Peroxisome proliferator-activated receptor delta

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E9PV57 (E9PV57_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Peroxisome proliferator-activated receptor delta Ensembl ENSMUSP00000133077

Gene names

Name:

Ppard Ensembl ENSMUSP00000133077 MGI 101884

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000133077

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	252 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS001628

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000133077

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS001628
Cellular component	Nucleus SAAS SAAS001628
Domain	Zinc-finger SAAS SAAS001628
Ligand	DNA-binding SAAS SAAS001628 Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adipose tissue development Inferred from mutant phenotype PubMed 11756685. Source: MGI anagen Inferred from mutant phenotype PubMed 15713628. Source: MGI apoptotic process Inferred from electronic annotation. Source: Compara axon ensheathment Inferred from mutant phenotype PubMed 10866668. Source: MGI cell differentiation Inferred from direct assay PubMed 16581799. Source: MGI cell-substrate adhesion Inferred from mutant phenotype PubMed 11514592. Source: MGI keratinocyte migration Inferred from mutant phenotype PubMed 11514592. Source: MGI keratinocyte proliferation Inferred from mutant phenotype PubMed 11511099. Source: MGI lipid metabolic process Inferred from mutant phenotype PubMed 10866668 PubMed 16581799. Source: MGI negative regulation of epithelial cell proliferation Inferred from genetic interaction PubMed 14758356. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 8041794. Source: MGI placenta development Inferred from mutant phenotype PubMed 11756685. Source: MGI positive regulation of cell proliferation Inferred from mutant phenotype PubMed 11756685. Source: MGI positive regulation of phosphatidylinositol 3-kinase cascade Inferred from direct assay PubMed 16581799. Source: MGI positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of fat cell differentiation Inferred from mutant phenotype PubMed 11756685. Source: MGI steroid hormone mediated signaling pathway Inferred from electronic annotation. Source: GOC wound healing Inferred from mutant phenotype PubMed 11514592. Source: MGI
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from direct assay PubMed 8041794. Source: MGI drug binding Inferred from electronic annotation. Source: Compara ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Traceable author statement PubMed 10866668. Source: MGI linoleic acid binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

252

Ensembl ENSMUSP00000133077

Sequences

Sequence

Length

Mass (Da)

Tools

E9PV57 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: D647BBE2FC1E78B6
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FASTA

252

28,212

        10         20         30         40         50         60 
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP SSLLDQLQMG 

        70         80         90        100        110        120 
CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLEYEKC DRICKIQKKN 

       130        140        150        160        170        180 
RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH 

       190        200        210        220        230        240 
IYNAYLKNFN MTKKKARSIL TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI 

       250 
SVHVFYRCQS TT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000133077.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000133077.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC126937 Genomic DNA. No translation available. CT025652 Genomic DNA. No translation available.
IPI	IPI00989128.
3D structure databases
ProteinModelPortal	E9PV57.
SMR	E9PV57. Positions 64-252.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000169040; ENSMUSP00000133077; ENSMUSG00000002250.
Organism-specific databases
MGI	MGI:101884. Ppard.
Phylogenomic databases
GeneTree	ENSGT00700000104361.
Gene expression databases
ArrayExpress	E9PV57.
Bgee	E9PV57.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR003074. 1Cnucl_rcpt. IPR003075. 1Cnucl_rcpt_B. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01288. PROXISOMEPAR. PR01290. PROXISOMPABR. PR00047. STROIDFINGER.
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35553831.
SOURCE	Search...

Entry information

Entry name

E9PV57_MOUSE

Accession

Primary (citable) accession number: E9PV57

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information