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E9PV57

- E9PV57_MOUSE

UniProt

E9PV57 - E9PV57_MOUSE

Protein
Submitted name:

Peroxisome proliferator-activated receptor delta

Gene

Ppard

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. drug binding Source: Ensembl
    3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    4. linoleic acid binding Source: Ensembl
    5. sequence-specific DNA binding Source: InterPro
    6. steroid hormone receptor activity Source: InterPro
    7. transcription coactivator activity Source: Ensembl
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adipose tissue development Source: MGI
    2. anagen Source: MGI
    3. apoptotic signaling pathway Source: Ensembl
    4. axon ensheathment Source: MGI
    5. cell differentiation Source: MGI
    6. cell proliferation Source: MGI
    7. cell-substrate adhesion Source: MGI
    8. cellular process Source: MGI
    9. cellular response to hypoxia Source: MGI
    10. decidualization Source: Ensembl
    11. embryo implantation Source: Ensembl
    12. epidermis development Source: MGI
    13. fatty acid oxidation Source: Ensembl
    14. heart development Source: Ensembl
    15. keratinocyte migration Source: MGI
    16. keratinocyte proliferation Source: MGI
    17. lipid metabolic process Source: MGI
    18. mRNA transcription Source: Ensembl
    19. negative regulation of apoptotic process Source: Ensembl
    20. negative regulation of cell growth Source: Ensembl
    21. negative regulation of collagen biosynthetic process Source: Ensembl
    22. negative regulation of epithelial cell proliferation Source: MGI
    23. negative regulation of inflammatory response Source: Ensembl
    24. negative regulation of smooth muscle cell migration Source: Ensembl
    25. negative regulation of smooth muscle cell proliferation Source: Ensembl
    26. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    27. phospholipid biosynthetic process Source: Ensembl
    28. placenta development Source: MGI
    29. positive regulation of cell proliferation Source: MGI
    30. positive regulation of epidermis development Source: Ensembl
    31. positive regulation of insulin secretion Source: Ensembl
    32. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
    33. positive regulation of transcription, DNA-templated Source: Ensembl
    34. positive regulation of vasodilation Source: Ensembl
    35. proteoglycan metabolic process Source: Ensembl
    36. regulation of cell proliferation Source: MGI
    37. regulation of fat cell differentiation Source: MGI
    38. response to activity Source: Ensembl
    39. response to glucose Source: Ensembl
    40. response to vitamin A Source: Ensembl
    41. vitamin A metabolic process Source: Ensembl
    42. wound healing Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peroxisome proliferator-activated receptor deltaImported
    Gene namesi
    Name:PpardImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:101884. Ppard.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    BgeeiE9PV57.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PV57.
    SMRiE9PV57. Positions 64-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115076.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR003075. 1Cnucl_rcpt_B.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR01290. PROXISOMPABR.
    PR00047. STROIDFINGER.
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    E9PV57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP    50
    SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT 100
    IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA 150
    EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL 200
    TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS 250
    TT 252
    Length:252
    Mass (Da):28,212
    Last modified:April 5, 2011 - v1
    Checksum:iD647BBE2FC1E78B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei252 – 2521Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126937 Genomic DNA. No translation available.
    CT025652 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000169040; ENSMUSP00000133077; ENSMUSG00000002250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126937 Genomic DNA. No translation available.
    CT025652 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9PV57.
    SMRi E9PV57. Positions 64-252.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000169040 ; ENSMUSP00000133077 ; ENSMUSG00000002250 .

    Organism-specific databases

    MGIi MGI:101884. Ppard.

    Phylogenomic databases

    GeneTreei ENSGT00740000115076.

    Miscellaneous databases

    NextBioi 35553831.
    SOURCEi Search...

    Gene expression databases

    Bgeei E9PV57.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR003075. 1Cnucl_rcpt_B.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR01290. PROXISOMPABR.
    PR00047. STROIDFINGER.
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9PV57_MOUSE
    AccessioniPrimary (citable) accession number: E9PV57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3