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E9PUR6 (E9PUR6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length792 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains nuclear receptor DNA-binding domain. SAAS SAAS001723

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000111233 Ensembl ENSMUSP00000025300 Ensembl ENSMUSP00000111229

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS001723 RuleBase RU004334
   Cellular componentNucleus SAAS SAAS001723 RuleBase RU004334
   DomainZinc-finger SAAS SAAS001723 RuleBase RU004334
   LigandDNA-binding SAAS SAAS001723 RuleBase RU004334
Metal-binding
Zinc
   Molecular functionReceptor RuleBase RU004334
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from mutant phenotype PubMed 7628695. Source: MGI

glucocorticoid metabolic process

Inferred from mutant phenotype PubMed 10509797. Source: MGI

glucocorticoid receptor signaling pathway

Inferred from direct assay PubMed 15199138. Source: MGI

mammary gland duct morphogenesis

Inferred from mutant phenotype PubMed 12198239. Source: MGI

positive regulation of neuron apoptotic process

Inferred from genetic interaction PubMed 10744634. Source: MGI

regulation of glucocorticoid biosynthetic process

Inferred from mutant phenotype PubMed 7628695. Source: MGI

regulation of gluconeogenesis

Inferred from mutant phenotype PubMed 7628695. Source: MGI

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 10224232. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytosol

Inferred from direct assay PubMed 7914432. Source: MGI

intracellular

Inferred from direct assay PubMed 9237103. Source: MGI

membrane

Inferred from direct assay PubMed 9237103. Source: MGI

nucleus

Inferred from direct assay PubMed 11555636PubMed 15870285PubMed 20660300PubMed 7914432. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15870285. Source: MGI

glucocorticoid receptor activity

Inferred from direct assay PubMed 15199138PubMed 7914432PubMed 9237103. Source: MGI

protein binding

Inferred from physical interaction PubMed 15870285. Source: MGI

protein dimerization activity

Inferred from direct assay PubMed 7883868. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 7883868. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

steroid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E9PUR6 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 528730BD2C517554

FASTA79287,164
        10         20         30         40         50         60 
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA AASQADSKQQ 

        70         80         90        100        110        120 
RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV SLSMGLYMGE TETKVMGNDL 

       130        140        150        160        170        180 
GYPQQGQLGL SSGETDFRLL EESIANLNRS TSRPENPKSS TPAAGCATPT EKEFPQTHSD 

       190        200        210        220        230        240 
PSSEQQNRKS QPGTNGGSVK LYTTDQSTFD ILQDLEFSAG SPGKETNESP WRSDLLIDEN 

       250        260        270        280        290        300 
LLSPLAGEDD PFLLEGDVNE DCKPLILPDT KPKIQDTGDT ILSSPSSVAL PQVKTEKDDF 

       310        320        330        340        350        360 
IELCTPGVIK QEKLGPVYCQ ASFSGTNIIG NKMSAISVHG VSTSGGQMYH YDMNTASLSQ 

       370        380        390        400        410        420 
QQDQKPVFNV IPPIPVGSEN WNRCQGSGED NLTSLGAMNF AGRSVFSNGY SSPGMRPDVS 

       430        440        450        460        470        480 
SPPSSSSTAT GPPPKLCLVC SDEASGCHYG VLTCGSCKVF FKRAVEGQHN YLCAGRNDCI 

       490        500        510        520        530        540 
IDKIRRKNCP ACRYRKCLQA GMNLEARKTK KKIKGIQQAT AGVSQDTSEN ANKTIVPAAL 

       550        560        570        580        590        600 
PQLTPTLVSL LEVIEPEVLY AGYDSSVPDS AWRIMTTLNM LGGRQVIAAV KWAKAIPGFR 

       610        620        630        640        650        660 
NLHLDDQMTL LQYSWMFLMA FALGWRSYRQ ASGNLLCFAP DLIINEQRMT LPCMYDQCKH 

       670        680        690        700        710        720 
MLFISTELQR LQVSYEEYLC MKTLLLLSSV PKEGLKSQEL FDEIRMTYIK ELGKAIVKRE 

       730        740        750        760        770        780 
GNSSQNWQRF YQLTKLLDSM HDVVENLLSY CFQTFLDKSM SIEFPEMLAE IITNQIPKYS 

       790 
NGNIKKLLFH QK 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.
RefSeqNP_032199.3. NM_008173.3.
XP_006525729.1. XM_006525666.1.
UniGeneMm.129481.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025300; ENSMUSP00000025300; ENSMUSG00000024431.
ENSMUST00000115567; ENSMUSP00000111229; ENSMUSG00000024431.
ENSMUST00000115571; ENSMUSP00000111233; ENSMUSG00000024431.
GeneID14815.
KEGGmmu:14815.
UCSCuc008esx.1. mouse.

Organism-specific databases

CTD2908.
MGIMGI:95824. Nr3c1.

Phylogenomic databases

GeneTreeENSGT00730000110451.
KOK05771.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR001409. Glcrtcd_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF02155. GCR. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00528. GLCORTICOIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNR3C1. mouse.
NextBio287015.
SOURCESearch...

Entry information

Entry nameE9PUR6_MOUSE
AccessionPrimary (citable) accession number: E9PUR6
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)