ID   E9PUM0_MOUSE            Unreviewed;       245 AA.
AC   E9PUM0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   SubName: Full=Excision repair cross-complementing rodent repair deficiency, complementation group 1 {ECO:0000313|Ensembl:ENSMUSP00000125655.2};
GN   Name=Ercc1 {ECO:0000313|Ensembl:ENSMUSP00000125655.2,
GN   ECO:0000313|MGI:MGI:95412};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000125655.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000125655.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125655.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000125655.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125655.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ERCC1/RAD10/SWI10 family.
CC       {ECO:0000256|ARBA:ARBA00008283}.
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DR   RefSeq; NP_001120796.1; NM_001127324.1.
DR   AlphaFoldDB; E9PUM0; -.
DR   SMR; E9PUM0; -.
DR   MaxQB; E9PUM0; -.
DR   PeptideAtlas; E9PUM0; -.
DR   ProteomicsDB; 312264; -.
DR   Antibodypedia; 3826; 1522 antibodies from 44 providers.
DR   Ensembl; ENSMUST00000160369.8; ENSMUSP00000125655.2; ENSMUSG00000003549.10.
DR   GeneID; 13870; -.
DR   UCSC; uc009fll.2; mouse.
DR   AGR; MGI:95412; -.
DR   CTD; 2067; -.
DR   MGI; MGI:95412; Ercc1.
DR   VEuPathDB; HostDB:ENSMUSG00000003549; -.
DR   GeneTree; ENSGT00390000011275; -.
DR   OrthoDB; 12065at2759; -.
DR   BioGRID-ORCS; 13870; 7 hits in 116 CRISPR screens.
DR   ChiTaRS; Ercc1; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000003549; Expressed in internal carotid artery and 244 other cell types or tissues.
DR   ExpressionAtlas; E9PUM0; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProt.
DR   GO; GO:0006302; P:double-strand break repair; IEA:UniProt.
DR   CDD; cd22325; ERCC1_C-like; 1.
DR   Gene3D; 3.40.50.10130; -; 1.
DR   InterPro; IPR047260; ERCC1-like_central_dom.
DR   InterPro; IPR004579; ERCC1/RAD10/SWI10.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   NCBIfam; TIGR00597; rad10; 1.
DR   PANTHER; PTHR12749:SF0; DNA EXCISION REPAIR PROTEIN ERCC-1; 1.
DR   PANTHER; PTHR12749; EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1; 1.
DR   Pfam; PF03834; Rad10; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   Genevisible; E9PUM0; MM.
PE   1: Evidence at protein level;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteomics identification {ECO:0007829|EPD:E9PUM0,
KW   ECO:0007829|MaxQB:E9PUM0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          100..213
FT                   /note="ERCC1-like central"
FT                   /evidence="ECO:0000259|Pfam:PF03834"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   245 AA;  26948 MW;  1AA0DD8EED2EE0B2 CRC64;
     MDPGKDEESR PQPSGPPTRR KFVIPLEEEE VPCAGVKPLF RSSRNPTIPA TSAHVAPQTY
     AEYAITQPPG GAGATVPTGS EPAAGENPSQ TLKTGAKSNS IIVSPRQRGN PVLKFVRNVP
     WEFGEVIPDY VLGQSTCALF LSLRYHNLHP DYIHERLQSL GKNFALRVLL VQVDVKDPQQ
     ALKELAKMCI LADCTLVLAW SAEEAGRYLE TYKAYEQKPA DLLMEKLEQN FLSRVSLCLL
     SSCTS
//