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E9PUR6

- E9PUR6_MOUSE

UniProt

E9PUR6 - E9PUR6_MOUSE

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Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. glucocorticoid receptor activity Source: MGI
  3. protein dimerization activity Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: InterPro
  6. steroid binding Source: InterPro
  7. zinc ion binding Source: InterPro

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. glucocorticoid metabolic process Source: MGI
  3. glucocorticoid receptor signaling pathway Source: MGI
  4. mammary gland duct morphogenesis Source: MGI
  5. maternal behavior Source: MGI
  6. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  7. positive regulation of neuron apoptotic process Source: MGI
  8. regulation of glucocorticoid biosynthetic process Source: MGI
  9. regulation of gluconeogenesis Source: MGI
  10. regulation of transcription, DNA-templated Source: MGI
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. intracellular Source: MGI
  4. membrane Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118887.
KOiK05771.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PUR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA
60 70 80 90 100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV
110 120 130 140 150
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS
160 170 180 190 200
TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK
210 220 230 240 250
LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD
260 270 280 290 300
PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF
310 320 330 340 350
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH
360 370 380 390 400
YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF
410 420 430 440 450
AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG
460 470 480 490 500
VLTCGSCKVF FKRAVEGQHN YLCAGRNDCI IDKIRRKNCP ACRYRKCLQA
510 520 530 540 550
GMNLEARKTK KKIKGIQQAT AGVSQDTSEN ANKTIVPAAL PQLTPTLVSL
560 570 580 590 600
LEVIEPEVLY AGYDSSVPDS AWRIMTTLNM LGGRQVIAAV KWAKAIPGFR
610 620 630 640 650
NLHLDDQMTL LQYSWMFLMA FALGWRSYRQ ASGNLLCFAP DLIINEQRMT
660 670 680 690 700
LPCMYDQCKH MLFISTELQR LQVSYEEYLC MKTLLLLSSV PKEGLKSQEL
710 720 730 740 750
FDEIRMTYIK ELGKAIVKRE GNSSQNWQRF YQLTKLLDSM HDVVENLLSY
760 770 780 790
CFQTFLDKSM SIEFPEMLAE IITNQIPKYS NGNIKKLLFH QK
Length:792
Mass (Da):87,164
Last modified:April 5, 2011 - v1
Checksum:i528730BD2C517554
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqiNP_032199.3. NM_008173.3.
XP_006525729.1. XM_006525666.1.
UniGeneiMm.129481.

Genome annotation databases

EnsembliENSMUST00000025300; ENSMUSP00000025300; ENSMUSG00000024431.
ENSMUST00000115567; ENSMUSP00000111229; ENSMUSG00000024431.
ENSMUST00000115571; ENSMUSP00000111233; ENSMUSG00000024431.
GeneIDi14815.
KEGGimmu:14815.
UCSCiuc008esx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqi NP_032199.3. NM_008173.3.
XP_006525729.1. XM_006525666.1.
UniGenei Mm.129481.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025300 ; ENSMUSP00000025300 ; ENSMUSG00000024431 .
ENSMUST00000115567 ; ENSMUSP00000111229 ; ENSMUSG00000024431 .
ENSMUST00000115571 ; ENSMUSP00000111233 ; ENSMUSG00000024431 .
GeneIDi 14815.
KEGGi mmu:14815.
UCSCi uc008esx.1. mouse.

Organism-specific databases

CTDi 2908.
MGIi MGI:95824. Nr3c1.

Phylogenomic databases

GeneTreei ENSGT00760000118887.
KOi K05771.

Miscellaneous databases

ChiTaRSi NR3C1. mouse.
NextBioi 287015.
SOURCEi Search...

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PUR6_MOUSE
AccessioniPrimary (citable) accession number: E9PUR6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3