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Protein

Protein-tyrosine-phosphatase

Gene

Ptpro

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-tyrosine-phosphataseSAAS annotation (EC:3.1.3.48SAAS annotation)
Gene namesi
Name:PtproImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097152. Ptpro.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9PVJ6.

Expressioni

Gene expression databases

BgeeiE9PVJ6.
ExpressionAtlasiE9PVJ6. baseline and differential.
GenevisibleiE9PVJ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076364.

Structurei

3D structure databases

ProteinModelPortaliE9PVJ6.
SMRiE9PVJ6. Positions 105-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00770000120452.
KOiK18035.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEVNPNVV VISVLAILST LLIGLLLVTL VILRKKHLQM ARECGAGTFV
60 70 80 90 100
NFASLEREGK LPYSWRRSVF ALLTLLPSCL WTDYLLAFYI NPWSKNGLKK
110 120 130 140 150
RKLTNPVQLD DFDSYIKDMA KDSDYKFSLQ FEELKLIGLD IPHFAADLPL
160 170 180 190 200
NRCKNRYTNI LPYDFSRVRL VSMNEEEGAD YINANYIPGY NSPQEYIATQ
210 220 230 240 250
GPLPETRNDF WKMVLQQKSH IIVMLTQCNE KRRVKCDHYW PFTEEPIAYG
260 270 280 290 300
DITVEMVSEE EEEDWASRHF RINYADEAQD VMHFNYTAWP DHGVPPANAA
310 320 330 340 350
ESILQFVFTV RQQAAKSKGP MIIHCSAGVG RTGTFIALDR LLQHIRDHEF
360 370 380 390 400
VDILGLVSEM RSYRMSMVQT EEQYIFIHQC VQLMWLRKKQ QFCISDVIYE

NVSKS
Length:405
Mass (Da):46,962
Last modified:April 5, 2011 - v1
Checksum:iFDA781061EB370FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
RefSeqiNP_001157874.1. NM_001164402.1.
UniGeneiMm.186361.
Mm.491536.

Genome annotation databases

EnsembliENSMUST00000167002; ENSMUSP00000131764; ENSMUSG00000030223.
GeneIDi19277.
KEGGimmu:19277.
UCSCiuc009emx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
RefSeqiNP_001157874.1. NM_001164402.1.
UniGeneiMm.186361.
Mm.491536.

3D structure databases

ProteinModelPortaliE9PVJ6.
SMRiE9PVJ6. Positions 105-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076364.

Proteomic databases

MaxQBiE9PVJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167002; ENSMUSP00000131764; ENSMUSG00000030223.
GeneIDi19277.
KEGGimmu:19277.
UCSCiuc009emx.2. mouse.

Organism-specific databases

CTDi5800.
MGIiMGI:1097152. Ptpro.

Phylogenomic databases

GeneTreeiENSGT00770000120452.
KOiK18035.

Miscellaneous databases

NextBioi296184.
SOURCEiSearch...

Gene expression databases

BgeeiE9PVJ6.
ExpressionAtlasiE9PVJ6. baseline and differential.
GenevisibleiE9PVJ6. MM.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PVJ6_MOUSE
AccessioniPrimary (citable) accession number: E9PVJ6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.