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Protein
Submitted name:

Eukaryotic translation initiation factor 4 gamma 1

Gene

Eif4g1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4 gamma 1Imported
Gene namesi
Name:Eif4g1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2384784. Eif4g1.

PTM / Processingi

Proteomic databases

EPDiE9PVC5.
MaxQBiE9PVC5.
PaxDbiE9PVC5.
PeptideAtlasiE9PVC5.
PRIDEiE9PVC5.

PTM databases

SwissPalmiE9PVC5.

Expressioni

Gene expression databases

BgeeiE9PVC5.
ExpressionAtlasiE9PVC5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047678.

Structurei

3D structure databases

ProteinModelPortaliE9PVC5.
SMRiE9PVC5. Positions 173-199, 749-989, 1228-1559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1235 – 1357123MIInterPro annotationAdd
BLAST
Domaini1423 – 1593171W2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
GeneTreeiENSGT00530000063038.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PVC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH
60 70 80 90 100
FYPSRAQPPS SAASRVQSAA PARPGPAPHV YPAGSQVMMI PSQISYSASQ
110 120 130 140 150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG
160 170 180 190 200
VQQFPASVAP APVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA
210 220 230 240 250
RTASTPTPPQ TGGSLEPQPN GESPQVAVII RPDDRSQGAA IGGRPGLPGP
260 270 280 290 300
EHSPGTESQP SSPSPTPSPP PILEPGSESN LGVLSIPGDT MTTGMIPMSV
310 320 330 340 350
EESTPISCET GEPYCLSPEP TLAEPILEVE VTLSKPIPES EFSSSPLQVS
360 370 380 390 400
TALVPHKVET HEPNGVIPSE DLEPEVESST EPAPPPLSPC ASESLVPIAP
410 420 430 440 450
TAQPEELLNG APSPPAVDLS PVSEPEEQAK KVSSAALASI LSPAPPVAPS
460 470 480 490 500
DTSPAQEEEM EEDDDDEEGG EAESEKGGED VPLDSTPVPA QLSQNLEVAA
510 520 530 540 550
ATQVAVSVPK RRRKIKELNK KEAVGDLLDA FKEVDPAVPE VENQPPTGSN
560 570 580 590 600
PSPESEGSMV PTQPEETEET WDSKEDKIHN AENIQPGEQK YEYKSDQWKP
610 620 630 640 650
LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHITDVVLDK ANKTPLRQLD
660 670 680 690 700
PSRLPGINCG PDFTPSFANL GRPALSNRGP PRGGPGGELP RGPQAGLGPR
710 720 730 740 750
RSQQGPRKET RKIISSVIMT EDIKLNKAEK AWKPSSKRTA ADKDRGEEDA
760 770 780 790 800
DGSKTQDLFR RVRSILNKLT PQMFQQLMKQ VTQLAIDTEE RLKGVIDLIF
810 820 830 840 850
EKAISEPNFS VAYANMCRCL MALKVPTTEK PTVTVNFRKL LLNRCQKEFE
860 870 880 890 900
KDKDDDEVFE KKQKEMDEAA TAEERGRLKE ELEEARDIAR RRSLGNIKFI
910 920 930 940 950
GELFKLKMLT EAIMHDCVVK LLKNHDEESL ECLCRLLTTI GKDLDFAKAK
960 970 980 990 1000
PRMDQYFNQM EKIIKEKKTS SRIRFMLQDV LDLRQSNWVP RRGDQGPKTI
1010 1020 1030 1040 1050
DQIHKEAEME EHREHIKVQQ LMAKGSDKRR GGPPGPPINR GLPLVDDGGW
1060 1070 1080 1090 1100
NTVPISKGSR PIDTSRLTKI TKPGSIDSNN QLFAPGGRLS WGKGSSGGSG
1110 1120 1130 1140 1150
AKPSDTASEA TRPATLNRFS ALQQTLPAEN TDNRRVVQRS SLSRERGEKA
1160 1170 1180 1190 1200
GDRGDRLERS ERGGDRGDRL DRARTPATKR SFSKEVEERS RERPSQPEGL
1210 1220 1230 1240 1250
RKAASLTEDR GRDPVKREAT LPPVSPPKAA LSVDEVEKKS KAIIEEYLHL
1260 1270 1280 1290 1300
NDMKEAVQCV QELASPSLLF IFVRLGIEST LERSTIAREH MGRLLHQLLC
1310 1320 1330 1340 1350
AGHLSTAQYY QGLYETLELA EDMEIDIPHV WLYLAELITP ILQEDGVPMG
1360 1370 1380 1390 1400
ELFREITKPL RPMGKATSLL LEILGLLCKS MGPKKVGMLW REAGLSWREF
1410 1420 1430 1440 1450
LAEGQDVGSF VAEKKVEYTL GEESEAPGQR TLAFEELRRQ LEKLLKDGGS
1460 1470 1480 1490 1500
NQRVFDWIDA NLNEQQIASN TLVRALMTTV CYSAIIFETP LRVDVQVLKV
1510 1520 1530 1540 1550
RARLLQKYLC DEQKELQALY ALQALVVTLE QPANLLRMFF DALYDEDVVK
1560 1570 1580 1590
EDAFYSWESS KDPAEQQGKG VALKSVTAFF NWLREAEDEE SDHN
Length:1,594
Mass (Da):175,459
Last modified:April 5, 2011 - v1
Checksum:i41962531963CF8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087898 Genomic DNA. No translation available.
RefSeqiXP_006522001.1. XM_006521938.1.
XP_006522002.1. XM_006521939.1.
UniGeneiMm.260256.

Genome annotation databases

EnsembliENSMUST00000115461; ENSMUSP00000111121; ENSMUSG00000045983.
GeneIDi208643.
UCSCiuc007yqu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087898 Genomic DNA. No translation available.
RefSeqiXP_006522001.1. XM_006521938.1.
XP_006522002.1. XM_006521939.1.
UniGeneiMm.260256.

3D structure databases

ProteinModelPortaliE9PVC5.
SMRiE9PVC5. Positions 173-199, 749-989, 1228-1559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047678.

PTM databases

SwissPalmiE9PVC5.

Proteomic databases

EPDiE9PVC5.
MaxQBiE9PVC5.
PaxDbiE9PVC5.
PeptideAtlasiE9PVC5.
PRIDEiE9PVC5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115461; ENSMUSP00000111121; ENSMUSG00000045983.
GeneIDi208643.
UCSCiuc007yqu.2. mouse.

Organism-specific databases

CTDi1981.
MGIiMGI:2384784. Eif4g1.

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
GeneTreeiENSGT00530000063038.

Miscellaneous databases

ChiTaRSiEif4g1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9PVC5.
ExpressionAtlasiE9PVC5. baseline and differential.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9PVC5_MOUSE
AccessioniPrimary (citable) accession number: E9PVC5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.