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Protein
Submitted name:

Peroxisome proliferator-activated receptor delta

Gene

Ppard

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adipose tissue development Source: MGI
  • apoptotic process Source: MGI
  • apoptotic signaling pathway Source: MGI
  • axon ensheathment Source: MGI
  • cell differentiation Source: MGI
  • cell proliferation Source: MGI
  • cell-substrate adhesion Source: MGI
  • cellular process Source: MGI
  • cellular response to hypoxia Source: MGI
  • decidualization Source: Ensembl
  • embryo implantation Source: MGI
  • epidermis development Source: MGI
  • fatty acid oxidation Source: Ensembl
  • heart development Source: Ensembl
  • intracellular receptor signaling pathway Source: MGI
  • keratinocyte migration Source: MGI
  • keratinocyte proliferation Source: MGI
  • lipid metabolic process Source: MGI
  • mRNA transcription Source: Ensembl
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of cell growth Source: Ensembl
  • negative regulation of collagen biosynthetic process Source: Ensembl
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of inflammatory response Source: Ensembl
  • negative regulation of smooth muscle cell migration Source: Ensembl
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • phospholipid biosynthetic process Source: Ensembl
  • placenta development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epidermis development Source: Ensembl
  • positive regulation of insulin secretion Source: Ensembl
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of vasodilation Source: Ensembl
  • proteoglycan metabolic process Source: Ensembl
  • regulation of cell proliferation Source: MGI
  • regulation of fat cell differentiation Source: MGI
  • response to activity Source: Ensembl
  • response to glucose Source: Ensembl
  • response to vitamin A Source: Ensembl
  • vitamin A metabolic process Source: Ensembl
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator-activated receptor deltaImported
Gene namesi
Name:PpardImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:101884. Ppard.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiE9PV57.
ExpressionAtlasiE9PV57. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002320.

Structurei

3D structure databases

ProteinModelPortaliE9PV57.
SMRiE9PV57. Positions 64-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121834.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PV57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP
60 70 80 90 100
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA
160 170 180 190 200
EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL
210 220 230 240 250
TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS

TT
Length:252
Mass (Da):28,212
Last modified:April 5, 2011 - v1
Checksum:iD647BBE2FC1E78B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei252 – 2521Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126937 Genomic DNA. No translation available.
CT025652 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000169040; ENSMUSP00000133077; ENSMUSG00000002250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126937 Genomic DNA. No translation available.
CT025652 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PV57.
SMRiE9PV57. Positions 64-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002320.

Chemistry

BindingDBiE9PV57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169040; ENSMUSP00000133077; ENSMUSG00000002250.

Organism-specific databases

MGIiMGI:101884. Ppard.

Phylogenomic databases

GeneTreeiENSGT00780000121834.

Miscellaneous databases

NextBioi35553831.
SOURCEiSearch...

Gene expression databases

BgeeiE9PV57.
ExpressionAtlasiE9PV57. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PV57_MOUSE
AccessioniPrimary (citable) accession number: E9PV57
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.