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Protein
Submitted name:

DNA excision repair protein ERCC-1

Gene

Ercc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. damaged DNA binding Source: MGI
  2. endonuclease activity Source: InterPro
  3. protein C-terminus binding Source: MGI
  4. protein domain specific binding Source: MGI
  5. single-stranded DNA binding Source: MGI
  6. TFIID-class transcription factor binding Source: MGI

GO - Biological processi

  1. cell development Source: MGI
  2. cell proliferation Source: MGI
  3. cellular response to DNA damage stimulus Source: MGI
  4. chromosome organization Source: MGI
  5. DNA catabolic process, endonucleolytic Source: MGI
  6. DNA recombination Source: MGI
  7. DNA repair Source: MGI
  8. double-strand break repair Source: MGI
  9. germ cell development Source: MGI
  10. interstrand cross-link repair Source: MGI
  11. isotype switching Source: MGI
  12. male gonad development Source: MGI
  13. mitotic recombination Source: MGI
  14. multicellular organismal aging Source: MGI
  15. multicellular organism growth Source: MGI
  16. negative regulation of telomere maintenance Source: MGI
  17. nucleotide-excision repair Source: MGI
  18. nucleotide-excision repair, DNA incision, 3'-to lesion Source: MGI
  19. nucleotide-excision repair, DNA incision, 5'-to lesion Source: MGI
  20. oogenesis Source: MGI
  21. post-embryonic hemopoiesis Source: MGI
  22. pyrimidine dimer repair by nucleotide-excision repair Source: MGI
  23. replicative cell aging Source: MGI
  24. response to oxidative stress Source: MGI
  25. response to X-ray Source: MGI
  26. spermatogenesis Source: MGI
  27. syncytium formation Source: MGI
  28. UV protection Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
DNA excision repair protein ERCC-1Imported
Gene namesi
Name:Ercc1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95412. Ercc1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear chromosome, telomeric region Source: MGI
  3. nucleoplasm Source: MGI
  4. nucleotide-excision repair complex Source: MGI
  5. nucleotide-excision repair factor 1 complex Source: MGI
  6. transcription factor TFIID complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9PUM0.

Expressioni

Gene expression databases

BgeeiE9PUM0.
ExpressionAtlasiE9PUM0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PUM0.
SMRiE9PUM0. Positions 99-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000011275.
KOiK10849.

Family and domain databases

InterProiIPR004579. DNA_repair_Rad10.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF03834. Rad10. 1 hit.
[Graphical view]
ProDomiPD013585. DNA_repair_Rad10. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR00597. rad10. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PUM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGKDEESR PQPSGPPTRR KFVIPLEEEE VPCAGVKPLF RSSRNPTIPA
60 70 80 90 100
TSAHVAPQTY AEYAITQPPG GAGATVPTGS EPAAGENPSQ TLKTGAKSNS
110 120 130 140 150
IIVSPRQRGN PVLKFVRNVP WEFGEVIPDY VLGQSTCALF LSLRYHNLHP
160 170 180 190 200
DYIHERLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLVLAW
210 220 230 240
SAEEAGRYLE TYKAYEQKPA DLLMEKLEQN FLSRVSLCLL SSCTS
Length:245
Mass (Da):26,948
Last modified:April 5, 2011 - v1
Checksum:i1AA0DD8EED2EE0B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148988 Genomic DNA. No translation available.
RefSeqiNP_001120796.1. NM_001127324.1.
UniGeneiMm.280913.

Genome annotation databases

EnsembliENSMUST00000160369; ENSMUSP00000125655; ENSMUSG00000003549.
GeneIDi13870.
KEGGimmu:13870.
UCSCiuc009fll.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148988 Genomic DNA. No translation available.
RefSeqiNP_001120796.1. NM_001127324.1.
UniGeneiMm.280913.

3D structure databases

ProteinModelPortaliE9PUM0.
SMRiE9PUM0. Positions 99-227.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9PUM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160369; ENSMUSP00000125655; ENSMUSG00000003549.
GeneIDi13870.
KEGGimmu:13870.
UCSCiuc009fll.2. mouse.

Organism-specific databases

CTDi2067.
MGIiMGI:95412. Ercc1.

Phylogenomic databases

GeneTreeiENSGT00390000011275.
KOiK10849.

Miscellaneous databases

NextBioi284784.
SOURCEiSearch...

Gene expression databases

BgeeiE9PUM0.
ExpressionAtlasiE9PUM0. baseline and differential.

Family and domain databases

InterProiIPR004579. DNA_repair_Rad10.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF03834. Rad10. 1 hit.
[Graphical view]
ProDomiPD013585. DNA_repair_Rad10. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR00597. rad10. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9PUM0_MOUSE
AccessioniPrimary (citable) accession number: E9PUM0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 1, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.