UniProtKB - E9PVJ6 (E9PVJ6_MOUSE)
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Protein
Tyrosine-protein phosphatase
Gene
Ptpro
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 325 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protein phosphataseUniRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PtproImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1097152. Ptpro. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 33 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 69 – 90 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030223. |
ExpressionAtlasi | E9PVJ6. baseline and differential. |
Genevisiblei | E9PVJ6. MM. |
Structurei
3D structure databases
ProteinModelPortali | E9PVJ6. |
SMRi | E9PVJ6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 127 – 384 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 258 | |
Domaini | 301 – 375 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 75 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG0791. Eukaryota. COG5599. LUCA. |
GeneTreei | ENSGT00900000140785. |
Family and domain databases
Gene3Di | 3.90.190.10. 1 hit. |
InterProi | View protein in InterPro IPR029021. Prot-tyrosine_phosphatase-like. IPR000242. PTPase_domain. IPR016130. Tyr_Pase_AS. IPR003595. Tyr_Pase_cat. IPR000387. TYR_PHOSPHATASE_dom. |
Pfami | View protein in Pfam PF00102. Y_phosphatase. 1 hit. |
PRINTSi | PR00700. PRTYPHPHTASE. |
SMARTi | View protein in SMART SM00194. PTPc. 1 hit. SM00404. PTPc_motif. 1 hit. |
SUPFAMi | SSF52799. SSF52799. 1 hit. |
PROSITEi | View protein in PROSITE PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. |
i Sequence
Sequence statusi: Complete.
E9PVJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVTEVNPNVV VISVLAILST LLIGLLLVTL VILRKKHLQM ARECGAGTFV
60 70 80 90 100
NFASLEREGK LPYSWRRSVF ALLTLLPSCL WTDYLLAFYI NPWSKNGLKK
110 120 130 140 150
RKLTNPVQLD DFDSYIKDMA KDSDYKFSLQ FEELKLIGLD IPHFAADLPL
160 170 180 190 200
NRCKNRYTNI LPYDFSRVRL VSMNEEEGAD YINANYIPGY NSPQEYIATQ
210 220 230 240 250
GPLPETRNDF WKMVLQQKSH IIVMLTQCNE KRRVKCDHYW PFTEEPIAYG
260 270 280 290 300
DITVEMVSEE EEEDWASRHF RINYADEAQD VMHFNYTAWP DHGVPPANAA
310 320 330 340 350
ESILQFVFTV RQQAAKSKGP MIIHCSAGVG RTGTFIALDR LLQHIRDHEF
360 370 380 390 400
VDILGLVSEM RSYRMSMVQT EEQYIFIHQC VQLMWLRKKQ QFCISDVIYE
NVSKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093120 Genomic DNA. No translation available. AC144767 Genomic DNA. No translation available. AC163627 Genomic DNA. No translation available. |
RefSeqi | NP_001157874.1. NM_001164402.1. |
UniGenei | Mm.186361. Mm.491536. |
Genome annotation databases
Ensembli | ENSMUST00000167002; ENSMUSP00000131764; ENSMUSG00000030223. |
GeneIDi | 19277. |
UCSCi | uc009emx.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | E9PVJ6_MOUSE | |
Accessioni | E9PVJ6Primary (citable) accession number: E9PVJ6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | March 28, 2018 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |