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Protein
Submitted name:

A disintegrin and metalloproteinase with thrombospondin motifs 4

Gene

Adamts4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi172Zinc; catalyticPROSITE-ProRule annotation1
Active sitei173PROSITE-ProRule annotation1
Metal bindingi176Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi182Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 4Imported
Gene namesi
Name:Adamts4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1339949. Adamts4.

PTM / Processingi

Proteomic databases

MaxQBiE9PV91.
PaxDbiE9PV91.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006403.
ExpressionAtlasiE9PV91. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PV91.
SMRiE9PV91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 239Peptidase M12BInterPro annotationAdd BLAST211

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
GeneTreeiENSGT00760000118880.

Family and domain databases

Gene3Di2.20.100.10. 1 hit.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. TSP1_rpt.
PfamiView protein in Pfam
PF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 1 hit.
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00209. TSP1. 1 hit.
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PV91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGERDLRT LLSLIFFLLL LKRFASLSRF VETLVVADDK MAAFHGTGLK
60 70 80 90 100
RYLLTVMAAA AKAFKHPSIR NPVNLVVTRL VILGSGQEGP QVGPSAAQTL
110 120 130 140 150
RSFCTWQRGL NTPNDSDPDH FDTAILFTRQ DLCGVSTCDT LGMADVGTVC
160 170 180 190 200
DPARSCAIVE DDGLQSAFTA AHELGHVFNM LHDNSKPCTN LNGQGGSSRH
210 220 230 240 250
VMAPVMAHVD PEEPWSPCSA RFITDFLDNG YGHCLLDKPE APLHLPATFP
260 270 280 290 300
GKDYDADRQC QLTFGPDSSH CPQLPPPCAA LWCSGHLNGH AMCQTKHSPW
310 320 330 340 350
ADGTPCGSSQ ACMGGRCLHV DQLKDFNVPQ AGGWGPWGPW GDCSRTCGGG
360 370 380 390 400
VQFSSRDCTR PVPRNGGKYC EGRRTRFRSC NTENCPHGSA LTFREEQCAA
410 420 430 440 450
YNHRTDLFKS FPGPMDWVPR YTGVAPRDQC KLTCQARALG YYYVLEPRVA
460 470 480 490 500
DGTPCSPDTS SVCVQGRCIH AGCDRIIGSK KKFDKCMVCG GDGSRCSKQS
510 520 530 540 550
GSFKKFRYGY SDVVTIPAGA THILVRQQGG SGLKSIYLAL KLSDGSYALN
560 570 580 590 600
GEYTLMPSPT DVVLPGAVSL RYSGATAASE TLSGHGPLAQ PLTLQVLVAG
610 620 630 640
NPQNARLRYS FFVPRPVPST PRPPPQDWLQ RRAEILKILR KRPWAGRK
Length:648
Mass (Da):70,429
Last modified:April 5, 2011 - v1
Checksum:i15E230E049B59751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084821 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000111314; ENSMUSP00000106946; ENSMUSG00000006403.
UCSCiuc007dno.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE9PV91_MOUSE
AccessioniPrimary (citable) accession number: E9PV91
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 5, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported