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E9PUL5

- PRRT2_MOUSE

UniProt

E9PUL5 - PRRT2_MOUSE

Protein

Proline-rich transmembrane protein 2

Gene

Prrt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. response to biotic stimulus Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline-rich transmembrane protein 2
    Alternative name(s):
    Dispanin subfamily B member 3
    Short name:
    DSPB3
    Gene namesi
    Name:Prrt2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1916267. Prrt2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctionsynapse 1 Publication

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI
    4. plasma membrane Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Proline-rich transmembrane protein 2PRO_0000415735Add
    BLAST

    Proteomic databases

    MaxQBiE9PUL5.
    PRIDEiE9PUL5.

    Expressioni

    Tissue specificityi

    Expressed in the brain (at protein level). Also highly expressed in spinal cord. Detected at low levels in the heart, lung, kidney and skin.2 Publications

    Developmental stagei

    Before 16 dpc, low levels in the developing brain. Expression markedly increases during early postnatal stages with a peak at P14. At this stage, expressed throughout the brain, with high levels in the cerebral cortex (cortical layers), hippocampus and cerebellum (granule cells and Purkinje cell layers). Progressively declines to relatively low levels in adulthood.1 Publication

    Gene expression databases

    BgeeiE9PUL5.

    Interactioni

    Subunit structurei

    Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliE9PUL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 274274ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 32328CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini345 – 3462ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei275 – 29521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 222181Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CD225/Dispanin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00530000063980.
    OMAiTQKPRDY.
    OrthoDBiEOG7NSB45.
    PhylomeDBiE9PUL5.
    TreeFamiTF331357.

    Family and domain databases

    InterProiIPR007593. CD225/Dispanin_fam.
    [Graphical view]
    PfamiPF04505. Dispanin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9PUL5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASSSQVSE MKGVEDSSKT QTEGPRHSEE GLGPVQVVAE IPDQPEALQP    50
    GPGITAAPVD SGPKAELAPE TTETPVETPE TVQATDLSLN PEEGSKASPS 100
    PSPSEARQEP ASKPDVNRET AAEEGSEPQS TAPPEPTSEP AFQINTQSDP 150
    QPTSQPPPKP PLQAEPPTQE DPTTEVLTES TGEKQENGAV VPLQAGDGEE 200
    GPAPQPHSPP STKTPPANGA PPRVLQKLVE EDRIGRAHGG HPGSPRGSLS 250
    RHPSSQLAGP GVEGGEGTQK PRDYIILAIL SCFCPMWPVN IVAFAYAVMS 300
    RNSLQQGDVD GAQRLGRVAK LLSIVALVGG VLIIIASCVI NLGVYK 346
    Length:346
    Mass (Da):35,924
    Last modified:April 5, 2011 - v1
    Checksum:iE7C3AF4159F4995F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122863 Genomic DNA. No translation available.
    CCDSiCCDS52405.1.
    RefSeqiNP_001096033.1. NM_001102563.1.
    UniGeneiMm.392047.

    Genome annotation databases

    EnsembliENSMUST00000159916; ENSMUSP00000124520; ENSMUSG00000045114.
    GeneIDi69017.
    KEGGimmu:69017.
    UCSCiuc009jty.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122863 Genomic DNA. No translation available.
    CCDSi CCDS52405.1.
    RefSeqi NP_001096033.1. NM_001102563.1.
    UniGenei Mm.392047.

    3D structure databases

    ProteinModelPortali E9PUL5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi E9PUL5.
    PRIDEi E9PUL5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000159916 ; ENSMUSP00000124520 ; ENSMUSG00000045114 .
    GeneIDi 69017.
    KEGGi mmu:69017.
    UCSCi uc009jty.1. mouse.

    Organism-specific databases

    CTDi 112476.
    MGIi MGI:1916267. Prrt2.

    Phylogenomic databases

    GeneTreei ENSGT00530000063980.
    OMAi TQKPRDY.
    OrthoDBi EOG7NSB45.
    PhylomeDBi E9PUL5.
    TreeFami TF331357.

    Miscellaneous databases

    NextBioi 328399.
    PROi E9PUL5.
    SOURCEi Search...

    Gene expression databases

    Bgeei E9PUL5.

    Family and domain databases

    InterProi IPR007593. CD225/Dispanin_fam.
    [Graphical view ]
    Pfami PF04505. Dispanin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Exome sequencing identifies truncating mutations in PRRT2 that cause paroxysmal kinesigenic dyskinesia."
      Chen W.J., Lin Y., Xiong Z.Q., Wei W., Ni W., Tan G.H., Guo S.L., He J., Chen Y.F., Zhang Q.J., Li H.F., Lin Y., Murong S.X., Xu J., Wang N., Wu Z.Y.
      Nat. Genet. 43:1252-1255(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. "High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes."
      Schwenk J., Harmel N., Brechet A., Zolles G., Berkefeld H., Muller C.S., Bildl W., Baehrens D., Huber B., Kulik A., Klocker N., Schulte U., Fakler B.
      Neuron 74:621-633(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN AMPAR COMPLEX, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
      Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
      PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiPRRT2_MOUSE
    AccessioniPrimary (citable) accession number: E9PUL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3