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Protein
Submitted name:

E3 ubiquitin-protein ligase MYCBP2

Gene

Mycbp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase MYCBP2Imported
Gene namesi
Name:Mycbp2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2179432. Mycbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9PUJ6.
PaxDbiE9PUJ6.
PeptideAtlasiE9PUJ6.
PRIDEiE9PUJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033004.
ExpressionAtlasiE9PUJ6. baseline and differential.
GenevisibleiE9PUJ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124710.

Structurei

3D structure databases

ProteinModelPortaliE9PUJ6.
SMRiE9PUJ6. Positions 1227-1387, 1723-1882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3789 – 3967179DOCInterPro annotationAdd
BLAST
Domaini4496 – 454752RING-typeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3265 – 328824Sequence analysisAdd
BLAST
Coiled coili3677 – 369923Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG1428. Eukaryota.
ENOG410XP1T. LUCA.
GeneTreeiENSGT00390000011403.
KOiK10693.
OMAiNSRGCPT.
OrthoDBiEOG091G0018.
TreeFamiTF313151.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM01337. APC10. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PUJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMCAATASP AAASSGPGGD GFFAAATISS SPAPGALFMP VPDGSVAAAG
60 70 80 90 100
LGLGLPTTDS RGHYQLLLSG RALADRYRRI YTTALSDRDQ AGSSTGHPAS
110 120 130 140 150
RNKKILNKKK LKRKQKSKSK VKTRSKSENV ENTVIIPDIK LHSNPSAFNI
160 170 180 190 200
YCNVRHCVLE WQKKETSLAA ASKNSVQSGE SDSDEEEESR EPPIKLPKII
210 220 230 240 250
EVGLCEVFEL IKETRFSHPS LCLRSLQALL NVLQGQQPEG LQSEPPEVLE
260 270 280 290 300
SLFQLLLEIT VRSTGMNDST GQSLTALSCA CLFSLVASWG ETGRTLQAIS
310 320 330 340 350
AILTNNGSHA CQTIQVPTIL NSLQRSVQAV LVGKIQVQDW FSNGIKKAAL
360 370 380 390 400
MHKWPLKEVS VDEDDQCLLQ NDGFFLYLLC KDGLYKIGSG YSGTVRGHIY
410 420 430 440 450
NSTSRIRNRK EKKSWLGYAQ GYLLYRDLNN HSMTAIRISP ETLEQDGTVL
460 470 480 490 500
LPDCHTEGQN ILFTDGEYIN QIAASRDDGF VVRIFATSTE PVLQQELQLK
510 520 530 540 550
LARKCLHACG ISLFDLEKDL HIISTGFDEE SAILGAGREF ALMKTANGKI
560 570 580 590 600
YYTGKYQSLG IKQGGPSAGK WVELPITKSP KIVHFSVGHD GSHALLVAED
610 620 630 640 650
GSVFFTGSAS KGEDGESTKS RRQSKPYKPK KIIKMEGKIV VYTACNNGSS
660 670 680 690 700
SVISKDGELY MFGKDAIYSD SSSLVSDLKG HFVTQVAMGK AHTCVLMKNG
710 720 730 740 750
EVWTFGVNNK GQCGRDTGAM NQGGKGFGVE NMATAMDEDL EEELDEKDEK
760 770 780 790 800
SMMCPPGMHK WKLEQCMVCT VCGDCTGYGA SCVSSGRPDR VPGGICGCGS
810 820 830 840 850
GESGCAVCGC CKACARELDG QEARQRGILD AVKEMIPLDL LLAVPVPGVN
860 870 880 890 900
IEEHLQLRQE EKRQRVIRRH RLEDGRGPLV FAGPIFMNHR EQALARLRSH
910 920 930 940 950
PAQLKHKRDK HKDGSGDRGE KDASKITTYP PGSVRFDCEL RAVQVSCGFH
960 970 980 990 1000
HSVVLMENGD VYTFGYGQHG QLGHGDVNSR GCPTLVQALP GPSTQVTAGS
1010 1020 1030 1040 1050
NHTAVLLMDG QVFTFGSFSK GQLGRPILDI PYWNAKPAPM PNIGSKYGRK
1060 1070 1080 1090 1100
ATWIGASGDQ TFLRIDEALI NSHVLATSEI FASKHIIGLV PASISEPPPF
1110 1120 1130 1140 1150
KCLLINKVDG SCKTFNDSEQ EDLQGFGVCL DPVYDVLWRF RPSTRELWCY
1160 1170 1180 1190 1200
NAVVADARLP SATDMQSRCS ILSPELALPT GSRALTTRSH AALHILGCLD
1210 1220 1230 1240 1250
TLAAMQDLKM GIASTEEETQ AVMKVYSKED YSVVNRFESH GGGWGYSAHS
1260 1270 1280 1290 1300
VEAIRFSADT DILLGGLGLF GGRGEYTAKI KLFELGPDGG DHETDGDLLA
1310 1320 1330 1340 1350
ETDVLAYDCA AREKYAMMFD EPVLLQAGWW YVAWARVSGP SSDCGSHGQA
1360 1370 1380 1390 1400
SITTDDGVIF QFKSSKKSNN GTDVNAGQIP QLLYRLPTSD GSTSKGKQQT
1410 1420 1430 1440 1450
SEPVHILKRS FARTVSVECF ESLLSILHWS WTTLVLGVEE LRGLKGFQFT
1460 1470 1480 1490 1500
ATLLDLERLR FVGTCCLRLL RVYTCEIYPV SATGKAVVEE TSKLAECIGK
1510 1520 1530 1540 1550
TRTLLRKILS EGVDHCMVKL DNDPQGYLSQ PLRLLEAVLQ ECHNTFTACF
1560 1570 1580 1590 1600
HSFYPTPALQ WACLCDLLNC LDQEANFKTS SSRLLAAVMS ALCHTSVKLT
1610 1620 1630 1640 1650
SLFPIAYDGE VLLRSIVKQV STENDSTLVH RFPLLVGHME KLSQSEENIS
1660 1670 1680 1690 1700
GMTSFREVLE KMLVIVVLPV RNSLRRESEL FSSHLVSNTC GLLASIVSEL
1710 1720 1730 1740 1750
TASALGSEVD GLNSLHSVKA SANRFTKTSQ GRSWNTGNGS PDAICFAVDK
1760 1770 1780 1790 1800
PGIVVVGFAV YGGGGIHEYE LEVLVDDSEH AGDSTHSHRW TSLELVKGTY
1810 1820 1830 1840 1850
TTDDSPSDIA EIRLDKVVPL KENVKYAVRL RNYGSRTANG DGGMTTVQCP
1860 1870 1880 1890 1900
DGVTFTFSTC SLSSNGTNQT RGQIPQILYY RSEFDGDLQS QLLSKANEED
1910 1920 1930 1940 1950
KNCSRALSVV STVVRAAKDL LHRALAVDAD DIPELLSSSS LFSMLLPLII
1960 1970 1980 1990 2000
AYIGPVAAAI PKVAVEVFGL VQQLLPSVAI LNQKYAPPAF NPNQSTDSTT
2010 2020 2030 2040 2050
GNQPEQGLSA CTTSNHYAVI ESEHPYKPAC VMHYKVTFPE CVRWMTIEFD
2060 2070 2080 2090 2100
PQCGTAQSED VIRLLIPVRT IQNSGYGAKL TSVHENLNSW VELKKYSGSS
2110 2120 2130 2140 2150
GWPTMVLVLP GNEALFSLET ASDYVKDDKA SFYGFKCFAI GYEFSPGPDE
2160 2170 2180 2190 2200
GVIQLEKELA NLGGVCAAAL MKKDLALPVG NELEEDLEIL EEAALQVCKT
2210 2220 2230 2240 2250
HSGILGKGLA LSHSPTILEA LEGNLPLQIQ SNEQSFLDDF IACVPGSSGG
2260 2270 2280 2290 2300
RLARWLQPDS YADPQKTSLI LNKDDIRCGW PTTITVQTKD QYGDVVHVPN
2310 2320 2330 2340 2350
MKVEVKAVPV SQKKTSLQQD QGKKCQRIPG SPSAAASSAD MTFGGLASPK
2360 2370 2380 2390 2400
LDVSYEPMIV KEARYIAITM MKVYENYSFE ELRFASPTPK RPSENMLIRV
2410 2420 2430 2440 2450
NNDGTYCANW TPGAIGLYTV HVTIDGIEID AGLEVKVKDP PKGMIPPGTQ
2460 2470 2480 2490 2500
LVKPKADPQP NKIRKFVAKD SAGLRIRSHP SLQSEQIGIV RVNGTITFID
2510 2520 2530 2540 2550
EIHNDDGVWL RLNEETIKKY VPNMNGYTEA WCLSFNQHLG KSLLVPVDNI
2560 2570 2580 2590 2600
FNASQGVRDL DVFSWTSKAF FPQEPKTNTD DFFKDMNSCG PQEATMQERD
2610 2620 2630 2640 2650
HPFLRGGPGM YKVVKTGPSG HNIRSCPNLR GIPIGMLVLG NKVKAVGEVT
2660 2670 2680 2690 2700
NSEGAWVQLD KNSMVEFCES DEGEAWSLAR DRGGNQYLRH EDEQVLLDQN
2710 2720 2730 2740 2750
SQPPPPSPFS VQAFNKGASC SAQGFDYGLG NNKGDQLSAI LNSIQSRPNL
2760 2770 2780 2790 2800
PAPSIFDQAA KPPSSLVHSP FVFGQPLSFQ QRQLQSDRGT ISTSSRPVST
2810 2820 2830 2840 2850
SGKSELPSKH SRSVKPDGHV SRTPADQKKP RGTEGLSASE SLMLKSDAAK
2860 2870 2880 2890 2900
LRSDSHSRSL SPNHNTLQTL KSDGRTSSGF RAESPGPGSR SSSPKPKPLP
2910 2920 2930 2940 2950
TPRSSPSGAS SPRSSSPQDK NLPQKSTAPA KTKLDPPRER SKSDSYTLDP
2960 2970 2980 2990 3000
DTLRKKKMPL TEPLRGRSTS PKPKPVPKDP KDSPGSENRA PSPHVVQENL
3010 3020 3030 3040 3050
HSEVVEVCTS STLKTNGVTD STCDDSGDLK SVDEGSNKVH FSIGKAPLKD
3060 3070 3080 3090 3100
EQEMRASPKI SRKCANRHTR PKKEKSNFLF KGDGTKSLEP AKQAMSPSVA
3110 3120 3130 3140 3150
ECARAVFASF LWHEGIVHDA MACSSFLKFN PDLSKEHAPI RSSLNSQPPT
3160 3170 3180 3190 3200
EEKEIKLKNR HSLEISSALN MFNIAPHGPD ISKMGSINKN KVLSMLKEPP
3210 3220 3230 3240 3250
LHEKCEDGKS EATFEMSMHH TMKSKSPLPL TLQHLVAFWE DISLATIKAA
3260 3270 3280 3290 3300
SQNMIFPSPG SCAVLKKKEC EKENKKTKKE KKKKEKTEIR PRGNLFGEMA
3310 3320 3330 3340 3350
QLAVGGPEKD TICELCGESH PYPVTYHMRQ AHPGCGRYAG GQGYNSIGHF
3360 3370 3380 3390 3400
CGGWAGNCGD GGMGGSTWYL VCDRCREKYL REKQAAAREK VKQSRRKPMQ
3410 3420 3430 3440 3450
VKTPRALPTM EAHQVIKANA LFLLSLSSAA EPSILCYHPA KPFQSQLPIV
3460 3470 3480 3490 3500
KEGVSEDLPV KMPCLYLQTL ARHHHENFVG YQDDNLFQDE MRYLRSTSVP
3510 3520 3530 3540 3550
APYISVTPDA SPNVFEEPES NMKSMPPSLE TSPITDTDLA KRTVFQRSYS
3560 3570 3580 3590 3600
VVASEYDKQH SILPARVKAI PRRRVNSGDT VGSSLLRHPS PELSRLISAH
3610 3620 3630 3640 3650
SSLSKGERNF QWPVLAFVIQ HHDLEGLEIA MKQALRKSAC RVFAMEAFNW
3660 3670 3680 3690 3700
LLCNVIQTTS LHDILWHFVA ALTPSPVEAE EDEDEDNKSN KENAEQEKDT
3710 3720 3730 3740 3750
RVCEHPLSDI VIAGEAAHPL PHTFHRLLQT ISDLMMSLPS GSSLQQMALR
3760 3770 3780 3790 3800
CWSLKFKQSD HQFLHQSNVF HHINNILSKS DDGDSEESFS ISVQSGFEAM
3810 3820 3830 3840 3850
SQELCIVMCL KDLTSIVDIK TSSRPAMIGS LTDGSTETFW ESGDEDKNKT
3860 3870 3880 3890 3900
KNITINCVKG INARYVSVHV DNSRDLGNKV TSMTFLTGKA VEELCRIKQV
3910 3920 3930 3940 3950
DLDSRHIGWV TSELPGGDNQ IIKIELKGPE NTLRVRQVKV LGWKDGESTK
3960 3970 3980 3990 4000
IAGQISASVA QQRSCEAETL RVFRLITSQV FGKLISGDAE PTPEQEEKAL
4010 4020 4030 4040 4050
LSSPEGEEKA TSDADLKEHM VGIIFSRSKL TNLQKQVCAH IVQAIRMEAT
4060 4070 4080 4090 4100
RVREEWEHAI SSKENANSQP SDEDASSDAY CFELLSMVLA LSGSNVGRQY
4110 4120 4130 4140 4150
LAQQLTLLQD LFSLLHTASP RVQRQVTSLL RRVLPEVTPN RLASIIGVKS
4160 4170 4180 4190 4200
LPPADISDII HSTEKGDWNK LGILDMFLGC IAKALTVQLK AKGTTITGTA
4210 4220 4230 4240 4250
GTTVGKGVTT VTLPMIFNSS YLRRGESHWW MKGSTPTQIS EIIIRLIKDM
4260 4270 4280 4290 4300
AAGHLSEAWS RVTKNAIAET IIALTKMEEE FRSPVRCIAT TRLWLALASL
4310 4320 4330 4340 4350
CVLDQDHVDR LSSGRWMGKD GQQKQMPMCD NHDDGETAAI ILCNICGNLC
4360 4370 4380 4390 4400
TDCDRFLHLH RRTKTHQRQV FKEEEEAIKV DLHEGCGRTK LFWLMALADS
4410 4420 4430 4440 4450
KTMKAMVEFR EHTGKPTTSS SEACRFCGSR SGTELSAVGS VCSDADCQEY
4460 4470 4480 4490 4500
AKIACSKTHP CGHPCGGVRN EEHCLPCLHG CDKSATTLKQ DADDMCMICF
4510 4520 4530 4540 4550
TEALSAAPAI QLDCSHVFHL QCCRRVLENR WLGPRITFGF ISCPICKNKI
4560 4570 4580 4590 4600
NHIVLKDLLD PIKELYEDVR RKALMRLEYE GLHKSEAITT PGVRFYNDAA
4610 4620 4630 4640 4650
GYAMNRYAYY VCYKCRKAYF GGEARCDAEA GQGDDYDPRE LICGACSDVS
4660 4670 4680 4690 4700
RAQMCPKHGT DFLEYKCRYC CSVAVFFCFG TTHFCNACHD DFQRMTSIPK
4710 4720 4730 4740
EELPHCPAGP KGKQLEGTEC PLHVVHPPTG EEFALGCGVC RNAHTF
Length:4,746
Mass (Da):520,855
Last modified:April 5, 2011 - v1
Checksum:i697FFD8B37DEB01E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114410 Genomic DNA. No translation available.
AC114585 Genomic DNA. No translation available.
CT025554 Genomic DNA. No translation available.
RefSeqiNP_997098.2. NM_207215.2.
UniGeneiMm.6478.

Genome annotation databases

EnsembliENSMUST00000159855; ENSMUSP00000124710; ENSMUSG00000033004.
GeneIDi105689.
KEGGimmu:105689.
UCSCiuc007uwl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114410 Genomic DNA. No translation available.
AC114585 Genomic DNA. No translation available.
CT025554 Genomic DNA. No translation available.
RefSeqiNP_997098.2. NM_207215.2.
UniGeneiMm.6478.

3D structure databases

ProteinModelPortaliE9PUJ6.
SMRiE9PUJ6. Positions 1227-1387, 1723-1882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124710.

Proteomic databases

MaxQBiE9PUJ6.
PaxDbiE9PUJ6.
PeptideAtlasiE9PUJ6.
PRIDEiE9PUJ6.

Protocols and materials databases

DNASUi105689.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159855; ENSMUSP00000124710; ENSMUSG00000033004.
GeneIDi105689.
KEGGimmu:105689.
UCSCiuc007uwl.1. mouse.

Organism-specific databases

CTDi23077.
MGIiMGI:2179432. Mycbp2.

Phylogenomic databases

eggNOGiKOG1428. Eukaryota.
ENOG410XP1T. LUCA.
GeneTreeiENSGT00390000011403.
KOiK10693.
OMAiNSRGCPT.
OrthoDBiEOG091G0018.
TreeFamiTF313151.

Miscellaneous databases

ChiTaRSiMycbp2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033004.
ExpressionAtlasiE9PUJ6. baseline and differential.
GenevisibleiE9PUJ6. MM.

Family and domain databases

Gene3Di2.130.10.30. 2 hits.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR017868. Filamin/ABP280_repeat-like.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR012983. PHR.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR003646. SH3-like_bac-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
PF00630. Filamin. 1 hit.
PF08005. PHR. 2 hits.
PF00415. RCC1. 1 hit.
PF08239. SH3_3. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SMARTiSM01337. APC10. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50985. SSF50985. 2 hits.
SSF81296. SSF81296. 2 hits.
PROSITEiPS51284. DOC. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 3 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PUJ6_MOUSE
AccessioniPrimary (citable) accession number: E9PUJ6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.