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E9PUR6

- E9PUR6_MOUSE

UniProt

E9PUR6 - E9PUR6_MOUSE

Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. glucocorticoid receptor activity Source: MGI
    3. protein binding Source: MGI
    4. protein dimerization activity Source: MGI
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: InterPro
    7. steroid binding Source: InterPro
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adrenal gland development Source: MGI
    2. glucocorticoid metabolic process Source: MGI
    3. glucocorticoid receptor signaling pathway Source: MGI
    4. mammary gland duct morphogenesis Source: MGI
    5. maternal behavior Source: MGI
    6. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
    7. positive regulation of neuron apoptotic process Source: MGI
    8. regulation of glucocorticoid biosynthetic process Source: MGI
    9. regulation of gluconeogenesis Source: MGI
    10. regulation of transcription, DNA-templated Source: MGI
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ReceptorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glucocorticoid receptorImported
    Gene namesi
    Name:Nr3c1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:95824. Nr3c1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. intracellular Source: MGI
    4. membrane Source: MGI
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110451.
    KOiK05771.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR001409. Glcrtcd_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF02155. GCR. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00528. GLCORTICOIDR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PUR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA    50
    AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV 100
    SLSMGLYMGE TETKVMGNDL GYPQQGQLGL SSGETDFRLL EESIANLNRS 150
    TSRPENPKSS TPAAGCATPT EKEFPQTHSD PSSEQQNRKS QPGTNGGSVK 200
    LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN LLSPLAGEDD 250
    PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 300
    IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH 350
    YDMNTASLSQ QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF 400
    AGRSVFSNGY SSPGMRPDVS SPPSSSSTAT GPPPKLCLVC SDEASGCHYG 450
    VLTCGSCKVF FKRAVEGQHN YLCAGRNDCI IDKIRRKNCP ACRYRKCLQA 500
    GMNLEARKTK KKIKGIQQAT AGVSQDTSEN ANKTIVPAAL PQLTPTLVSL 550
    LEVIEPEVLY AGYDSSVPDS AWRIMTTLNM LGGRQVIAAV KWAKAIPGFR 600
    NLHLDDQMTL LQYSWMFLMA FALGWRSYRQ ASGNLLCFAP DLIINEQRMT 650
    LPCMYDQCKH MLFISTELQR LQVSYEEYLC MKTLLLLSSV PKEGLKSQEL 700
    FDEIRMTYIK ELGKAIVKRE GNSSQNWQRF YQLTKLLDSM HDVVENLLSY 750
    CFQTFLDKSM SIEFPEMLAE IITNQIPKYS NGNIKKLLFH QK 792
    Length:792
    Mass (Da):87,164
    Last modified:April 5, 2011 - v1
    Checksum:i528730BD2C517554
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007995 Genomic DNA. No translation available.
    AC124417 Genomic DNA. No translation available.
    RefSeqiNP_032199.3. NM_008173.3.
    XP_006525729.1. XM_006525666.1.
    UniGeneiMm.129481.

    Genome annotation databases

    EnsembliENSMUST00000025300; ENSMUSP00000025300; ENSMUSG00000024431.
    ENSMUST00000115567; ENSMUSP00000111229; ENSMUSG00000024431.
    ENSMUST00000115571; ENSMUSP00000111233; ENSMUSG00000024431.
    GeneIDi14815.
    KEGGimmu:14815.
    UCSCiuc008esx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007995 Genomic DNA. No translation available.
    AC124417 Genomic DNA. No translation available.
    RefSeqi NP_032199.3. NM_008173.3.
    XP_006525729.1. XM_006525666.1.
    UniGenei Mm.129481.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025300 ; ENSMUSP00000025300 ; ENSMUSG00000024431 .
    ENSMUST00000115567 ; ENSMUSP00000111229 ; ENSMUSG00000024431 .
    ENSMUST00000115571 ; ENSMUSP00000111233 ; ENSMUSG00000024431 .
    GeneIDi 14815.
    KEGGi mmu:14815.
    UCSCi uc008esx.1. mouse.

    Organism-specific databases

    CTDi 2908.
    MGIi MGI:95824. Nr3c1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110451.
    KOi K05771.

    Miscellaneous databases

    ChiTaRSi NR3C1. mouse.
    NextBioi 287015.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR001409. Glcrtcd_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF02155. GCR. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00528. GLCORTICOIDR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9PUR6_MOUSE
    AccessioniPrimary (citable) accession number: E9PUR6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3