March 28, 2018
	This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E9PVJ6 (E9PVJ6_MOUSE)

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Tyrosine-protein phosphatase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ