Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Diacylglycerol kinase

Gene

Dgkd

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-114508. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DgkdImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138334. Dgkd.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9PUQ8.
PaxDbiE9PUQ8.
PeptideAtlasiE9PUQ8.
PRIDEiE9PUQ8.

PTM databases

iPTMnetiE9PUQ8.
PhosphoSitePlusiE9PUQ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000070738.
ExpressionAtlasiE9PUQ8. baseline and differential.
GenevisibleiE9PUQ8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027517.

Structurei

3D structure databases

ProteinModelPortaliE9PUQ8.
SMRiE9PUQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 146PHInterPro annotationAdd BLAST94
Domaini163 – 213Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini235 – 286Phorbol-ester/DAG-typeInterPro annotationAdd BLAST52
Domaini317 – 451DAGKcInterPro annotationAdd BLAST135
Domaini1151 – 1214SAMInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1170. Eukaryota.
ENOG410XSJR. LUCA.
GeneTreeiENSGT00760000119050.
InParanoidiE9PUQ8.
KOiK00901.
OMAiEVMAKKC.
OrthoDBiEOG091G00SK.
TreeFamiTF313104.

Family and domain databases

CDDicd00029. C1. 2 hits.
Gene3Di2.30.29.30. 1 hit.
3.40.50.10330. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase_sf.
IPR002219. PE/DAG-bd.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
IPR001660. SAM.
IPR013761. SAM/pointed_sf.
PfamiView protein in Pfam
PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF07647. SAM_2. 1 hit.
SMARTiView protein in SMART
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

E9PUQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGAPPP GPPQPPPPPP PEESSDSEPE AEPGSPQKLI RKVSTSGQIR
60 70 80 90 100
QKTILKEGML TKQNNSFQRS KRRYFKLRGR TLYYAKTAKS IIFDEVDLTD
110 120 130 140 150
ASVAESSTKN VNNSFTVITP CRKLILCADN RKEMEDWIAA LKTVQNKEHF
160 170 180 190 200
EPTQYSMDHF SGMHNWYACS HARPTYCNVC REVLSGVTSH GLSCEVCKFK
210 220 230 240 250
AHKRCAVRAT SNCKWTTLAS IGKDIIEDED GIAMPHQWLE GNLPVSAKCI
260 270 280 290 300
VCDKTCGSVL RLQDWRCLWC KAMVHTSCKE SLVMKCPLGL CKVSVIPPTA
310 320 330 340 350
LNSIDSDGFW KATCPPSCTS PLLVFVNSKS GDNQGVKFLR RFKQLLNPAQ
360 370 380 390 400
VFDLMNGGPH LGLRLFQKFD TFRILVCGGD GSVGWVLSEI DSLNLHKQCQ
410 420 430 440 450
LGVLPLGTGN DLARVLGWGS ACDDDTQLPQ ILAKLERAST KMLDRWSVMA
460 470 480 490 500
YETKLPRQAS SSTVTEDFSE DSEVQQILFY EDSVAAHLSK ILTSDQHSVV
510 520 530 540 550
ISSAKVLCET VKDFVARVGK AYEKTTESSQ ESEVMAKKCS VLKEKLDSLL
560 570 580 590 600
KTLDDESQAS SSLSNPPPTI AEEAEDGDGS GNICSSTGDH LVGSACPSRP
610 620 630 640 650
QIFRPREQLM LRANSLKKAI RQIIEHTEKA VDEQNAQTQE QQGFVLGLSE
660 670 680 690 700
SEKKDLKTDN RVCTSSVHSE SCVIAKGRSQ RKASRAPCEK LVSKGLSLGS
710 720 730 740 750
SASLPPGTGS RDSLPALNTK ILYPSVRAGM SGSLPGGSVI SRLLINADPF
760 770 780 790 800
NAEPENLEYY TEKCVMNNYF GIGLDAKISL DFNNKRDEHP EKCRSRTKNM
810 820 830 840 850
MWYGVLGTKE LLHRTYRNLE QKVLLECDGR PIPLPSLQGI AVLNIPSYAG
860 870 880 890 900
GTNFWGGTKE DDTFAAPSFD DKILEVVAVF GSMQMAVSRV IKLQHHRIAQ
910 920 930 940 950
CRTVKISILG DEGVPVQVDG EAWIQPPGYI RIVHKNRAQT LTRDRAFENT
960 970 980 990 1000
LKSWEDKQKC ELSRPPSFSL HPEILSEEEA TQMDQFGQAA GGLIHSIREI
1010 1020 1030 1040 1050
AQSHRAMEQE LAHAVNASSK AMERVYGKPR TAEGLNCSFV LEMVNNIRAL
1060 1070 1080 1090 1100
RSETELLLAG KMALQLDPPQ KERLGAALIE MDQQLRKLTD TPWLCQPLEP
1110 1120 1130 1140 1150
GEEESLQQNV MLDLTKRSRS GKFRLVTKFK KEKNNKNKEV HSNLGGPVHL
1160 1170 1180 1190 1200
WGTEEVAAWL EHLSLCEYKD IFTRHDIRGS ELLHLERRDL KDLGVTKVGH
1210 1220
MKRILCGIKE LSRSSPAAEA
Length:1,220
Mass (Da):135,208
Last modified:April 5, 2011 - v1
Checksum:i1635F45B96741B7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102630 Genomic DNA. No translation available.
AC162281 Genomic DNA. No translation available.
RefSeqiNP_808314.2. NM_177646.3.
UniGeneiMm.277217.

Genome annotation databases

EnsembliENSMUST00000027517; ENSMUSP00000027517; ENSMUSG00000070738.
GeneIDi227333.
KEGGimmu:227333.
UCSCiuc011wos.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiE9PUQ8_MOUSE
AccessioniPrimary (citable) accession number: E9PUQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported