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Protein
Submitted name:

A disintegrin and metalloproteinase with thrombospondin motifs 4

Gene

Adamts4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: MGI
  2. metallopeptidase activity Source: MGI
  3. protease binding Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. defense response to bacterium Source: MGI
  2. proteolysis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 4Imported
Gene namesi
Name:Adamts4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1339949. Adamts4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. extracellular space Source: MGI
  3. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9PV91.
ExpressionAtlasiE9PV91. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PV91.
SMRiE9PV91. Positions 26-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains peptidase M12B domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118880.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PV91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGERDLRT LLSLIFFLLL LKRFASLSRF VETLVVADDK MAAFHGTGLK
60 70 80 90 100
RYLLTVMAAA AKAFKHPSIR NPVNLVVTRL VILGSGQEGP QVGPSAAQTL
110 120 130 140 150
RSFCTWQRGL NTPNDSDPDH FDTAILFTRQ DLCGVSTCDT LGMADVGTVC
160 170 180 190 200
DPARSCAIVE DDGLQSAFTA AHELGHVFNM LHDNSKPCTN LNGQGGSSRH
210 220 230 240 250
VMAPVMAHVD PEEPWSPCSA RFITDFLDNG YGHCLLDKPE APLHLPATFP
260 270 280 290 300
GKDYDADRQC QLTFGPDSSH CPQLPPPCAA LWCSGHLNGH AMCQTKHSPW
310 320 330 340 350
ADGTPCGSSQ ACMGGRCLHV DQLKDFNVPQ AGGWGPWGPW GDCSRTCGGG
360 370 380 390 400
VQFSSRDCTR PVPRNGGKYC EGRRTRFRSC NTENCPHGSA LTFREEQCAA
410 420 430 440 450
YNHRTDLFKS FPGPMDWVPR YTGVAPRDQC KLTCQARALG YYYVLEPRVA
460 470 480 490 500
DGTPCSPDTS SVCVQGRCIH AGCDRIIGSK KKFDKCMVCG GDGSRCSKQS
510 520 530 540 550
GSFKKFRYGY SDVVTIPAGA THILVRQQGG SGLKSIYLAL KLSDGSYALN
560 570 580 590 600
GEYTLMPSPT DVVLPGAVSL RYSGATAASE TLSGHGPLAQ PLTLQVLVAG
610 620 630 640
NPQNARLRYS FFVPRPVPST PRPPPQDWLQ RRAEILKILR KRPWAGRK
Length:648
Mass (Da):70,429
Last modified:April 5, 2011 - v1
Checksum:i15E230E049B59751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084821 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000111314; ENSMUSP00000106946; ENSMUSG00000006403.
UCSCiuc007dno.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084821 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PV91.
SMRiE9PV91. Positions 26-616.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111314; ENSMUSP00000106946; ENSMUSG00000006403.
UCSCiuc007dno.1. mouse.

Organism-specific databases

MGIiMGI:1339949. Adamts4.

Phylogenomic databases

GeneTreeiENSGT00760000118880.

Miscellaneous databases

NextBioi35553845.
SOURCEiSearch...

Gene expression databases

BgeeiE9PV91.
ExpressionAtlasiE9PV91. baseline and differential.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PV91_MOUSE
AccessioniPrimary (citable) accession number: E9PV91
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 1, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.