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Protein
Submitted name:

Active breakpoint cluster region-related protein

Gene

Abr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Active breakpoint cluster region-related proteinImported
Gene namesi
Name:AbrImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107771. Abr.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9PUE7.
PaxDbiE9PUE7.
PeptideAtlasiE9PUE7.
PRIDEiE9PUE7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017631.
ExpressionAtlasiE9PUE7. baseline and differential.
GenevisibleiE9PUE7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091551.

Structurei

3D structure databases

ProteinModelPortaliE9PUE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 238DH (DBL-homology)InterPro annotationAdd BLAST194
Domaini255 – 413PHInterPro annotationAdd BLAST159
Domaini460 – 549C2InterPro annotationAdd BLAST90
Domaini601 – 799Rho-GAPInterPro annotationAdd BLAST199

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
GeneTreeiENSGT00860000133689.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PUE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYIDESPTM SPQLSARSQG GGDSVSPTPP EGLAPGVEAG KGLEMRKLVL
60 70 80 90 100
SGFLASEEIY INQLEALLLP MKPLKATATT SQPVLTIQQI ETIFYKIQDI
110 120 130 140 150
YEIHKEFYDN LCPKVQQWDS QVTMGHLFQK LASQLGVYKA FVDNYKVALE
160 170 180 190 200
TAEKCSQSNN QFQKISEELK VKGPKDSKDS HTSVTMEALL YKPIDRVTRS
210 220 230 240 250
TLVLHDLLKH TPVDHPDYPL LQDALRISQN FLSSINEDID PRRTAVTTPK
260 270 280 290 300
GETRQLVKDG FLVEMSESSR KLRHVFLFTD VLLCAKLKKT SAGKHQQYDC
310 320 330 340 350
KWYIPLADLV FPSPEESEAS PQVHPFPDHE LEDMKTKISA LKSEIQKEKA
360 370 380 390 400
NKGQSRAIER LKKKMFENEF LLLLNSPTIP FRIHNRNGKS YLFLLSSDYE
410 420 430 440 450
RSEWREAIQK LQKKDLQAFV LSSVELQVLT GSCFKLRTVH NIPVTSNKDD
460 470 480 490 500
DESPGLYGFL HVIVHSAKGF KQSANLYCTL EVDSFGYFVS KAKTRVFRDT
510 520 530 540 550
TEPKWDEEFE IELEGSQSLR ILCYEKCYDK TKVNKDNNEI VDKIMGKGQI
560 570 580 590 600
QLDPQTVESK NWHTDVIEMN GIKVEFSMKF TSRDMSLKRT PSKKQTGVFG
610 620 630 640 650
VKISVVTKRE RSKVPYIVRQ CIEEVEKRGI EEVGIYRISG VATDIQALKA
660 670 680 690 700
VFDANNKDIL LMLSDMDINA IAGTLKLYFR ELPEPLLTDR LYPAFMEGIA
710 720 730 740 750
LSDPAAKENC MMHLLRSLPD PNLITFLFLL EHLKRVAEKE PINKMSLHNL
760 770 780 790 800
ATVFGPTLLR PSEVESKAHL TSAADIWSHD VMAQVQVLLY YLQHPPISFA
810
ELKRNTLYFS TDV
Length:813
Mass (Da):92,487
Last modified:April 5, 2011 - v1
Checksum:i299806C1E614D803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591143 Genomic DNA. No translation available.
AL663050 Genomic DNA. No translation available.
RefSeqiNP_942597.1. NM_198894.2.
UniGeneiMm.258939.

Genome annotation databases

EnsembliENSMUST00000108407; ENSMUSP00000104044; ENSMUSG00000017631.
GeneIDi109934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591143 Genomic DNA. No translation available.
AL663050 Genomic DNA. No translation available.
RefSeqiNP_942597.1. NM_198894.2.
UniGeneiMm.258939.

3D structure databases

ProteinModelPortaliE9PUE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091551.

Proteomic databases

MaxQBiE9PUE7.
PaxDbiE9PUE7.
PeptideAtlasiE9PUE7.
PRIDEiE9PUE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108407; ENSMUSP00000104044; ENSMUSG00000017631.
GeneIDi109934.

Organism-specific databases

CTDi29.
MGIiMGI:107771. Abr.

Phylogenomic databases

eggNOGiKOG4269. Eukaryota.
ENOG410XPGZ. LUCA.
GeneTreeiENSGT00860000133689.

Miscellaneous databases

ChiTaRSiAbr. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017631.
ExpressionAtlasiE9PUE7. baseline and differential.
GenevisibleiE9PUE7. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PUE7_MOUSE
AccessioniPrimary (citable) accession number: E9PUE7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.