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E9PV57

- E9PV57_MOUSE

UniProt

E9PV57 - E9PV57_MOUSE

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Protein
Submitted name:

Peroxisome proliferator-activated receptor delta

Gene

Ppard

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. drug binding Source: Ensembl
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  4. linoleic acid binding Source: Ensembl
  5. sequence-specific DNA binding Source: InterPro
  6. steroid hormone receptor activity Source: InterPro
  7. transcription coactivator activity Source: Ensembl
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. adipose tissue development Source: MGI
  2. anagen Source: MGI
  3. apoptotic signaling pathway Source: Ensembl
  4. axon ensheathment Source: MGI
  5. cell differentiation Source: MGI
  6. cell proliferation Source: MGI
  7. cell-substrate adhesion Source: MGI
  8. cellular process Source: MGI
  9. cellular response to hypoxia Source: MGI
  10. decidualization Source: Ensembl
  11. embryo implantation Source: Ensembl
  12. epidermis development Source: MGI
  13. fatty acid oxidation Source: Ensembl
  14. heart development Source: Ensembl
  15. intracellular receptor signaling pathway Source: GOC
  16. keratinocyte migration Source: MGI
  17. keratinocyte proliferation Source: MGI
  18. lipid metabolic process Source: MGI
  19. mRNA transcription Source: Ensembl
  20. negative regulation of apoptotic process Source: Ensembl
  21. negative regulation of cell growth Source: Ensembl
  22. negative regulation of collagen biosynthetic process Source: Ensembl
  23. negative regulation of epithelial cell proliferation Source: MGI
  24. negative regulation of inflammatory response Source: Ensembl
  25. negative regulation of smooth muscle cell migration Source: Ensembl
  26. negative regulation of smooth muscle cell proliferation Source: Ensembl
  27. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  28. phospholipid biosynthetic process Source: Ensembl
  29. placenta development Source: MGI
  30. positive regulation of cell proliferation Source: MGI
  31. positive regulation of epidermis development Source: Ensembl
  32. positive regulation of insulin secretion Source: Ensembl
  33. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  34. positive regulation of transcription, DNA-templated Source: Ensembl
  35. positive regulation of vasodilation Source: Ensembl
  36. proteoglycan metabolic process Source: Ensembl
  37. regulation of cell proliferation Source: MGI
  38. regulation of fat cell differentiation Source: MGI
  39. response to activity Source: Ensembl
  40. response to glucose Source: Ensembl
  41. response to vitamin A Source: Ensembl
  42. vitamin A metabolic process Source: Ensembl
  43. wound healing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator-activated receptor deltaImported
Gene namesi
Name:PpardImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:101884. Ppard.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiE9PV57.
ExpressionAtlasiE9PV57. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PV57.
SMRiE9PV57. Positions 64-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119049.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PV57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP
60 70 80 90 100
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA
160 170 180 190 200
EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL
210 220 230 240 250
TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS

TT
Length:252
Mass (Da):28,212
Last modified:April 5, 2011 - v1
Checksum:iD647BBE2FC1E78B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei252 – 2521Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126937 Genomic DNA. No translation available.
CT025652 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000169040; ENSMUSP00000133077; ENSMUSG00000002250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126937 Genomic DNA. No translation available.
CT025652 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9PV57.
SMRi E9PV57. Positions 64-252.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000169040 ; ENSMUSP00000133077 ; ENSMUSG00000002250 .

Organism-specific databases

MGIi MGI:101884. Ppard.

Phylogenomic databases

GeneTreei ENSGT00760000119049.

Miscellaneous databases

NextBioi 35553831.
SOURCEi Search...

Gene expression databases

Bgeei E9PV57.
ExpressionAtlasi E9PV57. baseline and differential.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PV57_MOUSE
AccessioniPrimary (citable) accession number: E9PV57
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3